Article
Biochemistry & Molecular Biology
Ronodeep Mitra, Alina Nersesyan, Kaleigh Pentland, M. Mark Melin, Robert M. Levy, Eno E. Ebong
Summary: The endothelial glycocalyx (GCX), a protective covering for endothelial cells, plays an important role in maintaining endothelial function. This study investigated the effect of diosmin on GCX integrity and endothelial function in a mouse model. The results showed that diosmin treatment improved GCX coverage, reduced inflammation, and restored vascular tone. These findings suggest that diosmin may be a potential therapy for endothelial dysfunction.
Article
Multidisciplinary Sciences
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
Summary: The study demonstrates that beige adipocytes are crucial for the neuroprotective effects of subcutaneous fat, opposing cognitive decline induced by obesity and potentially involving the anti-inflammatory cytokine interleukin-4 (IL4).
NATURE COMMUNICATIONS
(2021)
Article
Geriatrics & Gerontology
Matti D. Allen, Brian H. Dalton, Kevin J. Gilmore, Chris J. McNeil, Timothy J. Doherty, Charles L. Rice, Geoffrey A. Power
Summary: Human biological aging is associated with the gradual loss of muscle mass and neuromuscular function, primarily due to the reduction in quantity and quality of motor units (MUs). While MUs are slowly lost throughout adulthood, habitual physical activity may help mitigate this loss. High levels of physical activity can potentially protect against the natural trajectory of MU loss and degradation in old age.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Mohammad Yassin Zamanian, Niloofar Taheri, Maria Jade Catalan Opulencia, Dmitry Olegovich Bokov, Sharif Y. Abdullaev, Mohammadreza Gholamrezapour, Mahsa Heidari, Gholamreza Bazmandegan
Summary: Traumatic brain injury (TBI) remains a major concern in public health, and pioglitazone (PG) has shown neuroprotective and anti-inflammatory effects through activating PPAR gamma. This study explores the literature to evaluate the impact of PG in TBI and discusses the role of microglia and cytokines. The findings suggest that PG can enhance neurobehavior, reduce brain edema and neuronal injury in TBI by stimulating PPAR gamma, decreasing oxidative stress, and limiting inflammation.
MEDIATORS OF INFLAMMATION
(2022)
Article
Agriculture, Multidisciplinary
Jinatta Jittiwat, Pennapa Chonpathompikunlert, Wanida Sukketsiri
Summary: The study shows that Apium graveolens extract can significantly reduce brain infarct volume in rats with cerebral ischemia, and improve neuronal density in the cortex and hippocampus. This neuroprotective effect is partly due to its antioxidant, anti-inflammatory, and anti-apoptotic effects.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Biochemistry & Molecular Biology
Dong Geun Hong, Seulah Lee, Jaehoon Kim, Seonguk Yang, Myunggyo Lee, Jinsook Ahn, Haeseung Lee, Seung-Cheol Chang, Nam-Chul Ha, Jaewon Lee
Summary: The present study found that a diet containing morin can prevent motor dysfunction and dopaminergic neuronal damage in a mouse model of Parkinson's disease. It can also significantly reduce neuroinflammation. In vitro studies showed that morin exerts its anti-inflammatory effects by blocking the ERK-p65 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Giuliana La Rosa, Maria Serena Lonardo, Nunzia Cacciapuoti, Espedita Muscariello, Bruna Guida, Raffaella Faraonio, Mariarosaria Santillo, Simona Damiano
Summary: Multiple sclerosis (MS) is a complex immune-mediated disease caused by gene-environment interactions. Dietary factors, particularly polyphenols, modulate inflammation and gut microbiota, making them potential adjuvant therapies for MS. This review explores the protective effects of polyphenols, such as resveratrol and curcumin, in MS through in vitro and animal studies. Clinical evidence is limited, but studies on substances like curcumin and epigallocatechin gallate show promise. Additionally, a clinical trial investigating the effects of polyphenols in MS patients is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Jia Hui Wong, Anna M. Barron, Jafri Malin Abdullah
