Article
Multidisciplinary Sciences
Veronica Moncho-Amor, Probir Chakravarty, Christophe Galichet, Ander Matheu, Robin Lovell-Badge, Karine Rizzoti
Summary: The study reveals the role of SOX2 in endocrine tumorigenesis in p27(-/-) pituitaries, showing that increased levels of SOX2 in both endocrine and stem cells are associated with pituitary hyperplasia. SOX2 is required cell autonomously in endocrine cells for tumor formation and in stem cells for promotion of tumorigenesis. Single cell transcriptomic analysis further highlights the importance of the SOX2-dependent MAPK pathway in stem cells for tumorigenesis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Medicine, General & Internal
Yuka Matsumiya-Matsumoto, Yoshihiro Morita, Narikazu Uzawa
Summary: This article reviews the role of epithelial-mesenchymal transition (EMT) in pleomorphic adenoma (PA) and explores the mechanisms of EMT in the development, chondrocyte differentiation, and malignant transformation of PA.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Xiqiang He, Chenyan Li, Hua Yin, Xiaojun Tan, Jun Yi, Shujun Tian, Yan Wang, Jian Liu
Summary: Mesenchymal stem cells have potential therapeutic potential in the treatment of diseases due to their anti-inflammatory and immunomodulatory effects. This study explores the effects of MSCs on lung cancer cells and acute respiratory distress syndrome (ARDS) in mice, indicating that MSCs can attenuate lung injury and inhibit inflammation.
Article
Medicine, Research & Experimental
Zhengguang Li, Zhirong Yang, Wei Liu, Wanglong Zhu, Lan Yin, Zhenyu Han, Yu Xian, Jie Wen, Hualong Tang, Xinyue Lin, Yuhan Yang, Jingyi Wang, Kun Zhang
Summary: The study revealed that DVL3 is overexpressed in colorectal cancer (CRC) and is associated with malignant behaviors, metastasis, and prognosis. Furthermore, DVL3 promotes epithelial-to-mesenchymal transition (EMT) and cancer stem-like cell (CSLC) properties in CRC through the activation of the Wnt/beta-catenin/c-Myc/SOX2 axis. This research provides a new strategy for successful treatment of CRC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Paulina Gil-Kulik, Malgorzata Swistowska, Arkadiusz Krzyzanowski, Alicja Petniak, Anna Kwasniewska, Bartosz J. Plachno, Dariusz Galkowski, Anna Bogucka-Kocka, Janusz Kocki
Summary: SOX2, a pluripotent transcription factor, plays a crucial role in stem cell homeostasis and development. Research indicates that maternal age, umbilical cord blood pH, and length of pregnancy can influence the quality of stem cells derived from Wharton's Jelly, highlighting the importance of assessing maternal and embryonic factors in cell quality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Yan Qu, Yifan He, Bowen Meng, Xiao Zhang, Junjun Ding, Xiaoxing Kou, Wei Teng, Songtao Shi
Summary: This study revealed that pluripotent stem cell-derived apoptotic vesicles (PSC-apoVs) can inherit pluripotent molecules and promote the activation of adult stem cells and skin wound healing. These findings provide a potential cell-free strategy for clinical applications using PSC-apoVs.
ACTA BIOMATERIALIA
(2022)
Article
Biology
Evelien Eenjes, Marjon Buscop-van Kempen, Anne Boerema-de Munck, Gabriela G. Edel, Floor Benthem, Lisette de Kreij-de Bruin, Marco Schnater, Dick Tibboel, Jennifer Collins, Robbert J. Rottier
Summary: SOX21 patterns the airway epithelium by antagonizing SOX2, regulating differentiation of airway progenitor cells. It inhibits basal to ciliated cell differentiation in both development and adult tracheal epithelium. The interplay between SOX2 and SOX21 is context and concentration dependent, crucial for regulating differentiation of the airway epithelium.
Article
Biochemistry & Molecular Biology
Tong Gao, Xu Yang, Masayoshi Fujisawa, Toshiaki Ohara, Tianyi Wang, Nahoko Tomonobu, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa
Summary: The downregulation of SPRED2 promotes EMT and stemness in hepatocellular carcinoma through the activation of the ERK1/2 pathway, leading to more malignant phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Rachel Vazana-Netzarim, Yishay Elmalem, Shachar Sofer, Hod Bruck, Naama Danino, Udi Sarig
Summary: By seeding hMSCs on pcECM, we observed a partial mesenchymal-to-epithelial transition (MET) and identified the crucial role of HAND2 gene in this process. HAND2 and its associated non-coding RNA are expressed at different levels in various tissues, and deviation from these basal levels is associated with various pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yizuo Song, Ruyi Li, Miaomiao Ye, Chunyu Pan, Lihong Zheng, Zhi-wei Wang, Xueqiong Zhu
Summary: This study found that MSCs from different tissues exhibit different chemotaxis towards cervical cancer cells, with chorion-derived MSC (CD-MSC) showing the strongest tropic capacity. The CXCL12/CXCR4 pathway was identified to contribute to the differential chemotaxis of MSCs to cervical cancer cells.
