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Biochemistry & Molecular Biology
Istvan Taisz, Erika Dona, Daniel Munch, Shanice N. Bailey, Billy J. Morris, Kimberly I. Meechan, Katie M. Stevens, Irene Varela-Martinez, Marina Gkantia, Philipp Schlegel, Carlos Ribeiro, Gregory S. X. E. Jefferis, Dana S. Galili
Summary: In Drosophila, a specific olfactory channel processes male pheromones, promoting female courtship and repelling males. The processing streams extract qualitative and positional information, with sensory neurons and projection neurons encoding concentration differences and angular positions of males. The third circuit layer consists of 47 cell types with diverse input-output connectivity, enabling behavioral responses in specific ethological contexts through multisensory integration.
Review
Behavioral Sciences
Caroline B. Palavicino-Maggio, Saheli Sengupta
Summary: Aggression is an intrinsic trait used by organisms to acquire resources and mates. The intensity of aggression can vary genetically or be induced externally, with neuromodulation playing a key role. The fruit fly model has provided valuable insights into the neural circuits and neuromodulatory mechanisms underlying aggression regulation, which can help us understand human aggression. This review focuses on the roles of different neuromodulators in fruit fly aggression.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
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Biochemical Research Methods
Sven Dorkenwald, Claire E. McKellar, Thomas Macrina, Nico Kemnitz, Kisuk Lee, Ran Lu, Jingpeng Wu, Sergiy Popovych, Eric Mitchell, Barak Nehoran, Zhen Jia, J. Alexander Bae, Shang Mu, Dodam Ih, Manuel Castro, Oluwaseun Ogedengbe, Akhilesh Halageri, Kai Kuehner, Amy R. Sterling, Zoe Ashwood, Jonathan Zung, Derrick Brittain, Forrest Collman, Casey Schneider-Mizell, Chris Jordan, William Silversmith, Christa Baker, David Deutsch, Lucas Encarnacion-Rivera, Sandeep Kumar, Austin Burke, Doug Bland, Jay Gager, James Hebditch, Selden Koolman, Merlin Moore, Sarah Morejohn, Ben Silverman, Kyle Willie, Ryan Willie, Szi-chieh Yu, Mala Murthy, H. Sebastian Seung
Summary: FlyWire is an online community and platform for proofreading connectome data of the Drosophila brain, using interactive segmentation technology and collaborative editing to distribute proofreading work globally. By utilizing an open community, it accelerates proofreading by recruiting more participants and promotes scientific discovery through information sharing.
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Biochemistry & Molecular Biology
Markus K. Klose, Paul J. Shaw
Summary: Recent studies have shown that high sleep pressure can quickly reprogram large ventrolateral clock neurons to express specific receptors, leading to increased waking and early mating success. This receptor respecification mechanism involves dopamine receptors and activation of transcriptional regulator proteins.
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Neurosciences
Georg Ammer, Etienne Serbe-Kamp, Alex S. Mauss, Florian G. Richter, Sandra Fendl, Alexander Borst
Summary: This study reveals multilevel opponent inhibition in the fly visual system, providing insights into the circuit architecture and network mechanisms generating opponency. The findings suggest that the neural architecture provides resilience to noise while enabling high selectivity for relevant sensory information.
NATURE NEUROSCIENCE
(2023)
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Multidisciplinary Sciences
Saurabh Thapliyal, Isabel Beets, Dominique A. Glauser
Summary: Animals integrate multiple inputs to switch between different behavioral states, such as dwelling, scanning, global or glocal search, matching their thermoregulatory and feeding needs. The transition between states involves regulation of various processes, including sensory neuron activity, neuropeptide expression, and circuit responsiveness. Specific neuropeptide signaling acts on inhibitory GPCR(s) to promote scanning or glocal search, bypassing dopamine and glutamate-dependent control. The integration of multimodal context in sensory circuits represents a conserved regulatory logic for flexible prioritization of multiple inputs during persistent behavioral state transitions.
NATURE COMMUNICATIONS
(2023)
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Biochemistry & Molecular Biology
Deepa L. Ramamurthy, Andrew Chen, Jiayu Zhou, Chanbin Park, Patrick C. Huang, Priyanka Bharghavan, Gayathri Krishna, Jinjian Liu, Kayla Casale, Daniel E. Feldman
Summary: VIP cells in whisker somatosensory cortex are activated by local sensory features and goal-directed actions, but not directly by reinforcement. In expert mice, VIP responses related to licking are suppressed when a reward is delivered, and the suppression increases with reward size, which is not observed in novice mice.
Article
Neurosciences
Yehuda Salzberg, Rizwanul Haque, Meital Oren-Suissa
Summary: This review provides an overview of the current state of research on synaptic dimorphism in invertebrates, discusses the available tools for studying this phenomenon, and highlights the remaining unanswered questions.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Neurosciences
Rongfeng K. Hu, Yanning Zuo, Truong Ly, Jun Wang, Pratap Meera, Ye Emily Wu, Weizhe Hong
Summary: The study demonstrates that adult mice of both sexes exhibit robust reinforcement of social interaction. Through targeted manipulations, GABAergic neurons in the medial amygdala are found to play a crucial role in promoting the positive reinforcement of social interaction. Additionally, these neurons mediate social reinforcement behavior by projecting to the medial preoptic area and enhancing dopamine release in the nucleus accumbens.
NATURE NEUROSCIENCE
(2021)
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Biochemistry & Molecular Biology
Daniel Bakopoulos, Sofya Golenkina, Callum Dark, Elizabeth L. Christie, Besaiz J. Sanchez-Sanchez, Brian M. Stramer, Louise Y. Cheng
Summary: This study shows that insulin and TGF-beta signalling converge via a BMP antagonist sog to regulate ECM remodelling in adipose tissue. In tumour bearing animals, Sog also modulates TGF-beta signalling to regulate ECM accumulation. Activation of insulin signalling, inhibition of TGF-beta signalling, or modulation of ECM levels can rescue tissue wasting in the presence of tumor.
