Article
Geriatrics & Gerontology
Ruiting Zhang, Peiyu Huang, Shuyue Wang, Yeerfan Jiaerken, Hui Hong, Yao Zhang, Xinfeng Yu, Min Lou, Minming Zhang
Summary: This study investigated the association between cerebral blood flow (CBF) and arterial transit with white matter hyperintensities (WMH) and lacunes in patients with cerebral small vessel disease (CSVD). The results showed that both CBF derived from two post-labeling delay times (PLDs) were associated with WMH volume and the presence of lacune. Additionally, delta CBF was correlated with WMH volume but not the presence of lacune. This suggests that delayed arterial transit has an independent effect on WMH.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Heng Du, Jianrong Zheng, Xuelong Li, Yanjing Dong, Yajing Cheng, Cong Liu, Jun Hu, Xiangyan Chen
Summary: This study aims to investigate the relationship between intracranial arterial calcification (IAC) pattern and white matter hyperintensities (WMH). The results show a positive correlation between medial IAC and WMH, suggesting underlying shared mechanisms of intracranial large artery disease and small vessel disease.
Article
Cardiac & Cardiovascular Systems
Lingling Ding, Bo Hou, Jie Zang, Tong Su, Feng Feng, Zhaohui Zhu, Bin Peng
Summary: This study investigated the relationship between angiogenesis and WMH penumbra in patients with WMHs, and found evidence of angiogenesis occurring in the WMH penumbra. Further studies are needed to verify the effect of angiogenesis on WMH growth.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Yiyi Chen, Xing Wang, Ling Guan, Yilong Wang
Summary: WMHs are imaging markers of cerebral small-vessel disease closely associated with cognitive impairment, but their heterogeneous nature makes early detection and diagnosis challenging. Limited understanding of the underlying pathological processes and biomarkers of WMHs in cognitive impairment has led to slow progress in prevention and treatment.
Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Emma Barinas-Mitchell, Yuefang Chang, Howard Aizenstein, Carol A. Derby, Pauline M. Maki
Summary: This study examined the association between carotid atherosclerosis and brain white matter hyperintensities in midlife women, and found that higher carotid intima media thickness is associated with greater WMH volume. The association is stronger among APOE ε4-positive women, indicating the importance of vascular risk for midlife brain health.
ALZHEIMERS & DEMENTIA
(2023)
Review
Medicine, General & Internal
Cun-Sheng Wei, Cai-Yun Yan, Xiao-Rong Yu, Lin Wang, Rui Zhang, Jun-Ying Jiang, Qi Dai, Jun-Rong Li, Xue Mei Chen
Summary: This study conducted a systematic review and meta-analysis to examine the association between white matter hyperintensities (WMH) and chronic kidney disease (CKD). The results showed that patients with CKD were more likely to have WMH in the brain compared to the normal controls. Additionally, patients with moderate to severe WMH had poorer renal function compared to those with no to mild WMH.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Junyan Huo, Gan Zhang, Wenjing Wang, Wen Cao, Mengxia Wan, Tao Huang, Dongsheng Fan, Yu Fu
Summary: In this study, the bidirectional causal relationship between migraine and white matter lesions was explored using a two-sample mendelian randomization method. The analysis of a recent large-scale genome-wide association study data did not provide evidence for causality between white matter lesions and migraine.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Natalia Pozo, Cesar Romero, Maricarmen Andrade, Paul H. Delano, Vicente Medel, Marco Troncoso, Patricia Orellana, Maria Isabel Rodriguez, Camila Fabres, Carolina Delgado
Summary: This study found that there is a mediating effect of frontal white matter hyperintensities on the association between frailty and executive dysfunction in older adults.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Jing Chen, Anyan Ge, Ying Zhou, Yuanyuan Ma, Shaoping Zhong, Caizhong Chen, Weibin Shi, Jing Ding, Xin Wang
Summary: The study examined the relationships between cognitive function and white matter hyperintensity volume (WMHV) in patients with silent cerebrovascular disease, and found that impaired white matter integrity mediates the impact of WMHV on cognitive function. The findings suggest the importance of white matter integrity in cognitive rehabilitation strategies for patients with silent cerebrovascular diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Catriona R. Stewart, Michael S. Stringer, Yulu Shi, Michael J. Thrippleton, Joanna M. Wardlaw
Summary: Cerebral small vessel disease (SVD) is a significant factor in stroke and dementia, with white matter hyperintensities (WMH) contributing to these conditions. Studies have shown that patients with lower cerebral blood flow (CBF) tend to have a heavier burden of WMH, but longitudinal associations remain inconclusive. Further research is needed to determine the role of CBF in the progression of SVD.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Rachel A. Crockett, Chun Liang Hsu, Elizabeth Dao, Roger Tam, Janice J. Eng, Todd C. Handy, Teresa Liu-Ambrose
Summary: White matter hyperintensities (WMH) are associated with cognitive impairment in cerebral small vessel disease, potentially due to disruption of large-scale functional networks. Lesion network mapping can help identify how disruptions to specific functional networks, such as the visual, ventral attention, and frontoparietal networks, are associated with poorer cognition in older adults with cerebral small vessel disease. In particular, disruption to the sensorimotor and ventral attention networks may contribute to deficits in global cognition.
