Article
Cardiac & Cardiovascular Systems
Kevin C. Pan, Sai Shankar, Johnny Millar, Roberto Chiletti, Warwick Butt, Yves d'Udekem, Siva P. Namachivayam
Summary: In children requiring VA ECMO after cardiac surgery, the use of levosimendan was associated with a decreased risk of weaning failure and in-hospital mortality.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Fridtjof Schiefenhoevel, Christian Berger, Liubov Penkova, Herko Grubitzsch, Bernhard Haller, Alexander Meyer, Matthias Heringlake, Michael Sander, Joachim M. Erb, Felix Balzer, Sascha Treskatsch
Summary: This study analyzed the influence of timing of Levosimendan administration on perioperative outcome in cardiac surgery patients and found that prolonged preoperative treatment with Levosimendan may be beneficial in terms of postoperative outcome.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Fridtjof Schiefenhoevel, Ralf F. Trauzeddel, Michael Sander, Matthias Heringlake, Heinrich Groesdonk, Herko Grubitzsch, Jochen Kruppa, Christian Berger, Sascha Treskatsch, Felix Balzer
Summary: The study analyzed over 11,000 adult patients who underwent cardiac surgery between 2006 and 2019 in ICUs, revealing that high CVP values were associated with increased ICU mortality and a higher incidence of complications.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Armelle Bridier, Monisha Shcherbakova, Atsushi Kawaguchi, Nancy Poirier, Carla Said, Rita Noumeir, Philippe Jouvet
Summary: Infrared thermography and blood gas analysis were used to monitor children with low cardiac output syndrome, and a significant but weak correlation was found between the thermal gradient obtained by infrared thermography and the oxygen extraction ratio.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Hannah Kipka, Roland Tomasi, Max Hubner, Uwe Liebchen, Christian Hagl, Klaus T. Wanner, Hanna Mannell, Georg Hofner
Summary: A highly sensitive LC-ESI-MS/MS method for simultaneous quantification of levosimendan and its metabolites was developed and validated. The study revealed constitutional isomers of levosimendan metabolites in surgical patients' samples, which were identified as metamizole metabolites. This research is important for efficient therapeutic drug monitoring (TDM) of cardiac surgery patients even with the additional administration of metamizole.
Review
Anesthesiology
Matthias Lapere, Filip Rega, Steffen Rex
Summary: This systematic review evaluates the safety and efficacy of peri-operative levosimendan administration in pediatric cardiac surgery. The use of levosimendan reduced the incidence of low cardiac output syndrome (LCOS) and increased cardiac index compared with other inotropes or placebo. However, it did not significantly improve other clinical outcomes.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2022)
Article
Multidisciplinary Sciences
Andreas Garcia-Bardon, Jens Kamuf, Alexander Ziebart, Tanghua Liu, Nadia Krebs, Bastian Duenges, Robert F. Kelm, Svenja Morsbach, Kristin Mohr, Axel Heimann, Erik K. Hartmann, Serge C. Thal
Summary: The study investigated the effects of levosimendan on hemodynamic parameters, cerebral perfusion, and oxygenation following cardiac arrest in juvenile male pigs. Levosimendan significantly increased brain PbtO(2) levels without affecting cardiac output or cerebral microcirculation, suggesting a local effect. This indicates that levosimendan may offer a promising therapeutic approach to rescue brain tissue at risk following cardiac arrest or ischemic events.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Lourdes Montero-Cruces, Manuel Carnero-Alcazar, Fernando Jose Reguillo-Lacruz, Francisco Javier Cobiella-Carnicer, Daniel Perez-Camargo, Paula Campelos-Fernandez, Luis Carlos Maroto-Castellanos
Summary: This study compares the hemodynamic performance of three different biological aortic prostheses one year post-surgery. Results show Trifecta(TM) to have superior performance over Crown PRTTM in terms of mean gradients and maximum velocity.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Critical Care Medicine
Julien Massol, Noemie Simon-Tillaux, Joanna Tohme, Geoffroy Hariri, Pauline Dureau, Baptiste Duceau, Lisa Belin, David Hajage, Yann De Rycke, Ahmed Charfeddine, Guillaume Lebreton, Alain Combes, Adrien Bougle
Summary: This study emulated a randomized trial using observational data to investigate the effect of levosimendan on weaning from VA-ECMO. No association was found between levosimendan treatment and successful ECMO weaning or mortality rates. However, the researchers suggest that subgroups within the population of interest may still benefit from levosimendan.
