Review
Gastroenterology & Hepatology
Sami R. Achem, Genaro Vazquez-Elizondo, Ronnie Fass
Summary: Jackhammer esophagus (JE) is a newly recognized esophageal motility disorder characterized by hypercontractile peristalsis. It predominantly affects women with an average age of 65.2 years, presenting with dysphagia, reflux, and chest pain. The cause and pathogenesis remain unclear, with a variety of associated conditions, and treatment efficacy is largely anecdotal with insufficient study.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Apichet Sirinawasatien, Pallop Sakulthongthawin
Summary: Jackhammer esophagus is a rare esophageal motility disorder that can cause symptoms like dysphagia. High-resolution manometry and upper gastrointestinal endoscopy are key in diagnosis, with treatment options including calcium channel blockers and proton pump inhibitors.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Pamela Milito, Stefano Siboni, Luigi Bonavina
Summary: Diagnosis of esophageal disorders is more advanced than available treatment options. A patient with hiatal hernia, experiencing reflux, dysphagia, and chest pain, was diagnosed with jackhammer esophagus and treated with a hybrid approach of POEM, crural repair, and Dor fundoplication.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J. Kahrilas, Isis K. Araujo, Mira Yang, Marie-Pier Tetreault, John E. Pandolfino
Summary: Classifying the physiological and mechanical esophageal function in EoE based on FLIP panometry features may help define the severity of the disease and guide its management.
Article
Gastroenterology & Hepatology
Axel Josefsson, Magnus Simren, Adam Smolak, Nour Sabbagh, Hans Toernblom
Summary: In patients with EGJOO, having a high IRP is associated with a higher risk of dysphagia during long-term follow-up. Approximately 70% of EGJOO patients experience dysphagia at 3 years of follow-up.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Mariam S. Zaghloul, Yasmine A. Elshaer, Mohamed E. Ramadan, Hassan E. ElBatae
Summary: Esophageal motility disorders (EMDs) are often underestimated in Egypt as the main cause of nonobstructive dysphagia (NOD). This HRM-based study used Chicago Classification version 3.0 (CC v3.0) to classify EMD among Egyptian patients with NOD. The study found that achalasia was the most common EMD in Egyptian patients with NOD.
Article
Gastroenterology & Hepatology
Corinne Delbaen, Paraskevas Gkolfakis, Jacques Deviere, Daniel Blero, Hubert Louis
Summary: This study retrospectively analyzed the failure rate of esophagogastric junction (EGJ) insertion during high-resolution manometry (HRM) and reported the use of guidewire-assisted procedures. The results showed that insertion of a water-perfused HRM probe using an endoscopically-placed nasogastric guidewire allowed successful assessment of EGJ and esophageal peristalsis in cases where EGJ traversal was not possible.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Ryan A. Balko, David A. Katzka, Joseph A. Murray, Jeffrey A. Alexander, Kristin C. Mara, Karthik Ravi
Summary: The study on acute opioid administration in opioid naive patients did not find any impact on high-resolution manometry results. Further research is needed to assess the pathophysiology of opioids in opioid-induced esophageal dysfunction (OIED) and their duration-dependent relationship.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Gastroenterology & Hepatology
Masaki Matsubara, Noriaki Manabe, Maki Ayaki, Jun Nakamura, Takahisa Murao, Minoru Fujita, Masahiko Kuinose, Tomoki Yamatsuji, Yoshio Naomoto, Ken Haruma
Summary: The study found a high detection rate of abnormal EGD findings among patients with esophageal motility disorders, with parameters such as resistance, esophageal residue, and spastic contractions significantly associated with these disorders.
DIGESTIVE ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Andrew Canakis, Guofeng Xie, Raymond E. Kim
Summary: This study investigated the clinical efficacy of Jackhammer esophagus (JE) and found that peroral endoscopic myotomy (POEM) is an effective treatment option with long-term efficacy. Larger, prospective studies are needed to validate these findings.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Anouk Overwater, Sjoerd G. Elias, Erik J. Schoon, Jacques J. G. H. M. Bergman, Roos E. Pouw, Bas L. A. M. Weusten
Summary: This study aimed to describe the course of pain and dysphagia after radiofrequency ablation (RFA) treatment for Barrett's esophagus (BE) neoplasia and identify associated risk factors. The results showed that 95% of patients reported post-RFA pain, with 64% experiencing major pain. Dysphagia was present in 83% of patients.
