Article
Biochemistry & Molecular Biology
Marilena Marraudino, Giovanna Ponti, Chantal Moussu, Alice Farinetti, Elisabetta Macchi, Paolo Accornero, Stefano Gotti, Paloma Collado, Matthieu Keller, Giancarlo Panzica
Summary: The study found that early exposure of mice to the phytoestrogen genistein can lead to long-term sex-specific organizational effects, impairing the reproductive system and causing an obesogenic effect only in females. This is likely due to alterations in neuroendocrine circuits controlling metabolism.
Review
Endocrinology & Metabolism
Kelsey R. Pool, Faustine Chazal, Jeremy T. Smith, Dominique Blache
Summary: Phytoestrogens have an impact on reproductive health and can influence reproductive capacity in various species. Our understanding of the mechanisms linking phytoestrogens and compromised reproduction in sheep is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Raquel Chamorro-Garcia, Nathalie Poupin, Marie Tremblay-Franco, Cecile Canlet, Riann Egusquiza, Roselyne Gautier, Isabelle Jouanin, Bassem M. Shoucri, Bruce Blumberg, Daniel Zalko
Summary: Metabolomics confirmed transgenerational obesogenic effects of environmentally relevant doses of TBT in male mice, while also showing impaired liver biotransformation capacity in females. This study demonstrates the transgenerational effects of EDC exposure and highlights the potential use of metabolomic fingerprints in identifying individuals susceptible to adverse health effects from ancestral exposure to obesogens.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Yuyang Wang, Hong-Sheng Wang
Summary: The study found that the impact of BPA on the pulsing rate of L. variegatus is likely mediated by an estrogenic mechanism instead of general toxicity. L. variegatus exhibits exceptionally high sensitivity to certain estrogens, making it a possible tool for estrogenic EDC screening.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Vanessa Delfosse, Tiphaine Huet, Deborah Harrus, Meritxell Granell, Maxime Bourguet, Caroline Gardia-Parege, Barbara Chiavarina, Marina Grimaldi, Sebastien Le Mevel, Pauline Blanc, David Huang, Jakub Gruszczyk, Barbara Demeneix, Sarah Cianferani, Jean-Baptiste Fini, Patrick Balaguer, William Bourguet
Summary: Humans are consistently exposed to mixtures of endocrine-disrupting chemicals which have been linked to various health issues. Recent data shows that the outcomes of using these chemicals in combination are unpredictable. Research has identified mechanisms for enhanced binding affinity and discovered active mixtures with synergistic effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Environmental
Keishi Ishida, Motoshi Furukawa, Masataka Kunitani, Rai Yamagiwa, Youhei Hiromori, Daisuke Matsumaru, Jianying Hu, Hisamitsu Nagase, Tsuyoshi Nakanishi
Summary: We developed a new short-term screening test using in vivo bioluminescence imaging to detect chemicals with estrogen-like effects. Our method is more sensitive and requires less time compared to traditional in vivo screening methods. Our results showed that our method could detect the estrogenic effects of BPA at doses below tolerable daily intakes, which traditional screening methods could not. Our study demonstrates that in vivo bioluminescence imaging is a highly effective tool for screening estrogenic chemicals and resolving the controversy about low-dose effects of endocrine-disrupting chemicals.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biology
Kang-Ying Qian, Wan-Xin Zeng, Yue Hao, Xian-Ting Zeng, Haowen Liu, Lei Li, Lili Chen, Fu-min Tian, Cindy Chang, Qi Hall, Chun-Xue Song, Shangbang Gao, Zhitao Hu, Joshua M. Kaplan, Qian Li, Xia-Jing Tong
Summary: The presence of a male environment in Caenorhabditis elegans increases cholinergic transmission in hermaphrodites, altering their locomotion velocity and mating efficiency. Sensory circuits mediating the perception of male pheromones can modulate synaptic transmission efficacy, ultimately impacting behavioral flexibility.
Article
Veterinary Sciences
Maurilio Lara-Flores, Jaime Rendon von Osten
Summary: The study demonstrated significant changes in the expression of vitellogenin and estrogen receptors in Japanese turtles exposed to petroleum hydrocarbons, with a notable increase in expression in male turtles exposed to oil spill.
