Article
Pharmacology & Pharmacy
Veronica Lunerti, Hongwu Li, Federica Benvenuti, Qianwei Shen, Ana Domi, Laura Soverchia, Rita Maria Concetta Di Martino, Giovanni Bottegoni, Carolina L. Haass-Koffler, Nazzareno Cannella
Summary: Tobacco use disorder is a worldwide health problem with limited efficacy in available medications. A study found that ARN15381, a multitarget compound with FAAH inhibition and DRD3 partial agonist activity, reduced nicotine self-administration in rats, suggesting the potential clinical importance of a multitarget approach in the treatment of tobacco use disorder.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Scott G. Weiner, Michelle A. Hendricks, Sanae El Ibrahimi, Grant A. Ritter, Sara E. Hallvik, Christi Hildebran, Roger D. Weiss, Edward W. Boyer, Diana P. Flores, Lewis S. Nelson, Peter W. Kreiner, Michael A. Fischer
Summary: This study examined the risks of chronic use and overdose associated with hydrocodone and oxycodone in opioid-naive patients following their initial prescription. The results showed that hydrocodone had a slightly higher risk of chronic use, while oxycodone, especially when used in monotherapy, posed a higher risk of overdose. This suggests that hydrocodone may be a preferable choice to reduce overdose-related deaths.
Article
Anesthesiology
Francisco I. Salgado Garcia, Premananda Indic, Joshua Stapp, Keerthi K. Chintha, Zhaomin He, Jeffrey H. Brooks, Stephanie Carreiro, Karen J. Derefinko
Summary: This study successfully detected the self-administration of opioids in patients after dental surgery using wearable sensors and machine learning technology. Four machine learning models achieved validation accuracies greater than 80%, indicating the significant potential of wearable technology in monitoring opioid use in pain patients.
Article
Neurosciences
Kendall Woodlief, Mia I. Allen, Jeremy C. Cornelissen, Matthew L. Banks, Amy Hauck Newman, Michael A. Nader
Summary: Recent studies suggest that dopamine D3 receptors (D3R) may be a therapeutic target for opioid use disorders (OUD). This study examined the effects of the D3R partial agonist (+/-)VK4-40 and the D3R-selective antagonist (+/-)VK4-116, compared to the mu-opioid receptor antagonist naltrexone (NTX), in nonhuman primate models of OUD and antinociception. The results suggest that (+/-)VK4-40 may be a novel pharmacotherapy for OUD.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Jacques D. Nguyen, Yanabel Grant, Michael A. Taffe
Summary: This study investigated the affective consequences of escalating prescription opioid use using rat models. The results showed that changes in brain reward function during escalated oxycodone self-administration are driven by an interplay between kappa-opioid receptor-mediated negative affective state associated with escalated oxycodone intake and dynamic restoration of brain reward status during longer periods of abstinence.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Cell Biology
Cherkaouia Kibaly, Jacob A. L. Alderete, Steven H. Liu, Hazem S. Nasef, Ping-Yee Law, Christopher J. Evans, Catherine M. Cahill
Summary: The abuse of opioid medications, particularly oxycodone, has become a significant crisis, leading to overdose deaths and addiction. Misuse of oxycodone is driven by its pharmacological properties, market strategies, and false claims of non-addictiveness, contributing to its high likability and abuse susceptibility. Understanding the unique pharmacology and marketing tactics of oxycodone is crucial in addressing the opioid epidemic and preventing further harm.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Brianna E. George, Monica H. Dawes, Emily G. Peck, Sara R. Jones
Summary: Chronic heroin exposure leads to low dopamine levels in the nucleus accumbens and alterations in dopamine release dynamics, which may contribute to increased heroin seeking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
C. Austin Zamarripa, Tanya Pareek, Hayley M. Schrock, Thomas E. Prisinzano, Bruce E. Blough, Kenneth J. Sufka, Kevin B. Freeman
Summary: Triazole 1.1 is a novel KOR agonist that can reduce the reinforcing effects of oxycodone and enhance oxycodone-induced antinociception to a degree similar to typical KOR agonists. Developing MOR-KOR agonist combinations from the triazole 1.1 series may lead to new pain therapeutics with reduced abuse liability.
