Article
Cell Biology
Li Ying, Jinlan Zhao, Yingshan Ye, Yutong Liu, Bin Xiao, Tao Xue, Hangfei Zhu, Yue Wu, Jing He, Sifei Qin, Yong Jiang, Fukun Guo, Lin Zhang, Nuyun Liu, Lu Zhang
Summary: This study revealed that the signaling of Cell division control protein 42 (Cdc42) was significantly decreased in the caudate putamen (CPu) of parkinsonian mice. Overexpression of Cdc42 reversed spine abnormalities and improved behavior deficits in these mice. Impaired Cdc42 signaling regulated by D2 receptor (D2R) played an important role in spine loss and behavioral deficits in Parkinson's disease (PD).
Article
Cell Biology
Alicia Rivera, Diana Suarez-Boomgaard, Cristina Miguelez, Alejandra Valderrama-Carvajal, Jerome Baufreton, Kirill Shumilov, Anne Taupignon, Belen Gago, M. Angeles Real
Summary: Long-term exposure to morphine induces structural and synaptic plasticity in reward-related regions of the brain, playing a critical role in addiction. However, the morphine-induced neuroadaptations in the dorsal striatum, which is crucial for drug-related habit learning, have not been well studied. This study finds that prolonged treatment with morphine leads to retraction of dendritic arbor and loss of dendritic spines in the dorsal striatal projection neurons. Additionally, the dopamine D-4 receptor (D4R) is found to modulate striatal morphine-induced plasticity, as the combined treatment of morphine with a D4R agonist restores dendritic arbor and spine density while altering the electrical properties of the neurons.
Article
Neurosciences
Li-Min Mao, Nirav Mathur, John Q. Wang
Summary: Pharmacological potentiation of mGlu2 receptors can attenuate ERK1/2 pathway activation and reduce locomotor activity response to cocaine in the mouse striatum.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
G. E. Pennacchio, F. E. Santonja, F. J. Neira, C. Bregonzio, M. Soaje
Summary: Prenatal exposure to amphetamine affects dopamine receptors and tyrosine hydroxylase expression, with gender differences observed. Estrogen modulates mRNA levels of dopamine receptors in the brain and plays a role in stress responses.
NEUROCHEMICAL RESEARCH
(2022)
Article
Cell Biology
Shannon L. Gourley, Kolluru D. Srikanth, Ellen P. Woon, Hava Gil-Henn
Summary: The study found that Pyk2 stabilizes the structure of the striatal medium spiny neurons, likely providing substrates for inputs, and supports the capacity of mice to arbitrate between novel and familiar behaviors through interactions with the medial prefrontal cortex. Experiments demonstrated that Pyk2 loss caused dendrite arbor and spine loss, while overexpression of Pyk2 or the closely related focal adhesion kinase (FAK) enhanced the ability of mice to arbitrate between rewarded and non-rewarded behaviors. Additionally, combinatorial viral vector strategies suggested that flexible, Pyk2-dependent action involves inputs from the medial prefrontal cortex (mPFC), not the ventrolateral orbitofrontal cortex (OFC).