VETERINARY RESEARCH FORUM
(2021)
Article
Chemistry, Multidisciplinary
Michael D. Garrison, Perrin J. Storch, William S. Eck, Valerie H. Adams, Patrick W. Fedick, Benjamin G. Harvey
Summary: This study evaluated the estrogenic activity of nine bio-based tris/bisphenols and synthesized bio-based polycarbonates with a wide range of glass transition temperatures and high thermal stabilities. The non-estrogenic properties of some compounds coupled with the good thermal properties of the bio-based polycarbonates make them sustainable, lower toxicity alternatives for BPA-based polycarbonates.
Article
Cell Biology
B. O. Jeminiwa, R. C. Knight, K. L. Abbot, S. R. Pondugula, B. T. Akingbemi
Summary: Environmental chemicals can disrupt the endocrine axis and are classified as endocrine disrupting chemicals. Some commonly used consumer product chemicals (such as Bisphenol S and 17 alpha-ethinyl estradiol) may have adverse effects on the population. In animal models, exposure to individual chemicals or combinations of multiple chemicals can lead to disturbances in sex steroid secretion.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Radwa Almamoun, Paula Pierozan, Lokeshwaran Manoharan, Oskar Karlsson
Summary: This study investigates the impact of di-n-butyl phthalate (DBP) on the gut microbiome and its correlation with immune system changes. DBP exposure significantly alters the composition of the gut microbial community, with increased abundances of Desulfovibrio and Enterorhabdus genera. Moreover, the abundance of certain microbial taxa correlates with the increase in non-classical monocytes observed in DBP-treated animals.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Laura Maria Daian, Gabriela Tanko, Andrei Mircea Vacaru, Luiza Ghila, Simona Chera, Ana-Maria Vacaru
Summary: Diabetes, affecting nearly half a billion people worldwide, is linked to dysfunction of beta-cells. Exposure to endocrine-disrupting chemicals, such as bisphenol A (BPA), has been correlated with increased diabetes incidence. This study explores the activation of unfolded protein response (UPR) pathways in beta-cells under BPA treatment and the potential recovery of endoplasmic reticulum (ER) homeostasis. The findings suggest that modulators of UPR, like the chemical chaperone TUDCA, could be used as therapeutic interventions to restore beta-cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Michiel A. van den Dries, Kelly K. Ferguson, Alexander P. Keil, Anjoeka Pronk, Suzanne Spaan, Akhgar Ghassabian, Susana Santos, Vincent W. V. Jaddoe, Leonardo Trasande, Henning Tiemeier, Monica Guxens
Summary: Prenatal exposure to nonpersistent chemical mixtures is associated with lower nonverbal IQ in children, but not emotional and behavioral problems. This exposure is universal and may impact neurodevelopment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Alana L. Rister, Ciro M. Amato, Tara Nash, Michael W. McCoy, Michael Bereman, Krista A. McCoy
Summary: The study found that dams have more detoxification pathways in response to EDCs and both dams and fetuses show changes in steroid levels under the guidance of detoxification proteins. Female fetuses enhance xenobiotic metabolism pathways while male fetuses increase oxidative phosphorylation pathways.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Marine & Freshwater Biology
Kaiqi Lai, Libin Zhang, Jialei Xu
Summary: In this study, metabolomics was used to investigate the metabolic response of sea cucumber exposed to BPAF, a type of bisphenol analogue. The results showed changes in lipid metabolism, glycerophospholipid metabolism, and amino acid synthesis following BPAF treatment. Sea cucumbers upregulated glycerophospholipid metabolism to repair intestinal cellular homeostasis destruction. Six metabolites were identified as potential biomarkers for BPAF exposure. This study provides theoretical support for assessing the risk of bisphenol analogues on economically important echinoderms such as A. japonicus.
AQUATIC TOXICOLOGY
(2023)
Article
Toxicology
Louise Ramhoj, Terje Svingen, Caroline Fraedrich, Eddy Rijntjes, Eva K. Wirth, Katrine Pedersen, Josef Koehrle, Marta Axelstad
Summary: Disruption of thyroid hormone system during development can cause irreversible damage to brain development. This study found that TPO-inhibitors like methimazole and amitrole can induce similar effects on brain development in rats, driven by T4 deficiency.
TOXICOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Louise Ramhoj, Karen Mandrup, Ulla Hass, Terje Svingen, Marta Axelstad
Summary: Developmental exposure to DE-71 affects reproductive toxicity, potentially through anti-androgenic, anti-estrogenic, and perhaps estrogenic mechanisms, causing endocrine disrupting effects and raising concerns for potential long-term consequences on human reproductive health.
