期刊
NEUROIMAGE
卷 182, 期 -, 页码 360-369出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2017.09.030
关键词
Transverse relaxation; Diffusion; MRI; Modeling
资金
- Research Foundation - Flanders (FWO) [12S1615N]
- Raymond and Beverly Sackler Laboratories for Convergence of Physical, Engineering and Biomedical Sciences
- Litwin Foundation for Alzheimer's Research
- National Institute of Neurological Disorders and Stroke of the NIH [R01NS088040]
- Center of Advanced Imaging Innovation and Research (CAI2R), a NIBIB Biomedical Technology Resource Center [P41 EB017183]
Biophysical modeling of macroscopic diffusion-weighted MRI signal in terms of microscopic cellular parameters holds the promise of quantifying the integrity of white matter. Unfortunately, even fairly simple multi-compartment models of proton diffusion in the white matter do not provide a unique, biophysically plausible solution. Here we report a nontrivial diffusion MRI signal dependence on echo time (T-E) in human white matter in vivo. We demonstrate that such T-E dependence originates from compartment-specific T-2 values and that it is a promising orthogonal measure able to break the degeneracy in parameter estimation, and to yield important relaxation metrics robustly. We thereby enable the precise estimation of the intra- and extra-axonal water T-2 relaxation times, which is precluded by a limited signal-to-noise ratio when using multi-echo relaxometry alone.
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