Review
Behavioral Sciences
Satoshi Ogawa, Ishwar S. Parhar
Summary: Social behaviors such as mating, parenting, fighting, and avoiding play crucial roles as communication tools in social animals. The social behaviors are controlled by a complex circuitry called the social behavior network (SBN), which integrates social information with internal and external factors to select appropriate behavioral responses. The habenula, recently recognized as a crucial center for emotion-associated adaptation behaviors, plays a key role in the vertebrate social decision-making network (SDMN).
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Kyle R. Gossman, Benjamin Dykstra, Byron H. Garcia, Arielle P. Swopes, Adam Kimbrough, Adam S. Smith
Summary: This study assessed the organization and functional connectivity models of the social decision-making network (SDMN) using c-Fos in prairie voles during specific social interactions. The results showed distinct patterns of c-Fos activity in different brain regions during social encounters, leading to the formation of discrete network modules. The partner functional connectivity network resembled the theoretical SDMN model, while stranger networks demonstrated different architecture with connections associated with threat and aggressive behaviors.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Chemistry, Physical
Matthew R. Hennefarth, Matthew R. Hermes, Donald G. Truhlar, Laura Gagliardi
Summary: Multiconfigurationpair-density functional theory (MC-PDFT) is a successful method for computing ground- and excited-state energies. However, it can lead to inaccurate potential energy surfaces near avoided crossings and conical intersections. In order to overcome this limitation and accurately describe molecular dynamics and Jahn-Teller instabilities, a new method called linearized PDFT (L-PDFT) is proposed. L-PDFT effectively recovers the correct potential energy surface topology and outperforms previous methods for predicting vertical excitations.
JOURNAL OF CHEMICAL THEORY AND COMPUTATION
(2023)
Article
Neurosciences
Rachel Corr, Sarah Glier, Joshua Bizzell, Andrea Pelletier-Baldelli, Alana Campbell, Candace Killian -Farrell, Aysenil Belger
Summary: This study examined the seed-to-voxel functional connectivity of the default mode network (DMN), salience network (SN), and central executive network (CEN) in adolescents under acute stress. The results indicate that acute stress alters the functional connectivity between these networks in adolescents and that this connectivity is further modulated by experiences of polyvictimization.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Review
Endocrinology & Metabolism
Nicole Rigney, Geert J. de Vries, Aras Petrulis, Larry J. Young
Summary: This article reviews the regulatory effects of oxytocin and vasopressin on social behavior and summarizes the circuit-based mechanisms related to social behaviors. It discusses the use of modern molecular genetic technologies to study neuropeptide circuits and explores the species diversity in the effects of oxytocin and vasopressin on social behaviors. Additionally, it discusses the translational implications of oxytocin and vasopressin for improving social functioning in disorders such as autism spectrum disorder.
Article
Psychology, Clinical
Ashish K. Sahib, Joana R. Loureiro, Megha Vasavada, Cole Anderson, Antoni Kubicki, Benjamin Wade, Shantanu H. Joshi, Roger P. Woods, Eliza Congdon, Randall Espinoza, Katherine L. Narr
Summary: This study found that subanesthetic ketamine infusion therapy can modify the functional connectome in patients with major depressive disorder (MDD), making it closer to the pattern seen in healthy controls. After treatment, there was a significant decrease in functional connectivity between the cerebellum and the salience network (SN). Additionally, patients who responded to treatment showed increased functional connectivity between the cerebellum and the striatum before treatment, which decreased after treatment.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Neurosciences
Yoon Ji Lee, Xavier Guell, Nicholas A. Hubbard, Viviana Siless, Isabelle R. Frosch, Mathias Goncalves, Nicole Lo, Atira Nair, Satrajit S. Ghosh, Stefan G. Hofmann, Randy P. Auerbach, Diego A. Pizzagalli, Anastasia Yendiki, John D. E. Gabrieli, Susan Whitfield-Gabrieli, Sheeba Arnold Anteraper
Summary: This study found differences in functional connectivity in the cerebellar output circuit among adolescents with anxiety disorders, indicating that the dentate nuclei may be a clinical and subclinical marker of anxiety.