Article
Environmental Sciences
Nichlas Davidsen, Louise Ramhoj, Claus Asger Lykkebo, Indusha Kugathas, Rikke Poulsen, Anna Kjerstine Rosenmai, Bertrand Evrard, Thomas A. Darde, Marta Axelstad, Martin Iain Bahl, Martin Hansen, Frederic Chalmel, Tine Rask Licht, Terje Svingen
Summary: Perfluorooctanesulfonic acid (PFOS) is a persistent chemical that can disrupt the thyroid hormone system in humans and animals through various mechanisms. In this study, exposure to PFOS resulted in a decrease in thyroid hormone levels and altered gene expression in the hypothalamus, pituitary, thyroid, and liver. The gut microbiota did not significantly affect the effects of PFOS exposure. These findings suggest that PFOS exposure may affect TH metabolism and transport, but the pituitary or thyroid gland may not be directly involved.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Terje Svingen, Camilla Lindgren Schwartz, Anna Kjerstine Rosenmai, Louise Ramhoj, Hanna Katarina Lilith Johansson, Ulla Hass, Monica Kam Draskau, Nichlas Davidsen, Sofie Christiansen, Anne-Sofie Ravn Ballegaard, Marta Axelstad
Summary: Endocrine disrupting chemicals (EDCs) are widespread in the environment and pose risks to humans and wildlife. Identifying them based on current guidelines and frameworks is challenging. Understanding the molecular pathways involved in normal development and function is crucial for determining disease causes, but predicting endocrine-related diseases in animals using non-animal test data is still difficult. It is important to focus on studying the mechanisms of EDC-induced adverse health effects to develop reliable non-animal testing strategies and reduce animal experiments in 21st-century chemical testing.
ENVIRONMENTAL POLLUTION
(2022)
Article
Reproductive Biology
Klara Matouskova, Gillian K. Szabo, Jessica Daum, Suzanne E. Fenton, Sofie Christiansen, Ana M. Soto, Jennifer E. Kay, Bethsaida Cardona, Laura N. Vandenberg
Summary: Research suggests that exposure to hormonally active chemicals during sensitive windows of development can impact mammary gland development, function, and disease risk. Stronger links between environmental pollutants and breast health disruptions continue to be found in human populations. This article provides technical guidance on collecting and evaluating the mammary gland in mice and rats, including methods for sample collection and analysis. The authors argue that the mammary gland should be considered in chemical safety assessments and recommend improved measures for evaluating mammary gland outcomes.
REPRODUCTIVE TOXICOLOGY
(2022)
Review
Environmental Sciences
Vicente Mustieles, Ria K. Balogh, Marta Axelstad, Parisa Montazeri, Sandra Marquez, Martine Vrijheid, Monica K. Draskau, Camilla Taxvig, Francisco M. Peinado, Tamar Berman, Hanne Frederiksen, Mariana F. Fernandez, Anne Marie Vinggaard, Anna-Maria Andersson
Summary: This study comprehensively evaluated the safety issues of BP-3 and BP-1 in the human body and found that they have endocrine disrupting properties. HBM studies showed that North Americans have potential exposure levels 10 to 20 times higher than Europeans and Asians. Therefore, it is recommended to use commercially available sunscreens with inorganic UV filters for susceptible populations.
ENVIRONMENT INTERNATIONAL
(2023)
Correction
Environmental Sciences
Nichlas Davidsen, Louise Ramhoj, Claus Asger Lykkebo, Indusha Kugathas, Rikke Poulsen, Anna Kjerstine Rosenmai, Bertrand Evrard, Thomas A. Darde, Marta Axelstad, Martin Iain Bahl, Martin Hansen, Frederic Chalmel, Tine Rask Licht, Terje Svingen
ENVIRONMENTAL POLLUTION
(2023)
Article
Toxicology
Julie Boberg, Hanna K. L. Johansson, Delphine Franssen, Monica Kam Draskau, Sofie Christiansen, Johannah Cramer, Mikael Pedersen, Anne-Simone Parent, Terje Svingen
Summary: Inhibiting androgen signaling during critical stages of ovary development may disrupt folliculogenesis and impact reproductive function. Developmental exposure to anti-androgenic chemicals, such as pesticides, can alter hormone profiles and gene expression in female rats, potentially leading to impaired follicle growth. Integrating data from multiple endocrine axes is crucial for investigating the effects of endocrine disruptors on female reproductive development and function.