Summary: Centella asiatica, a medicinal plant, has demonstrated anti-inflammatory, neuroprotective, and cognitive benefits which may be harnessed for treating brain aging and neurodegenerative diseases by its mitoprotective and antioxidative effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Seulah Lee, Yeon Ji Suh, Seonguk Yang, Dong Geun Hong, Akihito Ishigami, Hangun Kim, Jae-Seoun Hur, Seung-Cheol Chang, Jaewon Lee
Summary: The study demonstrates that evernic acid (EA) has neuroprotective and anti-inflammatory effects, protecting neurons against MPP+-induced cell death, mitochondrial dysfunction, and oxidative stress, and reducing astroglial activation. In mouse models, EA ameliorated MPTP-induced symptoms of PD, including motor dysfunction, dopaminergic neuronal loss, and neuroinflammation in the nigrostriatal pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Acoustics
Wen-Shin Song, Chen-Yu Sung, Chia-Hua Ke, Feng-Yi Yang
Summary: This study investigated the impact of low-intensity pulsed ultrasound (LIPUS) on the pathology of Parkinson's disease (PD) in an animal model. Results showed that LIPUS treatment inhibited glial activation, preserved neurotrophic factors, dopamine transporter and tight junction proteins of the blood-brain barrier, suggesting its potential as a treatment for PD through multiple neuroprotective mechanisms.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2022)
Article
Clinical Neurology
Alexey A. Shadrin, Soren Mucha, David Ellinghaus, Mary B. Makarious, Cornelis Blauwendraat, Ashwin A. K. Sreelatha, Antonio Heras-Garvin, Jinhui Ding, Monia Hammer, Alexandra Foubert-Samier, Wassilios G. Meissner, Olivier Rascol, Anne Pavy-Le Traon, Oleksandr Frei, Kevin S. O'Connell, Shahram Bahrami, Stefan Schreiber, Wolfgang Lieb, Martina Muller-Nurasyid, Ulf Schminke, Georg Homuth, Carsten O. Schmidt, Markus M. Nothen, Per Hoffmann, Christian Gieger, Gregor Wenning, J. Raphael Gibbs, Andre Franke, John Hardy, Nadia Stefanova, Thomas Gasser, Andrew Singleton, Henry Houlden, Sonja W. Scholz, Ole A. Andreassen, Manu Sharma
Summary: The study revealed a significant genetic overlap between multiple system atrophy (MSA) and inflammatory bowel disease, with shared genetic loci including the C7 gene. The C7 gene was found to play an important role in both phenotypes, suggesting the involvement of immune and gut dysfunction in the pathophysiology of MSA.
MOVEMENT DISORDERS
(2021)
Article
Plant Sciences
Joon-Il Lee, Jong-Hee Choi, Tae-Woo Kwon, Hyo-Sung Jo, Do-Geun Kim, Seong-Gyu Ko, Gyun Jee Song, Ik-Hyun Cho
Summary: Bornyl acetate (BA) extracted from pine oil has been found to have anti-inflammatory and blood-spinal cord barrier protective effects, which can effectively alleviate behavioral dysfunction and demyelination in an animal model of multiple sclerosis (MS) and may be a potential therapeutic agent for treating autoimmune demyelinating diseases.
Review
Geriatrics & Gerontology
Yi Zhang, Meng Zhang
Summary: Morinda officinalis How. (MO) is a traditional Chinese medicine with anti-inflammatory and antioxidant properties, making it effective in the treatment of Alzheimer's disease (AD) by suppressing inflammation and oxidative stress.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Xiang Gao, Zhihui Han, Cheng Huang, Huali Lei, Guangqiang Li, Lin Chen, Dandan Feng, Zijie Zhou, Qin Shi, Liang Cheng, Xiaozhong Zhou
Summary: The RA@BSA@Cur nanoparticles constructed in this study have multiple effects on SCI treatment, including suppressing inflammation, increasing neurite length and neural differentiation, and promoting neuron regeneration, which indicates their potential value in treating SCI.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Mi-Bo Kim, Hyeju Lee, Chaehyeon Lee, Yuqing Tan, Sang Gil Lee
Summary: The antioxidant activity of Ishige sinicola ethanol extract (ISE) and its fractions, particularly the butanol (BuOH) fraction, can protect against lipopolysaccharide (LPS)-induced muscle atrophy by attenuating the diameter of muscle cells and inhibiting muscle-specific E3 ubiquitin ligase expression. This protection may be mediated through the inhibition of pro-inflammatory cytokine and inflammation-inducible enzyme expression via the p38/extracellular signal-regulated kinase signaling pathway.
