Article
Horticulture
Hongfei Li, Fang Song, Xiaoxiao Wu, Chongling Deng, Qiang Xu, Shu'ang Peng, Zhiyong Pan
Summary: The study identified significant changes in rhizosphere and root bacterial genera in response to CLas infection, with particular impacts on carbohydrate metabolism and phosphoinositide signaling pathways.
Article
Microbiology
Alexander S. F. Berry, Meghann K. Pierdon, Ana M. Misic, Megan C. Sullivan, Kevin O'Brien, Ying Chen, Samuel J. Murray, Lydia A. Ramharack, Robert N. Baldassano, Thomas D. Parsons, Daniel P. Beiting
Summary: The study reveals that parity is an important factor modulating the gut microbiome during pregnancy, impacting the community of bacteria that colonize the offspring gut early in life, potentially influencing host metabolism. The results underscore the importance of considering parity in human microbiome studies during pregnancy and in infants.
Review
Infectious Diseases
Kristien Nel Van Zyl, Siphiwe R. Matukane, Bianca L. Hamman, Andrew C. Whitelaw, Mae Newton-Foot
Summary: Antibiotic use can alter the diversity and composition of the human microbiota. This systematic review found that certain antibiotics can cause long-term dysbiosis in the microbiome. The importance of longitudinal analysis and studies in pediatric populations was highlighted.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Microbiology
Sven Kleine Bardenhorst, Tom Berger, Frank Klawonn, Marius Vital, Andre Karch, Nicole Ruebsamen
Summary: Reproducibility in microbiome studies is hindered by a lack of consensus on data analysis strategies. The complex nature of microbiome data, combined with increasingly sophisticated research questions, requires more advanced analytical methods. Current analysis strategies in microbiome studies show significant heterogeneity, particularly in differential abundance testing, indicating a need for better guidance in analyzing increasingly complex research questions.
Article
Immunology
Hadar Mudrik-Zohar, Shaqed Carasso, Tal Gefen, Anat Zalmanovich, Michal Katzir, Yael Cohen, Yossi Paitan, Naama Geva-Zatorsky, Michal Chowers
Summary: Sequencing tools uncover the complex biodiversity of IDFU and highlight the high prevalence of anaerobes and Gram-negative bacteria in these ulcers. Furthermore, sequencing results reveal possible associations among certain genera, species, and bacterial functional genes to clinical outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Food Science & Technology
Yufang Liu, Junna Cai, Fuxin Zhang
Summary: The study found that different types of milk have different effects on the intestinal microbiota of mice. Significant differences in nutrient components between breast milk, cow milk, and goat milk can alter the composition and functional features of the intestinal microbiota. The protein, minerals, and amino acid content of milk are correlated with specific bacterial groups in the intestinal microbiota.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Health Care Sciences & Services
Souad Kartti, Houda Bendani, Nasma Boumajdi, El Mehdi Bouricha, Oumaima Zarrik, Hajar EL Agouri, Mohamed Fokar, Youssef Aghlallou, Rachid EL Jaoudi, Lahcen Belyamani, Basma Elkhannoussi, Azeddine Ibrahimi
Summary: This study analyzed the differences in bacterial composition between tumor and adjacent tissues in breast cancer patients in Morocco. The results showed that tumor tissues had a higher abundance of Bacilli and Actinobacteria, while adjacent tissues had a higher abundance of Gammaproteobacteria. Additionally, different microbial communities were identified in different breast cancer subtypes. These findings have implications for diagnosis and treatment strategies for breast cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biology
Thubasni Kunasegaran, Vinod R. M. T. Balasubramaniam, Valliammai Jayanthi T. Arasoo, Uma Devi Palanisamy, Amutha Ramadas
Summary: Recent studies have highlighted the importance of the microbiome, particularly the impact of gut microbiota changes on conditions like gestational diabetes mellitus. Specific microorganisms have been found to play a role in the onset and progression of GDM, with dietary factors influencing their presence. Incorporating individualized dietary interventions based on microbiome into GDM management shows great promise in improving health outcomes.
Article
Microbiology
Sarika Jaiswal, Bharti Aneja, Jaisri Jagannadham, Bharati Pandey, Rajender Singh Chhokar, Subhash Chander Gill, Om Parkash Ahlawat, Anuj Kumar, U. B. Angadi, Anil Rai, Ratan Tiwari, Mir Asif Iquebal, Dinesh Kumar
Summary: This study investigates the impact of different cropping patterns on the soil microbial diversity of wheat microbiome. The findings highlight the significant influence of crop rotation on soil microbial diversity and community composition, showcasing the economic and environmental importance of sustainable agricultural practices for food security and ecosystem health.