Review
Endocrinology & Metabolism
Paul R. Le Tissier, Joanne F. Murray, Patrice Mollard
Summary: Plasticity of function is crucial for the anterior pituitary endocrine axes to adapt to changes in hormone demand and environmental challenges. The size and organization of pituitary cell populations play a role in this plasticity. SOX2+ve cells act as sentinels and actuators of cell number, regulating secretion and other aspects of endocrine cell functional mass.
Article
Cell Biology
Hong You, Jian Xu, Xiaochun Qin, Guodong Qian, Yang Wang, Fulei Chen, Xiaoxu Shen, Dong Zhao, Qi Liu
Summary: This study aimed to investigate the role of fascin in pituitary adenoma cells. It was found that fascin expression was correlated with invasion, proliferation, and apoptosis of the tumor cells. Downregulation of fascin also affected the expression of various EMT markers, indicating its potential to regulate tumor progression through the EMT pathway.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Oncology
Rosemary J. Akhurst
Summary: Epithelial-to-mesenchymal transition (EMT) is a cell shape-changing process that plays a critical role in embryogenesis and disease progression. It is influenced by extracellular factors and intracellular signaling pathways. EMT is associated with tumor progression, development of a stem-like cell state, and drug resistance.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael Peeters, Julie Schenk, Thomas De Somer, Tania Roskams, Tatjana Locus, Sofieke Klamer, Lorenzo Subissi, Vanessa Suin, Jean Delwaide, Peter Starkel, Stephane De Maeght, Philippe Willems, Isabelle Colle, Marc Van Hoof, Jos Van Acker, Christophe Van Steenkiste, Christophe Moreno, Filip Janssens, Marijke Reynders, Matthias Steverlynck, Wim Verlinden, Luc Lasser, Chantal de Galocsy, Anja Geerts, Jeroen Maus, Marie Gallant, Steven Van Outryve, Astrid Marot, Hendrik Reynaert, Jochen Decaestecker, Emmanuel Bottieau, Jonas Schreiber, Jean-Pierre Mulkay, Sebastien de Goeij, Mikhael Salame, Diederik Dooremont, Sergio Negrin Dastis, Juul Boes, Jochen Nijs, Jan Beyls, Niel Hens, Frederik Nevens, Steven Van Gucht, Thomas Vanwolleghem
Summary: In this study, the researchers collected data from 274 confirmed HEV infections at the Belgian National Reference Centre. They found that HEV genotype 3 infections were mainly caused by the efg subtype, and these infections were associated with more severe disease presentation, higher levels of CXCL10, and more pronounced liver inflammation compared to other host risk factors.
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Lukas Van Melkebeke, Annelotte G. C. Broekhoven, Tessa Ostyn, Hannelie Korf, Minneke J. Coenraad, Roman Vangoitsenhoven, Bart van der Schueren, Matthias Lannoo, Hannah Van Malenstein, Tania Roskams, Schalk van der Merwe, Frederik Nevens, Jef Verbeek
Summary: This study assessed the impact of prior bariatric surgery on patients presenting with severe alcoholic hepatitis. The results showed that patients who had prior bariatric surgery were younger at the diagnosis of hepatitis, but there were no significant differences in disease severity or outcome compared to patients without prior surgery. These findings support the need for early detection of alcohol use disorder in patients who underwent bariatric surgery, particularly Roux-en-Y gastric bypass.
Article
Oncology
Anna C. H. Willemsen, Nina De Moor, Jeroen Van Dessel, Laura W. J. Baijens, Michel Bila, Esther Hauben, Mari F. C. M. van den Hout, Vincent Vander Poorten, Ann Hoeben, Paul M. Clement, Annemie M. W. J. Schols
Summary: This study evaluates the predictive and prognostic value of weight loss and changes in body composition in head and neck squamous cell carcinoma patients receiving immune checkpoint inhibitor therapy. The results show that early weight loss and cachexia are associated with worse overall survival.