APPLIED SCIENCES-BASEL
(2023)
Article
Biophysics
Fernando Plenge-Tellechea, Carlos A. Dominguez-Solis, Angel G. Diaz-Sanchez, David Melendez-Martinez, Javier Vargas-Medrano, Jorge A. Sierra-Fonseca
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
(2018)
Article
Neurosciences
Carolina Gil-Tommee, Guadalupe Vidal-Martinez, Annette Reyes, Javier Vargas-Medrano, Gloria V. Herrera, Silver M. Martin, Stephanie A. Chaparro, Ruth G. Perez
EXPERIMENTAL NEUROLOGY
(2019)
Article
Neurosciences
Javier Vargas-Medrano, Barbara Yang, Nathan T. Garza, Ismael Segura-Ulate, Ruth G. Perez
NEUROSCIENCE LETTERS
(2019)
Review
Neurosciences
Guadalupe Vidal-Martinez, Barbara Yang, Javier Vargas-Medrano, Ruth G. Perez
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Guadalupe Vidal-Martinez, Katherine Najera, Julie D. Miranda, Carolina Gil-Tommee, Barbara Yang, Javier Vargas-Medrano, Valeria Diaz-Pacheco, Ruth G. Perez
Article
Neurosciences
Guadalupe Vidal-Martinez, Ismael Segura-Ulate, Barbara Yang, Valeria Diaz-Pacheco, Jose A. Barragan, Jocelyn De-Leon Esquivel, Stephanie A. Chaparro, Javier Vargas-Medrano, Ruth G. Perez
EXPERIMENTAL NEUROLOGY
(2020)
Article
Neurosciences
Javier Vargas-Medrano, Ismael Segura-Ulate, Barbara Yang, Ramesh Chinnasamy, Jeffrey B. Arterburn, Ruth G. Perez
Article
Neurosciences
Jorge A. Sierra-Fonseca, Minerva Rodriguez, Anapaula Themann, Omar Lira, Francisco J. Flores-Ramirez, Javier Vargas-Medrano, Bharathi S. Gadad, Sergio D. Iniguez
Summary: Adolescent exposure to FLX may have enduring effects on the neuronal protein degradation machinery, particularly in the prefrontal cortex. Furthermore, FLX history may induce persistent accumulation of AD-associated variants of tau in both the hippocampus and prefrontal cortex.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Emre Umucu, Chu-Ling Lo, Beatrice Lee, Javier Vargas-Medrano, Valeria Diaz-Pacheco, Kiran Misra, Sarah L. Martin, Peter M. Thompson, Bharathi S. Gadad
Summary: This study aims to examine the effect of gratitude as an adaptive regulating mechanism on suicidal ideation in veterans with mental illness and student veterans with PTSD symptoms. The study found that higher levels of gratitude were associated with lower levels of suicidal ideation, and this association was supported in both studies. Therefore, gratitude interventions may be effective when working with veterans with mental illness.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2022)
Article
Psychiatry
Bharathi S. Gadad, Javier Vargas-Medrano, Enrique Ivan Ramos, Katherine Najera, Matthew Fagan, Angelica Forero, Peter M. Thompson
Summary: This study found significant correlations of IL-6 and GDNF between brain and CSF, and IL-6 between brain and plasma, suggesting blood IL-6, GDNF and BDNF could be potential peripheral biomarkers associated with mood disorders, substance disorders, and suicide.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Jordan Brown, Colleen Everett, Jose A. Barragan, Javier Vargas-Medrano, Bharathi S. Gadad, Frank Nichols, Jorge L. Cervantes
Summary: This study aimed to investigate the cellular response of human microglial cells to the first-line medications IFN-β and Fingolimod for multiple sclerosis (MS) management, and determine their effects on the cells' response to an MS-associated bacterial ligand, Lipid 654. The results showed that the medications induced differential secretion of pro-inflammatory cytokines and decreased the secretion of M1-associated cytokines when the cells were stimulated with Lipid 654. These findings provide new insights into the mechanisms of action of these medications in human microglia and their potential use in regulating the inflammatory response in MS.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Review