PSYCHOPHARMACOLOGY
(2021)
Article
Health Care Sciences & Services
Susan L. Calcaterra, Yingbo Lou, Rachel M. Everhart, Lindsey E. Fish, Rebecca Hanratty
Summary: This study examined the association between in-clinic opioid administration and opioid receipt at discharge as well as progression to chronic opioid use in urgent care patients. The results showed that patients who received in-clinic opioids were more likely to receive opioids at discharge and had a higher risk of progressing to chronic opioid use.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Simeone Marino, Hassan Jassar, Dajung J. J. Kim, Manyoel Lim, Thiago D. D. Nascimento, Ivo D. D. Dinov, Robert A. A. Koeppe, Alexandre F. F. DaSilva
Summary: This study utilized a novel machine learning method to accurately identify migraine patients based on the analysis of central mu-opioid and dopamine D2/D3 receptors. The results showed that dysfunction in the μ-opioid and D2/D3 receptors in the neurotransmission of migraine patients may partly explain the severe impact of migraine and associated neuropsychiatric comorbidities.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhi-Bing You, Eliot L. Gardner, Ewa Galaj, Allamar R. Moore, Tristram Buck, Chloe J. Jordan, Bree A. Humburg, Guo-Hua Bi, Zheng-Xiong Xi, Lorenzo Leggio
Summary: The study found that the use of oxycodone can increase ghrelin levels and upregulate GHS-R1a mRNA levels, leading to increased drug reward. Pretreatment with the antagonist JMV2959 can reduce oxycodone self-administration, indicating the importance of the ghrelin system in oxycodone use.
MOLECULAR PSYCHIATRY
(2022)
Article
Clinical Neurology
D'bora Dreher Nabinger, Stefani Altenhofen, Alexis Buatois, Amanda Facciol, Julia Vasconcellos Peixoto, Julia Maria Kuhl da Silva, Diptendu Chatterjee, Gabriel Rubensam, Robert Gerlai, Carla Denise Bonan
Summary: This study investigated the effects of the dopamine D2/D3 receptor agonist quinpirole on the behavior, brain-derived neurotrophic factor (BDNF), and neurotransmitter levels in adult zebrafish. The results showed that quinpirole administration caused decreased locomotor activity, increased anxiety-like behaviors, memory impairment, and stereotypic swimming in zebrafish. Furthermore, quinpirole treatment also decreased the number of BDNF-immunoreactive cells and altered glutamate and serotonin levels in the zebrafish brain. These findings suggest that quinpirole administration in adult zebrafish can be a useful tool for studying the mechanisms underlying neurological disorders related to the dopaminergic system.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Chemistry, Medicinal
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark, Bassem Sadek
Summary: The study demonstrates the significant mitigating effects of a multiple-active H3R/D2R/D3R antagonist on social deficits related to ASD.
Article
Behavioral Sciences
Rachel D. Altshuler, Kristine T. Garcia, Xuan Li
Summary: The study revealed that adolescents may show resistance to oxycodone relapse during early abstinence, but this resistance disappears quickly during the transition from adolescence to young adulthood. Group-housing plays a protective role against incubated oxycodone craving.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Cardiac & Cardiovascular Systems
Andrew Kisling, Shannon Byrne, Rohan U. Parekh, Deepthy Melit-Thomas, Lisandra E. de Castro Bras, Robert M. Lust, Stefan Clemens, Srinivas Sriramula, Laxmansa C. Katwa
Summary: Evidence suggests the existence of an intracardiac dopaminergic system that plays a pivotal role in regulating cardiac function and fibrosis through G-protein coupled receptors, particularly mediated by dopamine receptor 3 (D3R). The study found that D3R in cardiac fibroblasts plays a crucial role in proliferation and migration, potentially mediating cardiac fibroblast function during the wound healing response. Loss of function in D3R resulted in attenuation of both proliferation and migration in response to scratch injury, and significantly increased the expression of Col3a1 in LV fibroblasts.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Guo-Hua Bi, Ewa Galaj, Yi He, Zheng-Xiong Xi
Article
Pharmacology & Pharmacy
