Article
Cell Biology
Bowen Wan, Cong Li, Ming Wang, Fanqi Kong, Qirui Ding, Chenliang Zhang, Hao Liu, Dingfei Qian, Wenlin Deng, Jian Chen, Pengyu Tang, Qian Wang, Shujie Zhao, Zheng Zhou, Tao Xu, Yifan Huang, Jun Gu, Jin Fan, Guoyong Yin
Summary: The study demonstrates the crucial role of GIT1 in promoting MECs clearance of myelin debris and stimulating angiogenesis, making it a promising target for accelerating SCI recovery.
Review
Neurosciences
Sandra Zivkovic, Maryam Ayazi, Grace Hammel, Yi Ren
Summary: Neutrophils are crucial components of the innate immune system, playing a key role in defense against infections and tissue injuries by recognizing and neutralizing pathogens. They are proficient in various immune response mechanisms, such as phagocytosis, granule release, and formation of NETs. In the pathologic changes in injured spinal cord, neutrophils play a significant role.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Cell Biology
Xiaolong Sheng, Jinyun Zhao, Miao Li, Yan Xu, Yi Zhou, Jiaqi Xu, Rundong He, Hongbin Lu, Tianding Wu, Chunyue Duan, Yong Cao, Jianzhong Hu
Summary: The study demonstrated that BMSC-Exos treatment enhances the phagocytic ability of macrophages to clear myelin debris, promoting nerve injury repair and facilitating axon regeneration and functional recovery. Additionally, the promotion of MARCO expression in macrophages by BMSC-Exos contributes to improved myelin debris clearance and tissue repair following SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jinxin Li, Zhenyu Zhu, Yiteng Li, Yihao Chen, Xuyang Hu, Yanchang Liu, Yi Shi, Yao Hu, Yihui Bi, Xinzhong Xu, Meige Zheng, Li Cheng, Juehua Jing
Summary: We found that D-4F can promote the clearance of myelin debris and reduce the formation of foamy macrophages, leading to neuroprotection and motor function recovery. These beneficial effects may be associated with the upregulation of ABCA1 expression by D-4F.
Article
Cell Biology
Fei Yao, Yang Luo, Yihao Chen, Yiteng Li, Xuyang Hu, Xingyu You, Ziyu Li, Shuisheng Yu, Dasheng Tian, Meige Zheng, Li Cheng, Juehua Jing
Summary: Clearance of myelin debris is crucial for functional restoration after spinal cord injury. Researchers found that myelin debris uptake impairs tight junctions and promotes migration of endothelial cells, suggesting that myelin debris clearance is important for maintaining blood-spinal cord barrier integrity and facilitating recovery.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Review
Medicine, General & Internal
Arash Ghaffari-Rafi, Catherine Peterson, Jose E. Leon-Rojas, Nobuaki Tadokoro, Stefan F. Lange, Mayank Kaushal, Lindsay Tetreault, Michael G. Fehlings, Allan R. Martin
Summary: The use of MRI in the acute phase of spinal cord injury (SCI) remains controversial, but it has shown to be safe and frequently identifies findings that can change clinical management. While MRI is useful in pre- and post-surgical settings for SCI, further research is needed to determine its optimal timing and impact on outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study found that in individuals with clinically motor complete spinal cord injury, the extent of recovery of lower limb voluntary movements with scES is significantly influenced by the percentage of lumbosacral enlargement coverage by the electrode array and the position of the electrode relative to the lumbosacral enlargement and conus tip.
Article
Clinical Neurology
Samineh Mesbah, Tyler Ball, Claudia Angeli, Enrico Rejc, Nicholas Dietz, Beatrice Ugiliweneza, Susan Harkema, Maxwell Boakye
Summary: The study showed that in individuals with chronic spinal cord injury, there was a significant correlation between the coverage rate of lumbosacral enlargement by the electrode array and the position of the electrode, and the number of joints moved during voluntary lower limb movements. However, there was no significant correlation between the cross-section area of the spinal cord at C3 or the length of severe myelomalacia and the ability to move the lower limbs voluntarily.