Article
Gastroenterology & Hepatology
Sourav Halder, John E. Pandolfino, Peter J. Kahrilas, Andree Koop, Jacob Schauer, Isis K. Araujo, Guy Elisha, Wenjun Kou, Neelesh A. Patankar, Dustin A. Carlson
Summary: This study aimed to evaluate novel FLIP metrics of contraction power and displaced volume in asymptomatic controls and a patient cohort. The results showed that these metrics effectively quantify peristaltic vigor and are correlated with the DCI metric on HRM.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Gastroenterology & Hepatology
Isis K. Araujo, Sabine Roman, Marie Napoleon, Francois Mion
Summary: The study found that using solid food swallows (SFS) during esophageal motility assessment can improve diagnostic accuracy and is important for diagnosing clinically relevant disorders. The application of solid food swallows in HRM has a significant impact on changing diagnoses and can be widely used in daily clinical practice.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Medicine, General & Internal
Ahmed Alburakan, Aljoharah Alshunaifi, Razan AlRabah, Sulaiman Alshammari, Saleh Alnasser, Thamer Nouh
Summary: This case report presents an atypical manifestation of gastrointestinal motility disorder, resulting in peritonitis from sigmoid colon perforation. Early recognition and prompt treatment of gastrointestinal motility disorders are crucial in avoiding severe complications.
Article
Gastroenterology & Hepatology
Arash Babaei, Sadaf Shad, Benson T. Massey
Summary: The study found that esophageal hypercontractility is associated with cholinergic hyperactivity rather than loss of inhibitory innervation. Atropine was able to abolish hypercontractility, while abnormal responses to CCK primarily occurred in patients with outflow obstruction.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)
Article
Surgery
Gerd Jomrich, Matthias Paireder, Ivan Kristo, Andreas Baierl, Ayseguel Ilhan-Mutlu, Matthias Preusser, Reza Asari, Sebastian F. Schoppmann
Summary: The study aimed to determine the clinical role of the systemic immune-inflammation index in patients with resectable adenocarcinoma of the gastroesophageal junction treated with or without neoadjuvant therapy. The findings showed that elevated SII is an independent adverse prognostic factor in patients with resectable gastroesophageal adenocarcinomas with and without neoadjuvant treatment.
Article
Surgery
Luigi Bonavina, Thomas Horbach, Sebastian F. Schoppmann, Janet DeMarchi
Summary: The 3-year outcomes of Magnetic Sphincter Augmentation (MSA) and Laparoscopic Fundoplication (LF) in patients with GERD were evaluated in a prospective observational registry study, showing favorable clinical outcomes for both treatments with improvements in symptoms and satisfaction over time. In addition, both MSA and LF resulted in a decrease in PPI usage and low complication rates, highlighting their effectiveness and safety in treating GERD patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Gerd Jomrich, Dagmar Kollmann, Lavinia Wilfing, Sanja Radosavljevic, Dariga Ramazanova, Robin Ristl, Richard P. Grose, Ayseguel Ilhan-Mutlu, Matthias Preusser, Christina Fassnacht, Yi-Chien Tsai, Emmanuella Guenova, Sebastian F. Schoppmann
Summary: This study investigated the impact of cytotoxic chemotherapy on PD-L2 expression in patients with resectable AEG. The results showed that PD-L2 expression seemed to play no significant role in AEG in the study cohort.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2021)
Article
Oncology
N. Surci, G. Marchegiani, S. Andrianello, T. Pollini, J. Muehlbacher, G. Jomrich, P. Richwien, D. Tamandl, M. Schindl, C. Bassi, R. Salvia, K. Sahora
Summary: This study investigated incidentally detected pancreatic cystic neoplasms (PCLs) that were not included in a surveillance protocol, comparing their risk of malignant evolution with systematically surveilled lesions. The results showed that the risk of cancer development in non-surveilled PCLs was similar to that in systematically surveilled lesions.
Article
Oncology
Gerd Jomrich, Dagmar Kollmann, Dariga Ramazanova, Robin Ristl, Richard P. Grose, Ayseguel Ilhan-Mutlu, Matthias Preusser, Christina Fassnacht, Yi-Chien Tsai, Emmanuella Guenova, Sebastian F. Schoppmann
Summary: This study investigated the impact of neoadjuvant chemotherapy on the expression of PD-1 and PD-L1 in adenocarcinomas of the gastroesophageal junction. The results showed a significant increase in PD-1 expression and a decrease in PD-L1 expression after neoadjuvant therapy. These findings suggest that the combined use of cytotoxic chemotherapy and PD-1 axis blockade may be beneficial for patients with adenocarcinomas of the gastroesophageal junction.
