eIF5A facilitates translation termination globally and promotes the elongation of many non polyproline-specific tripeptide sequences

eIF5A Functions Globally in Translation Elongation and Termination

(2017) Anthony P. Schuller et al.   MOLECULAR CELL

Targeting the polyamine-hypusine circuit for the prevention and treatment of cancer

(2016) Shima Nakanishi et al.   AMINO ACIDS

Adjacent Codons Act in Concert to Modulate Translation Efficiency in Yeast

(2016) Caitlin E. Gamble et al.   CELL

Genome-wide quantification of 5′-phosphorylated mRNA degradation intermediates for analysis of ribosome dynamics

(2016) Vicent Pelechano et al.   Nature Protocols

Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center

(2016) James Marks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global quantitative proteomics reveal up-regulation of endoplasmic reticulum stress response proteins upon depletion of eIF5A in HeLa cells

(2016) Ajeet Mandal et al.   Scientific Reports

Msb2 is a Ste11 membrane concentrator required for full activation of the HOG pathway

(2015) Aurora Zuzuarregui et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The translation factor eIF5A and human cancer

(2015) Michael B. Mathews et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Widespread Co-translational RNA Decay Reveals Ribosome Dynamics

(2015) Vicent Pelechano et al.   CELL

Eukaryotic Translation Initiation Factor 5A (EIF5A) Regulates Pancreatic Cancer Metastasis by Modulating RhoA and Rho-associated Kinase (ROCK) Protein Expression Levels

(2015) Ken Fujimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Entropic Contribution of Elongation Factor P to Proline Positioning at the Catalytic Center of the Ribosome

(2015) Lili K. Doerfel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stall no more at polyproline stretches with the translation elongation factors EF-P and IF-5A

(2015) Jürgen Lassak et al.   MOLECULAR MICROBIOLOGY

Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome

(2015) Christian Schmidt et al.   NUCLEIC ACIDS RESEARCH

High-Precision Analysis of Translational Pausing by Ribosome Profiling in Bacteria Lacking EFP

(2015) Christopher J. Woolstenhulme et al.   Cell Reports

Dom34 Rescues Ribosomes in 3′ Untranslated Regions

(2014) Nicholas R. Guydosh et al.   CELL

The hypusine-containing translation factor eIF5A

(2014) Thomas E. Dever et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Fertility and Polarized Cell Growth Depends on eIF5A for Translation of Polyproline-Rich Formins in Saccharomyces cerevisiae

(2014) Tianlu Li et al.   GENETICS

Accounting for biases in riboprofiling data indicates a major role for proline in stalling translation

(2014) Carlo G. Artieri et al.   GENOME RESEARCH

Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site

(2014) Agata L. Starosta et al.   NUCLEIC ACIDS RESEARCH

Genome-Wide Analyses and Functional Classification of Proline Repeat-Rich Proteins: Potential Role of eIF5A in Eukaryotic Evolution

(2014) Ajeet Mandal et al.   PLoS One

The general mode of translation inhibition by macrolide antibiotics

(2014) Krishna Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EF-P Dependent Pauses Integrate Proximal and Distal Signals during Translation

(2014) Sara Elgamal et al.   PLoS Genetics

eIF5A has a function in the cotranslational translocation of proteins into the ER

(2013) Danuza Rossi et al.   AMINO ACIDS

Arrest Peptides:Cis-Acting Modulators of Translation

(2013) Koreaki Ito et al.   Annual Review of Biochemistry

Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation

(2013) Elisabeth Mémin et al.   CANCER RESEARCH

Rate-Limiting Steps in Yeast Protein Translation

(2013) Premal Shah et al.   CELL

eIF5A Promotes Translation of Polyproline Motifs

(2013) Erik Gutierrez et al.   MOLECULAR CELL

Proline: The Distribution, Frequency, Positioning, and Common Functional Roles of Proline and Polyproline Sequences in the Human Proteome

(2013) Alexander A. Morgan et al.   PLoS One

Nonsense-Mediated mRNA Decay Controls the Changes in Yeast Ribosomal Protein Pre-mRNAs Levels upon Osmotic Stress

(2013) Elena Garre et al.   PLoS One

Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P

(2013) L. Peil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nascent peptides that block protein synthesis in bacteria

(2013) C. J. Woolstenhulme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positively Charged Residues Are the Major Determinants of Ribosomal Velocity

(2013) Catherine A. Charneski et al.   PLOS BIOLOGY

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

eIF5A isoforms and cancer: two brothers for two functions?

(2011) M. Caraglia et al.   AMINO ACIDS

Yeast mRNA cap-binding protein Cbc1/Sto1 is necessary for the rapid reprogramming of translation after hyperosmotic shock

(2011) Elena Garre et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

(2011) Zhijian Li et al.   NATURE BIOTECHNOLOGY

Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae

(2011) A. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pH-sensitivity of the ribosomal peptidyl transfer reaction dependent on the identity of the A-site aminoacyl-tRNA

(2010) M. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional significance of eIF5A and its hypusine modification in eukaryotes

(2009) M. H. Park et al.   AMINO ACIDS

TheDrosophiladeoxyhypusine hydroxylase homologueneroand its target eIF5A are required for cell growth and the regulation of autophagy

(2009) Prajal H. Patel et al.   JOURNAL OF CELL BIOLOGY

Hypusine-containing protein eIF5A promotes translation elongation

(2009) Preeti Saini et al.   NATURE

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Modulation of the Rate of Peptidyl Transfer on the Ribosome by the Nature of Substrates

(2008) Ingo Wohlgemuth et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electrostatics in the Ribosomal Tunnel Modulate Chain Elongation Rates

(2008) Jianli Lu et al.   JOURNAL OF MOLECULAR BIOLOGY

Slow peptide bond formation by proline and other N-alkylamino acids in translation

(2008) M. Y. Pavlov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA