Article
Clinical Neurology
James R. Janopaul-Naylor, Manali Rupji, Jim Zhong, Bree R. Eaton, Naba Ali, Adriana G. Ioachimescu, Nelson M. Oyesiku, Hui-Kuo G. Shu
Summary: Modern LINAC RT is safe and effective for hormonal control and LC in patients with PAs. There was an increase in the proportion of patients requiring pituitary hormone replacement after RT.
WORLD NEUROSURGERY
(2022)
Article
Endocrinology & Metabolism
Cristina Lamas, Rosa Camara, Carmen Fajardo, Pablo Remon-Ruiz, Betina Biagetti, Fernando Guerrero-Perez, Marta Araujo-Castro, Mireia Mora, Felicia Hanzu, Pedro Iglesias, Rogelio Garcia-Centeno, Alfonso Soto
Summary: In this retrospective study, temozolomide was found to be an effective medical treatment for aggressive pituitary neuroendocrine tumors and pituitary carcinomas, but may sometimes lead to tumor progression. Co-administration with radiotherapy may increase progression-free survival.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Pablo Remon-Ruiz, Eva Venegas-Moreno, Elena Dios-Fuentes, Juan Manuel Canelo Moreno, Ignacio Fernandez Pena, Miriam Alonso Garcia, Miguel Angel Japon-Rodriguez, Florinda Roldan, Elena Fajardo, Ariel Kaen, Eugenio Cardenas Ruiz-Valdepenas, David Cano, Alfonso Soto-Moreno
Summary: Imaging and pathology evaluation may not accurately predict the aggressiveness of pituitary tumors, but histological examination can provide useful information. Our case report highlights the importance of suspicion for malignancy in pituitary tumors with aggressive features and the need for multidisciplinary team follow-up to manage potential metastases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Yijun Cheng, Hao Tang, Zhe Bao Wu
Summary: Glomus tumor is a rare mesenchymal tumor with an organ-like structure. Sellar glomus tumors are extremely rare and can be easily misdiagnosed as other sellar tumors. This study reported a case of a 69-year-old male with hypopituitarism who was initially misdiagnosed as a non-functional pituitary adenoma.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yi Fang, He Wang, Ming Feng, Wentai Zhang, Lei Cao, Chenyu Ding, Hongjie Chen, Liangfeng Wei, Shuwen Mu, Zhijie Pei, Jun Li, Heng Zhang, Renzhi Wang, Shousen Wang
Summary: Accurate predictive models for hormonal prognosis in NFPA were lacking. Machine learning models were developed to assess pituitary hormonal outcomes post-surgery, showing significant changes in hormone levels and the effectiveness of ML in predicting outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Clinical Neurology
Diana C. Lopez, Joao Paulo Almeida, Arbaz A. Momin, Erion Junior de Andrade, Pranay Soni, Divya Yogi-Morren, Varun R. Kshettry, Pablo F. Recinos
Summary: This study aims to evaluate the postoperative fluid and sodium balance after endoscopic endonasal craniopharyngioma resection, and to compare the triphasic response, time to diabetes insipidus (DI), and time to antidiuretic hormone (ADH) replacement therapy based on the status of infundibular transection.
JOURNAL OF NEUROSURGERY
(2022)
Review
Oncology
Jordan Bouter, Yves Reznik, Juliette Thariat
Summary: The effects of radiation on the hypothalamic-pituitary axis have been studied for a long time, but many unknowns still exist. The rate and time of onset of deficit, the radiation dose that can cause damage, and the comparison of different radiation techniques are still not clear. Neuroendocrine impairment after radiotherapy is diverse, with new deficiencies occurring in 40% of patients within a median follow-up of 5.6 years. The sensitivity of different pituitary axes to radiation varies, with the growth hormone axis being the most sensitive and the thyroid hormone axis being the least sensitive.
Review
Endocrinology & Metabolism
David S. McLaren, Aarani Devi, Nikolaos Kyriakakis, Michelle Kwok-Williams, Robert D. Murray
Summary: Multimodality cancer therapy has greatly improved survival rates of childhood and young adult cancer, but it also comes with its own adverse effects. Among them, radiation-related adverse effects are the most prevalent. Advances in radiotherapy techniques, such as intensity-modulated radiotherapy and proton beam therapy, have been developed to reduce the dose and volume of normal tissue irradiated. Theoretical benefits of these newer techniques include a lower prevalence of hypopituitarism. However, there is currently limited clinical data to confirm these theoretical benefits.
ENDOCRINE CONNECTIONS
(2023)
Article
Multidisciplinary Sciences
Angelica Gualtieri, Nikolina Kyprianou, Louise C. Gregory, Maria Lillina Vignola, James G. Nicholson, Rachael Tan, Shin-ichi Inoue, Valeria Scagliotti, Pedro Casado, James Blackburn, Fernando Abollo-Jimenez, Eugenia Marinelli, Rachael E. J. Besser, Wolfgang Hoegler, I. Karen Temple, Justin H. Davies, Andrey Gagunashvili, Iain C. A. F. Robinson, Sally A. Camper, Shannon W. Davis, Pedro R. Cutillas, Evelien F. Gevers, Yoko Aoki, Mehul T. Dattani, Carles Gaston-Massuet
Summary: Mutations in BRAF and other components of the MAP kinase pathway are associated with RASopathies, leading to congenital syndromes such as Septo-Optic Dysplasia and Cardio-Facio-Cutaneous syndrome. The gain-of-function mutations in BRAF are shown to play a critical role in the development of the hypothalamo-pituitary axis, resulting in endocrine deficiencies in patients with RASopathies.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
I. M. A. A. van Roessel, J. van Schaik, A. Y. N. Schouten-van Meeteren, A. M. Boot, H. L. Claahsen-van der Grinten, S. C. Clement, L. van Iersel, K. S. Han, A. S. P. van Trotsenburg, W. P. Vandertop, L. C. M. Kremer, H. M. van Santen
Summary: This study examines the association between BMI at diagnosis of childhood brain tumor and hypothalamic-pituitary (HP) dysfunction at diagnosis or during follow-up in a Dutch cohort of 685 CBTS. The results suggest that overweight or obesity at diagnosis is not associated with pituitary deficiencies, indicating that genetics and lifestyle may play a more important role than hypothalamic dysfunction in higher BMI at diagnosis in these children.
SUPPORTIVE CARE IN CANCER
(2022)
Review
Medicine, General & Internal
Valentina Puglisi, Elisabetta Morini, Fiammetta Biasini, Luisa Vinciguerra, Giuseppe Lanza, Placido Bramanti
Summary: This is a case report on giant pituitary tumor apoplexy, presenting a rare case of an 81-year-old female with this condition. The authors highlight the importance of prompt diagnosis and multidisciplinary management in achieving significant improvement in symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Gabriele Molteni, Nicole Caiazza, Gianfranco Fulco, Andrea Sacchetto, Antonio Gulino, Daniele Marchioni
Summary: This study analyzed the pituitary endocrine secretion after endoscopic endonasal approach (EEA) for pituitary neuroendocrine tumors, aiming to identify potential predictors of functioning gland recovery. The results showed that younger patients and those with functioning tumors were more likely to completely recover pituitary hormonal function. This study is of great importance for preserving pituitary function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dario De Alcubierre, Giulia Puliani, Alessia Cozzolino, Valeria Hasenmajer, Marianna Minnetti, Valentina Sada, Valentina Martines, Antonella Zaccagnino, Andrea Gennaro Ruggeri, Riccardo Pofi, Emilia Sbardella, Mary Anna Venneri
Summary: The study aimed to evaluate the impact of tumor consistency on postoperative pituitary function. The results showed that compared to fibrous consistency, other tumor types were more likely to cause postoperative hormone deficiencies and had lower resection rates. These findings provide guidance for preoperative surgical planning.
BMC ENDOCRINE DISORDERS
(2023)
Review
Endocrinology & Metabolism
Ugur Ture, Annamaria De Bellis, Mehmet Volkan Harput, Giuseppe Bellastella, Melih Topcuoglu, Cumhur Kaan Yaltirik, Paolo Cirillo, Rima Nur Yola, Aydin Sav, Fahrettin Kelestimur
Summary: The case study describes a 35-year-old female with autoimmune hypothalitis, presenting with central diabetes insipidus, partial empty sella, hypopituitarism, and hyperprolactinemia. Immunohistochemical examination of the surgically removed suprasellar mass confirmed autoimmune involvement, with the presence of antihypothalamus antibodies and high AVPcAb titers, suggesting isolated hypothalamitis. This observation suggests hypothalamitis as a new isolated autoimmune disease involving the hypothalamus, with potential consequences such as lymphocytic infundibuloneurohypophysitis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Review
Endocrinology & Metabolism
Athanasios Fountas, Aikaterini Lavrentaki, Anuradhaa Subramanian, Konstantinos A. Toulis, Krishnarajah Nirantharakumar, Niki Karavitaki
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Endocrinology & Metabolism
Friso de Vries, Mees Bruin, Daniel J. Lobatto, Olaf M. Dekkers, Jan W. Schoones, Wouter R. van Furth, Alberto M. Pereira, Niki Karavitaki, Nienke R. Biermasz, Amir H. Zamanipoor Najafabadi
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2020)
Review
Endocrinology & Metabolism
Krystallenia Alexandraki, Gregory A. Kaltsas, Niki Karavitaki, Ashley B. Grossman
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2019)
Review
Endocrinology & Metabolism
P. Souteiro, N. Karavitaki
Review
Medicine, General & Internal
Irene Samperi, Kirstie Lithgow, Niki Karavitaki
JOURNAL OF CLINICAL MEDICINE
(2019)
Article
Endocrinology & Metabolism
Maria Fleseriu, Olaf M. Dekkers, Niki Karavitaki
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Monica R. Gadelha, Niki Karavitaki, Jeffrey Fudin, Jeffrey J. Bettinger, Hershel Raff, Anat Ben-Shlomo
Summary: Opioids have a significant impact on hypothalamic-pituitary axes, potentially leading to various endocrine abnormalities. However, these clinical manifestations are often underestimated and poorly managed. There is a lack of comprehensive research on biochemical testing and treatment strategies for these opioid-induced endocrine effects.
