Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum

Crystal Structure of the Human Cannabinoid Receptor CB 1

(2016) Tian Hua et al.   CELL

Presynaptic adenosine A2Areceptors dampen cannabinoid CB1receptor-mediated inhibition of corticostriatal glutamatergic transmission

(2015) S G Ferreira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Striatal adenosine-cannabinoid receptor interactions in rats over-expressing adenosine A2A receptors

(2015) Valentina Chiodi et al.   JOURNAL OF NEUROCHEMISTRY

Inactivation of adenosine A 2A receptors reverses working memory deficits at early stages of Huntington's disease models

(2015) Wei Li et al.   NEUROBIOLOGY OF DISEASE

Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1receptors on developing cortical neurons

(2015) Adán de Salas-Quiroga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric interactions between agonists and antagonists within the adenosine A2Areceptor-dopamine D2receptor heterotetramer

(2015) Jordi Bonaventura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

(2015) Xavier Viñals et al.   PLOS BIOLOGY

Reassessing Models of Basal Ganglia Function and Dysfunction

(2014) Alexandra B. Nelson et al.   Annual Review of Neuroscience

Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex

(2014) Leo T. O. Lee et al.   FASEB JOURNAL

Differential Effects of Presynaptic versus Postsynaptic Adenosine A2A Receptor Blockade on  9-Tetrahydrocannabinol (THC) Self-Administration in Squirrel Monkeys

(2014) Z. Justinova et al.   JOURNAL OF NEUROSCIENCE

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

(2014) A. Chiarlone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid CB1 Receptor in Dorsal Telencephalic Glutamatergic Neurons: Distinctive Sufficiency for Hippocampus-Dependent and Amygdala-Dependent Synaptic and Behavioral Functions

(2013) S. Ruehle et al.   JOURNAL OF NEUROSCIENCE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

l-DOPA-treatment in primates disrupts the expression of A2A adenosine–CB1 cannabinoid–D2 dopamine receptor heteromers in the caudate nucleus

(2013) Jordi Bonaventura et al.   NEUROPHARMACOLOGY

Adenosine A2A–cannabinoid CB1 receptor interaction: An integrative mechanism in striatal glutamatergic neurotransmission

(2012) Maria Teresa Tebano et al.   BRAIN RESEARCH

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Structure-based drug screening for G-protein-coupled receptors

(2012) Brian K. Shoichet et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Prospects for cannabinoid therapies in basal ganglia disorders

(2011) Javier Fernández-Ruiz et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional changes in postsynaptic adenosine A2A receptors during early stages of a rat model of Huntington disease

(2011) Marco Orrú et al.   EXPERIMENTAL NEUROLOGY

Worsening of Huntington disease phenotype in CB1 receptor knockout mice

(2011) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease

(2011) Valentina Chiodi et al.   NEUROBIOLOGY OF DISEASE

Facilitation of μ-Opioid Receptor Activity by Preventing δ-Opioid Receptor-Mediated Codegradation

(2011) Shao-Qiu He et al.   NEURON

A New Drug Design Targeting the Adenosinergic System for Huntington's Disease

(2011) Nai-Kuei Huang et al.   PLoS One

Structure of an Agonist-Bound Human A2A Adenosine Receptor

(2011) F. Xu et al.   SCIENCE

Key Modulatory Role of Presynaptic Adenosine A2AReceptors in Cortical Neurotransmission to the Striatal Direct Pathway

(2011) César Quiroz et al.   TheScientificWorldJOURNAL

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

Adenosine-cannabinoid receptor interactions. Implications for striatal function

(2010) Sergi Ferré et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interactions between Intracellular Domains as Key Determinants of the Quaternary Structure and Function of Receptor Heteromers

(2010) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocannabinoid Signaling Mediates Psychomotor Activation by Adenosine A2A Antagonists

(2010) T. N. Lerner et al.   JOURNAL OF NEUROSCIENCE

Bimodal control of stimulated food intake by the endocannabinoid system

(2010) Luigi Bellocchio et al.   NATURE NEUROSCIENCE

A2A receptor knockout worsens survival and motor behaviour in a transgenic mouse model of Huntington's disease

(2010) Stéphane Mievis et al.   NEUROBIOLOGY OF DISEASE

Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum

(2010) David M. Lovinger   NEUROPHARMACOLOGY

Physiology and Pharmacology of Striatal Neurons

(2009) Anatol C. Kreitzer   Annual Review of Neuroscience

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

(2009) Carla Ferrada et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells

(2009) Nuria Cabello et al.   JOURNAL OF NEUROCHEMISTRY

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization

(2008) Karima Azdad et al.   NEUROPSYCHOPHARMACOLOGY

Detection of Heteromers Formed by Cannabinoid CB1, Dopamine D2, and Adenosine A2AG-Protein-Coupled Receptors by Combining Bimolecular Fluorescence Complementation and Bioluminescence Energy Transfer

(2008) Gemma Navarro et al.   TheScientificWorldJOURNAL