Review
Oncology
Beatriz G. Cavalheiro, Jatin P. Shah, Gregory W. Randolph, Jesus E. Medina, Ralph P. Tufano, Mark Zafereo, Dana M. Hartl, Iain J. J. Nixon, Orlando Guntinas-Lichius, Vincent Vander Poorten, Fernando Lopez, Avi Hefetz Khafif, Randall P. Owen, Ashok Shaha, Juan P. Rodrigo, Alessandra Rinaldo, Antti A. Maekitie, Carl E. Silver, Alvaro Sanabria, Luiz P. Kowalski, Alfio Ferlito
Summary: Surgery is often the preferred treatment for locoregional recurrences of well-differentiated thyroid carcinomas, but other therapies can be considered on an individual basis. These patients have prolonged survival, but may require long periods of active disease and subsequent treatments. This review discusses various treatment options for well-differentiated thyroid cancer, including surgery, active surveillance, radioactive iodine therapy, and more.
Review
Oncology
Bertram J. de Kleijn, Gijs T. N. Heldens, Jasmijn M. Herruer, Cornelis F. M. Sier, Cesare Piazza, Remco de Bree, Orlando Guntinas-Lichius, Luiz P. Kowalski, Vincent Vander Poorten, Juan P. Rodrigo, Nina Zidar, Cherie-Ann Nathan, Raymond K. Tsang, Pawel Golusinski, Ashok R. Shaha, Alfio Ferlito, Robert P. Takes
Summary: In head and neck cancer surgery, complete removal of the tumor is necessary for optimal therapy, but this is challenging in vulnerable areas with potential functional limitations. Various imaging techniques can assist in distinguishing tumor from healthy tissue and aid in achieving complete tumor removal. This paper provides an overview of imaging techniques for oropharyngeal squamous cell carcinoma and discusses the potential for optimizing surgical outcomes.
Article
Oncology
Justine Vancanneyt, Bie Wilmsen, Caroline Luyten, Chris Verslype, Eric Van Cutsem, Tania Roskams, Sabine Tejpar, Isabelle Vanden Bempt, Jeroen Dekervel
Summary: Current systemic therapies for advanced cholangiocarcinoma (CCA) are limited in their effectiveness, but next-generation sequencing (NGS) technologies have provided a better understanding of the genetic basis of the disease. This study aimed to determine the proportion of actionable genetic alterations in CCA patients and evaluate the impact of targeted treatment on disease control.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Melanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O'Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V. V. Swinnen
Summary: This study identifies the role of FASN in therapy resistance in cancer. By inhibiting FASN and inducing ROS, therapy resistance can be delayed. The combination of MAPK inhibitors, FASN inhibitors, and ROS inducers significantly increases survival in therapy-resistant models.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Elena Kotsiliti, Valentina Leone, Svenja Schuehle, Olivier Govaere, Hai Li, Monika J. Wolf, Helena Horvatic, Sandra Bierwirth, Jana Hundertmark, Donato Inverso, Laimdota Zizmare, Avital Sarusi-Portuguez, Revant Gupta, Tracy O'Connor, Anastasios D. Giannou, Ahmad Mustafa Shiri, Yehuda Schlesinger, Maria Garcia Beccaria, Charlotte Rennert, Dominik Pfister, Rupert Oellinger, Iana Gadjalova, Pierluigi Ramadori, Mohammad Rahbari, Nuh Rahbari, Marc E. Healy, Mirian Fernandez-Vaquero, Neda Yahoo, Jakob Janzen, Indrabahadur Singh, Chaofan Fan, Xinyuan Liu, Monika Rau, Martin Feuchtenberger, Eva Schwaneck, Sebastian J. Wallace, Simon Cockell, John Wilson-Kanamori, Prakash Ramachandran, Celia Kho, Timothy J. Kendall, Anne-Laure Leblond, Selina J. Keppler, Piotr Bielecki, Katja Steiger, Maike Hofmann, Karsten Rippe, Horst Zitzelsberger, Achim Weber, Nisar Malek, Tom Luedde, Mihael Vucur, Hellmut G. Augustin, Richard Flavell, Oren Parnas, Roland Rad, Olivier Pabst, Neil C. Henderson, Samuel Huber, Andrew Macpherson, Percy Knolle, Manfred Claassen, Andreas Geier, Christoph Trautwein, Kristian Unger, Eran Elinav, Ari Waisman, Zeinab Abdullah, Dirk Haller, Frank Tacke, Quentin M. Anstee, Mathias Heikenwalder
Summary: This study found that the gut-liver axis plays an important role in the progression of non-alcoholic steatohepatitis (NASH) to fibrosis and hepatocellular carcinoma (HCC). It was demonstrated that intestinal B cells have a promoting effect on the development of NASH, and IgA secretion is an important regulatory factor for fibrosis induction by activating hepatic myeloid cells. Therefore, intestinal B cells and the IgA-FcR signaling axis may be potential therapeutic targets for the treatment of NASH.