TOXICOLOGY LETTERS
(2023)
Article
Endocrinology & Metabolism
Delphine Franssen, Hanna K. L. Johansson, David Lopez-Rodriguez, Arnaud Lavergne, Quentin Terwagne, Julie Boberg, Sofie Christiansen, Terje Svingen, Anne-Simone Parent
Summary: This study found that estrogenic endocrine disrupting chemicals such as diethylstilbestrol (DES) and ketoconazole (KTZ) can affect the hypothalamic transcriptome and gonadotropin-releasing hormone (GnRH) release in female rats before puberty. However, exposure during puberty or adulthood had no effect on GnRH release. The study also identified specific signaling pathways that were significantly affected by these chemicals, suggesting their potential negative impact on reproductive health.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Legal
Louise Ramhoj, Romain Guyot, Terje Svingen, Andreas Kortenkamp, Frederic Flamant, Marta Axelstad
Summary: In rats, hypothyroidism during fetal and neonatal development can lead to periventricular heterotopia formation in the brain. This study investigated whether this also occurs in mice and if it could be used as a toxicological endpoint for assessing thyroid hormone (TH) disrupting chemicals. Severe hypothyroidism was induced in pregnant mice using propylthiouracil (PTU), and although small heterotopia were observed in some offspring, their limited size makes them unsuitable for studying TH-mediated developmental neurotoxicity. However, decreased parvalbumin expression in the cortex of hypothyroid mice suggests an effect on brain development.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Reproductive Biology
Tianyi Li, Julie Boberg, Hanna K. L. Johansson, Valentina Di Nisio, Sofie Christiansen, Terje Svingen, Pauliina Damdimopoulou
Summary: Female reproductive toxicity assessments currently rely on labor-intensive and costly histological evaluation of ovaries. However, an alternative method based on quantification of antral follicles and corpora lutea using ovarian surface photographs, known as 'surface photo counting' (SPC), has been developed and validated in this study.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Endocrinology & Metabolism
Julie Boberg, Tianyi Li, Sofie Christiansen, Monica K. Draskau, Pauliina Damdimopoulou, Terje Svingen, Hanna K. L. Johansson
Summary: A prevailing challenge in testing chemical substances for their potential to cause female reproductive toxicity is the lack of suitable toxicological test methods. This study suggests that starting a 28-day experiment at weaning and including assessment of vaginal opening can increase the sensitivity to detect endocrine disruptors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Toxicology
Louise Ramhoj, Marta Axelstad, Yoni Baert, Ana I. Canas-Portilla, Frederic Chalmel, Lars Dahmen, Antonio De La Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, Kim Heikamp, Henrik Holbech, Patricia Iglesias-Hernandez, Dries Knapen, Lorna Marchandise, Jane E. Morthorst, Nikolai Georgiev Nikolov, Ana C. V. E. Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schueuermann, Evelyn Stinckens, Mette H. Stub, Monica Torres-Ruiz, Majorie Van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen
Summary: Current test strategies for identifying thyroid hormone (TH) system disruptors are insufficient for robust chemical risk assessment, and alternative test methods are needed to infer a causal relationship between initial chemical disruption and adverse outcomes. This project aims to develop specific new approaches to TH system disruption by characterizing in vivo mechanisms of action and incorporating non-mammalian vertebrate test species alongside traditional laboratory rat species and human-derived in vitro assays.
FRONTIERS IN TOXICOLOGY
(2023)
Article
Toxicology
Emilie Bak Pedersen, Sofie Christiansen, Terje Svingen
Summary: In this study, a Key Event Relationship (KER) linking androgen receptor antagonism and increased areola/nipple retention was developed. A literature review was conducted to support a causal relationship between androgen receptor (AR) antagonism and nipple retention in male rats.
CURRENT RESEARCH IN TOXICOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Jennifer E. Kay, Bethsaida Cardona, Ruthann A. Rudel, Laura N. Vandenberg, Ana M. Soto, Sofie Christiansen, Linda S. Birnbaum, Suzanne E. Fenton
Summary: Population studies have shown worrying trends in breast development, breastfeeding difficulties, and increased breast cancer rates in young women. Chemical exposures have been linked to these outcomes, with endocrine-disrupting chemicals often disrupting hormonal regulation. Current toxicological approaches are inadequate in detecting these effects, hindering our ability to identify harmful exposures to the breast and prevent them.
CURRENT ENVIRONMENTAL HEALTH REPORTS
(2022)