☆ 4.7 Article

Dissociation in the effects of stress and D1 receptors activation on basolateral amygdalar LTP in juvenile and adult animals

NEUROPHARMACOLOGY (2017)

期刊

NEUROPHARMACOLOGY

卷 113, 期 -, 页码 511-518

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PERGAMON-ELSEVIER SCIENCE LTD

DOI: 10.1016/j.neuropharm.2016.11.005

关键词

Post-weanling; Prefrontal cortex; Amygdala; Stress; LTP; Extinction; Metaplasticity

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Neurosciences Pharmacology & Pharmacy

资金

Israel Science Foundation [663/13]

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摘要

Post-weaning or juvenility is a critical developmental stage during which neural structures as the medial prefrontal cortex (mPFC) and amygdala and the neurotransmitter systems undergo major reorganization and thus are susceptible to the effects of environmental factors. Interactions between the mPFC and the amygdala are critical for fear regulation. Changes in plasticity in the projections from the mPFC to the basolateral amygdala (BLA) were previously shown following stress and fear. In the present study, we examined possible differences between adult and PW animals in the (1) effects of exposure to stress on BLA- LTP and (2) the possible dependency of mPFC-BLA LTP on N-methyl-D-aspartate (NMDA) and Dopamine (D) receptors activation. The results show that similarly to the adults, the mPFC- BLA pathway in the PW animals is not amenable to the induction of LTP. However, in contrast to adult animals, exposure to stress in PW animals did not result in enhanced BLA-LTP. Interestingly, only under activation of the D1 receptors, PW animals expressed LTP in the BLA. In both groups of age, the NMDA partial agonist D-cycloserine (DCS) did not result in any change in the levels of potentiation. Our results confirm differences between the PW and the adult animal and show that stress and the activation of Dopamine are associated with different effects; which may have potential implications for the treatment of anxiety and stress disorders across development. (C) 2016 Published by Elsevier Ltd.

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Differential Age-dependent Mechanisms of High-frequency Stimulation-induced Potentiation in the Prefrontal Cortex-Basolateral Amygdala Pathway Following Fear Extinction

Kuldeep Shrivastava, Rachel Schayek, Milly Kritman, Mouna Maroun

Summary: Post-weaning is a critical period for brain maturation in rats, comparable to childhood and adolescence in humans. The basolateral amygdala (BLA) and medial prefrontal cortex (mPFC) continue to mature during this period and play a crucial role in regulating conditioned fear acquisition and extinction. Previous studies have shown that stress exposure leads to differences in extinction behavior and long-term potentiation between adults and post-weaning rats. In this study, the researchers investigated whether fear or extinction learning would affect the ability to induce electrical long-term potentiation (LTP) in the mPFC-BLA pathway in adult and post-weaning animals. The results showed that comparable extinction kinetics were necessary for LTP induction in both age groups, and significant differences in potentiation levels were observed after extinction between adults and post-weaning rats. These findings suggest that synaptic changes following fear extinction are different in adult and post-weaning animals, supporting the notion that fear extinction learning may rely on different mechanisms during these developmental stages.

NEUROSCIENCE (2022)