Review
Chemistry, Inorganic & Nuclear
Masrat Bashir, Imtiyaz Ahmad Mantoo, Farukh Arjmand, Sartaj Tabassum, Imtiyaz Yousuf
Summary: The development of metal compounds as therapeutics and diagnostics drugs has increased due to the successful clinical use of platinum drugs for cancer treatment. Non-platinum anticancer agents, particularly ruthenium-based compounds, have emerged as promising alternatives due to their lower toxicity and ability to specifically accumulate and activate in tumor cells. Organoruthenium(II) complexes have attracted special attention because of their favorable biochemical properties and their dominant role in targeted chemotherapy. This review provides an overview of the latest advancements in developing organoruthenium(II) compounds as prospective anticancer agents and alternatives to platinum drugs, including their mechanisms of action, cytotoxic potential, and progress in clinical trials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Caio Cesar Candido, Henrique Vieira Reis Silva, Bruno Zavan, Marisa Ionta, Marilia Imaculada Frazao Barbosa, Antonio Carlos Doriguetto
Summary: In this study, novel ruthenium(II) complexes with metronidazole as a ligand were synthesized and characterized. The results showed that complexes (1) and (3) exhibited inhibitory effects on the proliferation of MCF-7 cells and induced apoptosis.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Plant Sciences
Jessica Maiuolo, Natalizia Miceli, Federica Davi, Irene Bava, Luigi Tucci, Salvatore Ragusa, Maria Fernanda Taviano, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Roberta Macri, Federica Scarano, Anna Rita Coppoletta, Antonio Cardamone, Carolina Muscoli, Ezio Bombardelli, Ernesto Palma, Vincenzo Mollace
Summary: Ferula L. plant extract has therapeutic effects on breast cancer and can be used in combination with tamoxifen to enhance its effectiveness and reduce side effects.
Article
Biochemistry & Molecular Biology
Pruthviraj Limbachiya, Vipul Patel, Gaurang Rami, Jabali Vora
Summary: This study investigates the synthesis and characterization of two chitosan dibenzylideneacetone Schiff bases, using various analytical techniques. The antimicrobial activity of the chitosan derivatives was tested against bacterial and fungal strains, while cytotoxicity tests were conducted on different cell lines. The results demonstrate that CHDBA shows promise as a potential treatment option for breast cancer and lung cancer, as it exhibits significant effectiveness and low cytotoxicity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Maria Azmanova, Laia Rafols, Patricia A. Cooper, Colin C. Seaton, Steven D. Shnyder, Anais Pitto-Barry
Summary: This study presents the synthesis, characterization, and evaluation of the in vitro cytotoxicity of five maleonitriledithiolate-based ruthenium metal complexes with various phosphine ligands. These complexes showed promising in vitro cytotoxicity against ovarian and lung cancer cell lines, as well as no toxicity in preliminary in vivo pilot studies. The mechanism of action suggests an apoptotic pathway based on ROS production.
Article
Multidisciplinary Sciences
Govindan Nadar Rajivgandhi, Gnansekaran Chackaravarthi, Govindan Ramachandran, Chenthis Kanisha Chelliah, Muthuchamy Maruthupandy, Mohammed S. Alharbi, Naiyf S. Alharbi, Jamal M. Khaled, Wen-Jun Li
Summary: In this study, the excellent anti-cancer activity of silver nanoparticles against MCF-7 breast cancer cells was demonstrated. The nanoparticles induced cytotoxicity, morphological changes, and damage to intracellular structures.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
G. Kalaiarasi, M. Mohamed Subarkhan, C. K. Fathima Safwana, S. Sruthi, T. Sathiya Kamatchi, B. Keerthana, S. L. Ashok Kumar
Summary: In this study, four Schiff base ligands were synthesized and reacted with [RuCl2(η6-p-cymene)] to obtain new cationic ruthenium arene complexes. The compounds exhibited significant anticancer activity and low toxicity. Moreover, the complexes induced cell death through apoptosis in tumor cells.
INORGANICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Sema Caglar, Ahmet Altay, Mehmet Kuzucu, Bulent Caglar
Summary: This study reports the synthesis, characterization, and anticancer activity of six novel complexes of niflumic acid with Co(II) and Ni(II), with complex 3 and complex 6 showing the highest cytotoxicity against MCF-7 cells. Mechanistic studies revealed that these complexes induce apoptosis through the mitochondrial-dependent pathway, affecting various apoptotic marker proteins in MCF-7 cells. Additionally, the complexes inhibit the PI3K/Akt signaling pathway, providing insights into their anticancer mechanisms in MCF-7 cells.
