Article
Neurosciences
Simona Schiavi, Po-Jui Lu, Matthias Weigel, Antoine Lutti, Derek K. Jones, Ludwig Kappos, Cristina Granziera, Alessandro Daducci
Summary: This study introduces a new method called myelin streamline decomposition (MySD), which extends convex optimization modeling to microstructure informed tractography (COMMIT), allowing the deconvolution of the actual value measured by a microstructural map on each individual streamline to recover unique bundle specific myelin fractions (BMFs).
Article
Neurosciences
Kurt G. Schilling, Chantal M. W. Tax, Francois Rheault, Bennett A. Landman, Adam W. Anderson, Maxime Descoteaux, Laurent Petit
Summary: Characterizing and understanding the limitations of diffusion MRI fiber tractography is crucial for accurately mapping human brain connections. The study aims to quantify bottleneck regions in white matter, finding that over 50-70% of fixels in the brain exhibit bottlenecks. This phenomenon affects all types of white matter fibers and underscores the need for a paradigm shift in the tractography process.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Josue M. Avecillas-Chasin, Simon Levinson, Taylor Kuhn, Mahmoud Omidbeigi, Jean-Philippe Langevin, Nader Pouratian, Ausaf Bari
Summary: The amygdala is important in emotion, learning, and memory, and is associated with behavioral disorders. Understanding the amygdala circuitry is crucial for developing new therapies. Using data from 200 healthy subjects, we created statistical maps of amygdala connectivity to brain regions involved in different circuits. Clustering analysis revealed three clusters of the amygdala based on its connectivity, showing a medial-to-lateral pattern.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Dongha Lee, Hae-Jeong Park
Summary: This study investigates the three-dimensional organization of neural fiber connections in the white matter of the brain. By analyzing connection distribution maps and related parameters, the study reveals the patterns of major fiber bundle connections in the white matter.
Article
Neuroimaging
Onur Tanglay, Isabella M. Young, Nicholas B. Dadario, Robert G. Briggs, R. Dineth Fonseka, Vukshitha Dhanaraj, Jorge Hormovas, Yueh-Hsin Lin, Michael E. Sughrue
Summary: The precuneus is a heterogeneous cortical region with five major types of connections present bilaterally. Short association fibers connect the gyri of the precuneus and to other brain regions, cingulum bundle parts connect to frontal and temporal lobes, middle longitudinal fasciculus connects to temporal regions, parietopontine fibers connect to pontine regions, and a commissural bundle connects the precuneus bilaterally.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Yueh-Hsin Lin, Vukshitha Dhanaraj, Alana E. Mackenzie, Isabella M. Young, Onur Tanglay, Robert G. Briggs, Arpan R. Chakraborty, Jorge Hormovas, R. Dineth Fonseka, Sihyong J. Kim, Jacky T. Yeung, Charles Teo, Michael E. Sughrue
Summary: The study on the parahippocampal gyrus using diffusion tensor imaging revealed its critical role in cognitive functions and memory processing. It identified connections with the inferior longitudinal fasciculus and cingulum, providing insights into potential postoperative cognitive decline. The research contributes to a better understanding of executive functioning following surgery for limbic tumors.
WORLD NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stephan Meesters, Maud Landers, Geert-Jan Rutten, Luc Florack
Summary: MRI-based tractography is not widely used in brain tumor surgery due to method heterogeneity and lack of a turn-key system. This work evaluated the robustness and reliability of tractography results in healthy subjects, demonstrating promising potential for future validation and implementation in clinical populations.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Multidisciplinary Sciences
Mareike Grotheer, Mona Rosenke, Hua Wu, Holly Kular, Francesca R. Querdasi, Vaidehi S. Natu, Jason D. Yeatman, Kalanit Grill-Spector
Summary: In this study, the development of white matter in infants from 0 to 6 months was investigated using diffusion MRI and quantitative MRI measurements. The researchers found that the longitudinal relaxation rate (R1) of white matter increased over time, with faster development in less mature areas of white matter in newborns.