JOURNAL OF HEPATOLOGY
(2023)
Article
Surgery
Manon Van Hecke, Lucas Van Hoof, Magdalena Sikole, Hozan Mufty, Piet Claus, Peter Verbrugghe, John Ely, Geoffrey A. Berg, Tania Roskams, Bart Meuris
Summary: This study assessed the safety and efficacy of an experimental large-diameter vascular graft externally sealed with an elastomeric polymer when used as an interposition graft in the descending aorta of sheep. The results showed that the experimental graft had a similar safety and performance profile compared to a commonly used prosthetic vascular graft, with no significant difference in surgical handling, hemostasis time, hematologic and radiologic results between the study groups.
JOURNAL OF SURGICAL RESEARCH
(2023)
Review
Oncology
Fernando Lopez, Abir Al Ghuzlan, Mark Zafereo, Vincent Vander Poorten, K. Thomas Robbins, Marc Hamoir, Iain J. Nixon, Ralph P. Tufano, Gregory Randolph, Pia Pace-Asciak, Peter Angelos, Andres Coca-Pelaz, Avi Khafif, Ohad Ronen, Juan Pablo Rodrigo, Alvaro Sanabria, Carsten E. Palme, Antti A. Makitie, Luiz P. Kowalski, Alessandra Rinaldo, Alfio Ferlito
Summary: In non-well differentiated thyroid cancer, the rate of nodal involvement varies depending on the histology of the tumor. Treatment for anaplastic carcinoma, medullary carcinoma, and poorly differentiated carcinoma of the thyroid is well-established. However, treatment for other rare tumors needs to be individualized based on histology and anatomical distribution. The rate of lymph node involvement in non-well differentiated thyroid cancer is variable. Different types of thyroid cancer require different approaches to neck management.
Review
Biochemistry & Molecular Biology
Carlos M. Chiesa-Estomba, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P. Takes, Remco de Bree, Gyorgy B. Halmos, Nabil F. Saba, Sandra Nuyts, Alfio Ferlito
Summary: Radiomics is a promising tool for the diagnosis, treatment, and follow-up of patients with hypopharyngeal squamous cell carcinoma (HPSCC). Further large-scale prospective studies are needed to validate its effectiveness in this patient population.
Article
Endocrinology & Metabolism
Olivier Govaere, Megan Hasoon, Leigh Alexander, Simon Cockell, Dina Tiniakos, Mattias Ekstedt, Joern M. Schattenberg, Jerome Boursier, Elisabetta Bugianesi, Vlad K. Ratziu, Ann K. M. Daly, Quentin M. Anstee, LITMUS Investigators
Summary: Govaere et al. integrated circulating protein data with transcriptomics to develop a non-invasive diagnostic tool for identifying at-risk patients with non-alcoholic fatty liver disease (NAFLD) based on body mass index, type 2 diabetes and four circulating proteins.
Meeting Abstract
Obstetrics & Gynecology
Xavier Santramaria, Beatriz Roson, Raul Perez, Nanda Kumar, Javier Gonzalez-Fernandez, Estefania Fernandez, Inmaculada Moreno, Hugo Vankelecom, Felipe Vilella, Carlos Simon
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Shuanggang Hu, Zhe Sun, Boyu Li, Hanting Zhao, Yuan Wang, Guangxin Yao, Xinyu Li, Xuejiao Bian, Tin Chiu Li, Hugo Vankelecom, Yun Sun
Summary: Identification of key molecules involved in endometrial receptivity is crucial for understanding human implantation and improving pregnancy rates in assisted reproduction treatment. This study used proteomics to profile the proteomes of different phases of endometrial tissues and identified differentially expressed proteins. The findings contribute to the understanding of the mechanisms governing endometrial receptivity.
Meeting Abstract
Gastroenterology & Hepatology
Dina Tiniakos, Asier Antoranz-Martinez, Trieu My Van, Daniel Newhouse, James Clark, Ann K. Daly, Tania Roskams, Quentin Anstee, Olivier Govaere
JOURNAL OF HEPATOLOGY
(2023)