A structural basis for the antibiotic resistance conferred by an N1-methylation of A1408 in 16S rRNA

Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs

(2014) Juan Pablo Maianti et al.   ACS Chemical Biology

Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA

(2014) J. A. Dunkle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aminoglycoside resistance 16S rRNA methyltransferases block endogenous methylation, affect translation efficiency and fitness of the host

(2014) V. S. Lioy et al.   RNA

Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4′-deoxy-4′-fluoro neomycin analogs

(2014) S. Hanessian et al.   Chemical Science

Crystal Structures of a Bioactive 6′-Hydroxy Variant of Sisomicin Bound to the Bacterial and Protozoal Ribosomal Decoding Sites

(2013) Jiro Kondo et al.   ChemMedChem

Identification of the molecular attributes required for aminoglycoside activity against Leishmania

(2013) M. Shalev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenously acquired 16S rRNA methyltransferases found in aminoglycoside-resistant pathogenic Gram-negative bacteria: An update

(2012) Jun-ichi Wachino et al.   DRUG RESISTANCE UPDATES

Crystal Structure and Specific Binding Mode of Sisomicin to the Bacterial Ribosomal Decoding Site

(2012) Jiro Kondo et al.   ACS Medicinal Chemistry Letters

A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides

(2011) Jiro Kondo   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues

(2011) Janek Szychowski et al.   ChemMedChem

Genetic code translation displays a linear trade-off between efficiency and accuracy of tRNA selection

(2011) M. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: A synergistic hydrophobic effect against resistant bacteria

(2010) Stephen Hanessian et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria

(2010) Rachel Macmaster et al.   NUCLEIC ACIDS RESEARCH

Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit

(2010) Nilofer Husain et al.   NUCLEIC ACIDS RESEARCH

The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates

(2008) Jiro Kondo et al.   NUCLEIC ACIDS RESEARCH

Designer aminoglycosides: the race to develop improved antibiotics and compounds for the treatment of human genetic diseases

(2007) Mariana Hainrichson et al.   ORGANIC & BIOMOLECULAR CHEMISTRY