Review
Oncology
Michael Xu, Latese Evans, Candice L. Bizzaro, Fabio Quaglia, Cecilia E. Verrillo, Li Li, Julia Stieglmaier, Matthew J. Schiewer, Lucia R. Languino, William K. Kelly
Summary: Despite therapeutic advances in prostate cancer treatment, metastatic castration-resistant prostate cancer remains a challenge. Highly expressed proteins STEAP1-4 have been identified as significant drivers of prostate cancer aggressiveness and metastasis. However, their other biological functions and understanding of heterotrimers and homotrimers are limited. This review highlights the importance of further research on the role of STEAP1-4 in prostate cancer and their potential clinical applications.
Article
Environmental Sciences
Xin Wang, Zhenxing Shen, Shasha Huang, Huizheng Che, Leiming Zhang, Yali Lei, Jian Sun, Guofeng Shen, Hongmei Xu, Junji Cao
Summary: Water-soluble iron (ws-Fe) in PM2.5 plays a crucial role in biogeochemical cycles and atmospheric chemical processes. The concentration of ws-Fe in Chinese urban areas is higher than in the United States and remote oceans. The dominant form of ws-Fe differs in Beijing and other cities, with a positive correlation observed between ws-Fe and particle-bound reactive oxygen species (ROS).
ENVIRONMENTAL POLLUTION
(2022)
Article
Pharmacology & Pharmacy
Saurabh Kumar, Pooja Rani Mina, Ravi Kumar, Anirban Pal, Ateeque Ahmad, Sudeep Tandon, Mahendra P. Darokar
Summary: 4-Chlorothymol demonstrates potential antiplasmodial activity by increasing ROS and RNS levels, modulating enzyme activity, showing synergy with chloroquine, significantly suppressing parasitemia in vivo, and being safe for further exploration of therapeutic properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Wen-Ya Ma, Qiu-Yun Qin, Ying-Ning Zou, Kamil Kuca, Bhoopander Giri, Qiang-Sheng Wu, Abeer Hashem, Al-Bandari Fahad Al-Arjani, Khalid F. Almutairi, Elsayed Fathi Abd Allah, Yong-Jie Xu
Summary: AMF enhances drought tolerance in walnut by activating antioxidant defense systems and Hsfs transcription levels, reducing oxidative damage.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Junping Bao, Zhanyang Qian, Lei Liu, Xin Hong, Hui Che, Xiaotao Wu
Summary: The study reveals that the eIF2 alpha/ATF4/Ihh signaling pathway is involved in regulating ROS levels and apoptosis in NP cells, and disrupting this pathway may provide promising methods in preventing IDD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Plant Sciences
Inmaculada Sanchez-Vicente, Oscar Lorenzo
Summary: Climate change affects plant growth with heat and cold waves, but identification of key signaling molecules like nitric oxide can help mitigate adverse effects and improve plant tolerance. NO is a central gasotransmitter in stress responses, enhancing plant adaptation to heat and cold stress and suggesting new approaches for future environmental challenges.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Plant Sciences
Vimalraj Kantharaj, Nirmal Kumar Ramasamy, Young-Eun Yoon, Mi Sun Cheong, Young-Nam Kim, Keum-Ah Lee, Vikranth Kumar, Hyeonji Choe, Song Yeob Kim, Hadjer Chohra, Yong Bok Lee
Summary: This study investigated the protective role of Indole-3-acetic acid (IAA) in mitigating Hydroxyurea (HU)-induced toxicity in rice seedlings. The results showed that IAA augmentation improved the growth and biomass production of the seedlings by reducing hydrogen peroxide (H2O2) and malondialdehyde (MDA) levels and enhancing antioxidant enzyme activity under HU stress. Additionally, the study revealed that HU-induced DNA damage activated uridine 5'-diphosphate-glucosyltransferase (UGT), which mediates auxin homeostasis and promotes plant growth and development.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Environmental Sciences
