Article
Neurosciences
K. Amande M. Pauls, Olesia Korsun, Jukka Nenonen, Jussi Nurminen, Mia Liljestrom, Jan Kujala, Eero Pekkonen, Hanna Renvall
Summary: Exaggerated subthalamic beta oscillatory activity and increased beta range cortico-subthalamic synchrony are the electrophysiological hallmarks of Parkinson's disease. This study found that these characteristics can also be observed in the sensorimotor cortex of Parkinson's disease patients. Chronic subthalamic deep brain stimulation can modulate these changes and improve motor function at the behavioral level.
Article
Engineering, Biomedical
AmirAli Farokhniaee, Madeleine M. Lowery
Summary: High frequency deep brain stimulation of the subthalamic nucleus suppresses excessive beta band activity in the motor cortex in Parkinson's disease. Modulation of cortical network activity by changing synaptic coupling strength between different neurons can lead to increased or decreased beta activity and neural synchrony.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Neurosciences
Brett A. Campbell, Leonardo Favi Bocca, David Escobar Sanabria, Julio Almeida, Richard Rammo, Sean J. Nagel, Andre G. Machado, Kenneth B. Baker
Summary: The timing of pulse intervals has a significant impact on the modulation of the basal ganglia thalamocortical circuit. Short pulse intervals have minimal effect on the evoked response, while longer intervals within a specific range lead to increased beta frequency activity in both the scalp EEG and STN local field potential response.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Katy A. Cross, Mahsa Malekmohammadi, Jeong Woo Choi, Nader Pouratian
Summary: The study found that local alpha/beta power in the globus pallidus and motor cortex is suppressed during both action execution and observation, with less suppression during observation. However, pallidocortical phase synchrony and GPi and motor cortical alpha/beta-gamma PAC are only suppressed during action execution, indicating the important role of network coupling in motor execution.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Bryan Howell, Faical Isbaine, Jon T. Willie, Enrico Opri, Robert E. Gross, Coralie De Hemptinne, Philip A. Starr, Cameron C. McIntyre, Svjetlana Miocinovic
Summary: This study evaluated the accuracy of patient-specific estimates of neural pathway activations in the subthalamic region using connectomic modeling of subthalamic DBS. Results showed that good model performance required accurate lead localization, image fusions, and appropriate selection of fiber diameter in the biophysical model. The findings demonstrated that connectomic models of DBS with sufficient anatomical and electrical details can predict recruitment dynamics of white matter, aiding in defining standards for surgical targeting and patient programming applications.
Article
Neurosciences
Andrea Ibarra Chaoul, Markus Siegel
Summary: The study investigated the correlation of aperiodic neuronal population activity in the human brain using resting-state magnetoencephalography, finding robust correlations across the cortex with structured spatial patterns. The cortical correlation structure of aperiodic activity was found to be similar but distinct from oscillatory neuronal activity, particularly in anterior cortical regions. The results suggest that aperiodic population activity serves as markers of cortical network interactions and provides non-redundant information about large-scale neuronal correlations.
Article
Neurosciences
Rachel K. Spooner, Bahne H. Bahners, Alfons Schnitzler, Esther Florin
Summary: Research shows that optimal contact orientations in subthalamic deep brain stimulation can lead to larger cortical responses and smoother hand movements in patients with Parkinson's disease. These findings have clinical implications for optimizing DBS parameter settings to alleviate motor symptoms.
NPJ PARKINSONS DISEASE
(2023)
Article
Clinical Neurology
Florian Lange, Hazem Eldebakey, Alexandra Hilgenberg, Benedikt Weigl, Marie Eckert, Angela DeSunda, Hermann Neugebauer, Robert Peach, Jonas Roothans, Jens Volkmann, Martin M. Reich
Summary: Through studying 24 patients, we found strong connections between stimulation-induced dysarthria and brain regions associated with motor speech control, especially highlighting the disruption of corticobulbar fibers that may cause spastic dysarthria. These findings provide insights into the mechanism of dysarthria caused by deep brain stimulation of the subthalamic nucleus and may guide individual reprogramming attempts for Parkinson's patients based on pathophysiological understanding of the affected networks.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Lais M. Oliveira, Marta Ruiz-Lopez, Alexandre Boutet, Gavin J. B. Elias, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Renato P. Munhoz, Alfonso Fasano
Summary: The study found that using the advanced functions of the patient programmer delays programming optimization and is associated with a higher number of side effects. Therefore, there is a need for other faster and safer stimulation programming methods.
