Article
Radiology, Nuclear Medicine & Medical Imaging
Ke Fang, Zejun Wang, Zhaoqing Li, Bao Wang, Guangxu Han, Zhaowei Cheng, Zhihong Chen, Chuanjin Lan, Yi Zhang, Peng Zhao, Xinyu Jin, Yingchao Liu, Ruiliang Bai
Summary: A convolutional neural network (CNN) was developed to accelerate the computation and fitting of the extended Tofts model, showing comparable results to conventional nonlinear least square fitting while significantly reducing the computation time.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Ruixue Wei, Yang Liu, Jinhao Gao, V. Wee Yong, Mengzhou Xue
Summary: The study developed iron-based nanoparticles for dual brain MRI and fluorescence imaging studies to improve the accuracy of brain disease diagnosis. The nanoparticles displayed good biocompatibility, enabling simultaneous MRI and fluorescence imaging, and showed high sensitivity and accuracy in imaging mouse brain tumors.
Review
Immunology
Boxun Zhang, Ke Liu, Haoyu Yang, Zishan Jin, Qiyou Ding, Linhua Zhao
Summary: Traditional Chinese herbal medicine often treats different diseases with the same method, but the underlying mechanism is unclear. Recent studies have shown that gut microbiota dysbiosis may play a significant role in the therapeutic effect of herbal medicine. This study focused on ulcerative colitis and type 2 diabetes and found that various Chinese herbal medicines can potentially treat these diseases by improving the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lin Chen, Jing Liu, Chengyan Chu, Zheng Han, Nirhbay Yadav, Jiadi Xu, Renyuan Bai, Verena Staedtke, Monica Pearl, Piotr Walczak, Peter van Zijl, Miroslaw Janowski, Guanshu Liu
Summary: This study demonstrates the potential use of D2O as a negative MRI contrast medium for guiding endovascular neurointervention, providing a safe and quantitative approach without the concern of contrast accumulation. The established D2O-MRI method shows promising results in small and large animals, making it a valuable tool for various endovascular procedures.
Article
Biochemistry & Molecular Biology
Jin Ah Shin, Hyerim Park, Hyunsu Choi, Yoon-Kyung Chang, Jwa-Jin Kim, Young Rok Ham, Ki Ryang Na, Kang Wook Lee, Dae Eun Choi
Summary: This study examined whether ?-3 PUFAs can attenuate damage to the BBB caused by uremia and contrast agents, and evaluated its associated mechanisms. The results showed that ?-3 PUFAs can protect the BBB from damage caused by uremia and contrast agents, and reduce brain-cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rajat Thawani, Lina Gao, Ajay Mohinani, Alina Tudorica, Xin Li, Zahi Mitri, Wei Huang
Summary: This preliminary study investigated the predictive performances of quantitative dynamic contrast-enhanced (DCE) MRI parameters, alone and in combination with clinicopathological variables, for prediction of recurrence in breast cancer patients treated with neoadjuvant chemotherapy (NACT). The results showed that pre- and post-NACT DCE-MRI parameters performed better than tumor size measurement in predicting recurrence, especially when combined with post-NACT K-trans, residual cancer burden, and age.
BMC MEDICAL IMAGING
(2022)
Article
Pharmacology & Pharmacy
Barbara Sanchez-Dengra, Isabel Gonzalez-Alvarez, Flavia Sousa, Marival Bermejo, Marta Gonzalez-Alvarez, Bruno Sarmento
Summary: This study aimed to improve a previously proposed in vitro cell-based model by using a more physiological cell line and established four linear IVIVCs to predict the pharmacokinetic parameters related to drug access and distribution in the CNS. The results showed that the best IVIVCs were those correlating in vitro and in vivo parameters related to the binding rate of a substance to brain tissue, highlighting the importance of using brain homogenate in in vitro brain permeability assays.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingfeng Shao, Chenyang Zhao, Qinyang Shou, Keith S. St Lawrence, Danny J. J. Wang
Summary: This study presents a pulse sequence and mathematical models for quantification of blood-brain barrier water exchange and permeability. The MCDW-pCASL sequence allows visualization of intravascular/extravascular ASL signals across multiple PLDs. The three-compartment SPA model provides a comprehensive measurement of blood-brain barrier water dynamics from group-averaged data, and a simplified LRL method was proposed for individual k(w) quantification.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neuroimaging
Paul Nichols, Javier Urriola, Stephanie Miller, Tracey Bjorkman, Kate Mahady, Viktor Vegh, Fatima Nasrallah, Craig Winter
Summary: This study revealed a correlation between DCE measures and MMP values in patients with TBI, suggesting that serum MMP-7 may be considered as a peripheral biomarker for quantifying BBB dysfunction in TBI patients.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
Axel Montagne, Samuel R. Barnes, Daniel A. Nation, Kassandra Kisler, Arthur W. Toga, Berislav Zlokovic
Summary: Recent studies have found subtle blood-brain barrier leaks in the human brain during normal aging, age-related cognitive dysfunction, genetic risk for Alzheimer's disease, mild cognitive impairment, early Alzheimer's disease, cerebral small vessel disease, and other neurodegenerative disorders using dynamic contrast-enhanced magnetic resonance imaging. The quantified leaks are typically much lower than those in brain tumors, stroke, and multiple sclerosis relapses. The challenges lie in improving the detectability, reliability, and reproducibility of the technique, as well as standardizing and harmonizing data between different scanners.
Article
Medicine, Research & Experimental
Valerie C. Anderson, Ian J. Tagge, Aaron Doud, Xin Li, Charles S. Springer, Joseph F. Quinn, Jeffrey A. Kaye, Katherine Wild, William D. Rooney
Summary: Metabolic deficits at brain-fluid barriers, including reduced water efflux rate constant at the blood-cerebrospinal fluid barrier, are associated with cognitive decline in older adults. Significant associations were observed between water efflux rate constant and cognitive dysfunction, indicating a potential biomarker for cognitive impairment in later life.
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.