Yunjiang Yu, Haobo Guo, Zijuan Zhong, Anqi Wang, Mingdeng Xiang, Senhao Xu, Chenyin Dong, Zhaofeng Chang
Summary: This study compared the efficiency of different catalysts in removing Bisphenol A (BPA) using activated persulfate (PDS), and found that Fe3O4@MBC800 showed the best BPA removal efficiency. Fe3O4@MBC800 exhibited excellent resistance to environmental interference and had good catalytic reusability and stability.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Zheng, Xueying Jin, Jingyi Wang, Wei Chen, Zhen Yang, Yaxin Chen, Yonghua Yang, Guihua Lu, Bo Sun
Summary: Drought stress severely affects cereal crop yield. This study characterized a sorghum NAC gene, SbNAC9, and found that it is highly induced by PEG-simulated dehydration treatments. Overexpression of SbNAC9 in sorghum seedlings enhances drought stress tolerance, while silencing SbNAC9 weakens it. SbNAC9 also activates genes related to ROS scavenging and ABA biosynthesis. These findings highlight the important role of SbNAC9 in sorghum's response to drought stress and offer insights for genetic improvement of other crops.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lijun Wang, Jiayu Wang, Huijuan Guo, Ying Wang, Baohua Xu, Xingqi Guo, Chen Wang
Summary: AccATF2 plays a crucial role in maintaining redox homeostasis and protecting honeybees from oxidative stress caused by various environmental stimuli. It is highly expressed in key areas and stages of honeybee development, and its knockdown leads to oxidative damage and decreased resistance to oxidative stress.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Oncology
Ze-Xuan Fang, Chun-Lan Li, Wen-Jia Chen, Hua-Tao Wu, Jing Liu
Summary: This study analyzed the expression of STEAP family members in CRC. Among different STEAP family members, STEAP4 plays a different role in CRC compared to STEAPs 1-3. In CRC, the expression of STEAP4 is not only lower than that in normal tissues, but it is also positively correlated with immune infiltration and immune-related biomarkers. These findings suggest that STEAP4 may be a potential biomarker for predicting CRC immune infiltration status.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chia-Hui Chen, Chien-Chung Hsia, Po-An Hu, Chung-Hsin Yeh, Chun-Tang Chen, Cheng-Liang Peng, Chih-Hsien Wang, Tzong-Shyuan Lee
Summary: Bromelain, a cysteine protease found in pineapple, has been found to have beneficial effects in the treatment of inflammatory diseases. In this study, the effects of bromelain on hyperlipidemia and atherosclerosis in mice were investigated. It was found that daily administration of bromelain improved hyperlipidemia, reduced aortic inflammation, and slowed down the progression of atherosclerosis. The mechanisms underlying these effects involve the promotion of cholesteryl ester hydrolysis, autophagy, and antioxidant capacity through the AMPK/TFEB signaling pathway.
Article
Environmental Sciences
Hamed Vafaei Molamahmood, Wei Geng, Yan Wei, Jie Miao, Shiqin Yu, Ali Shahi, Chao Chen, Mingce Long
Summary: This study investigates the decomposition of H2O2 over six different iron minerals and finds hematite and goethite to be the most promising minerals for environmental cleanup due to their high ROS production. Magnetite and maghemite are highly active for both H2O2 decomposition and O-2 production at neutral and basic pHs. Ferrihydrite and feroxyhyte, on the other hand, are problematic minerals for CHP as they have high O-2 production and negligible ROS generation at all pHs.