Neurosciences
Valeria Diaz-Pacheco, Javier Vargas-Medrano, Eric Tran, Meza Nicolas, Diamond Price, Richa Patel, Silvina Tonarelli, Bharathi S. Gadad
Summary: Mild traumatic brain injury (mTBI) is the most common type of TBI, characterized by a lack of noticeable changes in neuroimaging studies. Accurate diagnosis of mTBI is crucial due to its potential to cause post-concussion syndrome and cognitive impairments. This review focuses on the role of biomarkers in diagnosing mTBI, including protein-based markers, genetic markers, imaging markers, neurophysiological markers, and clinical trials.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Behavioral Sciences
Alyssa Salcido, Eden Hernandez Robles, Kiran Chaudhary, Luis Alvarado, Sergio D. Iniguez, Javier Vargas-Medrano, Valeria Diaz-Pacheco, Maria Theresa Villanos, Bharathi S. Gadad, Sarah L. Martin
Summary: Pediatric obesity and ADHD are growing health concerns in the US, particularly among Hispanic children and adolescents. Existing research indicates higher obesity prevalence rates in this community, but there is limited data on ADHD rates. This study aims to examine the prevalence of obesity in children with ADHD compared to the general population.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Psychiatry
Javier Vargas-Medrano, Luis M. Carcoba, Guadalupe Vidal Martinez, Zuber D. Mulla, Victoria Diaz, Alejandra Ruiz-Velasco, Fabian Alvarez-Primo, Gabriela Colina, Sergio D. Iniguez, Peter M. Thompson, Laura E. O'Dell, Bharathi S. Gadad
Summary: Chronic nicotine exposure affects the expression of regulatory genes associated with metabolic function and neuronal alterations in the brain. The effects of sex and diet on gene expression in nicotine-exposed brains have not been well studied. Comparing pre-clinical models and human subjects can provide valuable insights into biomarkers of nicotine's harmful effects and help develop interventions for smoking cessation.
FRONTIERS IN PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Bharathi Gadad, Javier-Vargas Medrano, Valeria Diaz-Pacheco, Enrique Ramos, Barbara Yang, Ming-Ying Leung, Nikolaos Mellios, Manish Jha, Madhukar Trivedi, Peter Thompson
BIOLOGICAL PSYCHIATRY
(2021)
Correction
Neurosciences
Lucia Privitera, Ellen L. Hogg, Matthias Gaestel, Mark J. Wall, Sonia A. L. Correa
Article
Neurosciences
Li-Ya Jiang, Guan-Hao Wang, Jing-Jiao Xu, Xiao-Li Li, Xiao-Yan Lin, Xiang Fang, Hong-Xu Zhang, Mei Feng, Chun-Ming Jiang
Summary: This study reveals the importance of LINC00473 in regulating temozolomide (TMZ) resistance in glioblastoma (GB) and its potential mechanism. By regulating the expression of CEBP alpha and MGMT, LINC00473 promotes the formation of chemoresistance. Furthermore, LINC00473 can transfer chemoresistance to adjacent sensitive cells through exosomes.
Article
Neurosciences
Olga Kopach, Tetyana Pivneva, Nataliya Fedirko, Nana Voitenko
Summary: This study found that diabetic animals exhibit severe xerostomia characterized by reduced saliva flow rate, diminished total protein content, and decreased amylase activity. The impaired saliva production in diabetes is associated with reduced and delayed intracellular Ca2+ signals in submandibular acinar cells, caused by malfunctioning mitochondria. Targeting malfunctioning mitochondria may be a potential strategy for the treatment of diabetic xerostomia.
