期刊
NEUROSCIENCE LETTERS
卷 652, 期 -, 页码 41-49出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.11.003
关键词
Spinal cord injury; Aging; Axon growth; Axon regeneration; Neuron-intrinsic; CNS injury
资金
- NIH/NINDS [R01NS054734, R01NS093055]
- Craig H. Neilsen Foundation [190181, 384971]
- Wings for Life Foundation [WFL-US-014/13]
- UCSD Neuroplasticity of Aging Training Program [T32AG000216]
Age is an important consideration for recovery and repair after spinal cord injury. Spinal cord injury is increasingly affecting the middle-aged and aging populations. Despite rapid progress in research to promote axonal regeneration and repair, our understanding of how age can modulate this repair is rather limited. In this review, we discuss the literature supporting the notion of an age-dependent decline in axonal growth after central nervous system (CNS) injury. While both neuron-intrinsic and extrinsic factors are involved in the control of axon growth after injury, here we focus on possible intrinsic mechanisms for this age-dependent decline. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据