Article
Geriatrics & Gerontology
Jinsong Cai, Jianzhong Sun, Haiyan Chen, Ying Chen, Ying Zhou, Min Lou, Risheng Yu
Summary: This study found different mechanisms in PWMHs and DWMHs, with PWMHs mainly attributed to venous damage and dysfunction of the glymphatic pathway, and DWMHs potentially affected by both ischemia-hypoperfusion and dysfunction of the glymphatic pathway.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Gemma Sole-Guardia, Emma Custers, Arthur de Lange, Elyne Clijncke, Bram Geenen, Jose Gutierrez, Benno Kusters, Jurgen A. H. R. Claassen, Frank-Erik De Leeuw, Maximilian Wiesmann, Amanda J. Kiliaan
Summary: Cerebral small vessel disease (SVD), including white matter hyperintensities (WMH), is the major vascular cause of dementia. Chronic hypertension and neuroinflammation are recognized as important risk factors for SVD and the conversion of normal-appearing white matter (NAWM) to WMH. This study investigated the impact of hypertension on perivascular- and neuroinflammation in WMH and NAWM using high field brain magnetic resonance imaging (MRI) and (immuno-)histopathological staining. The findings suggest that neurovascular inflammation plays a critical role in the etiology of WMH, and future therapeutic strategies targeting hypertension and neuroinflammation may ameliorate WMH progression.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Federico Greco, Luigi Giuseppe Quarta, Paul M. Parizel, Bruno Beomonte Zobel, Carlo Cosimo Quattrocchi, Carlo Augusto Mallio
Summary: This systematic review summarizes the relationship between white matter hyperintensities (WMH) volumetric quantification and chronic kidney disease (CKD). The review highlights the heterogeneity in methodology and samples in the literature. The evidence suggests a relationship between CKD and WMH volume in the brain.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Geriatrics & Gerontology
Christopher E. Bauer, Valentinos Zachariou, Elayna Seago, Brian T. Gold
Summary: This study investigated the associations between three potential early markers of white matter hyperintensity volume and found that white matter microstructure may be a better predictor of WMH volume compared to brain iron concentration and cerebral blood flow. It also highlighted that some early WMH markers may be location-specific.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
David Della-Morte, Chuanhui Dong, Matthew S. Markert, Mitchell S. V. Elkind, Ralph L. Sacco, Clinton B. Wright, Tatjana Rundek
Review
Biochemistry & Molecular Biology
Patrizia Ferroni, Piero Barbanti, David Della-Morte, Raffaele Palmirotta, Emilio Jirillo, Fiorella Guadagni
ANTIOXIDANTS & REDOX SIGNALING
(2018)
Review
Biochemistry & Molecular Biology
Francesca Pacifici, David Della Morte, Barbara Capuani, Donatella Pastore, Alfonso Bellia, Paolo Sbraccia, Nicola Di Daniele, Renato Lauro, Davide Lauro
ANTIOXIDANTS & REDOX SIGNALING
(2019)
Article
Geriatrics & Gerontology
Ilaria Liguori, Gennaro Russo, Vincenzo Coscia, Luisa Aran, Giulia Bulli, Francesco Curcio, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2018)
Article
Nutrition & Dietetics
Ilaria Liguori, Francesco Curcio, Gennaro Russo, Michele Cellurale, Luisa Aran, Giulia Bulli, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
NUTRITION IN CLINICAL PRACTICE
(2018)
Article
Clinical Neurology
Alessandro Micarelli, Andrea Viziano, David Della-Morte, Ivan Augimeri, Marco Alessandrini
OTOLOGY & NEUROTOLOGY
(2018)
Letter
