Article
Neurosciences
Jingyi Wang, Yohan John, Helen Barbas
Summary: The ACC is one of the few prefrontal areas that receives direct hippocampal terminations, potentially influencing goal-directed actions and emotional regulation. Hippocampal terminations mainly target the posterior A25 region, with strong excitatory effects on neurons. Additionally, the proximity of hippocampal terminations to D1 receptors in the deep layers of A25 may enhance dopamine effects on information transfer and emotional control.
Article
Biology
Lilya Andrianova, Steliana Yanakieva, Gabriella Margetts-Smith, Shivali Kohli, Erica S. Brady, John P. Aggleton, Michael T. Craig
Summary: The connectivity and interplay between the prefrontal cortex and hippocampus are important for cognitive processes, but the existence of a direct glutamatergic projection from the anterior cingulate cortex to the hippocampus has been questioned. In this study, multiple methods were used to validate a recent finding of this projection, but no evidence of such a projection was found.
Article
Behavioral Sciences
Andrew J. D. Nelson
Summary: The anterior thalamic nuclei play a crucial role in spatial learning and memory, but recent research has shown that their functions extend beyond spatial processing to include temporal discrimination and processing of other contextual information. Additionally, these nuclei are also important for non-spatial learning, including attentional mechanisms. This indicates the need to reconsider the functions of the anterior thalamic nuclei within a broader framework of connections with sites supporting non-spatial functions such as the anterior cingulate cortex.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna Todeva-Radneva, Sevdalina Kandilarova, Rositsa Paunova, Drozdstoy Stoyanov, Tina Zdravkova, Ronald Sladky
Summary: This study aimed to explore possible differences in whole-brain functional connectivity in patients with major depressive disorder (MDD), bipolar disorder (BD), and healthy controls (HC). The results showed increased connectivity in certain brain regions in the BD group compared to the HC group, while the MDD group showed enhanced connectivity in different regions. These findings suggest that these connectivity patterns may serve as potential diagnostic biomarkers for MDD and BD.
Article
Clinical Neurology
Ruiyang Ge, Elizabeth Gregory, Jian Wang, Nicholas Ainsworth, Wei Jian, Chunlin Yang, Gang Wang, Fidel Vila-Rodriguez
Summary: This study is the first quantitative fMRI study to investigate the neural correlates of MST treatment for MDD patients. The results showed that increased functional connectivity between the subgenual anterior cingulate cortex and the parietal cortex was associated with clinical improvement, while greater decrease in functional connectivity between the right anterior hippocampus and the prefrontal cortex was correlated with lesser clinical and cognitive improvements.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Keith A. Misquitta, Amy Miles, Thomas D. Prevot, Jaime K. Knoch, Corey Fee, Dwight F. Newton, Jacob Ellegood, Jason P. Lerch, Etienne Sibille, Yuliya S. Nikolova, Mounira Banasr
Summary: Chronic stress can lead to volumetric and synaptic alterations in specific brain regions, with reductions in ACC volume negatively correlated with behavioral emotionality. Shared volumetric variance analysis revealed decreasing ACC degree and increasing AMY degree following CRS, indicating altered synaptic strength as a potential mechanism for the effects of chronic stress.
Article
Neurosciences
Eliza Bliss-Moreau, Anthony C. Santistevan, Jeffrey Bennett, Gilda Moadab, David G. Amaral
Summary: The study investigates the causal role of ACC in affective responding to threat in primates. Results suggest that the primate ACC is necessary for maintaining appropriate affective responses towards potentially harmful and/or novel stimuli, and that ACC lesions can lead to a reduced reactivity towards these stimuli, with implications for mood disorders.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Carlos Silva, Blake S. Porter, Kristin L. Hillman
Summary: Animals must continually assess effort and physiological states during tasks, with the ACC and anterior insular cortex implicated in cost-benefit decision-making. Contrary to predictions, stimulation of Cg1 did not increase persistence in the task, while stimulation of the anterior insula had little effect on effortful behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Jose Francis-Oliveira, Owen Leitzel, Minae Niwa
Summary: This article discusses the nomenclature of the medial prefrontal cortex (mPFC) subdivisions, proposing a change in the naming of the rodent cingulate cortex to anterior cingulate cortex (aCg) and mid-cingulate cortex (mCg). Based on data, the authors show evidence of distinct cortico-cortical projections from aCg and mCg to the PrL, as well as a sex difference in the aCg with males having a higher proportion of layer V neurons projecting to the PrL.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Neurosciences
Marcos Domic-Siede, Martin Irani, Joaquin Valdes, Marcela Perrone-Bertolotti, Tomas Ossandon
Summary: The study reveals the importance of cognitive planning in human goal-directed behavior, with different brain regions playing specific roles in the planning process. Activity in the prefrontal cortex is associated with increased time needed for plan elaboration, while activity in the frontopolar cortex is negatively correlated with execution time, indicating its role in efficiency and accuracy in plan execution. Theta activity in different brain regions reflects high cognitive demand and the successful generation of self-made plans.