NATURE COMMUNICATIONS
(2022)
Article
Behavioral Sciences
Robert G. Briggs, Isabella M. Young, Nicholas B. Dadario, R. Dineth Fonseka, Jorge Hormovas, Parker Allan, Micah L. Larsen, Yueh-Hsin Lin, Onur Tanglay, B. David Maxwell, Andrew K. Conner, Jordan F. Stafford, Chad A. Glenn, Charles Teo, Michael E. Sughrue
Summary: This study aimed to create an anatomically specific connectivity model of the neural substrates involved in salience processing. By using functional MRI and fiber tractography, the researchers identified nine cortical regions and their structural connections. These findings provide an important foundation for further research and clinical applications.
BRAIN AND BEHAVIOR
(2022)
Article
Clinical Neurology
Ali H. Palejwala, Nicholas B. Dadario, Isabella M. Young, Kyle O'Connor, Robert G. Briggs, Andrew K. Conner, Daniel L. O'Donoghue, Michael E. Sughrue
Summary: The medial occipital lobe is highly interconnected, supporting both visual processing and nonvisual functions such as language and memory. The research findings can be used to guide multimodal navigation of white matter lesions to prevent neurological deficits.
WORLD NEUROSURGERY
(2021)
Article
Multidisciplinary Sciences
Mykyta Smirnov, Igor Lima Maldonado, Christophe Destrieux
Summary: This paper presents an original method to label the arterial supply of macroscopic white matter fasciculi based on post-mortem injection of colored material and fiber dissection. The method provides a precise anatomical description of the vascularization of the main white matter tracts.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Sebastien Naze, Timothee Proix, Selen Atasoy, James R. Kozloski
Summary: Recent studies have shown that local gray matter connections play a crucial role in the formation of connectome harmonic patterns, which is consistent across different cortical surface templates and resolutions. Alterations of local and long-range connectivity matrices can affect the spatial patterns of connectome harmonics.
Article
Behavioral Sciences
Camille K. Milton, Vukshitha Dhanaraj, Isabella M. Young, Hugh M. Taylor, Peter J. Nicholas, Robert G. Briggs, Michael Y. Bai, Rannulu D. Fonseka, Jorge Hormovas, Yueh-Hsin Lin, Onur Tanglay, Andrew K. Conner, Chad A. Glenn, Charles Teo, Stephane Doyen, Michael E. Sughrue
Summary: The study built a neuroanatomical model of the semantic network using fMRI studies, revealing the roles of multiple left hemisphere cortical regions in semantic processing and indicating that future research will further characterize the neuroanatomical details of the semantic network.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Qiang Wei, Shanshan Cao, Yang Ji, Jun Zhang, Chen Chen, Xiaojing Wang, Yanghua Tian, Bensheng Qiu, Kai Wang
Summary: This study investigated the relationship between parietal subregions alterations and cognitive impairments in WMHs using resting-state functional connectivity analyses. Significant differences were found in the connectivity strength between parietal subregions and cortex regions, which may be associated with cognitive deficits in WMHs.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Muhamed Barakovic, Gabriel Girard, Simona Schiavi, David Romascano, Maxime Descoteaux, Cristina Granziera, Derek K. Jones, Giorgio M. Innocenti, Jean-Philippe Thiran, Alessandro Daducci
Summary: Our novel microstructure-informed tractography approach, COMMITAxSize, resolves axon diameter index estimates at the streamline level, providing invariant estimates along trajectories. By jointly estimating tissue microstructure properties and macroscopic white matter connectivity organization, our method offers a more robust estimation of axon diameter index for pathways compared to existing methods. We demonstrate the efficacy of our approach by comparing estimates with histologically-derived measurements in specific brain regions.
FRONTIERS IN NEUROSCIENCE
(2021)
Editorial Material
Biochemical Research Methods
Prashant S. Emani, Jonathan Warrell, Alan Anticevic, Stefan Bekiranov, Michael Gandal, Michael J. McConnell, Guillermo Sapiro, Alan Aspuru-Guzik, Justin T. Baker, Matteo Bastiani, John D. Murray, Stamatios N. Sotiropoulos, Jacob Taylor, Geetha Senthil, Thomas Lehner, Mark B. Gerstein, Aram W. Harrow
Summary: Quantum computing, leveraging the unique properties of quantum mechanics, addresses the challenges of scale and complexity in biological sciences and facilitates the integration of insights across different areas.