CELL BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Immunology
Norma Estrada, Erick J. Nunez-Vazquez, Alejandra Palacios, Felipe Ascencio, Laura Guzman-Villanueva, Ruben G. Contreras
Summary: Programmed cell death (PCD) plays a crucial role in cellular immunity, helping eliminate infected or unnecessary cells. Research has shown that marine toxins can induce different types of PCD in bivalve mollusk hemocytes, including apoptosis and pyroptosis-like cell death. Different toxins can cause varying degrees of cell death in hemocytes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
F. Martorana, I. Colombo, G. Treglia, S. Gillessen, A. Stathis
Summary: Phase II trials evaluating the combinations of PD-1/PD-L1 inhibitors with other anti-cancer therapies are diverse, with PD-1 inhibitors being the most frequently studied. Only a minority of indications have received regulatory approval from authorities.
CANCER TREATMENT REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Sushma Singh, Mokshada Varma, Bhupendra Shravage, Prasad Kulkarni, Avinash Kumbhar
Summary: By incorporating the photosensitizer Ru(II) polypyridyl complexes into the cis-PtCl2 moiety, the anticancer properties of the complexes were improved, leading to increased cytotoxicity against MCF-7 cells and potential candidacy for Photodynamic Therapy.
JOURNAL OF CHEMICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ye Zhong, Xing Tian, Xinyue Jiang, Wen Dang, Maosheng Cheng, Ning Li, Yang Liu
Summary: A series of novel ziyuglycoside II derivatives were synthesized, with compound Z-15 showing the most potent antiproliferative effect on K562, MCF-7, and MV411 cell lines. Z-15 did not exhibit cytotoxicity on MCF-10A cells and could inhibit cell proliferation more robustly than ziyuglycoside II and 5-fluorouracil. It also significantly inhibited MCF-7 cell migration and induced mitochondrial-mediated apoptosis and autophagy in a dose-dependent manner.
BIOORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Katarzyna Biezunska-Kusiak, Julita Kulbacka, Anna Choromanska, Nina Rembialkowska, Olga Michel, Jolanta Saczko
Summary: Breast cancer is one of the most common malignant neoplasms in Poland. The use of calcium ion-assisted electroporation has been proven effective in recent studies. This research aimed to investigate the antitumor effects of electroporation and calcium ion-assisted electroporation on human mammary adenocarcinoma cells. The obtained results confirmed the effectiveness of the investigated therapeutic method, providing a basis for further in vivo research and the development of a more effective and safer treatment for breast cancer patients.
Article
Chemistry, Applied
Priyanka Khanvilkar, Soumya R. Dash, Devjani Banerjee, Aliasgar Vohra, Ranjitsinh Devkar, Debjani Chakraborty
Summary: A series of piano-stool-type binuclear ruthenium (II)-arene-thiosemicarbazone complexes were synthesized using pyrazol-derived thiosemicarbazone ligands and demonstrated good binding efficacy with DNA and BSA. These complexes exhibited cytotoxicity towards the HeLa cell line and interacted with DNA through intercalative interaction and interacted with BSA through static interaction. Molecular docking studies confirmed interactions with biomolecules.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Dimakatso Mokoena, Blassan P. George, Heidi Abrahamse
Summary: Breast cancer, a common and treatment-resistant cancer, can be effectively treated using photodynamic therapy with the aid of gold nanoparticles. This study demonstrates the successful adsorption of a photosensitizer onto gold nanoparticles and its application in inducing apoptosis in MCF-7 breast cancer cells in vitro.