Zheng-Xiong Xi, Pretal Muldoon, Xiao-Fei Wang, Guo-Hua Bi, M. Imad Damaj, Aron H. Lichtman, Roger G. Pertwee, Eliot L. Gardner
BRITISH JOURNAL OF PHARMACOLOGY
(2019)
Article
Clinical Neurology
Ewa Galaj, Zheng-Xiong Xi
Article
Neurosciences
Ewa Galaj, Guo-Hua Bi, Hong-Ju Yang, Zheng-Xiong Xi
Article
Pharmacology & Pharmacy
Xiao-Fei Wang, Ewa Galaj, Guo-Hua Bi, Cindy Zhang, Yi He, Jia Zhan, Michael H. Bauman, Eliot L. Gardner, Zheng-Xiong Xi
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Chloe J. Jordan, Yi He, Guo-Hua Bi, Zhi-Bing You, Jianjing Cao, Zheng-Xiong Xi, Amy Hauck Newman
BRITISH JOURNAL OF PHARMACOLOGY
(2020)
Article
Neurosciences
Ewa Galaj, Xiao Han, Hui Shen, Chloe J. Jordan, Yi He, Bree Humburg, Guo-Hua Bi, Zheng-Xiong Xi
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Ewa Galaj, Guo-Hua Bi, Allamar Moore, Kai Chen, Yi He, Eliot Gardner, Zheng-Xiong Xi
Summary: The FDA-approved food additive beta-caryophyllene (BCP) has shown potential in attenuating cocaine self-administration and conditioned place preference in rats, suggesting a possible treatment for cocaine use disorder. BCP's action appears to be independent of CB1, CB2, and GPR55 receptors, and may involve stimulation of PPAR alpha and PPAR gamma in the mesolimbic system.
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Galaj, Zheng-Xiong Xi
Summary: CBD shows therapeutic potential in reducing drug reward and relapse, with multiple receptor mechanisms involved in modulating brain dopamine and attenuating drug-taking and drug-seeking behavior. Further research is needed to verify its safety, pharmacological efficacy, and underlying receptor mechanisms in both experimental animals and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Rebeca Mejias, Juan J. Rodriguez-Gotor, Minae Niwa, Irina N. Krasnova, Abby Adamczyk, Mei Han, Gareth M. Thomas, Zheng-Xiong Xi, Richard L. Huganir, Mikhail Pletnikov, Akira Sawa, Jean-Lud Cadet, Tao Wang
Summary: This study explores the role of zdhhc15 gene in novelty-seeking behaviors and impulsivity by using knockout mice as experimental models. The research reveals that the absence of zdhhc15 gene may lead to elevated locomotion and extracellular dopamine levels in response to novel environments, suggesting a novel regulatory mechanism of dopamine in the striatum.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Bree A. Humburg, Chloe J. Jordan, Hai-Ying Zhang, Hui Shen, Xiao Han, Guo-Hua Bi, Briana Hempel, Ewa Galaj, Michael H. Baumann, Zheng-Xiong Xi
Summary: Despite extensive research, the rewarding effects of cannabinoids are still debated. Using a new animal procedure oICSS, it was found that most cannabinoids are not reward enhancing, but rather reward attenuating or aversive in mice. Activation of CB1R and/or CB2R in different populations of neurons in the brain may underlie the observed actions.
Editorial Material
Behavioral Sciences
Chloe J. Jordan, Roy Wise, Zheng-Xiong Xi
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Neurosciences
Hong-Ju Yang, Briana J. Hempel, Guo-Hua Bi, Yi He, Hai-Ying Zhang, Eliot L. Gardner, Zheng-Xiong Xi
Summary: Glutamate negatively regulates the rewarding effects of cocaine in the nucleus accumbens, but excess glutamate in multiple brain regions can trigger reinstatement of drug-seeking behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Cell Biology
Omar Soler-Cedeno, Zheng-Xiong Xi
Summary: CB1R has been a major target for treating SUDs, but the adverse effects of rimonabant led to its withdrawal. Therefore, developing neutral CB1R antagonists has gained research interest as a potential treatment for SUDs.
Article
Neurosciences
Xiao Han, Ying Liang, Briana Hempel, Chloe J. Jordan, Hui Shen, Guo-Hua Bi, Jin Li, Zheng-Xiong Xi
Summary: Cannabinoids modulate dopamine transmission and behavior through activation of CB1 receptors. This study found that CB1 receptors are expressed in a subset of dopamine neurons and are involved in cannabinoid modulation of dopamine release and behavior. Deletion of CB1 receptors from dopamine neurons attenuated the effects of cannabinoids on dopamine release, locomotion, and anxiety.
JOURNAL OF NEUROSCIENCE
(2023)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.