Article
Endocrinology & Metabolism
Chien-Ting Pan, Xue-Ming Wu, Cheng-Hsuan Tsai, Yi-Yao Chang, Zheng-Wei Chen, Chin-Chen Chang, Bo-Ching Lee, Che-Wei Liao, Ya-Li Chen, Lung-Chun Lin, Yi-Ru Chang, Chi-Sheng Hung, Yen-Hung Lin
Summary: Patients with primary aldosteronism (PA) experience cardiac remodeling primarily due to hemodynamic and non-hemodynamic causes. This study found that adrenalectomy in patients with aldosterone-producing adenoma (APA) can improve both hemodynamic and non-hemodynamic components of left ventricular remodeling. The regression of predicted left ventricular mass index (pLVMI) and inappropriately excessive LVMI (ieLVMI) was correlated with decreases in blood pressure and aldosterone-to-renin ratio (ARR).
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Omar Asdrubal Vilca Mejia, Gabrielle Barbosa Borgomoni, Nilza Lasta, Mariana Yumi Okada, Mariana Silva Biason Gomes, Mary Lee Norris Nelsen Foz, Helga Priscila Giugno Bischoff, Tatiana Saruhashi, Livia Maria Garcia Melro, Marcio Campos Sampaio, Pedro Gabriel Melo de Barros e Silva, Jose Carlos Teixeira Garcia, Valter Furlan
Summary: The study evaluated the impact of ERAS protocol on cardiac surgery and found that the TotalCor protocol reduced hospital stay. There were no significant differences in complications and mortality between the two groups, indicating the safety and effectiveness of the TotalCor protocol.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Multidisciplinary
Delin Zhang, Yi Shen, Zhiyun Chen, Yang Guo, Zaifeng Gao, Jian Huang, Xiqian Lu
Summary: Cognitive dysfunction after anesthesia and surgery has long been recognized. Recent empirical evidence shows that patients may experience social cognition dysfunction (SCD), particularly deficits in emotion recognition, following cardiac surgery. This study focused on examining patients' abilities of biological motion (BM) emotion perception and action perception before and after anesthesia and surgery. Results revealed that while action perception remained intact after cardiac surgery, 18.3% of patients exhibited deficits in emotion perception, further confirming the existence of SCD after anesthesia and surgery.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Critical Care Medicine
Ben Gelbart, Anatole Harrois, Lauren Gardiner, Cherie Mcgregor, Laurent Bitker, Eva Van Zanten, Emma Beel, Rinaldo Bellomo, Trevor Duke, Warwick Butt
Summary: This study investigated the hemodynamic response in children receiving fluid boluses for hypotension in a cardiac ICU. The findings suggest that most patients had a mean arterial pressure response to fluid boluses, but this response often returned to baseline levels.
PEDIATRIC CRITICAL CARE MEDICINE
(2021)
Letter
Medicine, General & Internal
Felix Hennig, Christoph Knosalla
Summary: Devereaux et al. have contributed to the characterization of appropriate thresholds for defining myocardial damage after cardiac surgery, particularly in relation to the use of different cardioplegic solutions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Chemistry, Medicinal
Panagiotis Ftikos, Areti Falara, Panagiota Rellia, Evangelos Leontiadis, George Samanidis, Natalia Kamperi, Artemios Piperakis, Constantin Tamvakopoulos, Theofani Antoniou, Kassiani Theodoraki
Summary: This study aimed to examine the impact of the duration of cardiopulmonary bypass on the therapeutic drug monitoring and evaluate the effect of preemptive administration of levosimendan on perioperative hemodynamic and echocardiographic parameters in patients with preexisting pulmonary hypertension. The results showed that the measured plasma concentrations of levosimendan were inversely related to the duration of cardiopulmonary bypass. Preemptive administration of levosimendan effectively reduced pulmonary artery pressure and improved hemodynamic parameters, with a more pronounced and durable effect at a higher dose of 12 μg/kg.
Article
Cardiac & Cardiovascular Systems
Andrea Scotti, Azeem Latib, Antonio Popolo Rubbio, Luca Testa, Marianna Adamo, Paolo Denti, Francesco Melillo, Maurizio Taramasso, Antonio Sisinni, Federico De Marco, Carmelo Grasso, Arturo Giordano, Antonio L. Bartorelli, Nicola Buzzatti, Rodolfo Citro, Francesco De Felice, Ciro Indolfi, Ida Monteforte, Emmanuel Villa, Cristina Giannini, Anna Sonia Petronio, Gabriele Crimi, Giuseppe Tarantini, Antonio Colombo, Eustachio Agricola, Marco Metra, Alberto Zangrillo, Alberto Margonato, Corrado Tamburino, Francesco Maisano, Francesco Bedogni, Cosmo Godino
Summary: This study aimed to develop and validate a clinical risk score to predict the risk of death or heart failure hospitalization in COAPT-ineligible patients who underwent TEER. The study found that the CITE score is a simple and effective tool for predicting adverse outcomes and can support clinical decision-making.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Engineering, Biomedical
Maria Benedetto, Giulia Piccone, Massimo Baiocchi, Elisa Cerchierini, Marco Adversi, Agostino Rossi, Alessio Dell'Olio, Daniela Di Luca, Andrea Castelli, V. Marco Ranieri, Tommaso Tonetti
Summary: This study analyzed the demographic features, clinical course, and outcomes of COVID-19 patients treated with V-V ECLS during the Italian 'third wave'. The unadjusted mortality rate of COVID-19 ARDS patients receiving V-V ECLS was similar to pre-pandemic cases, but the duration of ECLS was significantly longer and complications were frequent. This may be attributed to the selection of critically ill patients at baseline who developed multiorgan failure during the course of ECLS.