Review
Medicine, General & Internal
Ross Hamblin, Georgios Tsermoulas, Niki Karavitaki
Summary: Craniopharyngiomas are rare epithelial tumors with unpredictable growth patterns and proximity to vital structures, posing significant threats. Research on genetic pathogenesis may lead to targeted medical therapy. Current primary treatments include surgery and radiotherapy, with long-term management requiring a multidisciplinary team.
Review
Endocrinology & Metabolism
Ross Hamblin, Amy Coulden, Athanasios Fountas, Niki Karavitaki
Summary: Endogenous Cushing's syndrome (CS) is rarely encountered during pregnancy and the diagnosis is challenging. Conclusive recommendations or a standardized management approach for all patients with CS in pregnancy cannot be made due to the lack of comprehensive literature. Management decisions, including surgery, medical control, or conservative approach, should be highly individualized and consider various factors such as stage of gestation, tumor localization, severity of CS, maternal comorbidity, and patient choice.
JOURNAL OF NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Amy Coulden, Ross Hamblin, John Wass, Niki Karavitaki
Summary: Exposure to excess cortisol in Cushing's disease results in increased cardiovascular morbidity and reduces survival. Timely diagnosis and successful management of the condition are of great importance to prevent cardiovascular complications.
Article
Endocrinology & Metabolism
Ross Hamblin, Athanasios Fountas, Miles Levy, Niki Karavitaki
Summary: The optimal management approach for presumed non-functioning pituitary microadenomas (microNFPAs) remains unclear. Two surveys conducted in 2009-2010 and 2021-2022 captured current UK practice and identified changes over time. The surveys showed that diagnostic and management approaches for microNFPAs have evolved, with more adherence to consensus guidelines for biochemical investigations. However, there is still variability in the frequency and duration of imaging intervals until discharge. Further research on the long-term natural history of microNFPAs is necessary to unify clinician approach.
Article
Endocrinology & Metabolism
Sandrine A. Urwyler, Niki Karavitaki
Summary: A small subset of lactotroph adenomas exhibit resistance to dopamine agonists and can show aggressive or malignant behavior, with unclear mechanisms. Management of these cases is challenging and requires a multidisciplinary approach. Options include switching to alternative dopamine agonists, surgery, radiotherapy, temozolomide, and immune checkpoint inhibitors, while the efficacy of other treatments needs further assessment.
Article
Endocrinology & Metabolism
Sunil Aggarwal, Alessandro Prete, Vasileios Chortis, Miriam Asia, Robert P. Sutcliffe, Wiebke Arlt, Cristina L. Ronchi, Niki Karavitaki, John Ayuk, Yasir S. Elhassan
Summary: This study aimed to assess the proportion and characteristics of incidentally detected pheochromocytomas. The majority of pheochromocytomas are diagnosed incidentally and have distinct clinical, radiological, biochemical, and genetic features. These tumors are detected at older age but smaller size, which may indicate a different underlying tumor biology.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Athanasios Fountas, Niki Karavitaki
Summary: Nelson's syndrome is a severe condition that can develop in patients with Cushing's disease after bilateral adrenalectomy. Medical therapy has not been consistently proven effective, and individualized treatment approaches are necessary.
MEDICINA-LITHUANIA
(2022)
Article
Endocrinology & Metabolism
Usama Kanj, Sam Sum Lee, Milanka Wattegama, Swarupsinh Chavda, Niki Karavitaki, Ruchika Batra
Summary: This case report presents a 21-year-old male patient with a giant prolactinoma causing hypogonadotropic hypogonadism. The patient's vision improved to normal after treatment, highlighting the importance of frequent monitoring of visual function during the follow-up of pituitary adenomas.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
