Article
Endocrinology & Metabolism
Eira Karvonen, Kai J. E. Krohn, Annamari Ranki, Annika Hau
Summary: APECED is a severe and incurable autoimmune disease that can be treated with stem cell therapy. The study shows that patient-derived iPSCs have stem cell properties and can be used for gene correction, confirming their pluripotency and potential therapeutic use.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cell Biology
Claudia Rejano-Gordillo, Ana Ordiales-Talavero, Ana Nacarino-Palma, Jaime M. Merino, Francisco J. Gonzalez-Rico, Pedro M. Fernandez-Salguero
Summary: The transcription factor aryl hydrocarbon receptor (AHR) is a key regulator involved in cell functions and tumor progression. It can act as either an oncogene or a tumor suppressor, depending on the specific organ, tissue and cell type. In addition to its role in cell adhesion and migration, AHR has potential as a therapeutic tool, diagnosis and prognosis marker.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Menno ter Huurne, Hendrik G. Stunnenberg
Summary: During early embryonic development, the rapid increase in cell number and the expression of genes that control developmental decisions are tightly regulated and interconnected processes. Transcription factors and signaling pathways play a crucial role in maintaining pluripotency and cell cycle progression, while canonical cell cycle regulators impact molecular networks controlling pluripotency and lineage specification.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Xuepeng Wang, Chengcheng Song, Ying Ye, Yashi Gu, Xuemei Li, Peixin Chen, Dongliang Leng, Jing Xiao, Hao Wu, Sisi Xie, Weiwei Liu, Qi Zhao, Di Chen, Xi Chen, Qiang Wu, Guokai Chen, Wensheng Zhang
Summary: BRD9 plays a crucial role in the regulation of self-renewal and differentiation of human embryonic stem cells, and is involved in the progression of pancreatic and breast cancers.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Masayuki Hagiwara, Atsushi Fushimi, Nami Yamashita, Atrayee Bhattacharya, Hasan Rajabi, Mark D. Long, Yota Yasumizu, Mototsugu Oya, Song Liu, Donald Kufe
Summary: The study demonstrates that MUC1-C induces the expression of PBRM1, ARID2, and BRD7 by E2F1 activation, subsequently influencing the PBAF pathway and NRF2 antioxidant gene transcriptome in PC cells. This pathway plays a crucial role in regulating ROS levels, pluripotency factor expression, and cancer stem cell state.
Article
Multidisciplinary Sciences
Andy Chan, Sophia Ma, Bret J. Pearson, Danny Chan
Summary: The extracellular matrix plays a crucial role in the maintenance, regeneration, and differentiation of stem cells within their niche. By studying the collagen gene family in the freshwater planarian Schmidtea mediterranea, researchers have identified a key gene, col4-1, which influences the proliferation of neoblasts. Furthermore, evidence suggests that an interaction between type IV collagen, the discoidin domain receptor, and neuregulin-7 regulate the balance of symmetric and asymmetric division of neoblasts through the NRG-7/EGFR pathway.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Huajin Li, Wenting Xu, Sijia Xiang, Leiting Tao, Wen Fu, Jinhui Liu, Wenbin Liu, Yamei Xiao, Liangyue Peng
Summary: Pluripotency is a transient state in early embryos regulated by a network of pluripotency-related genes. This study identified four pluripotent genes in zebrafish and crucian carp and verified that three of them can be used as markers for pluripotency in induced pluripotent stem cells in fish.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Liang Bai, Zhifeng Gao, An Jiang, Song Ren, Baotai Wang
Summary: This study found that circ_0001535 is significantly upregulated in colorectal cancer. Silencing circ_0001535 can inhibit colorectal cancer cell proliferation, invasion, stemness, and tumor growth by regulating the expression of miR-485-5p and LASP1, and induce cell apoptosis.
BALKAN MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Giacomo Furlan, Aurelia Huyghe, Noemie Combemorel, Fabrice Lavial
Summary: A challenge in development is to ensure lineage segregation while preserving plasticity. This review focuses on how developmental transitions are coordinated through redeployments of cellular components. The authors propose the concept of Molecular Versatility to group mechanisms by which molecules are repurposed for different functions in stem cell configurations.
NATURE COMMUNICATIONS
(2023)
Article
Cell & Tissue Engineering
Violetta R. Beklemisheva, Polina S. Belokopytova, Veniamin S. Fishman, Aleksei G. Menzorov
Summary: Researchers have successfully generated multipotent stem cell line in ringed seals, capable of differentiation into adipocytes and osteocytes, but it does not resemble human pluripotent cells.
CELLULAR REPROGRAMMING
(2021)
Article
Cell Biology
Hong-Fen Shen, Yong-Long Li, Shi-Hao Huang, Jia-Wei Xia, Zhi-Fang Yao, Gao-Fang Xiao, Ying Zhou, Ying-Chun Li, Jun-Wen Shi, Xiao-Lin Lin, Wen-Tao Zhao, Yan Sun, Yu-Guang Tian, Jun-Shuang Jia, Dong Xiao
Summary: This study successfully generated Oct4-GFP miPSCs from mouse somatic cells, which exhibited similar morphology, proliferation, and gene expression to mESCs. Oct4-GFP miPSCs could differentiate and retain pluripotency, and their pluripotency could be monitored in real-time using a GFP reporter system.
Review
Biotechnology & Applied Microbiology
Fuga Takahashi, Praneel Patel, Takahiro Kitsuka, Kenichi Arai
Summary: Induced pluripotent stem cells (iPSCs) have gained attention as an ethical alternative to embryonic stem cells (ESCs) and hold promise for the treatment of heart failure through differentiated cardiomyocytes. This paper explores the differentiation process of human iPSC-derived cardiomyocytes and their potential applications, addressing ethical concerns.