Article
Cardiac & Cardiovascular Systems
David Conen, Ekaterine Popova, Michael Ke Wang, Matthew T. V. Chan, Giovanni Landoni, Cara Reimer, Sadeesh K. Srinathan, Juan P. Cata, Sean R. McLean, Juan Carlos Trujillo Reyes, Ascension Martin Grande, Anna Gonzalez Tallada, Daniel I. Sessler, Edith Fleischmann, Donna E. Maziak, Barbara Kabon, Luca Voltolini, Laura Gutierrez-Soriano, Vikas Tandon, Deborah DuMerton, Biniam Kidane, Ravi Rajaram, Yaron Shargall, John D. Neary, Jennifer R. Wells, William F. McIntyre, Steffen Blum, Sandra N. Ofori, Jessica Vincent, Lizhen Xu, Zhuoru Li, Jeff S. Healey, Amit X. Garg, P. J. Devereaux
Summary: The COP-AF trial aims to test whether colchicine reduces the incidence of perioperative atrial fibrillation and myocardial injury after noncardiac surgery.
AMERICAN HEART JOURNAL
(2023)
Editorial Material
Anesthesiology
Yuki Kotani, Alessandro Belletti, Jacopo D'Andria Ursoleo, Stefano Salvati, Giovanni Landoni
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Letter
Geriatrics & Gerontology
Giacomo Maiucci, Stefano Fresilli, Giovanni Landoni
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Anesthesiology
Fabrizio Monaco, Gaia Barucco, Caterina C. Lerose, Monica DE Luca, Margherita Licheri, Marta Mucchetti, Rosa Labanca, Federica Morselli, Cristina Mattioli, Federica Russetti, Alberto Zangrillo
Summary: This study compared the sedative effects of midazolam with remifentanil to dexmedetomidine in patients undergoing complex endovascular aortic repair. The results showed that the remifentanil group had higher satisfaction and the dexmedetomidine group had stronger sedative effects.
MINERVA ANESTESIOLOGICA
(2023)
Article
Medicine, General & Internal
Ludhmila Abrahao Hajjar, Marco B. Ancona, Roberto Kalil Filho, Moreno Tresoldi, Jose Guilherme Caldas, Giacomo Monti, Francisco Cesar Carnevale, Francesco De Cobelli, Andre Moreira de Assis, Fabio Ciceri, Giovanni Landoni, Jouke Dijkstra, Francesco Moroni, Alexandre Antonio Cunha Abizaid, Fernanda Willemann Ungaretti, Maria Jose Carvalho Carmona, Daniel De Backer, Carlos Eduardo Pompilio, Fabio S. de Britto Jr, Carlos M. Campos, Alberto Zangrillo, Matteo Montorfano
Summary: This study aimed to evaluate the diagnostic value of optical coherence tomography (OCT) for pulmonary microvascular thromboinflammatory syndrome in patients with COVID-19 pneumonia. The results showed that OCT assessment of the distal pulmonary arteries in hospitalized COVID-19 patients is safe and accurate, enabling the first in vivo documentation of distal pulmonary arterial thrombosis in patients with elevated thromboinflammatory markers, even when their CT angiogram was negative for pulmonary thrombosis.