Article
Chemistry, Applied
P. Naveen, B. Vijaya Pandiyan, D. Anu, F. Dallemer, P. Kolandaivel, R. Prabhakaran
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Chemistry, Inorganic & Nuclear
Krishnaswamy Savithri, Rathinasabapathi Prabhakaran, Manickam Paulpandi, Israel V. M. V. Enoch, Palathurai Subramaniam Mohan
TRANSITION METAL CHEMISTRY
(2020)
Article
Chemistry, Applied
Mathiyazhagan Sindhu, Palaniappan Kalaivani, Rathinasabapathi Prabhakaran
APPLIED ORGANOMETALLIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
G. Kalaiarasi, S. Dharani, S. Rex Jeya Rajkumar, Vincent M. Lynch, R. Prabhakaran
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Chemistry, Physical
Palanivel Sathishkumar, Zhaofa Li, Raji Govindan, Rajarajeswaran Jayakumar, Chaoyang Wang, Feng Long Gu
Summary: In this study, a zinc oxide-quercetin nanocomposite was developed as a smart nano-drug delivery system. The release kinetics showed faster release of quercetin in acidic conditions, with specific interactions between quercetin and zinc oxide identified. The nanocomposite demonstrated effective inhibition of breast cancer cells and high biocompatibility.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
G. Kalaiarasi, S. Dharani, S. Rex Jeya Rajkumar, M. Ranjani, Vincent M. Lynch, R. Prabhakaran
Summary: This study synthesized and characterized four Co(III) complexes derived from 7-hydroxy-4-oxo-4H-chromene-3-carbaldehyde-4(N)-substituted thiosemicarbazones. X-ray crystallographic analysis confirmed the structure of complexes 2 and 3, showing coordination with the ligands' azomethine nitrogen, ring carbonyl oxygen, and thiol sulfur atoms. The complexes demonstrated binding ability to biomolecules, antimicrobial activity, cytotoxic potential against cancer cells, and induction of apoptotic cell death.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Giriraj Kalaiarasi, Amirthalingam Mohankumar, Sivadasan Dharani, Frederic Dallemer, Palanisamy Sundararaj, Rathinasabapathi Prabhakaran
Summary: Four copper(II) complexes 1-4 of 3-acetylchromene-2-one and its derivatives were synthesized and characterized, with complex 1 having its molecular structure confirmed by X-ray diffraction studies. These complexes demonstrated potent antioxidant and anti-aggregative properties, effectively reducing amyloid-beta toxicity associated with Alzheimer's disease in transgenic Caenorhabditis elegans strains expressing human A beta(1-42). The results suggest a potential for delaying Alzheimer's disease pathologies and warrant further investigation in higher models.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
G. Kalaiarasi, S. Dharani, S. Rex Jeya Rajkumar, Werner Kaminsky, R. Prabhakaran
Summary: The four Ru(II) carbonyl complexes synthesized showed good antimicrobial and cytotoxic potential, potentially surpassing cisplatin in similar experimental conditions.
INORGANICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Prasad Narayanan, Reyhaneh Farghadani, Shaik Nyamathulla, Jayakumar Rajarajeswaran, R. Thirugnanasampandan, Gunasekaran Bhuwaneswari
Summary: Thymoquinone, plumbagin and juglone have promising anticancer effects on human pancreatic cancer cells, inhibiting cell growth and inducing apoptosis through increased reactive oxygen species (ROS) levels. In addition, they also inhibit cell migration and reduce the expression of matrix metalloproteinase-9 (MMP-9).
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Review
Chemistry, Applied
Kannan Mohan, Abirami Ramu Ganesan, P. N. Ezhilarasi, Kiran Kumar Kondamareddy, Durairaj Karthick Rajan, Palanivel Sathishkumar, Jayakumar Rajarajeswaran, Lorenza Conterno
Summary: Chitin is a diverse and naturally occurring biopolymer found in crustaceans, insects, and fungi. Green extraction techniques have been successfully developed for extracting chitin and chitosan from various sources, leading to significant advancements in the field of polymer chemistry.
CARBOHYDRATE POLYMERS
(2022)
Review
Environmental Sciences
Kannan Mohan, Palanivel Sathishkumar, Durairaj Karthick Rajan, Jayakumar Rajarajeswaran, Abirami Ramu Ganesan
Summary: Black soldier fly larvae (BSFL) is a fast-growing and promising insect species that can achieve high-fat content through organic dietary supplements and environmental conditions. The fatty acids in their body can be converted into biodiesel with high efficiency, resulting in reduced energy input and carbon emissions. This review focuses on evaluating the optimal dietary source and growth conditions to produce fatty acid-rich larvae from agro food waste, and discusses the optimization and refining of lipids using novel techniques.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Food Science & Technology
Durairaj Karthick Rajan, Kannan Mohan, Jayakumar Rajarajeswaran, Dharmaraj Divya, Ragavendhar Kumar, Sabariswaran Kandasamy, Shubing Zhang, Abirami Ramu Ganesan
Summary: The study evaluates the extraction of beta-chitin and chitosan from mollusk shell waste, discusses their feasibility and functional properties. The genetic pathway of mollusk chitin synthesis and industrial upscaling challenges are also discussed.
