Article
Oncology
Aina Calls, Abel Torres-Espin, Xavier Navarro, Victor J. Yuste, Esther Udina, Jordi Bruna
Summary: The study used single-cell RNA sequencing to investigate the transcriptomic profile of sensory neurons in a CIPN mouse model, revealing that cisplatin treatment upregulates biological pathways related to DNA damage response in DRG neurons. Following cisplatin-induced DNA damage, DRG neurons exhibited senescence hallmarks without activation of apoptosis pathways.
Article
Engineering, Environmental
Dongmeng Liu, Dahui Xue, Wencan Lu, Zhuochun Yang, Li Li, Beibei Xia, Jinhua Wei, Xianxiong Chen, Yi Yang, Xiaomei Wang, Guimiao Lin
Summary: Research has shown that BDE-47 can lead to changes in cell morphology, apoptosis, and ROS production in PC-12 cells, as well as promote cell differentiation. Animal studies confirmed that BDE-47 causes a decrease in neurons in the brain, and transcriptome sequencing revealed significant regulation of multiple signaling pathways related to neuron death and nerve function.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Sara A. Wahdan, Doaa A. Elsherbiny, Samar S. Azab, Ebtehal El-Demerdash
Summary: Piceatannol (PIC) may protect against cisplatin-induced peripheral neuropathy by reversing behavioral changes, reducing neurotensin levels, decreasing platinum accumulation in nerves, and restoring nerve structure.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Oncology
Xindi Zhang, Matthew R. Trendowski, Emma Wilkinson, Mohammad Shahbazi, Paul C. Dinh, Megan M. Shuey, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Robert Huddart, Neil E. Martin, Victoria A. Sanchez, Robert D. Frisina, Lawrence H. Einhorn, Nancy J. Cox, Lois B. Travis, M. Eileen Dolan
Summary: This study identified comorbidities for cisplatin-induced neurotoxicities and found that TXNRD1 and WNT8A are notable risk factors for hearing loss and tinnitus, respectively.
Review
Toxicology
Lenka Pulkrabkova, Barbora Svobodova, Jan Konecny, Tereza Kobrlova, Lubica Muckova, Jiri Janousek, Jaroslav Pejchal, Jan Korabecny, Ondrej Soukup
Summary: Organophosphorus compounds are a constant problem in both military and civilian fields, causing acute poisoning and long-term consequences. The key mechanism of their toxicity is the inhibition of acetylcholinesterase, leading to overstimulation of receptors and the activation of the glutamatergic system. This review presents neuroprotection strategies that can slow down nerve cell damage and alleviate neurological and neuropsychiatric disturbance.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ivo Lambrichts, Esther Wolfs, Annelies Bronckaers, Pascal Gervois, Tim Vangansewinkel
Summary: This study explored the biological properties and effects of leukocyte- and platelet-rich fibrin (L-PRF) on cells from the central and peripheral nervous system. The findings showed that L-PRF had positive effects on peripheral neurons, but had detrimental effects on central neurons and their neurite outgrowth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Anna Wellenberg, Lea Weides, Jennifer Kurzke, Till Hennecke, Julia Bornhorst, Barbara Crone, Uwe Karst, Vanessa Brinkmann, Gerhard Fritz, Sebastian Honnen
Summary: By studying platinum-induced neurotoxicity in C. elegans, the molecular mechanism has been elucidated and NAC and WR1065 were found to have protective effects against platinum-induced toxicity.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Hucke, Rita Schroeter, Cecilia Ceresa, Alessia Chiorazzi, Annalisa Canta, Sara Semperboni, Paola Marmiroli, Guido Cavaletti, Burkhard Gess, Giuliano Ciarimboli
Summary: CDDP is an efficient chemotherapeutic agent, but it has significant unwanted side effects. This study suggests that OCT may play a role in causing these side effects by facilitating the uptake of CDDP. Mice lacking the OCT2 gene showed reduced kidney and neurological impairments compared to wild-type mice. OCT could be potential targets for reducing unwanted side effects and improving CDDP anticancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ewa Dudzinska, Kinga Szymona, Renata Kloc, Tomasz Kocki, Paulina Gil-Kulik, Jacek Bogucki, Janusz Kocki, Roman Paduch, Ewa M. Urbanska
Summary: Fractalkine levels were significantly higher in AN patients, while sICAM-1, KYNA, KYN, TRP, and 3-OH-KYN levels were unchanged. The expression of KAT3 gene was increased in AN patients, but KAT1 and KAT2 genes showed no significant change. Fractalkine positively correlated with TRP, while sICAM-1 was negatively associated with 3-OH-KYN and positively linked with the ratio KYN/3-OH-KYN.
Review
Oncology
Sarah Trouvilliez, Chann Lagadec, Robert-Alain Toillon
Summary: This review summarizes the failures of targeted therapies against TrkA, focusing on non-genomic resistance. It highlights that overexpression of TrkA can lead to ligand-independent activation, bypassing the effect of kinase inhibitors, resulting in treatment failures. These observations suggest that genetics alone cannot explain all therapeutic failures, and new hypotheses are needed to understand these failures.