FRONTIERS IN MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Maria Lombardi, Marta Bonora, Luca Baldetti, Marina Pieri, Anna Mara Scandroglio, Giovanni Landoni, Alberto Zangrillo, Chiara Foglieni, Filippo Consolo
Summary: This study found significant differences in the expression levels of platelet miR-126, miR-374b, miR-223, and miR-320a between LVAD patients and healthy controls. The expression levels of platelet miR-25, miR-144, miR-320, and miR-451a changed significantly during LVAD support, and these miRs were implicated in cardiac- and coagulation-associated pathways. Patients who experienced bleeding had significantly higher expression levels of platelet miR-151a and miR-454 before LVAD implantation, and these miRs were also differentially expressed before the clinical manifestation of bleeding events. This study provides evidence of significant modulation of platelet miRs expression driven by LVADs and suggests the potential predictive value of platelet miRs in bleeding events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Irene Steinberg, Damiano Patrono, Enrico De Cesaris, Michele Luca, Giorgia Catalano, Matteo Marro, Giorgia Rizza, Erika Simonato, Luca Brazzi, Renato Romagnoli, Marinella Zanierato
Summary: This study examined the use of A-NRP for liver viability assessment in DCD donors. The results showed that DO2-normalized lactate clearance could be an important parameter for assessing liver viability during A-NRP.
Article
Medicine, Research & Experimental
Giacomo Monti, Aidos Konkayev, Sonia Carta, Nikola Bradic, Andrea Bruni, Yuki Kotani, Fabio Guarracino, Ivan Redkin, Giuseppe Biondi-Zoccai, Umberto Benedetto, Fabrizio D'Ascenzo, Eugenio Garofalo, Martina Baiardo Redaelli, Giulia Brizzi, Francesco Forfori, Giovanni Borghi, Sara Scapol, Elena Momesso, Raffaele Cuffaro, Nicoletta Boffa, Simon Rauch, Filippo D'Amico, Giorgia Montrucchio, Maria Caterina Pace, Carola Galbiati, Stefano Bosso, Francesco Savelli, Giuseppe Giardina, Simona Silvetti, Vincenzo Francesco Tripodi, Rosa Labanca, Rosalba Lembo, Marilena Marmiere, Matteo Marzaroli, Cristina Nakhnoukh, Davide Valsecchi, Gabriele Finco, Felice Eugenio Agro, Tiziana Bove, Francesco Corradi, Federico Longhini, Giovanni Landoni, Rinaldo Bellomo, Alberto Zangrillo
Summary: This study aims to investigate the efficacy of high dose esomeprazole in reducing organ dysfunction in patients with sepsis or septic shock. Through a randomized trial, the study will compare the mean daily Sequential Organ Failure Assessment (SOFA) score over 10 days between the high dose esomeprazole group and the placebo group, as well as secondary outcomes such as antibiotic-free days, single organ failure severity, intensive care unit-free days at day 28, and mortality. The results of this study are expected to provide new insights for the treatment of sepsis or septic shock.
CONTEMPORARY CLINICAL TRIALS
(2023)
Article
Anesthesiology
Stefano Fresilli, Rosa Labanca, Fabrizio Monaco, Alessandro Belletti, Filippo D'Amico, Andrea Blasio, Yuki Kotani, Giovanni Landoni
Summary: This systematic review and meta-analysis compares the outcomes of patients receiving del Nido solution with other types of cardioplegia in cardiac surgery. The results indicate that del Nido cardioplegia is associated with a lower rate of postoperative stroke and/or transient ischemic attack. It also reduces aortic cross-clamp time, the need for defibrillation, and the risk of postoperative acute kidney injury, without affecting mortality.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Article
Critical Care Medicine
Yuki Kotani, Alessandro Pruna, Stefano Turi, Giovanni Borghi, Todd C. C. Lee, Alberto Zangrillo, Giovanni Landoni, Laura Pasin
Summary: This study conducted a systematic review and meta-analysis, and found that propofol may reduce survival in perioperative and critically ill patients compared to other hypnotic agents. Therefore, a careful assessment of the risk versus benefit of propofol compared to other agents is needed when planning for large, pragmatic multicentric randomized controlled trials to provide a definitive answer.
Letter
Critical Care Medicine
Yuki Kotani, Giovanni Landoni, Alessandro Belletti, Ashish K. Khanna
Letter
Critical Care Medicine
Alessandro Belletti, Jacopo D'Andria Ursoleo, Anna Mara Scandroglio, Giovanni Landoni, Alberto Zangrillo
ANNALS OF INTENSIVE CARE
(2023)
Article
Andrology
Paolo Capogrosso, Alessandro Bertini, Marina Pontillo, Anna Maria Ferrara, Alice Cotelessa, Cristina Carenzi, Giuseppe A. Ramirez, Cristina Tresoldi, Massimo Locatelli, Antonella Castagna, Francesco De Cobelli, Moreno Tresoldi, Alberto Zangrillo, Giovanni Landoni, Patrizia Rovere-Querini, Fabio Ciceri, Francesco Montorsi, Giacomo Monti, Andrea Salonia
Summary: This study found lower circulating tT levels in male patients with COVID-19 compared to those without COVID-19, despite both groups being admitted to the ICU for severe ARDS.