期刊
NEUROLOGIC CLINICS
卷 35, 期 2, 页码 295-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2017.01.007
关键词
Vascular cognitive impairment; Vascular dementia; Diagnosis; Treatment; Neuropathology; MRI; White matter hyperintensity; Silent brain infarct
资金
- National Institute on Aging [1P50-05142]
Cerebrovascular disease (CVD) is the second leading cause of cognitive impairment in late life. Structural neuroimaging offers the most sensitive and specific biomarkers for hemorrhages and infarcts, but there are significant limitations in its ability to detect microvascular disease, microinfarcts, dynamic changes in the blood-brain barrier, and preclinical cerebrovascular disease. Autopsy studies disclose the common co-occurrence of vascular and neurodegenerative conditions, suggesting that in late life, a multifactorial approach to cognitive impairment may be more appropriate than traditional dichotomous classifications. Management of vascular risk factors remains a proven and practical approach to reducing acute and progressive cognitive impairment and dementia.
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