Article
Neurosciences
Ryutaro Tanno, Daniel E. Worrall, Enrico Kaden, Aurobrata Ghosh, Francesco Grussu, Alberto Bizzi, Stamatios N. Sotiropoulos, Antonio Criminisi, Daniel C. Alexander
Summary: This study introduces a method to improve the accuracy of medical image super-resolution problems and demonstrates the potential benefits of integrating uncertainty modeling into DL algorithms through detailed analysis and evaluation.
Article
Neurosciences
Michiel Cottaar, Matteo Bastiani, Nikhil Boddu, Matthew F. Glasser, Suzanne Haber, David C. van Essen, Stamatios N. Sotiropoulos, Saad Jbabdi
Summary: Many brain imaging studies measure structural connectivity with diffusion tractography, but biases in the data can limit accuracy. A new algorithm reduces these biases by modeling fiber density and orientation.
Article
Clinical Neurology
Dewen Meng, Ali-Reza Mohammadi-Nejad, Stamatios N. Sotiropoulos, Dorothee P. Auer
Summary: The use of anticholinergic medication is associated with cognitive decline and structural and functional impairment of the cholinergic nucleus basalis of Meynert. The study found that individuals on long-term anticholinergic medication have lower gray matter density and reduced functional connectivity in the nucleus basalis of Meynert, leading to cognitive impairment.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Jivesh Ramduny, Matteo Bastiani, Robin Huedepohl, Stamatios N. Sotiropoulos, Magdalena Chechlacz
Summary: This study used a multimodal approach to investigate the link between inadequate sleep and accelerated brain aging. The findings indicate significant associations between sleep quality, brain age delta, and inadequate sleep.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Jennifer Stine Elam, Matthew F. Glasser, Michael P. Harms, Stamatios N. Sotiropoulos, Jesper L. R. Andersson, Gregory C. Burgess, Sandra W. Curtiss, Robert Oostenveld, Linda J. Larson-Prior, Jan-Mathijs Schoffelen, Michael R. Hodge, Eileen A. Cler, Daniel M. Marcus, Deanna M. Barch, Essa Yacoub, Stephen M. Smith, Kamil Ugurbil, David C. Van Essen
Summary: The Human Connectome Project (HCP) aims to accelerate advances in human neuroimaging by studying a large number of healthy young adults and sharing data and tools. The WU-Minn-Ox consortium has achieved its core objectives and emerged as a set of best-practice strategies for optimizing data acquisition and analysis.
Article
Clinical Neurology
Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos, Rebecca C. Trueman, Marcus D. Wallis, Ferah Yildirim, Tracy D. Farr
Summary: This study presents a pipeline for structural and functional connectivity analysis of the mouse brain and applies it to a mouse model of vascular dementia. The findings reveal brain lesions in the model and provide insights into the mouse connectome and how it is affected by vascular insufficiency.
Article
Mathematical & Computational Biology
Vaanathi Sundaresan, Christoph Arthofer, Giovanna Zamboni, Robert A. Dineen, Peter M. Rothwell, Stamatios N. Sotiropoulos, Dorothee P. Auer, Daniel J. Tozer, Hugh S. Markus, Karla L. Miller, Iulius Dragonu, Nikola Sprigg, Fidel Alfaro-Almagro, Mark Jenkinson, Ludovica Griffanti
Summary: The study aimed to detect CMB candidate subjects from the UK Biobank dataset using a machine learning-based, computationally light pipeline. Evaluation results showed that our method achieved subject-level detection accuracy of over 80% on all datasets, and demonstrated good generalisability across datasets.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Neurosciences
Prejaas Tewarie, Bastian Prasse, Jil Meier, Kanad Mandke, Shaun Warrington, Cornelis J. Stam, Matthew J. Brookes, Piet Van Mieghem, Stamatios N. Sotiropoulos, Arjan Hillebrand
Summary: This study investigates the role of structural eigenmodes in the formation and dissolution of temporally evolving functional brain networks. The results suggest that structural eigenmodes can partly explain the phase and amplitude connectivity at short timescales. The expression of eigenmodes is related to cognitive performance and fluctuations in the community structure of functional networks.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