Article
Surgery
Milena Nikolic, Aleksa Matic, Ivan Kristo, Matthias Paireder, Reza Asari, Bogdan Osmokrovic, Georg Semmler, Sebastian F. Schoppmann
Summary: Standardized additional fundophrenicopexia in patients undergoing Nissen fundoplication significantly reduces postoperative dysphagia in patients without division of the short gastric vessels and reoperation rates in patients with division of the short gastric vessels. However, division of the short gastric vessels has no influence on the postoperative outcome of Nissen fundoplication.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Hannah C. Puhr, Thorsten J. Reiter, Mohamed El-Mahrouk, Lena Saliternig, Peter Wolf, Maximilian J. Mair, Ariane Steindl, Matthias Paireder, Reza Asari, Sebastian F. Schoppmann, Anna S. Berghoff, Matthias Preusser, Ayseguel Ilhan-Mutlu
Summary: Thyroid hormones and their therapeutic interventions may be associated with the overall survival in patients with resectable gastroesophageal cancer. There is a tendency towards prolonged survival in hypothyroid patients and a significant positive correlation of thyroid hormone replacement therapy with the overall survival. The study suggests that thyroid disorders and their therapeutic interventions could serve as potential prognostic tools, warranting further prospective analyses.
Article
Surgery
Andrea Beer, Annabell Reber, Matthias Paireder, Sebastian F. Schoppmann, Stefan Heber, Ana-Iris Schiefer
Summary: In pretherapeutic biopsies of esophageal and gastroesophageal junction tumors, the number of budding foci can predict overall survival independently, especially for grade 2 tumors.
Article
Surgery
Milena Bologheanu, Aleksa Matic, Joy Feka, Reza Asari, Razvan Bologheanu, Franz M. Riegler, Lisa Gensthaler, Bogdan Osmokrovic, Sebastian F. Schoppmann
Summary: This study evaluated postoperative dysphagia rates, risk factors, and management after magnetic sphincter augmentation (MSA). The study found that severe dysphagia requiring intervention was rare after MSA, with only 1% of patients undergoing endoscopic dilatation and 1% treated conservatively for dysphagia. LINX (R) device size <= 13 was identified as the only factor associated with postoperative dysphagia. Overall, postoperative total GERD-HRQL score was significantly lower than preoperative score, and most gastrointestinal symptoms improved in the majority of patients.
WORLD JOURNAL OF SURGERY
(2022)
Article
Gastroenterology & Hepatology
Sebastian F. Schoppmann
Summary: This article discusses the prevalence of laryngopharyngeal reflux (LPR) symptoms in patients with gastroesophageal reflux disease (GERD), and the treatment options of laparoscopic fundoplication and magnetic sphincter augmentation (MSA) for GERD and LPR.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Surgery
Lisa Gensthaler, Gerd Jomrich, Jonas Brugger, Dagmar Kollmann, Matthias Paireder, Milena Bologheanu, Alexander Horn, Franz M. Riegler, Reza Asari, Sebastian F. Schoppmann
Summary: The aim of this study was to investigate the prognostic value of pretherapeutic BChE levels in patients with resectable adenocarcinoma of the gastroesophageal junction (AEG), treated with or without neoadjuvant therapy. The results showed that diminished preoperative serum BChE levels were significantly associated with shorter overall and disease-free survival in patients who received neoadjuvant treatment and/or primary resection. This suggests that serum BChE levels can serve as a strong, independent, and cost-effective prognostic biomarker for worse outcome in patients with resectable AEG who had received neoadjuvant chemotherapy.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Review
Surgery
B. P. Mueller-Stich, P. Probst, H. Nienhueser, S. Fazeli, J. Senft, E. Kalkum, P. Heger, R. Warschkow, F. Nickel, A. T. Billeter, P. P. Grimminger, C. Gutschow, T. S. Dabakuyo-Yonli, G. Piessen, M. Paireder, S. F. Schoppmann, D. L. van der Peet, M. A. Cuesta, P. van der Sluis, R. van Hillegersberg, A. H. Hoelscher, M. K. Diener, T. Schmidt
Summary: The minimally invasive approach for esophagectomy leads to fewer postoperative complications, particularly pulmonary complications, compared to the open approach, while long-term oncological outcomes are comparable.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Surgery
Matthias Paireder, Ivan Kristo, Milena Nikolic, Gerd Jomrich, Johannes Steindl, Erwin Rieder, Reza Asari, Sebastian F. Schoppmann
Summary: Electrical stimulation therapy (EST) for treating GERD by increasing LES pressure through chronic stimulation could be an effective and safe novel technique to improve patients' quality of life. However, the considerably high rate of device dysfunction requires further investigation.
EUROPEAN SURGERY-ACTA CHIRURGICA AUSTRIACA
(2021)
Article
Surgery
Matthias Paireder, Ivan Kristo, Reza Asari, Gerd Jomrich, Johannes Steindl, Erwin Rieder, Sebastian F. Schoppmann
Summary: After undergoing LES-EST treatment, patients with GERD and IEM showed significant improvement in health-related quality of life, but the normalization or significant improvement of esophageal acid exposure was limited.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)