Editorial Material
Oncology
David Mizrahi
Summary: There is currently a lack of effective interventions for preventing chemotherapy-induced peripheral neuropathy (CIPN), but exercising during chemotherapy treatment may have protective effects. This Editorial discusses a randomized control study on the efficacy of strength or balance exercise in preventing CIPN.
BRITISH JOURNAL OF CANCER
(2021)
Article
Medicine, Research & Experimental
Xiaoyu Duan, Jing Wen, Min Zhang, Chao Wang, Yalan Xiang, Lu Wang, Changwei Yu, Gongying Deng, Miao Yan, Bikui Zhang, Pingfei Fang
Summary: The acute toxicity of Semen Strychni and the detoxification effect of liquorice were investigated in this study. The results showed that treatment with Semen Strychni extracts caused oxidative stress and inflammation in the hippocampus of rats. Liquorice and its active components mitigated Semen Strychni-induced neurotoxicity partly through the HMGB1-related pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Canelif Yilmaz, Thanasis Rogdakis, Alessia Latorrata, Evangelia Thanou, Eleftheria Karadima, Eleni Papadimitriou, Eleni Siapi, Ka Wan Li, Theodora Katsila, Theodora Calogeropoulou, Ioannis Charalampopoulos, Vasileia Ismini Alexaki
Summary: The newly synthesized small molecule ENT-A010 exhibited neuroprotective effects and modulated microglial function through the activation of the TRKA receptor signaling pathway, showing potential in the treatment of CNS disorders.
Article
Environmental Sciences
Hend Mohamed Hussien, Mokhtar Ibrahim Yousef
Summary: This study aimed to investigate the neuroprotective effect of ginseng extract against neurological and behavior abnormalities induced by cisplatin. The results showed that ginseng extract could alleviate the memory dysfunction and locomotor disability induced by cisplatin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ezgi Eroglu, Cigdem Cengelli Unel, Nusin Harmanci, Kevser Erol, Neziha Senem Ari, Orhan Ozatik
Summary: The study aimed to investigate the potential protective effects of 2-APB on cisplatin-induced neurotoxicity. Results showed that 2-APB ameliorated cisplatin-induced neurotoxicity by improving mechanical and cold allodynia and motor coordination impairment, as well as reducing structural toxicity in peripheral tissues.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2022)
Article
Neurosciences
Lais Silva Fernandes, Neife Aparecida G. dos Santos, Guilherme Luz Emerick, Antonio Cardozo dos Santos
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Rafaela Scalco Ferreira, Neife Aparecida Guinaim dos Santos, Carolina P. Bernardes, Flavia Malvestio Sisti, Lilian Amaral, Andreia C. K. Fontana, Antonio Cardozo dos Santos
NEUROTOXICITY RESEARCH
(2019)
Article
Neurosciences
Carolina P. Bernardes, Neife A. G. Santos, Tassia R. Costa, Flavia Sisti, Lilian Amaral, Danilo L. Menaldo, Martin K. Amstalden, Diego L. Ribeiro, Lusania M. G. Antunes, Suely Vilela Sampaio, Antonio C. Santos
NEUROTOXICITY RESEARCH
(2020)
Review
Food Science & Technology
Neife Aparecida Guinaim dos Santos, Rafaela Scalco Ferreira, Antonio Cardozo dos Santos
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Article
Pharmacology & Pharmacy
Rebeca Araujo Cantelmo, Neife Aparecida G. dos Santos, Antonio Cardozo dos Santos, Samia Regiane Lourenco Joca
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2020)
Article
Neurosciences
Flavia Malvestio Sisti, Neife Aparecida Guinaim dos Santos, Lilian do Amaral, Antonio Cardozo dos Santos
Summary: Carvacrol (CARV) is a phytochemical with promising neurotrophic effects in neuronal models, potentially beneficial in treating neurodegenerative and neurological diseases by inducing neurite outgrowth and enhancing neuronal plasticity and bioenergetics.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lilian do Amaral, Neife Aparecida Guinaim dos Santos, Flavia Malvestio Sisti, Elaine Del Bel, Antonio Cardozo dos Santos
Summary: This study demonstrates the neurotrophic potential of doxycycline by inducing neurite outgrowth through activation of the trkA receptor and downstream signaling pathways, without inducing the expression of NGF. Additionally, doxycycline increased the expression of proteins involved in axonal and synaptic plasticity, suggesting a potential role in restoring neuronal connectivity lost at the initial phase of neurodegeneration.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Pharmacology & Pharmacy
Lilian do Amaral, Gabriel Rocha Caldas, Neife Aparecida Guinaim dos Santos, Renato Luis Tame Parreira, Jairo Kennup Bastos, Antonio Cardozo dos Santos
Summary: Baccharin, a small neurotrophic molecule, has the potential to induce neuritogenesis and promote axonal and synaptic plasticity. It acts by activating the trkA receptor and downstream signaling pathways, similar to the action of nerve growth factor. Additionally, baccharin has favorable pharmacokinetic properties and drug-like characteristics.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)