Article
Otorhinolaryngology
You Young An, Eek-Sung Lee, Se A. Lee, Joon Ho Choi, Jung Mi Park, Tae-Kyeong Lee, Hajoon Kim, Jong Dae Lee
Summary: Hearing loss is a significant risk factor for cognitive impairment. This study aimed to investigate the association between hearing loss and anatomical and functional connectivity in patients with mild cognitive impairment (MCI) using multimodal imaging technology.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Neurosciences
Matthew A. Cormie, Batu Kaya, Georgia E. Hadjis, Pedram Mouseli, Massieh Moayedi
Summary: The insula and the cingulate are key brain regions involved in processing affective, cognitive, and interoceptive stimuli. Using ultra-high field 7T diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), this study investigated the structural connectivity (SC) and functional connectivity (FC) between insula and cingulate subregions. The findings suggest strong connections between posterior INS and posterior MCC, and a potential mediating structure between the anterior insula and anterior mid-cingulate cortex.
Article
Neurosciences
Burcu Ozkul, Cemre Candemir, Kaya Oguz, Seda Eroglu-Koc, Gozde Kizilates-Evin, Onur Ugurlu, Yigit Erdogan, Defne Dakota Mull, Mehmet Cagdas Eker, Omer Kitis, Ali Saffet Gonul
Summary: Group support plays a role in brain functioning, and the loss of social group support leads to reduced brain activity. Being part of a social group and receiving support enhances cognitive functioning, while the loss of group support activates brain regions associated with attention and survival.
Review
Behavioral Sciences
Jane Kohlhoff, Sara Cibralic, David J. Hawes, Valsamma Eapen
Summary: This study systematically reviewed the available evidence on the relationship between oxytocin receptor gene polymorphisms and socio-emotional and behavioral functioning in children and adolescents. The results suggest that OXTR polymorphisms are associated with social, emotional, or behavioral functioning in this population, but further research is needed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Mingyue Xiao, Ximei Chen, Haijing Yi, Yijun Luo, Qiaoling Yan, Tingyong Feng, Qinghua He, Xu Lei, Jiang Qiu, Hong Chen
Summary: The COVID-19 pandemic has negatively impacted mental health due to health and financial uncertainties, as well as social distancing measures. The study found that functional connectivity within specific brain networks, along with social support, play a key role in protecting against negative affect during and after the pandemic.
NEUROBIOLOGY OF STRESS
(2021)
Article
Psychology, Clinical
Fengqiong Yu, Huihua Fang, Junfeng Zhang, Zhihao Wang, Hui Ai, Veronica P. Y. Kwok, Ya Fang, Yaru Guo, Xin Wang, Chunyan Zhu, Yuejia Luo, Pengfei Xu, Kai Wang
Summary: This study shows that brain functional connectivity, especially the connectivity of the salience network (SN), frontoparietal network (FPN), and default mode network (DMN), can specifically predict individualized consummatory anhedonia in MDD. These findings suggest the potential of functional connectomes for the diagnosis and prognosis of anhedonia in MDD and other disorders.
DEPRESSION AND ANXIETY
(2022)
Review
Neurosciences
Meghan E. Flanigan, Thomas L. Kash
Summary: The bed nucleus of the stria terminalis (BNST) has been implicated in neuropsychiatric disorders characterized by stress and drug-induced alterations in mood, arousal, motivation, and social behavior. However, its role in social behavior has been understudied, especially in terms of cell types and circuits. This review summarizes the existing literature, focusing on pharmacological and circuit-based behavioral studies in rodents.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Francesco Bavato, Fabrizio Esposito, Dario A. Dornbierer, Niklaus Zolch, Boris B. Quednow, Philipp Staempfli, Hans-Peter Landolt, Erich Seifritz, Oliver G. Bosch
Summary: Sodium oxybate (GHB) is used clinically to promote sleep and reduce sleepiness in disorders like narcolepsy and fibromyalgia, but the neural mechanisms behind its effects are unknown.
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)