Article
Chemistry, Applied
K. Mohan, T. Muralisankar, R. Jayakumar, C. Rajeevgandhi
Summary: In this study, chitin was extracted from marine crustacean shell waste using traditional chemical methods, and its physicochemical and structural properties were characterized. The extracted chitin was found to be in the alpha-form with similar properties and structure to commercial chitin.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
C. Elamathi, R. J. Butcher, A. Mohankumar, P. Sundararaj, K. P. Elango, P. Kalaivani, R. Prabhakaran
Summary: A novel quinoline-based Schiff base sensor has been developed for selective sensing of methionine and aspartic acid through on-off-on type detection of copper ions, demonstrating bright green fluorescence in live cells both in vitro and in vivo.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
C. Elamathi, Frank R. Fronczek, A. Madankumar, R. Prabhakaran
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Zihan Ma, Lishuang Wang, Tingting Chen, Guangning Wang
Summary: In this study, two kinds of 3D self-doped (N/O) lilac-based and coriander-based porous carbons with high performance have been prepared.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Qin Wang, Yun-Fan Yan, Jiao-Lin Weng, Ying Huang, Fu Yang, Hao-Hui Xie, Fei Tan, Fa-Kun Zheng, Jian-Gang Xu
Summary: Balancing energy and mechanical sensitivities is a challenging issue in the field of energetic materials. This study constructed a 3D energetic metal-organic framework with nitrogen-rich ligand and NO3- anions. The framework demonstrated high stability, energy density, and excellent mechanical sensitivities, making it a potential insensitive energetic material.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Marrium Saeed, Urooj Kamran, Amina Khan, Md Irfanul Haque Siddiqui, Hasan Jamal, Haq Nawaz Bhatti
Summary: In this study, magnesium-aluminum layered double hydroxides (Mg-Al-LDH) were synthesized using an environmentally friendly hydrothermal technique for adsorbing the dye reactive green 5 (RG5). To improve the adsorption capability, composites were prepared by combining Mg-Al-LDH with low-cost Mangifera indica stone biomass (MISB). The results showed that the composites had high adsorption capacities for RG5 dye and could be regenerated.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Xuanlin Zhan, Xiaojie Li, Yunyan Zeng, Siyan Jiang, Chao Pan, Shiyu Pan, Jiaquan Huang, Heqian Zhang, Zhiwei Qin
Summary: This study reports on the potential prospects of natural products derived from the rhizosphere for the development of antibiotics and herbicides, as well as the advancements in cultivating a mutant strain that produces a substantial quantity of lydicamycins, a potent family for herbicide development.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Jie Zhu, Jiangtao Yu, Linhua Zhu, Xiaoxiao Yu, Jixing Liu, Yanhong Chao, Jingzhou Yin, Peiwen Wu, Jian Liu, Wenshuai Zhu
Summary: This study successfully demonstrates the 3D printing of attapulgite monoliths and investigates the influence of thermal treatment on their properties. The thermal treated monoliths show superior catalytic performance at low temperatures.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yanzhu Ye, Yixiang Ye, Jiannan Cai, Zhongshui Li, Shen Lin
Summary: In this paper, a novel Pt/CoP/C photo-electro synergistic catalyst was successfully synthesized and its performance was investigated. The catalyst exhibited excellent photo-electro catalytic performance, with significantly higher hydrogen production compared to a commercial catalyst. The introduction of cobalt phosphide and the existence of Co3O4 were identified as key factors for enhancing the catalytic activity.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nurul Hidayah Abu Bakar, Wan Norfazilah Wan Ismail, Hartina Mohd Yusop, Noreen Farzuhana Mohd Zulkifli
Summary: Hydrophobic coatings inspired by the lotus effect have gained popularity for their ability to solve various problems. The sol-gel method, utilizing silica, alumina, and titania, is explored as an environmentally friendly approach to produce water-based hydrophobic coatings. This study focuses on producing water-based hydrophobic coatings for cotton and polyester fabrics using a one-step sol-gel method. The coated fabrics exhibited improved hydrophobic properties, altered surface morphologies, and lower air permeability compared to uncoated fabrics. TEOS-PDMS coating provides a promising approach for enhancing the hydrophobic and surface properties of cotton and polyester fabrics.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Nikita Belko, Hanna Maltanava, Anatol Lugovski, Polina Shabunya, Sviatlana Fatykhava, Evgeny Bondarenko, Pavel Chulkin, Sergey Poznyak, Michael Samtsov