Article
Cardiac & Cardiovascular Systems
Naomi Yasuda, Yosuke Kuroda, Toshiro Ito, Masanori Sasaki, Shinichi Oka, Ryo Ukai, Keitaro Nakanishi, Takuma Mikami, Tsuyoshi Shibata, Ryo Harada, Shuichi Naraoka, Takeshi Kamada, Nobuyoshi Kawaharada
Summary: The study found that MRI plays an important role in evaluating ischemic spinal cord injury after cardiovascular surgery and aortic events, clearly showing the sites of infarction. MRI can help reveal etiology and analyze infarction patterns in different cases.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Neurosciences
Yang Liu, Grace Hammel, Minjun Shi, Zhijian Cheng, Sandra Zivkovic, Xiaoqi Wang, Pingyi Xu, Xijing He, Bing Guo, Yi Ren, Li Zuo
Summary: The study found that some infiltrated bone marrow-derived macrophages are early contributors to NG2/CSPG4 expression after spinal cord injury, showing enhanced proliferation and decreased phagocytic capacity under the influence of lesion-related cellular debris from damaged myelin sheaths. This suggests a more nuanced role for these macrophages in secondary spinal cord injury, including their contribution to the NG2 component of the glial scar.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Biology
Omar Hussain, Mayank Kaushal, Nitin Agarwal, Shekar Kurpad, Saman Shabani
Summary: Traumatic spinal injuries have long-term negative impacts and can cause death. Timely diagnosis and proper management of mechanical instability and spinal cord injury are crucial for preventing further neurological deterioration. This review examines the role of computed tomography (CT) and magnetic resonance imaging (MRI) in diagnosing, managing, and predicting the outcome of spinal cord injury, including advancements such as multidetector CT (MDCT), dual energy CT (DECT), diffusion weighted imaging (DWI), diffusion tractography (DTI), functional MRI (fMRI), and perfusion MRI.
Review
Clinical Neurology
Roberta Costanzo, Lara Brunasso, Federica Paolini, Umberto Emanuele Benigno, Massimiliano Porzio, Giuseppe Roberto Giammalva, Rosa Maria Gerardi, Giuseppe Emmanuele Umana, Rina di Bonaventura, Carmelo Lucio Sturiale, Massimiliano Visocchi, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Magnetic resonance imaging is the most accurate examination to study the spinal cord, but diffusion tensor imaging (DTI) can provide additional details about spinal cord lesions. This literature review investigated the role, limitations, and potential use of DTI as a prognostic tool in spinal cord injury (SCI). The findings suggest that DTI parameters have promising utility as noninvasive biomarkers for SCI grade evaluation.
WORLD NEUROSURGERY
(2022)
Article
Neurosciences
Chengjie Wu, Yalan Pan, Lining Wang, Mengmin Liu, Pengcheng Tu, Sixian Chen, Lei Shi, Danqing Yan, Yong Ma, Yang Guo
Summary: This study aimed to find an effective strategy for promoting microvascular endothelial cells (MECs) to phagocytize myelin debris and reduce secretion of inflammatory factors following spinal cord injury (SCI). A coculture model of myelin debris and vascular-like structures was established, and the efficiency of MECs phagocytizing myelin debris under different conditions was examined. The HDAC6 inhibitor Tubastatin-A was used to interfere with the coculture model, and its anti-inflammatory effects were observed.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Elia Sechi, Sara Mariotto, Andrew McKeon, Karl N. Krecke, Sean J. Pittock, Sergio Ferrari, Salvatore Monaco, Eoin P. Flanagan, Serena Zanzoni, Alejandro A. Rabinstein, Dean M. Wingerchuk, Deena M. Nasr, Nicholas L. Zalewski
Summary: The study demonstrated that the neurofilament light chain/area ratio (NAR) is a novel and promising biomarker for differentiating between SCI and acute myelitis, with high specificity and sensitivity.
Article
Critical Care Medicine
Seung-Yi Lee, Brian D. Schmit, Shekar N. Kurpad, Matthew D. Budde
Summary: This study investigated the relationship between early MRI biomarkers and long-term functional outcomes in cervical spinal cord injury. The extent of edema was found to be greater in bilateral injuries compared with unilateral injuries. Diffusion tensor imaging showed microscopic damage, while filtered diffusion-weighted imaging clearly delineated acute axonal damage. The extent of edema was most strongly correlated with motor functional outcomes.
