Review
Neurosciences
Michael K. Yeung
Summary: This article provides a systematic review of fNIRS studies on brain function in children and adolescents, evaluating methodological aspects such as research design, experimental paradigm, fNIRS measurement, data preprocessing, statistical analysis, and result presentation. It also includes a qualitative synthesis of study findings on the effects of age and other factors on changes in oxyhemoglobin concentration.
Article
Multidisciplinary Sciences
Shai Sabbah, Michael S. Worden, Dimitrios D. Laniado, David M. Berson, Jerome N. Sanes
Summary: Studies with experimental animals have found a neural pathway connecting intrinsically photosensitive retinal ganglion cells (ipRGCs) and the prefrontal cortex (PFC) that is involved in mood disorders. This study aimed to investigate whether a similar pathway exists in humans. Functional MRI analysis revealed activation in 26 human brain regions that either decreased or increased monotonically with light intensity, including regions related to visual image formation, motor control, cognition, and emotion. PFC activation was suppressed by light, decreasing monotonically with increasing light intensity. The sustained time course and susceptibility to prior light exposure of light-evoked PFC responses resembled those of ipRGCs. These findings provide a functional link between light exposure and PFC-mediated cognitive and affective phenomena.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Janja Kopic, Alisa Junakovic, Iva Salamon, Mladen-Roko Rasin, Ivica Kostovic, Zeljka Krsnik
Summary: The early regional and laminar positioning of cortical projection neurons is regulated by transcriptional factors and RNA binding proteins. These molecules control various neurogenetic processes within specific cellular compartments, such as proliferation, migration, differentiation, and synaptogenesis. This study examined the distribution of transcription factors and RNA binding proteins in the human frontal cortex during early embryonic development. The results showed distinct regional patterning of deep-layer projection neurons, subplate neurons, and Cajal-Retzius neurons during different developmental phases.
Article
Multidisciplinary Sciences
Yipeng Zhang, Zahra M. Aghajan, Matias Ison, Qiujing Lu, Hanlin Tang, Guldamla Kalender, Tonmoy Monsoor, Jie Zheng, Gabriel Kreiman, Vwani Roychowdhury, Itzhak Fried
Summary: Computer vision guided by deep learning has made significant progress in recognizing specific identities despite variable attributes, similar to the concept cells in the human brain. This study recorded neuronal activity from multiple brain regions to decode identity information and found that only a small population of neurons is necessary for robust decoding.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Sandra Skuja, Simons Svirskis, Modra Murovska
Summary: The study evaluated the infection of HHV-6 and -7 in the brain, finding higher expression of HHV-7 in the temporal gray matter of patients with unspecified encephalopathy. Additionally, HHV-6 predominantly infected oligodendrocytes, while HHV-7 was detected in both astrocytes and oligodendrocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biophysics
Shizhe Li, Li An, Maria Ferraris Araneta, Milalynn Victorino, Christopher S. Johnson, Jun Shen
Summary: This study successfully measured CA activity in the frontal lobe of the human brain for the first time, demonstrating that CA activity in the frontal lobe is essentially indistinguishable from that in the occipital lobe. This provides an important foundation for future psychiatric studies.
NMR IN BIOMEDICINE
(2021)
Article
Endocrinology & Metabolism
Kathleen M. Krol, Nauder Namaky, Mikhail Monakhov, Poh San Lai, Richard Ebstein, Tobias Grossmann
Summary: The study found that genetic variation in the CD38 gene can impact frontal brain asymmetry and looking preferences in 11-month-old infants. Non-risk A-allele carriers showed left lateralization towards smiling individuals, while infants with the risk CC genotype tended to withdraw from smiling faces. This suggests that the oxytocin system is connected to social motivation markers in infancy.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Neurosciences
Bryan Kolb
Summary: This article discusses Milner's contribution to our understanding of frontal lobes through her studies on patients who had undergone frontal lobe excisions. Her research has had a significant impact on our understanding of frontal lobe function.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Biochemical Research Methods
Brian Coughlin, William Munoz, Yoav Kfir, Michael J. Young, Domokos Meszena, Mohsen Jamali, Irene Caprara, Richard Hardstone, Arjun Khanna, Martina L. Mustroph, Eric M. Trautmann, Charlie Windolf, Erdem Varol, Dan J. Soper, Sergey D. Stavisky, Marleen Welkenhuysen, Barundeb Dutta, Krishna V. Shenoy, Leigh R. Hochberg, R. Mark Richardson, Ziv M. Williams, Sydney S. Cash, Angelique C. Paulk
Summary: Neuropixels probes are silicon-based electrophysiology-recording tools with high channel count and recording-site density. They have been successfully used in clinical surgeries to study human neurophysiology, demonstrating their potential and challenges as research devices.
Article
Clinical Neurology
Dandan Sheng, Yefan Lv, Xinru Li, Jing Liu, Weiping Liu
Summary: Differentiating between non-rapid eye movement (NREM) parasomnias and sleep-related hypermotor epilepsy (SHE) is challenging. This study describes a case of a 17-year-old male patient with KCNT1 mutation who exhibited complex abnormal behaviors during sleep, confirmed to be epileptic seizures combined with NREM parasomnias. The study suggests a potential association between NREM parasomnias and KCNT1 mutations.
FRONTIERS IN NEUROLOGY
(2023)
Article
Cell Biology
Daniel R. Schonhaut, Zahra M. Aghajan, Michael J. Kahana, Itzhak Fried
Summary: Time and space are primary dimensions of human experience, and little is known about how they converge during self-guided experience. A recent study investigated the neural correlates of time and space in a virtual navigation game and found that time cells and place cells activate simultaneously during timed navigation intervals. Time cells exhibit selective remapping between different tasks, while place cells remain stable. This suggests that the brain can represent time and space as overlapping but dissociable dimensions.