Summary: This study investigates the difference in electrochemical behavior between rhodamine B hydrazide and rhodamine B acylhydrazone, and finds that rhodamine B acylhydrazone exhibits higher reversibility in electrooxidation. These results can be applied for developing new sensors with desired electrochemical properties.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Showket Ahmad Bhat, Mohd Ikram
Summary: In this study, 0-3 particulate multiferroic composites were synthesized and characterized. The composites exhibited excellent ferroelectric and ferromagnetic properties, as well as high piezoelectric strain and magnetoelectric coupling effects.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Carla Gomes, Mariana Costa, Susana M. M. Lopes, Bernardo Albuquerque Nogueira, Rui Fausto, Jose A. Paixao, Teresa M. V. D. e Melo, Luisa M. D. R. S. Martins, Marta Pineiro
Summary: The development of sustainable processes requires the integration of green chemistry principles. In this study, a solvent-free synthesis method was developed to prepare new copper catalysts, which efficiently catalyze cycloaddition reactions under solvent-free mechanochemical conditions. Through this process, the principles of atom economy, reduction of solvents and auxiliaries, design for energy efficiency, and reduction of derivatives and catalysis are combined.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Zhihua Liu, Jinzhe Li, Jianguo Zhou
Summary: This study demonstrates the enhancement of photoelectrochemical activity of BiFeO3 photoelectrodes through ion modification, which increases visible light absorption and active area, leading to improved PEC water splitting performance.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yisheng Zhang, Wensong Li, Jing Li, Fang Li, Wei Xue, Xinqiang Zhao, Yanji Wang
Summary: Pt/C and SO42-/ZrO2 were used as catalysts for the synthesis of p-aminophenol through the catalytic transfer hydrogenation of nitrobenzene in water with formic acid as the hydrogen source. The optimal Pt loading for PAP selectivity was found to be 1 wt%. The presence of different valence states of Pt affected both the nitrobenzene hydrogenation and formic acid decomposition. Among different solid acid catalysts tested, SO42-/ZrO2 exhibited the highest catalytic activity for p-aminophenol formation. Under the optimized reaction conditions, the conversion of nitrobenzene reached 80.0%, with a selectivity of 47.6% for p-aminophenol.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Pradyota Kumar Behera, Papita Behera, Amlan Swain, Santosh Kumar Sahu, Ajeena Sahoo, Laxmidhar Rout
Summary: We have developed a simple and direct method for the synthesis of diaryl ether using an oxygen bridged bimetallic CuMoO4 nanocatalyst under mild reaction conditions. The catalyst exhibited tolerance towards a wide range of substrates with various functional groups. It is efficient and recyclable. This methodology allows easy access to nitrofen derivatives (herbicides) from unactivated 2,4-dichlorophenol, which are important for agriculture and pharmaceuticals.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Yihua Fu, Yan Zhang, Changwei Hu, Zhishan Su
Summary: The mechanism of the reaction between CO2 and styrene oxide for cyclic carbonate was revealed using density functional theory calculations. The noncatalytic reaction occurred via a concerted mechanism, while in the presence of guanidine and tetrabutylammonium iodide (TBAI) co-catalysts, the epoxide ring-opening by nucleophilic attack of an iodide anion was predicted to be the rate-determining step. Guanidine acted as the H-bond donor to activate styrene oxide, facilitating the reaction with a lower activation barrier.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
Saikat Khamarui, Sirshendu Ghosh
Summary: Copper nanorods (Cu-NRs) exhibit significant plasmonic behavior and can act as efficient catalysts in redox processes and coupling. A benign decarboxylative approach, utilizing localized surface plasmon resonance (LSPR) assisted catalysis with Cu-NRs, has been developed for the production of alkane analogues from alkyl carboxylic acids under visible light. The catalyst shows a broad substrate scope and high functional group tolerance, without the need for an external oxidant or proton source. A plausible mechanism for this recyclable nano-catalyst has also been proposed based on control experiments.
NEW JOURNAL OF CHEMISTRY
(2024)