BIOENGINEERING-BASEL
(2023)
Article
Cell Biology
Deepa Bhartiya, Nitu Jha, Anish Tripathi, Ashish Tripathi
Summary: The concept of dedifferentiation and reprogramming of mature somatic cells shows promise in the battle against tissue damage, cancer, and aging. However, clinical applications remain challenging due to various factors such as instability, tumorigenicity, immunogenicity, and heterogeneity. The potential of very small embryonic-like stem cells (VSELs) in addressing these issues is examined, as they have been found to replace diseased tissue, ensure regeneration, and differentiate into adult counterparts.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Cell Biology
Xinyue Zhou, Mingming Zhou, Minying Zheng, Shifeng Tian, Xiaohui Yang, Yidi Ning, Yuwei Li, Shiwu Zhang
Summary: Polyploid giant cancer cells (PGCCs) are a significant feature of cellular atypia, and their formation and function mechanisms are unclear. Recent studies have shown that these cells have cancer stem cell-like characteristics and can generate progeny cells through asymmetric division, promoting tumor invasion and migration. The formation of PGCCs can be induced by various factors such as hypoxia, chemotherapeutic reagents, and radiation. These cells can differentiate into non-tumor cells and produce highly oxygen-affine red blood cells to survive in hypoxic environments. The number of these cells is associated with tumor metastasis, resistance to chemoradiotherapy, and recurrence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Meeting Abstract
Oncology
Jungsun Kim, Kenneth S. Zaret
Meeting Abstract
Oncology
Jungsun Kim, Greg Donahue, Wenli Yang, Kenneth S. Zaret
Article
Cell Biology
Jungsun Kim, William R. Bamlet, Ann L. Oberg, Kari G. Chaffee, Greg Donahue, Xing-Jun Cao, Suresh Chari, Benjamin A. Garcia, Gloria M. Petersen, Kenneth S. Zaret
SCIENCE TRANSLATIONAL MEDICINE
(2017)
Article
Chemistry, Medicinal
Jung Sun Kim, Byung Soo Kim, Jiha Kim, Choon-Sik Park, Il Yup Chung
ARCHIVES OF PHARMACAL RESEARCH
(2010)
Meeting Abstract
Oncology
Jungsun Kim, John P. Hoffman, Maximilian Reichert, Andrew Rhim, Ben Z. Stanger, Andrew Gumbs, Kenneth S. Zaret
MOLECULAR CANCER RESEARCH
(2014)
Article
Cell Biology
Jungsun Kim, John P. Hoffman, R. Katherine Alpaugh, Andrew D. Rhim, Maximilian Reichert, Ben Z. Stanger, Emma E. Furth, Antonia R. Sepulveda, Chao-Xing Yuan, Kyoung-Jae Won, Greg Donahue, Jessica Sands, Andrew A. Gumbs, Kenneth S. Zaret
Article
Oncology
Shirsa Udgata, Naomi Takenaka, William R. Bamlet, Ann L. Oberg, Stephanie S. Yee, Erica L. Carpenter, Daniel Herman, Jungsun Kim, Gloria M. Petersen, Kenneth S. Zaret
Summary: PDAC is often diagnosed too late for effective therapy, and the classic strategy for early detection biomarker advancement involves retrospective phases of discovery and validation. However, a new study shows that THBS2 and CA19-9 fail to distinguish patients from healthy controls in the 1 to 15 years prior to a PDAC diagnosis.
CANCER PREVENTION RESEARCH
(2021)
Review
Cell & Tissue Engineering
Jungsun Kim
STEM CELL RESEARCH
(2020)
Article
Oncology
Jungsun Kim, Taelor Ekstrom, Wenli Yang, Greg Donahue, Dmytro Grygoryev, Thuy T. M. Ngo, John L. Muschler, Terry Morgan, Kenneth S. Zaret
Summary: This study utilized an isogenic model to investigate the transition from precursor lesions to pancreatic ductal adenocarcinoma (PDAC), revealing transient expression changes of many genes during PDAC progression. Additionally, two transcription factors, HMG-box transcription factor 1 (HBP1) and BTB domain and CNC homolog 1 (BACH1), were identified as regulators of dynamically expressed genes during PDAC progression, with their expressions inversely correlating with PDAC patients' prognosis. The findings provide insights into the networks underlying human PDAC progression and pathogenesis.
MOLECULAR CANCER RESEARCH
(2021)
Review
Cell Biology
Jungsun Kim
Summary: Pancreatic cancer is characterized by high recurrence rate and low survival rate. Surgery is the most effective treatment, but most patients experience recurrence after surgery. Subclinical dormant pancreatic cancer cells are believed to disseminate before developing metastatic or recurring cancer, and there are multiple routes and mechanisms involved in pancreatic cancer migration and adaptation.
Article
Biochemistry & Molecular Biology
JS Kim, J Kim, BS Kim, HY Chung, YY Lee, CS Park, YS Lee, YH Lee, IY Chung
EXPERIMENTAL AND MOLECULAR MEDICINE
(2005)
Article
Immunology
HS Chang, JS Kim, JH Lee, J Cho, TY Rhim, ST Uh, BL Park, IY Chung, CS Park, HD Shin
JOURNAL OF IMMUNOLOGY
(2005)
Article
Biochemistry & Molecular Biology
HD Shin, LH Kim, BL Park, JH Jung, JY Kim, IY Chung, JS Kim, JH Lee, SH Chung, YH Kim, HS Park, JH Choi, YM Lee, SW Park, BW Choi, SJ Hong, CS Park
HUMAN MOLECULAR GENETICS
(2003)
Article
Allergy
CS Park, EN Choi, JS Kim, YS Choi, TY Rhim, HS Chang, IY Chung
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2005)