Article
Chemistry, Multidisciplinary
Ting Fan, Peng-Fei Guan, Xiao-Fang Zhong, Meng-Ya Xiang, Ying-Qiu Peng, Ruo-Qiao Zhou, Jia-Min Gong, Yu-Qing Zheng, A-Qiang Dai, Jia-Ling Feng, Hong-Zhe Yu, Jian Li, Hua-Wei Li, Yun-Feng Wang
Summary: Compared with individuals with hearing loss, tinnitus patients without hearing loss have more psychological or emotional problems. This study found that tinnitus is closely associated with abnormal metabolism and function in the limbic system, but the specific molecular mechanism is unknown. The anterior cingulate cortex (ACC) was identified as a key brain region involved in the onset of tinnitus in mice, and there were changes in metabolism and phosphorylation patterns in the glutamatergic synaptic pathway. Additionally, the electroencephalogram of tinnitus patients showed increased functional connectivity between the ACC and the primary auditory cortex, which was correlated with the serum glutamate level.
Article
Psychiatry
Zui Narita, Kun Yang, Hironori Kuga, Peeraya Piancharoen, Semra Etyemez, Andreia Faria, Marina Mihaljevic, Luisa Longo, Ho Namkung, Jennifer M. Coughlin, Gerald Nestadt, Frederik C. Nucifora, Thomas W. Sedlak, Rebecca Schaub, Jeff Crawford, David J. Schretlen, Jun Miyata, Koko Ishizuka, Akira Sawa
Summary: The study revealed that FEP patients showed poorer recognition accuracy and slower response times in face processing, particularly in memory tasks. Memory response time was selectively correlated with specific rsFCs and brain volume in FEP patients, indicating the importance of the sub-callosal sub-region of BA24 in the ACC in FEP-associated abnormalities of social cognition.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yixin Tian, Jiapeng Yin, Chengyao Wang, Zhenliang He, Jingyi Xie, Xiaoshan Feng, Yang Zhou, Tianyu Ma, Yang Xie, Xue Li, Tianming Yang, Chi Ren, Chengyu Li, Zhengtuo Zhao
Summary: Researchers have developed a mechanically robust ultraflexible electrode array, the MERF, for high-density, large-scale, and chronic recording of neurons in the nonhuman primate brain. The MERF array has shown promising results in basic neuroscience studies and brain-machine interface applications.
Article
Anesthesiology
Nir Samuel, Eilat Kahana, Aryeh Taub, Tamar Reitich-Stolero, Rony Paz, Aeyal Raz
Summary: The study found that nonhuman primates under sedation with ketamine and midazolam showed signs of memory formation in response to aversive stimuli. By measuring neural responses during acquisition, it was discovered that activity in the amygdala and dorsal anterior cingulate cortex could predict memory retention.
Review
Geriatrics & Gerontology
Hiroyuki Shimada, Seongryu Bae, Kenji Harada, Keitaro Makino, Ippei Chiba, Osamu Katayama, Sangyoon Lee
Summary: This study found a positive association between driving and brain health, with drivers having larger hippocampal volumes. Additionally, individuals who drove less frequently had smaller occipital cortex volumes compared to drivers and high-frequency drivers. Active drivers had larger volumes in the temporal cortex and cingulate cortex, as well as larger hippocampal volumes compared to non-drivers.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Medicine, General & Internal
Jamie N. Justice, Anoop M. Nambiar, Tamar Tchkonia, Nathan K. LeBrasseur, Rodolfo Pascual, Shahrukh K. Hashmi, Larissa Prata, Michal M. Masternak, Stephen B. Kritchevsky, Nicolas Musi, James L. Kirkland
Review
Geriatrics & Gerontology
Christy S. Carter, Jamie N. Justice, LaDora Thompson
Review
Nutrition & Dietetics
Flavia G. De Carvalho, Jamie N. Justice, Ellen C. de Freitas, Erin E. Kershaw, Lauren M. Sparks
Editorial Material
Geriatrics & Gerontology
Stephen B. Kritchevsky, Jamie N. Justice
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Geriatrics & Gerontology
Shokouh Ahmadi, Atefeh Razazan, Ravinder Nagpal, Shalini Jain, Bo Wang, Sidharth P. Mishra, Shaohua Wang, Jamie Justice, Jingzhong Ding, Donald A. McClain, Stephen B. Kritchevsky, Dalane Kitzman, Hariom Yadav
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Editorial Material
Biology
Jamie N. Justice, Stephen B. Kritchevsky
Article
Geriatrics & Gerontology
Jamie N. Justice, Sriram Gubbi, Ameya S. Kulkarni, Jenna M. Bartley, George A. Kuchel, Nir Barzilai
Summary: Geroscience interventions targeting biological aging offer hope for improving outcomes in response to infectious disease, reducing chronic pathology, and promoting immune memory, with metformin being a potential candidate for large-scale clinical trials.