MICROBIOLOGY SPECTRUM
(2022)
Article
Clinical Neurology
Jaidaa Mekky, Richard Wani, Sameh M. Said, Mona Ashry, Ahmed Elsayed Ibrahim, Shwikar Mahmoud Ahmed
Summary: This study aims to identify the gut microbiome related to Multiple Sclerosis and explore its role in the susceptibility and progression of the disease. The results demonstrate that patients with relapsing remitting multiple sclerosis have a distinct gut microbiome compared to healthy controls, with certain gut microbes showing decreased or increased abundance in Multiple Sclerosis patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Microbiology
Clarisse Marotz, Kellen J. Cavagnero, Se Jin Song, Daniel McDonald, Stephen Wandro, Greg Humphrey, MacKenzie Bryant, Gail Ackermann, Edgar Diaz, Rob Knight
Summary: This study reanalyzed data from a large sample storage study, confirming that 95% ethanol is an effective, practical, and cost-effective preservative that can preserve samples at room temperature for weeks. It also identified the optimal ratio of 95% ethanol to sample in stool and saliva samples, providing a solution that enables crowdsourcing microbiome studies and lowers the barrier for collecting diverse samples.
Article
Gastroenterology & Hepatology
Zijie Jin, Andy Ng, Corinne F. Maurice, David Juncker
Summary: MiCoMo is a low-cost, benchtop multi-bioreactor system that simulates the human colon environment, allowing for the study of gut microbial communities with high throughput and multiplexing capabilities.
Review
Microbiology
Sonia Nath, Shaju Jacob Pulikkotil, Laura Weyrich, Peter Zilm, Kostas Kapellas, Lisa Jamieson
Summary: This systematic review evaluated the effect of periodontal interventions on the diversity and composition of periodontal microbiota. The results showed that periodontal interventions can decrease bacterial diversity and richness, and alter the composition of oral microbiota.
Article
Fisheries
Christina Pavloudi, Maria Ioanna Tsertou, Efthimia Antonopoulou, Pantelis Katharios
Summary: Systemic granulomatosis is a mysterious disease affecting the important aquaculture fish species, Argyrosomus regius, and its etiology remains unknown. Through amplicon metagenomics analysis of the 16S rRNA gene in fish kidneys, it was found that all fish had similar bacterial communities. The presence of only three significantly enriched OTUs in sick individuals, none of which were known granuloma-causing species, supports the hypothesis of a non-infectious cause of this disease in this fish species.
Article
Biochemistry & Molecular Biology
Sam J. R. Stevenson, Kevin C. Lee, Kim M. Handley, Esther R. Angert, W. Lindsey White, Kendall D. Clements
Summary: The symbiotic gut microbiota of Kyphosus sydneyanus, a herbivorous marine fish, plays a crucial role in converting refractory algal carbohydrates into short-chain fatty acids. This study characterized the community composition of the gut microbiota using both 16S rRNA gene amplicon sequencing and shotgun-metagenome sequencing. The results showed that the distribution of the gut microbiota in different sections of the hindgut was influenced by selection pressures and varied among individual fish. However, metagenomic analysis revealed a high functional similarity in the enzymatic degradation of algal-derived substrates, suggesting that the host gut environment selects for functional capacity rather than taxonomic identity of the symbionts. Functional annotation of the microbiota's enzymes provided insights into the metabolic pathways involved in the degradation of important dietary substrates.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Clinical Neurology
Geoffrey Liang, Feng Zhu, Ali Mirza, Amit Bar-Or, Charles N. Bernstein, Christine Bonner, Jessica D. Forbes, Morag Graham, Janace Hart, Natalie C. Knox, Ruth Ann Marrie, Julia O'Mahony, Gary Van Domselaar, E. Ann Yeh, Yinshan Zhao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
Summary: This study examined the changes in gut microbiota composition across repeated samples in paediatric-onset multiple sclerosis (MS) and monophasic-acquired demyelinating syndromes (monoADS). The results showed stability in microbiota composition between different stool samples, suggesting that single stool sample procurement is a reasonable first approach.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Article
Clinical Neurology
Jonas Graf, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Jose M. A. Wijnands, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: This study describes the emergency department visits of multiple sclerosis patients in British Columbia, Canada, and finds that the emergency department plays a crucial role in the healthcare and infection management of these patients.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Clinical Neurology
