期刊
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
卷 73, 期 -, 页码 255-275出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.11.021
关键词
Anorexia nervosa; Dopamine; Ghrelin; Goal-directed action; Motivation; Parkinson's disease
资金
- French Ministry for Higher Education and Research
- University of Lille, INSERM, PHRC [PARKFANORD 2005/1914, PARADIGME 2002/1918, CONVERGENCE 2008/0811]
- Australian National Health and Medical Research Council [546131, 1084344]
The gastro-intestinal peptide ghrelin has been assigned many functions. These include appetite regulation, energy metabolism, glucose homeostasis, intestinal motility, anxiety, memory or neuroprotection. In the last decade, this pleiotropic peptide has been proposed as a therapeutic agent in gastroparesis for diabetes and in cachexia for cancer. Ghrelin and its receptor, which is expressed throughout the brain, play an important role in motivation and reward. Ghrelin finely modulates the mesencephalic dopaminergic signaling and is thus currently studied in pathological conditions including dopamine-related disorders. Dopamine regulates motivated behaviors, modulating reward processes, emotions and motor functions to enable the survival of individuals and species. Numerous dopamine-related disorders including Parkinson's disease or eating disorders like 'anorexia nervosa involve altered ghrelin levels. However, despite the growing interest for ghrelin in these pathological conditions, global integrative studies investigating its role in brain dopaminergic structures are still lacking. In this review, we discuss the role of ghrelin on dopaminergic neurons and its relevance in the search for new therapeutics for Parkinson's disease- and anorexia nervosa-related dopamine deficits. (C) 2016 Elsevier Ltd. All rights reserved.
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