Article
Geriatrics & Gerontology
Brett M. Frye, Payton M. Valure, Suzanne Craft, Mark G. Baxter, Christie Scott, Shanna Wise-Walden, David W. Bissinger, Hannah M. Register, Carson Copeland, Matthew J. Jorgensen, Jamie N. Justice, Stephen B. Kritchevsky, Thomas C. Register, Carol A. Shively
Summary: The study showed that gait speed and cognitive performance decline in older vervet monkeys, there is a strong agreement in performance between the novel executive function task and the established working memory assessment, and slow gait is associated with poor cognitive performance in both domains.
Correction
Geriatrics & Gerontology
Brett M. Frye, Payton M. Valure, Suzanne Craft, Mark G. Baxter, Christie Scott, Shanna Wise-Walden, David W. Bissinger, Hannah M. Register, Carson Copeland, Matthew J. Jorgensen, Jamie N. Justice, Stephen B. Kritchevsky, Thomas C. Register, Carol A. Shively
Article
Geriatrics & Gerontology
Mark A. Espeland, Jamie Nicole Justice, Judy Bahnson, Joni K. Evans, Medha Munshi, Kathleen M. Hayden, Felicia R. Simpson, Karen C. Johnson, Craig Johnston, Stephen R. Kritchevsky
Summary: Multimorbidity and frailty indices can predict subsequent decline in cognitive and physical function, as well as increased risk of mortality. Accelerated biological aging is captured by these indices. Whether intensive lifestyle interventions targeting these indices can reduce risks for downstream outcomes remains to be seen.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Xiao Zhang, Jason L. Sanders, Robert M. Boudreau, Alice M. Arnold, Jamie N. Justice, Mark A. Espeland, George A. Kuchel, Nir Barzilai, Lewis H. Kuller, Oscar L. Lopez, Stephen B. Kritchevsky, Anne B. Newman
Summary: By analyzing the relationships between multiple biomarkers and mortality, a biomarker index (BI) was found to be significantly associated with the composite outcome of death and chronic disease. It may serve as a practical intermediate phenotype for interventions aiming to modify the course of aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Jamie N. Justice, Xiaoyan Leng, Nathan K. Lebrasseur, Tamara Tchkonia, James L. Kirkland, Natalia Mitin, Yongmei Liu, Stephen B. Kritchevsky, Barbara J. Nicklas, Jingzhong Ding
Summary: Cellular senescence is an aging process exacerbated by obesity and linked to inflammation and chronic diseases. Caloric restriction may improve metabolism by reducing cellular senescence and inflammation. This randomized controlled trial showed that caloric restriction intervention altered specific circulating biomarkers of cellular senescence in middle-aged and older adults with obesity and prediabetes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Joshua R. Stapleton, Jamy D. Ard, Daniel P. Beavers, Lori S. Cogdill, Adolfo Z. Fernandez, Marjorie J. Howard, Jamie N. Justice, S. Delanie Lynch, Jovita J. Newman, Ashley A. Weaver, Kristen M. Beavers
Summary: The STRONG BONES trial aims to investigate the effectiveness of risedronate treatment in reducing bone loss associated with sleeve gastrectomy. Approximately 120 middle-aged and older patients undergoing sleeve gastrectomy will be randomly assigned to risedronate or placebo treatment, with skeletal outcomes measured at baseline, 6 months, and 12 months post-surgery. The primary outcome is the change in total hip areal bone mineral density over 12 months. The results of this study may have implications for clinical practice and the management of bone loss in sleeve gastrectomy patients.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2023)
Meeting Abstract
Critical Care Medicine
A. M. Nambiar, J. N. Justice, R. Pascual, S. K. Hashmi, T. Tchkonia, N. K. LeBrasseur, J. L. Kirkland, N. Musi, S. B. Kritchevsky
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Review
Cardiac & Cardiovascular Systems
Jamie N. Justice, Laura Niedernhofer, Paul D. Robbins, Vanita R. Aroda, Mark A. Espeland, Stephen B. Kritchevsky, George A. Kuchel, Nir Barzilai
CARDIOVASCULAR ENDOCRINOLOGY & METABOLISM
(2018)
Article
Behavioral Sciences
Edna C. Cieslik, Markus Ullsperger, Martin Gell, Simon B. Eickhoff, Robert Langner
Summary: Previous studies on error processing have primarily focused on the posterior medial frontal cortex, but the role of other brain regions has been underestimated. This study used activation likelihood estimation meta-analyses to explore brain activity related to committing errors and responding successfully in interference tasks. It was found that the salience network and the temporoparietal junction were commonly involved in both correct and incorrect responses, indicating their general involvement in coping with situations that require increased cognitive control. Error-specific convergence was observed in the dorsal posterior cingulate cortex, posterior thalamus, and left superior frontal gyrus, while successful responding showed stronger convergence in the dorsal attention network and lateral prefrontal regions. Underrecruitment of these regions in error trials may reflect failures in activating the appropriate stimulus-response contingencies necessary for successful response execution.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2024)