Article
Biochemistry & Molecular Biology
Tatsuya Tatz Hayashi, Alexander John MacKenzie, Ishani Ganguly, Kaitlyn Elizabeth Ellis, Hayley Marie Smihula, Miles Solomon Jacob, Ashok Litwin -Kumar, Sophie Jeanne Cecille Caron
Summary: The connectivity pattern between the Kenyon cells and projection neurons in the insect mushroom body can be encoded by fixed genetic programs, and this pattern may be the result of evolved prioritization of ecologically and ethologically salient stimuli.
Article
Neurosciences
Xiaolu Wan, Peng Shen, Kai Shi, Jing Li, Fengming Wu, Chuan Zhou
Summary: Females increase aggression for mating opportunities and acquiring reproductive resources. Virgin female Drosophila exhibit high-frequency attacks towards mated females, which is regulated by the male-derived pheromone 11-cis-vaccenyl acetate (cVA). A neural circuit consisting of four orders of neurons mediates the cVA-induced aggression in Drosophila females, with the release of acetylcholine (ACh) by aSP-g neurons exciting pC1 neurons.
NEUROSCIENCE BULLETIN
(2023)
Article
Neurosciences
Jun Ma, Johann du Hoffmann, Morgan Kindel, B. Sofia Beas, Yogita Chudasama, Mario A. Penzo
Summary: The study found that in mice, the paraventricular thalamus (PVT) mediates the selection of defensive behaviors by interacting with the central nucleus of the amygdala (CeA) and the nucleus accumbens (NAc), driving passive or active defensive responses respectively. The PVT-CeA pathway drives conditioned freezing responses, while the PVT-NAc pathway signals active avoidance events. Optogenetic manipulations showed that activity in these pathways biases behavior towards passive or active defensive responses, demonstrating the PVT's role in flexible switching between different defensive behaviors.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Yang Yang, Tao Jiang, Xueyan Jia, Jing Yuan, Xiangning Li, Hui Gong
Summary: This study comprehensively mapped the long-range connectivity of different sectors in the mouse ZI using fluorescence micro-optical sectioning tomography and viral tracing techniques. The results show that the input-output circuits of ZI GABAergic neurons are topologically organized, and the medial and lateral ZI are two different major functional compartments.
NEUROSCIENCE BULLETIN
(2022)
Article
Multidisciplinary Sciences
Kenichi Ishii, Matteo Cortese, Xubo Leng, Maxim N. Shokhirev, Kenta Asahina
Summary: This study reveals the genetic and neuronal mechanisms by which the nervous system suppresses aggression in a social experience-dependent manner, highlighting the importance of this process for maintaining animal fitness.
Editorial Material
Cell Biology
Hui Chiu, Chieh Chang
Article
Biochemistry & Molecular Biology
Chun-che Chang, Ting-Yu Huang, Chun-Liang Shih, Gee-Way Lin, Te-Pin Chang, Hui Chiu, Wen-Chang Chang
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2008)
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Genetics & Heredity
Hui Chiu, Hillel T. Schwartz, Igor Antoshechkin, Paul W. Sternberg
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Biochemistry & Molecular Biology
Andrew M. Davenport, Leslie N. Collins, Hui Chiu, Paul J. Minor, Paul W. Sternberg, Andre Hoelz
JOURNAL OF MOLECULAR BIOLOGY
(2014)
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Multidisciplinary Sciences
Yan Zou, Hui Chiu, Anna Zinovyeva, Victor Ambros, Chiou-Fen Chuang, Chieh Chang
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Biochemistry & Molecular Biology
Yan Zou, Hui Chiu, Dorothee Domenger, Chiou-Fen Chuang, Chieh Chang
Review
Neurosciences
Hui Chiu, Amel Alqadah, Chieh Chang
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
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Multidisciplinary Sciences
Nicholas C. Flytzanis, Claire N. Bedbrook, Hui Chiu, Martin K. M. Engqvist, Cheng Xiao, Ken Y. Chan, Paul W. Sternberg, Frances H. Arnold, Viviana Gradinaru
NATURE COMMUNICATIONS
(2014)
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Cell Biology
Hui Chiu, Amel Alqadah, Chiou-Fen Chuang, Chieh Chang
CELL ADHESION & MIGRATION
(2011)
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Optics
Jiun-Yann Yu, Jonghyun Kim, Daniel B. Holland, Yun Mou, Hui Chiu, Geoffrey A. Blake, Wonhee Lee, Chin-Lin Guo
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Multidisciplinary Sciences
Hui Chiu, Yan Zou, Nobuko Suzuki, Yi-Wen Hsieh, Chiou-Fen Chuang, Yi-Chun Wu, Chieh Chang
NATURE COMMUNICATIONS
(2018)
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Neurosciences
Yonil Jung, Ann Kennedy, Hui Chiu, Farhan Mohammad, Adam Claridge-Chang, David J. Anderson
Article
Biochemistry & Molecular Biology
Hui Chiu, Eric D. Hoopfer, Maeve L. Coughlan, David J. Anderson
Summary: This passage discusses the function and gender differences of three cell types that regulate aggression in Drosophila, as well as how these circuits affect the aggressive behaviors of male and female flies from the appetitive phase to the consummatory phase. The strength of the connection between monomorphic and dimorphic behaviors is increased by social isolation, indicating a possible locus for isolation-dependent enhancement of aggression.