Article
Multidisciplinary Sciences
Xiangling Meng, David Yao, Kent Imaizumi, Xiaoyu Chen, Kevin W. Kelley, Noah Reis, Mayuri Vijay Thete, Arpana Arjun McKinney, Shravanti Kulkarni, Georgia Panagiotakos, Michael C. Bassik, Sergiu P. Pasca
Summary: This study uses CRISPR screening and assembloid technology to investigate the involvement of 425 neurodevelopmental disorder genes in human interneuron development. The results identified candidate genes and discovered the displacement of endoplasmic reticulum during interneuron migration, with LNPK gene deletion resulting in abnormal migration.
Article
Multidisciplinary Sciences
Jodie A. Watkins, James J. P. Alix, Pamela J. Shaw, Richard J. Mead
Summary: Most preclinical studies on ALS have focused on transgenic models with overexpression of mutant SOD1, which have been considered ineffective in terms of therapeutic effects. There is still a lack of widely accepted models for other genetic subtypes of ALS. Most ALS patients show ubiquitinated cytoplasmic inclusions of TDP-43, and TDP-43 transgenic mouse models have been produced for research purposes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Anna Maria Lavezzi
Summary: This study found anatomical and functional degenerations of dopaminergic neurons in most SIDS cases, indicating that dopamine depletion, which is already known to be linked especially to Parkinson's disease, is strongly involved in the pathogenesis of SIDS.
Article
Biochemistry & Molecular Biology
Esther F. Kutter, Jan Bostrom, Christian E. Elger, Andreas Nieder, Florian Mormann
Summary: This study investigates the neural mechanisms involved in simple arithmetic operations by recording single-neuron activity in the medial temporal lobe of human subjects. The findings reveal abstract and notation-independent codes for addition and subtraction in neuronal populations, with drastic differences in neuronal coding across different brain areas.
Article
Medicine, General & Internal
Adriano Barreto Nogueira, Ariel Barreto Nogueira, Anderson Lino Costa, Fabiana Roberto Lima, Sheila Aparecida Siqueira, Manoel Jacobsen Teixeira
SAO PAULO MEDICAL JOURNAL
(2015)
Article
Medicine, Research & Experimental
Adriano Barreto Nogueira, Eva Annen, Oliver Boss, Faraneh Farokhzad, Christopher Sikorski, Emanuela Keller
JOURNAL OF TRANSLATIONAL MEDICINE
(2017)
Article
Clinical Neurology
Adriano Barreto Nogueira, Ariel Barreto Nogueira, Jose Carlos Esteves Veiga, Manoel Jacobsen Teixeira
FRONTIERS IN NEUROLOGY
(2017)
Letter
Clinical Neurology
Adriano Barreto Nogueira, Ariel Barreto Nogueira, Jose Carlos Esteves Veiga, Manoel Jacobsen Teixeira
Article
Medicine, Research & Experimental
Adriano Barreto Nogueira, Mari Cleide Sogayar, Alison Colquhoun, Sheila Aparecida Siqueira, Ariel Barreto Nogueira, Paulo Euripedes Marchiori, Manoel Jacobsen Teixeira
JOURNAL OF TRANSLATIONAL MEDICINE
(2014)
Article
Clinical Neurology
Adriano B. Nogueira, Ariel B. Nogueira, Jose C. Esteves Veiga, Manoel J. Teixeira
Article
Medicine, General & Internal
Adriano Barreto Nogueira, Ariel Barreto Nogueira, Fernanda Regina Gemi
SAO PAULO MEDICAL JOURNAL
(2011)
Review
Clinical Neurology
Hillary Sayuri Ramires Hoshino, Bruna Grazielle Silva dos Santos, Adriano Barreto Nogueira, Antonio Celso Alvarenga Guimaraes
Summary: Papillary glioneuronal tumour is a rare brain tumor that commonly presents with symptoms such as headaches, seizures, vomiting, language or visual disturbances, and hemiparesis. Total surgical resection is the preferred treatment for this type of tumor, with long-term follow-up showing no recurrence.
BRITISH JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Adriano Barreto Nogueira, Manoel Teixeira
Summary: The study focuses on analyzing the circadian rhythm of temperature in healthy individuals to see if it correlates with chronological age and changes more intensely in individuals with obesity. This could lead to the discovery of a simple and non-invasive method related to biological age for the prevention and treatment of aging-related diseases.
ARCHIVES OF NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Adriano Barreto Nogueira, Hillary Sayuri Ramires Hoshino, Natalia Camargo Ortega, Bruna Grazielle Silva dos Santos, Manoel Jacobsen Teixeira
Summary: Research suggests that adult human neurogenesis occurs in the subgranular zone of the dentate gyrus and the subventricular zone, with varying levels of intensity. However, there are indications that adult human neurogenesis may also be orchestrated in a broader brain area.
METABOLIC BRAIN DISEASE
(2022)
Meeting Abstract
Clinical Neurology
B. Kim, A. B. Nogueira, S. Thome-Souza, S. Souza, K. Kapur, J. Klehm, M. Jackson, L. St Louis, C. Papadelis, C. Doshi, T. Loddenkemper
ANNALS OF NEUROLOGY
(2015)
Article
Behavioral Sciences
RL Marchetti, LA Fiore, KD Valente, G Gronich, AB Nogueira, WH Tzu
EPILEPSY & BEHAVIOR
(2003)