Review
Clinical Neurology
Hengameh Zahed, Jose Rafael Pantoja Zuzuarregui, Ro'ee Gilron, Timothy Denison, Philip A. Starr, Simon Little
Summary: Sleep disturbances are common nonmotor complications of Parkinson's disease, potentially contributing to disease progression. Limited options currently exist to modulate sleep disturbances, prompting the need for further research into neurophysiological changes affecting sleep in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Katharine A. Henry, Rohin Singh, Nan Zhang, Mark K. Lyons, Karen McNett, Matthew T. Neal, Shyamal H. Mehta
Summary: This study aimed to objectively assess changes in swallowing in Parkinson's disease (PD) patients following Deep Brain Stimulation (DBS) surgery using gold standard video fluoroscopy (VFS). The results showed that there was no clinically meaningful improvement or reduction in swallow function with DBS, regardless of the site of bilateral lead implantation.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Shimiao Wang, Shun Gong, Yingqun Tao, Guobiao Liang, Rong Sha, Aotan Xie, Zirui Li, Lijia Yuan
Summary: The study demonstrated that utilizing a modified power-on programming method in DBS for PD can achieve similar clinical outcomes to the traditional method, while being more efficient.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Xinxia Guo, Chen Feng, Jiali Pu, Hongjie Jiang, Zhoule Zhu, Zhe Zheng, Jianmin Zhang, Gao Chen, Junming Zhu, Hemmings Wu
Summary: The cost-effectiveness of deep brain stimulation (DBS) is more favorable than best medical treatment (BMT) for advanced Parkinson disease (PD) in developed countries. However, it remains unclear in developing countries. This study modeled and evaluated the long-term cost-effectiveness of DBS for advanced PD in China and found that DBS is cost-effective over a 15-year time horizon.
Article
Clinical Neurology
Henry M. Skelton, Dayton P. Grogan, Nealen G. Laxpati, Svjetlana Miocinovic, Robert E. Gross, Nicholas Au Yong
Summary: This study found that there is a significant underutilization of deep brain stimulation (DBS) in Black patients with Parkinson's disease (PD). The rate of evaluation for DBS in Black patients was lower than expected, and patients from regions with larger Black populations were underrepresented. Further research should focus on understanding the reasons behind the disparity in the transition from medical management to surgical evaluation and increase outreach efforts in underserved areas.
Article
Neurosciences
Amanda R. Merner, Thomas Frazier, Paul J. Ford, Scott E. Cooper, Andre Machado, Brittany Lapin, Jerrold Vitek, Cynthia S. Kubu
Summary: The study found that patients undergoing deep brain stimulation (DBS) treatment experience significant changes in their desired control and perception of global life control. Most participants reported increased perception of global life control post-treatment, while their desired control of stimulation decreased. Furthermore, the data show that patients have nuanced levels of desired control over stimulation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Wei Liu, Shikun Zhan, Dianyou Li, Zhengyu Lin, Chencheng Zhang, Tao Wang, Sijian Pan, Jing Zhang, Chunyan Cao, Haiyan Jin, Yongchao Li, Bomin Sun
Article
Clinical Neurology
Chencheng Zhang, Linbin Wang, Wei Hu, Tao Wang, Yijie Zhao, Yixin Pan, Leonardo Almeida, Adolfo Ramirez-Zamora, Bomin Sun, Dianyou Li
Letter
Clinical Neurology
Suzhen Lin, Chencheng Zhang, Yiwen Wu, Bomin Sun, Dianyou Li
Article
Clinical Neurology
Wenying Xu, Chencheng Zhang, Bomin Sun, Dianyou Li
WORLD NEUROSURGERY
(2020)
Article
Medicine, Research & Experimental
Chencheng Zhang, Kaiwen Zhu, Zhengyu Lin, Peng Huang, Yixin Pan, Bomin Sun, Dianyou Li
Summary: The study found that during the COVID-19 pandemic, the number of DBS telemedicine service requests and patients examined increased. The main reason for requests was poor symptom control, with most patients experiencing satisfactory adjustments in DBS tele-programming parameters, and no significant adverse events or treatment interruptions due to connection failures or other issues.