Cardiac & Cardiovascular Systems
Gianluca Testa, Ilaria Liguori, Francesco Curcio, Gennaro Russo, Giulia Bulli, Gianlugi Galizia, David Della-Morte, Gaetano Gargiulo, Claudia Basile, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2019)
Review
Biochemistry & Molecular Biology
Francesca Pacifici, Davide Di Cola, Donatella Pastore, Pasquale Abete, Fiorella Guadagni, Giulia Donadel, Alfonso Bellia, Eleonora Esposito, Chiara Salimei, Paola Sinibaldi Salimei, Camillo Ricordi, Davide Lauro, David Della-Morte
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Nutrition & Dietetics
Marialaura Simonetto, Marco Infante, Ralph L. Sacco, Tatjana Rundek, David Della-Morte
Article
Cell Biology
David Della-Morte, Francesca Pacifici, Camillo Ricordi, Renato Massoud, Valentina Rovella, Stefania Proietti, Mariannina Iozzo, Davide Lauro, Sergio Bernardini, Stefano Bonassi, Nicola Di Daniele
Summary: This study found a significant association between low plasminogen levels and inflammatory markers, coagulation markers, and organ dysfunction markers in COVID-19 patients. Plasminogen may play a vital role in controlling the complex mechanisms behind the complications of COVID-19, serving as both a biomarker for prognosis and a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Review
Nutrition & Dietetics
Francesca Pacifici, Valentina Rovella, Donatella Pastore, Alfonso Bellia, Pasquale Abete, Giulia Donadel, Silvia Santini, Heinz Beck, Camillo Ricordi, Nicola Di Daniele, Davide Lauro, David Della-Morte
Summary: This article reviewed the association between polyphenols and stroke protection, including prevention, acute phase effects, and rehabilitation. These compounds have clinical relevance in reducing vascular risk factors for stroke.
Article
Medicine, General & Internal
Marco Infante, Massimo Pieri, Santina Lupisella, Ali Mohamad, Sergio Bernardini, David Della-Morte, Andrea Fabbri, Alberto De Stefano, Marco Iannetta, Lorenzo Ansaldo, Angela Crea, Massimo Andreoni, Maria Morello
Summary: Type 2 diabetes mellitus and impaired kidney function are linked to a higher risk of adverse outcomes in COVID-19. This study found that admission estimated glomerular filtration rate and white blood cell count were significantly associated with in-hospital mortality among patients with diabetes and COVID-19.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Immunology
Marco Infante, Laura Vitiello, Andrea Fabbri, Camillo Ricordi, Nathalia Padilla, Francesca Pacifici, Pasquale Di Perna, Marina Passeri, David Della-Morte, Massimiliano Caprio, Luigi Uccioli
Summary: We describe a case of a 22-year-old Italian man with new-onset type 1 diabetes who experienced an unusually prolonged clinical remission phase (31 months). The patient was treated with calcifediol and low-dose insulin, resulting in the maintenance of residual beta-cell function and clinical remission. This may be attributed to the immunoregulatory properties of calcifediol.
Review
Geriatrics & Gerontology
Ilaria Liguori, Gennaro Russo, Luisa Aran, Giulia Bulli, Francesco Curcio, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Andrea Ungar, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2018)
Review
Geriatrics & Gerontology
Francesco Curcio, Giuseppe Sasso, Ilaria Liguori, Gaetana Ferro, Gennaro Russo, Michele Cellurale, David Della-Morte, Gaetano Gargiulo, Gianluca Testa, Francesco Cacciatore, Domenico Bonaduce, Pasquale Abete
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2018)