Ruth Ann Marrie, Mark Allegretta, Lisa F. Barcellos, Bruce Bebo, Peter A. Calabresi, Jorge Correale, Benjamin Davis, Philip L. De Jager, Christiane Gasperi, Carla Greenbaum, Anne Helme, Bernhard Hemmer, Pamela Kanellis, Walter Kostich, Douglas Landsman, Christine Lebrun-Frenay, Naila Makhani, Kassandra L. Munger, Darin T. Okuda, Daniel Ontaneda, Ronald B. Postuma, Jacqueline A. Quandt, Sharon Roman, Shiv Saidha, Maria Pia Sormani, Jon Strum, Pamela Valentine, Clare Walton, Kathleen M. Zackowski, Yinshan Zhao, Helen Tremlett
Summary: This article discusses the importance of studying the prodromal stage of multiple sclerosis and the need to develop standardized criteria to accurately identify high-risk individuals for intervention.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Clinical Neurology
Ali Mirza, Feng Zhu, Natalie Knox, Jessica D. Forbes, Christine Bonner, Gary Van Domselaar, Charles N. Bernstein, Morag Graham, Ruth Ann Marrie, Janace Hart, E. Ann Yeh, Douglas L. Arnold, Amit Bar-Or, Julia O'Mahony, Yinshan Zhao, William Hsiao, Brenda Banwell, Emmanuelle Waubant, Helen Tremlett
Summary: This study examined the metabolic potential of the gut microbiome in pediatric-onset multiple sclerosis (MS) patients. The results showed that compared to controls, MS patients had a higher potential for lipopolysaccharide metabolism but a lower potential for peptidoglycan and starch metabolism.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Review
Clinical Neurology
Jo Lane, Huah Shin Ng, Carmel Poyser, Robyn M. Lucas, Helen Tremlett
Summary: The incidence of multiple sclerosis (MS) has not significantly changed globally over time, but there are certain regions where the incidence is increasing.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Clinical Neurology
Huah Shin Ng, Feng Zhu, Elaine Kingwell, Shenzhen Yao, Okechukwu Ekuma, Charity Evans, John D. Fisk, Ruth Ann Marrie, Yinshan Zhao, Helen Tremlett
Summary: This study examined the association between disease-modifying drugs (DMDs) for multiple sclerosis (MS) and survival, and found that exposure to DMDs is associated with a lower hazard of mortality. Early initiation of DMDs is associated with a significant survival advantage, although this advantage diminishes over time.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Anibal Chertcoff, Huah Shin Ng, Fong Zhu, Yinshan Zhao, Helen Tremlett
Summary: This study estimated the prevalence of polypharmacy in individuals with multiple sclerosis (MS) and compared the characteristics of those with and without polypharmacy. The results showed that more than one in four MS patients met the criteria for polypharmacy. The likelihood of polypharmacy was higher in women, older individuals, those with multiple comorbidities, and lower socioeconomic status.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: The study found that lower socioeconomic status is associated with a higher mortality risk in persons with multiple sclerosis (PwMS).
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Jose M. A. Wijnands, Mohammad Ehsanul Karim, Elaine Kingwell, Feng Zhu, Charity Evans, John D. Fisk, Yinshan Zhao, Ruth Ann Marrie, Helen Tremlett
Summary: Sex and age differences in healthcare utilization were observed during the prodromal phase of multiple sclerosis. Males and older individuals had higher rates of healthcare utilization and were more likely to visit general practitioners, while younger individuals were more likely to visit ophthalmologists. However, no significant sex and age differences were found in the smaller clinical cohort.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Fardowsa L. A. Yusuf, Ayesha Asaf, Ruth Ann Marrie, Ping Li, Kyla McKay, Yinshan Zhao, Feng Zhu, Colleen Maxwell, Helen Tremlett
Summary: Canada has one of the highest rates of paediatric-onset multiple sclerosis (PoMS) globally, and the prevalence, but not incidence, has increased over time. Allocation of resources to support the growing youth population with MS should be a priority.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
A. Chertcoff, H. S. Ng, F. Zhu, Y. Zhao, H. Tremlett
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
F. L. A. Yusuf, J. M. A. Wijnands, M. E. Karim, E. Kingwell, F. Zhu, C. Evans, J. D. Fisk, Y. Zhao, R. A. Marrie, H. Tremlett
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
H. Tremlett
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
F. La Yusuf, A. Asaf, P. Li, K. A. Mckay, Y. Zhao, F. Zhu, H. Tremlett, R. A. Marrie, C. Maxwell
MULTIPLE SCLEROSIS JOURNAL
(2022)
Meeting Abstract
Clinical Neurology
X. Zhou, M. Horton, K. Mccauley, L. Krupp, J. Tillema, M. P. Gorman, L. Benson, J. Ness, B. Weinstock-Guttman, A. T. Waldman, J. Hart, T. Casper, S. Lynch, H. Tremlett, E. Waubant
MULTIPLE SCLEROSIS JOURNAL
(2022)