Review
Medicine, Research & Experimental
Yijie Zhao, Samantha N. Sallie, Hailun Cui, Ningning Zeng, Jiang Du, Tifei Yuan, Dianyou Li, Dirk De Ridder, Chencheng Zhang
Summary: This review discusses the anterior cingulate cortex (ACC) as a neuromodulation target for substance use disorder (SUD), highlighting its central role in addiction-related neural networks and potential for more precise and effective treatment approaches targeting different subregions based on patients' symptom profiles and cognitive deficits.
Article
Medicine, Research & Experimental
Hongxia Li, Tao Wang, Chencheng Zhang, Daoqing Su, Yijie Lai, Bomin Sun, Dianyou Li, Yiwen Wu
Summary: Asleep DBS is an accurate, effective, and safe method for treating patients with isolated dystonia, resulting in significantly improved dystonia scores at 12-month follow-up, with high targeting accuracy and low complication rates.
Article
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: Our study reveals the potential effectiveness of GPi-DBS in treating camptocormia in PD patients, showing significant improvement in patients' postural deformity. Pre-surgical TCC angle, levodopa responsiveness of the TCC angle, and structural connectivity from volume of tissue activated to somatosensory cortex are closely associated with improvement in the TCC angle.
NPJ PARKINSONS DISEASE
(2021)
Correction
Neurosciences
Yijie Lai, Yunhai Song, Daoqing Su, Linbin Wang, Chencheng Zhang, Bomin Sun, Jorik Nonnekes, Bastiaan R. Bloem, Dianyou Li
Summary: A correction to this paper has been published.
NPJ PARKINSONS DISEASE
(2021)
Review
Neurosciences
Zhengyu Lin, Chencheng Zhang, Dianyou Li, Bomin Sun
Summary: The current literature on the lateralized effects of DBS in PD patients is of low quality and biased by various confounders. Studies have mostly focused on PD patients receiving STN DBS, while the potential lateralized effects of GPi DBS have not been adequately studied. Evidence suggests potential lateralized effects of STN DBS on axial motor symptoms and deleterious effects of left-sided DBS on language-related functions, particularly verbal fluency, in PD. However, the effects on appendicular motor symptoms and other neurocognitive and neuropsychiatric domains remain inconclusive.
NPJ PARKINSONS DISEASE
(2021)
Review
Clinical Neurology
Weibin He, Chenhui Li, Hongjuan Dong, Lingmin Shao, Bo Yin, Dianyou Li, Liguo Ye, Ping Hu, Chencheng Zhang, Wei Yi
Summary: Globus pallidus internus deep brain stimulation (GPi-DBS) is an effective and safe treatment option for chorea-acanthocytosis (ChAc) patients, especially for those with oromandibular dystonia. However, there are no reliable predictors of efficacy at the moment.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Luis Manssuer, Qiong Ding, Yingying Zhang, Hengfeng Gong, Wei Liu, Ruoqi Yang, Chencheng Zhang, Yijie Zhao, Yixin Pan, Shikun Zhan, Dianyou Li, Bomin Sun, Valerie Voon
Summary: Neurons in the primate lateral habenula fire in response to punishments and are inhibited by rewards. By recording local field potentials directly from the habenula in human patients, the authors found that high-frequency gamma activity in the habenula encoded punishment, reward, and risk during decision-making tasks. These findings suggest that habenula high gamma could be used as a biomarker for closed-loop deep brain stimulation therapy in psychiatric disorders.
Letter
Clinical Neurology
Zhitong Zeng, Zhengyu Lin, Peng Huang, Halimureti Paerhati, Chencheng Zhang, Dianyou Li
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Zhengyu Lin, Linbin Wang, Peng Huang, Yixin Pan, Yuyan Tan, Shengdi Chen, Dianyou Li
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Linbin Wang, Jun Li, Yixin Pan, Peng Huang, Dianyou Li, Valerie Voon
Summary: This study evaluated the subacute effect of bilateral ventral subthalamic nucleus stimulation at 10Hz on emotional processing in Parkinson's disease patients. The results showed that 10Hz stimulation increased arousal ratings in patients with higher depression scores and induced a positive shift in valence ratings to negative emotional stimuli in patients with lower apathy scores. In contrast, 130Hz stimulation led to reduced arousal ratings in all patients and more positive valence ratings in patients with higher apathy scores.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