Article
Chemistry, Physical
Lin -Lin Su, Rong-Jian Li, Na Huang, Ting -Ting Zhu, Shi-Huai Deng, Xian-Xiang Wang, Gang Yang, Yan-Zong Zhang, Lu-Lu Long
Summary: In this work, the role of silicon (Si) in peroxymonosulfate (PMS) activation was examined using iron silicate (FeSi) as an example. The results showed that Si played a significant role in PMS activation in addition to the traditional metal sites. This study deepened our understanding of the role of Si in silicates for PMS activation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Cell Biology
M. Ines Pascoal Ramos, Can Kesmir, Jorn E. Stok, Ruben Geerdink, Nikolaos Satravelas, Geertje H. A. Westerlaken, Linde Meyaard, Michiel van der Vlist
Summary: Inhibitory and activating immune receptors are crucial for regulating immune responses and maintaining immune balance; CD200R1L, a putative activating receptor on human neutrophils, activates cellular functions via multiple signaling pathways.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai
Summary: Unlike healthy cells, cancer cells heavily rely on the molecular chaperone protein TRiC, particularly its subunit CCT4, for protein folding and maintenance of proteostasis. In this study, we demonstrate that targeting CCT4 with the compound anticarin-beta can effectively inhibit osteosarcoma cell survival and impede STAT3 maturation. Anticarin-beta shows high selectivity for cancer cells and exhibits remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Gastroenterology & Hepatology
Marta Alonso-Nocelo, Laura Ruiz-Canas, Patricia Sancho, Kivanc Gorgulu, Sonia Alcala, Coral Pedrero, Mireia Vallespinos, Juan Carlos Lopez-Gil, Marina Ochando, Elena Garcia-Garcia, Sara Maria David Trabulo, Paola Martinelli, Patricia Sanchez-Tomero, Carmen Sanchez-Palomo, Patricia Gonzalez-Santamaria, Lourdes Yuste, Sonja Maria Wormann, Derya Kabacaoglu, Julie Earl, Alberto Martin, Fernando Salvador, Sandra Valle, Laura Martin-Hijano, Alfredo Carrato, Mert Erkan, Laura Garcia-Bermejo, Patrick C. Hermann, Hana Algul, Gema Moreno-Bueno, Christopher Heeschen, Francisco Portillo, Amparo Cano, Bruno Sainz
Summary: LOXL2 plays an important role in pancreatic ductal adenocarcinoma (PDAC), with its loss inhibiting metastasis and prolonging overall survival, while overexpression promotes tumor growth and decreases overall survival. Macrophage-secreted OSM is an inducer of LOXL2 expression, with targeting macrophages affecting its expression and collagen fiber alignment.
Article
Multidisciplinary Sciences
Marta Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad, Vivi Ann Florenes, Lina Prasmickaite, Gunhild Mari Maelandsmo, Kotryna Seip
Summary: This study investigated the therapeutic potential of combining an AXL inhibitor (AXLi) and a clinically relevant BRAF inhibitor (BRAFi) for the treatment of metastatic melanoma. The results showed that AXL was expressed in the majority of melanoma lymph node metastases. In vitro experiments demonstrated that the combination of AXLi and BRAFi resulted in the largest reduction in cell viability. Moreover, pre-clinical studies using AXL(high) melanoma models showed a therapeutic benefit of adding AXLi to the BRAF-targeted therapy. Mechanistic insights revealed that AXLi potentiated BRAFi-induced apoptosis, stimulated ferroptosis, and inhibited autophagy. Overall, this study suggests that combining AXLi with standard therapy could improve the therapeutic outcome in metastatic melanoma.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Rourou Xiao, Lixin You, Li Zhang, Xichen Guo, Ensong Guo, Faming Zhao, Bin Yang, Xi Li, Yu Fu, Funian Lu, Zizhuo Wang, Chen Liu, Wenju Peng, Wenting Li, Xiaohang Yang, Yingyu Dou, Jingbo Liu, Wei Wang, Tianyu Qin, Yaoyuan Cui, Xiaoxiao Zhang, Fuxia Li, Yang Jin, Qingping Zeng, Beibei Wang, Gordon B. Mills, Gang Chen, Xia Sheng, Chaoyang Sun
Summary: The WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the PERK and IRE1 alpha branches of the unfolded protein response in TP53 mutant ovarian cancer models. Inhibition of the IRE1 alpha-XBP1s pathway may enhance the efficacy of AZD1775.