Article
Neurosciences
Nicholas M. Timme, Cherish E. Ardinger, Seth D. C. Weir, Rachel Zelaya-Escobar, Rachel Kruger, Christopher C. Lapish
Summary: This study aimed to assess aversion-resistant drinking behavior in head-fixed mice and explore the relationship between non-consummatory behaviors and aversion-resistant drinking. The results showed that head-fixed mice exhibited heterogenous levels of aversion-resistant drinking and non-consummatory behaviors were related to the intensity of this behavior.
Article
Neurosciences
David R. Maguire, Charles P. France
Summary: Methocinnamox (MCAM) is a novel, long-acting opioid receptor antagonist that effectively decreases fentanyl self-administration and prevents opioid overdose in monkeys. The study demonstrates the potential therapeutic utility of MCAM in the treatment of opioid use disorder.
Article
Neurosciences
Xiang Li, Dan Feng, Shenglu Ma, Mingxing Li, Shulei Zhao, Man Tang
Summary: This study investigated the effects of fluoxetine on neurochemical, neurobiological, and neurobehavioral changes in different subregions of the hippocampus. The results showed that fluoxetine increased dialysate 5-HT, decreased membrane 5-HTT protein, and increased cytoplasmic fraction. Additionally, fluoxetine reduced immobility times in behavioral tests, with greater effects observed in the ventral subregion compared to the dorsal subregion.
Article
Neurosciences
Alexander V. Zholos, Mariia I. Melnyk, Dariia O. Dryn
Summary: Acetylcholine is an important neurotransmitter in visceral smooth muscles, activating M2 and M3 muscarinic receptors to cause smooth muscle excitation and contraction. This review focuses on the cellular and molecular mechanisms underlying acetylcholine-induced depolarisation and smooth muscle contraction, as well as the effects of anticholinergic drugs on gastrointestinal motility. The knowledge gained from recent studies has greatly expanded our understanding of these processes.
Article
Neurosciences
Zhenlong Li, Hsien-Yu Peng, Chau-Shoun Lee, Tzer-Bin Lin, Ming-Chun Hsieh, Cheng-Yuan Lai, Han-Fang Wu, Lih-Chyang Chen, Mei-Ci Chen, Dylan Chou
Summary: Methylone shows significant efficacy in treating depression and social deficits, making it an ideal candidate for anti-depressant medication.
Article
Neurosciences
Aline Freyssin, Allison Carles, Sarra Guehairia, Gilles Rubinstenn, Tangui Maurice
Summary: This study explores the potential of combining FENM and S1R agonists in the treatment of Alzheimer's disease. The results showed that most FENM-based combinations can protect against learning deficits caused by A beta 25-35, with better efficacy in short-term memory.
Article
Neurosciences
J. D. Lorente, J. Cuitavi, L. Rullo, S. Candeletti, P. Romualdi, L. Hipolito
Summary: This study analyzed the effects of pain on negative affect in different sexes and time courses, as well as the involvement of the dynorphinergic and corticotropin releasing factor systems in these pain-related behaviors. The results showed sex and time-dependent anxiety- and anhedonia-like behaviors induced by pain in female rats. The recruitment of KOR/DYN in the NAc was identified as a key neurological substrate mediating pain-induced behavioral alterations.
Article
Neurosciences
Rongjun Liu, Daofan Sun, Xiuzhong Xing, Qingge Chen, Bo Lu, Bo Meng, Hui Yuan, Lan Mo, Liufang Sheng, Jinwei Zheng, Qiusheng Wang, Junping Chen, Xiaowei Chen
Summary: The coexistence of pain and depression is frequently observed in patients with chronic pain and depression. Oxytocin, a neuropeptide, has been reported to relieve chronic pain and depressive symptoms. This study investigated the effect of intranasal oxytocin on neuropathic pain and comorbid depressive symptoms, and found that oxytocin attenuated depression-like behavior but did not alleviate mechanical hyperalgesia. The results suggest that intranasal oxytocin may have the potential to treat depressive symptoms in neuropathic pain patients.