JOURNAL OF NEUROTRAUMA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shirin Sabouri, Ladan Fazli, Silvia D. Chang, Richard Savdie, Edward C. Jones, S. Larry Goldenberg, Peter C. Black, Piotr Kozlowski
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Geoffrey J. Topping, Andrew Yung, Paul Schaffer, Cornelia Hoehr, Rick Kornelsen, Piotr Kozlowski, Vesna Sossi
Article
Biophysics
Piotr Kozlowski, Silvia D. Chang, Edward C. Jones, S. Larry Goldenberg
NMR IN BIOMEDICINE
(2018)
Article
Multidisciplinary Sciences
Stuart M. Cain, Barry Bohnet, Jeffrey LeDue, Andrew C. Yung, Esperanza Garcia, John R. Tyson, Sascha R. A. Alles, Huili Han, Arn M. J. M. van den Maagdenberg, Piotr Kozlowski, Brian A. MacVicar, Terrance P. Snutch
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shirin Sabouri, Silvia D. Chang, Richard Savdie, Jing Zhang, Edward C. Jones, S. Larry Goldenberg, Peter C. Black, Piotr Kozlowski
Article
Oncology
S. Sara Mandavi, Ingrid T. Spodinger, Septimiu E. Salcudean, Piotr Kozlowski, Silvia D. Chang, Tony Ng, Julio Lobo, Guy Nir, Hand Moradi, Michael Peacock, W. James Morris
JOURNAL OF CONTEMPORARY BRACHYTHERAPY
(2017)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ai-Ling Hsu, Henry Szu-Meng Chen, Ping Hou, Changwei W. Wu, Jason M. Johnson, Kyle R. Noll, Sujit S. Prabhu, Sherise D. Ferguson, Vinodh A. Kumar, Donald F. Schomer, Jyh-Horng Chen, Ho-Ling Liu
MAGNETIC RESONANCE IN MEDICINE
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeremiah W. Sanders, Henry Szu-Meng Chen, Jason M. Johnson, Donald F. Schomer, Jorge E. Jimenez, Jingfei Ma, Ho-Ling Liu
Summary: Perfusion MRI using gadolinium-based contrast agents is important for brain tumor diagnosis and treatment response evaluation. Synthesizing rCBV maps from DCE MRI enables robust brain tumor perfusion imaging with a single gadolinium-based contrast agent administration.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Clinical Neurology
Kyle R. Noll, Henry S. Chen, Jeffrey S. Wefel, Vinodh A. Kumar, Ping Hou, Sherise D. Ferguson, Ganesh Rao, Jason M. Johnson, Donald F. Schomer, Dima Suki, Sujit S. Prabhu, Ho-Ling Liu
Summary: The study found that decline in neurocognitive functioning was common shortly following resection of glioma involving eloquent brain regions, most frequently in verbal learning/memory and executive functioning. Better postoperative outcomes accompanied reductions in centrality and resilience connectomic measures.
Article
Radiology, Nuclear Medicine & Medical Imaging
Moiz Ahmad, Megan C. Jacobsen, M. Allan Thomas, Henry S. Chen, Rick R. Layman, A. Kyle Jones
Summary: The study benchmarks the accuracy of the global noise (GN) algorithm for automatic noise measurement in contrast-enhanced abdomen CT exams, showing high accuracy and applicability across image sets of varying noise magnitude. The GN algorithm was further optimized for automatic measurement of soft-tissue noise in abdomen CT exams.
Article
Radiology, Nuclear Medicine & Medical Imaging
Henry Szu-Meng Chen, Vinodh A. Kumar, Jason M. Johnson, Melissa M. Chen, Kyle R. Noll, Ping Hou, Sujit S. Prabhu, Donald F. Schomer, Ho-Ling Liu
Summary: This study compared the impact of three different normalization methods on connectomic measures in patients with glioma, finding that modern methods (Default and DARTEL) outperformed the older method (Original) and that the use of CFM did not significantly improve results. The sensitivity of connectomic measures to normalization performance varied, with the clustering coefficient being the most sensitive and modularity the least sensitive.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Henry Szu-Meng Chen, Mu-Lan Jen, Pin Hou, R. Jason Stafford, Ho-Ling Liu
Summary: This study aimed to develop DROs to validate the leakage correction of software using Weisskoff model and to examine the effect of background signal time curves that are required by the model. The accuracy of leakage correction was verified using different types of background signals, showing that brain segmentation can achieve the lowest error in the particular software tested. DSC-MRI DROs with a matched biophysical model can be effectively used for software validation, as long as the background signals are appropriately simulated.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Yu Yeh, Henry S. Chen, Ping Hou, Vinodh A. Kumar, Jason M. Johnson, Kyle R. Noll, Sujit S. Prabhu, Sherise D. Ferguson, Donald F. Schomer, Hsu-Hsia Peng, Ho-Ling Liu
Summary: This study investigated the utilization of resting-state blood oxygenation level-dependent signal for cerebrovascular reactivity mapping in patients with gliomas. The optimal frequency ranges for rs-CVR were determined to be 0.04-0.08 Hz and 0.02-0.04 Hz, showing higher correlations with breath-hold MRI results compared to resting-state fluctuation amplitude method.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Computer Science, Software Engineering
Jeremiah W. Sanders, Justin R. Fletcher, Steven J. Frank, Ho-Ling Liu, Jason M. Johnson, Zijian Zhou, Henry Szu-Meng Chen, Aradhana M. Venkatesan, Rajat J. Kudchadker, Mark D. Pagel, Jingfei Ma
Article
Neurosciences
Jose Sanchez-Bornot, Roberto C. Sotero, J. A. Scott Kelso, Ozguer Simsek, Damien Coyle
Summary: This study proposes a multi-penalized state-space model for analyzing unobserved dynamics, using a data-driven regularization method. Novel algorithms are developed to solve the model, and a cross-validation method is introduced to evaluate regularization parameters. The effectiveness of this method is validated through simulations and real data analysis, enabling a more accurate exploration of cognitive brain functions.