A. David Edwards, Daniel Rueckert, Stephen M. Smith, Samy Abo Seada, Amir Alansary, Jennifer Almalbis, Joanna Allsop, Jesper Andersson, Tomoki Arichi, Sophie Arulkumaran, Matteo Bastiani, Dafnis Batalle, Luke Baxter, Jelena Bozek, Eleanor Braithwaite, Jacqueline Brandon, Olivia Carney, Andrew Chew, Daan Christiaens, Raymond Chung, Kathleen Colford, Lucilio Cordero-Grande, Serena J. Counsell, Harriet Cullen, John Cupitt, Charles Curtis, Alice Davidson, Maria Deprez, Louise Dillon, Konstantina Dimitrakopoulou, Ralica Dimitrova, Eugene Duff, Shona Falconer, Seyedeh-Rezvan Farahibozorg, Sean P. Fitzgibbon, Jianliang Gao, Andreia Gaspar, Nicholas Harper, Sam J. Harrison, Emer J. Hughes, Jana Hutter, Mark Jenkinson, Saad Jbabdi, Emily Jones, Vyacheslav Karolis, Vanessa Kyriakopoulou, Gregor Lenz, Antonios Makropoulos, Shaihan Malik, Luke Mason, Filippo Mortari, Chiara Nosarti, Rita G. Nunes, Camilla O'Keeffe, Jonathan O'Muircheartaigh, Hamel Patel, Jonathan Passerat-Palmbach, Maximillian Pietsch, Anthony N. Price, Emma C. Robinson, Mary A. Rutherford, Andreas Schuh, Stamatios Sotiropoulos, Johannes Steinweg, Rui Pedro Azeredo Gomes Teixeira, Tencho Tenev, Jacques-Donald Tournier, Nora Tusor, Alena Uus, Katy Vecchiato, Logan Z. J. Williams, Robert Wright, Julia Wurie, Joseph V. Hajnal
Summary: The Developing Human Connectome Project is an open science resource that provides researchers with data on typical and atypical brain development during the perinatal period. With a collection of MRI brain datasets and collateral data from fetal and neonatal participants, this project offers valuable insights into brain development.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Shaun Warrington, Elinor Thompson, Matteo Bastiani, Jessica Dubois, Luke Baxter, Rebeccah Slater, Saad Jbabdi, Rogier B. Mars, Stamatios N. Sotiropoulos
Summary: This study proposes a novel framework that integrates structural connectivity maps from humans and nonhuman primates onto a common space, allowing the study of divergences and similarities in connectivity over evolutionary and developmental scales to reveal brain maturation trajectories.
Article
Medicine, General & Internal
Ali-Reza Mohammadi-Nejad, Richard J. Allen, Luke M. Kraven, Olivia C. Leavy, R. Gisli Jenkins, Louise V. Wain, Dorothee P. Auer, Stamatios N. Sotiropoulos, DEMISTIFI Consortium
Summary: This study explored the association between genetic risk of idiopathic pulmonary fibrosis (IPF) and brain structure. The results revealed strong associations between IPF risk loci and cortical morphological features, as well as white matter microstructure. The DEPTOR variant may mediate the association between IPF risk and white matter microstructure.
Article
Neurosciences
Prejaas K. B. Tewarie, Rikkert Hindriks, Yi Ming Lai, Stamatios N. Sotiropoulos, Morten Kringelbach, Gustavo Deco
Summary: Characterising brain states during tasks using electrophysiological modalities is common practice in neuroscience. Non-reversibility, or the temporal asymmetry in functional interactions, may be more sensitive to characterise task induced brain states than functional connectivity. Using whole brain computational models, we find that non-reversibility outperforms functional connectivity in the identification of task induced brain states, particularly in capturing bottom-up gamma induced brain states.
Article
Clinical Neurology
Meadhbh B. Brosnan, Nir Shalev, Jivesh Ramduny, Stamatios N. Sotiropoulos, Magdalena Chechlacz
Summary: Exposure to enriched environments throughout a lifetime protects against cognitive decline. This study shows that enriched environments are associated with better microstructural properties of fronto-parietal white matter and attention in older adults. The microstructure of the right superior longitudinal fasciculus mediates the association between enriched environments and neurocognitive health.
BRAIN COMMUNICATIONS
(2022)
Article
Neurosciences
Michael Forrester, Jonathan J. Crofts, Stamatios N. Sotiropoulos, Stephen Coombes, Reuben D. O'Dea
NETWORK NEUROSCIENCE
(2020)