Article
Neurosciences
Vasily Vorobyov, Alexander Deev, Frank Sengpiel, Vladimir Nebogatikov, Aleksey A. Ustyugov
Summary: The study aims to examine the contribution of DA mediation in the striatum-cortex networks in ALS progression. In young Tg mice, baseline EEG spectra in M1 were comparable to nTg mice, while beta activity in Pt was enhanced. In older Tg mice, beta dominated in EEG from both M1 and Pt, with reduced theta and delta 2 activities.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Enrica Montalban, Roman Walle, Julien Castel, Anthony Ansoult, Rim Hassouna, Ewout Foppen, Xi Fang, Zach Hutelin, Sophie Mickus, Emily Perszyk, Anna Petitbon, Jeremy Berthelet, Fernando Rodrigues-Lima, Alberto Cebrian-Serrano, Giuseppe Gangarossa, Claire Martin, Pierre Trifilieff, Clementine Bosch-Bouju, Dana M. Small, Serge Luquet
Summary: This study reveals the importance of the TaqIA genetic variant in the development of psychiatric and metabolic conditions. Using transgenic and viral-mediated techniques, the researchers found that the Ankk1 gene plays a crucial role in the regulation of striatal functions, learning, impulsivity, and flexibility. Additionally, Ankk1 has an unexpected role in the regulation of energy metabolism.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Anatomy & Morphology
Zhuo Wang, Erin K. Donahue, Yumei Guo, Michael Renteln, Giselle M. Petzinger, Michael W. Jakowec, Daniel P. Holschneider
Summary: This study analyzed the metabolic connectivity changes in the cortico-basal ganglia-thalamic network during exercise and found that exercise can increase the efficiency of neural circuit connections and reduce the involvement of the prefrontal cortex, thereby enhancing motor skills. This provides insights into the effects of exercise on brain functions.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Psychiatry
Jason Smucny, Timothy D. Hanks, Tyler A. Lesh, Randall C. O'Reilly, Cameron S. Carter
Summary: This study aimed to investigate the neuronal mechanisms underlying deficits in effort cost computation in schizophrenia (SZ) under difficult and rewarded task conditions. A total of 52 individuals with recent onset SZ and 48 healthy controls performed a fMRI task. The results showed that the SZ group had deficits in task performance parameter (drift rate), but did not differ in overall connectivity or valence-specific deficit in connectivity compared to the control group. However, the relationship between right dorsolateral prefrontal (DLPFC)-striatal connectivity and task performance was more positive in the difficult-rewarded condition for the control group compared to SZ.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Endocrinology & Metabolism
Esmeralda Hidalgo-Lopez, Belinda Pletzer
Summary: The study suggests that different phases of the menstrual cycle can affect the brain activation and connectivity patterns in women, especially during verbal working memory tasks. Variations in hormone levels during different phases may lead to changes in top-down regulation of the brain, affecting cognitive function and neural network activity.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Anatomy & Morphology
Rong-Jun Ni, Yu-Mian Shu, Tao Li, Jiang-Ning Zhou
Summary: The day-active tree shrews have a well-defined internal capsule that separates the caudate nucleus and putamen in the striatum. They receive inputs from various brain regions, with differences compared to rats in terms of immunoreactivity. Mapping the whole-brain input neurons to the striatum of tree shrews provides insights into the diverse functions of the striatal subregions.
FRONTIERS IN NEUROANATOMY
(2021)
Article
Neurosciences
Mimi Tian, Feifei Xu, Qing Xia, Yuchun Tang, Zhonghe Zhang, Xiangtao Lin, Haiwei Meng, Lei Feng, Shuwei Liu
Summary: This study provides a detailed description of the morphological development of the fetal striatum during the second trimester. The volume of the caudate nucleus shows linear growth with gestational age, while the relative volume shows quadratic growth. Shape analysis reveals specific changes in local structure development. The study also highlights hemispheric differences in the striatum's development, with the right caudate nucleus being larger than the left.
Article
Neurosciences
Qing Shang, Jing Xiao, Baoyao Gao, Min Liang, Jing Wang, Hongyan Qian, Zhijia Xi, Tao Li, Xinshe Liu
Summary: This study investigated the mechanisms underlying hyperlocomotion induced by acute methamphetamine (METH) administration. The results suggest that the D1R/PP2A/p-CaMKII alpha signaling cascade in the caudate putamen (CPu) may be involved in hyperlocomotion after single METH administration.
NEUROSCIENCE LETTERS
(2021)
Article
Medicine, General & Internal
Chao Wang, Cheng Zhou, Tao Guo, Yeerfan Jiaerken, Siyu Yang, Xiaopei Xu, Ling Hu, Peiyu Huang, Xiaojun Xu, Minming Zhang
Summary: This study found that current coffee consumption is associated with decreased striatal dopamine transporter availability in the caudate. However, the effects of caffeine on dopamine transporter may fade and disappear after quitting coffee consumption.
Article
Anatomy & Morphology
Brian Dang, Fabian N. Necker, Siddhant Suri Dhawan, Tara Murty, Tarik F. Massoud
Summary: This study retrospectively analyzed MRI images of 34 healthy individuals to reveal the structure and dimensions of the caudolenticular gray bridges (CLGBs) in normal individuals. These findings will guide future studies on the potential role of CLGBs morphometry in predisposition to Parkinson's disease.
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)