Article
Oncology
Chengcheng Shi, Faming Zhao, Tingting Zhang, Denghui Xu, Zhuangyu Hao, Fengzhen Cui, Ji-Hua Shi, Yang Jin, Ningning Li, Caihong Yang, Yi Zhang, Xia Sheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Ruohan Li, Huaixiang Zhou, Mingzhe Li, Qiuyan Mai, Zhang Fu, Youheng Jiang, Changxue Li, Yunfei Gao, Yunping Fan, Kaiming Wu, Clive Da Costa, Xia Sheng, Yulong He, Ningning Li
Summary: This study found that GREM1 protein promotes invasion and metastasis of colorectal cancer cells by regulating the expression of ATF6 and ATF4, possibly through the modulation of PI3K/AKT/mTOR and BMP2 signaling pathways.
Article
Oncology
Yixin Jin, Kristina Berg Lorvik, Yang Jin, Carole Beck, Adam Sike, Irene Persiconi, Emilie Kvaloy, Fahri Saatcioglu, Claire Dunn, Jon Amund Kyte
Summary: This study describes a CAR T cell targeting STEAP1 and demonstrates its potential clinical application in prostate cancer. The CAR T cells showed specific response against STEAP1 and effectively inhibited tumor growth and prolonged survival in vivo.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Environmental Sciences
Fengzhen Cui, Hongxiu Liu, Yuanyuan Li, Tong-Zhang Zheng, Shunqing Xu, Wei Xia, Xia Sheng
Summary: The study found a positive association between maternal exposure to PFASs and serum Hb and HCT levels. Furthermore, iron supplementation during pregnancy may influence this relationship.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Letter
Oncology
Okan Safak, Shenghan Wang, Carmen Mota Reyes, Ibrahim Halil Guercinar, Sergey Tokalov, Nedim Can Cevik, Kivanc Goerguelue, Bengi Su Yilmaz, Emre Erdogan, Linhan Ye, Qiaolin Li, Elif Arik Sever, Samed Oezer, Gueldal Sueyen, Helmut Friess, Gueralp Onur Ceyhan, Rouzanna Istvanffy, Hana Alguel, Ihsan Ekin Demir
CANCER COMMUNICATIONS
(2023)
Article
Oncology
Vigdis Nygaard, Anne Hansen Ree, Vegar Johansen Dagenborg, Anne-Lise Borresen-Dale, Bjorn Edwin, Asmund Avdem Fretland, Krzysztof Grzyb, Mads H. Haugen, Gunhild M. Maelandsmo, Kjersti Flatmark
Summary: A mesenchymal subgroup with an immunosuppressive phenotype, characterized by high expression of immune checkpoints HAVCR2/TIM-3 and VISTA, as well as the M2 macrophage marker CD163, was identified in colorectal cancer liver metastases. These findings suggest potential novel opportunities for immune-based therapy approaches in microsatellite stable colorectal cancer.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada, Anne Hansen Ree, Samuel Klempner, Gunhild Mari Maelandsmo, Kjersti Flatmark, Hege G. Russnes, James M. Cleary, Harshabad Singh, Elisa Sottotetti, Antonia Martinetti, Giovanni Randon, Andrea Sartore-Bianchi, Iolanda Capone, Massimo Milione, Maria Di Bartolomeo, Filippo Pietrantonio
Summary: This study collected data from patients with GI cancers and ALK rearrangements, showing remarkable responses and clinical benefit with ALK inhibitors. Despite the low frequency, ALK rearrangements play an important role in personalized treatment for GI cancers.
JCO PRECISION ONCOLOGY
(2022)
Article
Oncology
Jorgen Sikkeland, Matthew Yoke Wui Ng, Hatice Zeynep Nenseth, Bilal Unal, Su Qu, Yang Jin, Anne Simonsen, Fahri Saatcioglu
Summary: STAMP2 suppresses autophagy through modulation of the integrated stress response axis and regulates mitochondrial respiration, both of which have significant metabolic effects and support PCa growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)