期刊
NEUROSCIENCE RESEARCH
卷 121, 期 -, 页码 43-48出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2017.03.007
关键词
Neuropathic pain; Small fiber; A delta-fiber; C-fiber; Intraepidermal electrical stimulation; Pain-related evoked potentials
资金
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [KAKENHI-23591267]
- Japan Society for the Promotion of Science [KAKENHI-24790901]
- Grants-in-Aid for Scientific Research [17K09791, 26461305, 26860659] Funding Source: KAKEN
Neuropathic pain can result from neuronal hyperexcitability and complex interactions of the nociceptive pathways. Intraepidermal electrical stimulation (IES) is a novel technique that can selectively activate A delta and C fibers. To investigate patterns of changes in A delta- and C-mediated brain responses in patients with neuropathic pain using IES, we recorded pain-related evoked potential (PREP) after IES of A delta and C fibers in 20 patients with neuropathic pain and 15 age-matched healthy volunteers. We evaluated PREP latencies, amplitudes, and amplitude ratios of PREPs after C/A delta-fiber stimulation. PREP amplitudes after A delta-fiber stimulation tended to be smaller in the patient group, whereas there were no significant differences in amplitudes after C-fiber stimulation between the patient and normal control groups. PREP amplitude ratios after C/A delta-fiber stimulation were significantly greater in the patient group than in the control group, and the higher ratio tended to be associated with a greater visual analog scale score. Patients with neuropathic pain had a tendency towards decreased A delta amplitudes and significantly increased C/A delta PREP amplitude ratios and this ratio appeared to be associated with the intensity of pain. Our findings suggest that decreased inhibition of the A delta to C nociceptive systems is associated with generation of neuropathic pain. (C) 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.
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