期刊
NEUROGASTROENTEROLOGY AND MOTILITY
卷 29, 期 11, 页码 -出版社
WILEY
DOI: 10.1111/nmo.13119
关键词
deglutition; dysphagia; peristalsis; pharyngeal manometry; swallowing; variability
资金
- [P01DK068051]
- [R01DK025731]
- [T32DK061923]
- [UL1TR001436]
BackgroundRecent technological advances incorporated in high resolution manometry have justifiably heightened interest in manometric evaluation of the pharynx. Despite this interest, from both physiologic and clinical perspective there remain a number of unanswered questions regarding the magnitude of variability of pharyngeal pressure phenomena. Therefore, the aim of the present study was to characterize in healthy individuals the inter-subject and recording-site specific variability of pharyngeal peristaltic pressure phenomena. MethodsWe studied 32 healthy subjects (age: 21-83years,20 under 35years) during dry,5 and 10mL water swallows x3. Pharyngeal peristaltic pressures were recorded using a high resolution (HR) manometric system and a catheter assembly with 36 circumferential sensors spaced at 1cm intervals positioned trans-nasally to traverse the pharynx, UES and proximal esophagus. Key ResultsBoth site-specific pressure data and the Pharyngeal contractile integral (PhCI) showed wide dispersion ranging between values under 50mm Hg to over 300mm Hg and 100-600mm Hg/cm/s,respectively. There was also wide range of dispersion of data for both the standard deviations and the coefficient of variation for all sites (P=.001). The coefficient of variation for PhCI ranged between 0.02 and 0.25 representing data dispersion of 2-25 percent of the mean among subjects (P=.001). Position, age and volume of swallowed fluid did not influence the magnitude of variability. ConclusionsDeglutitive Pharyngeal peristalsis generates pressures with significant degree of site-related and inter-subject variability. This variability is not influenced by age, position and volume of swallowed fluid.
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