Article
Pediatrics
Stephen Trinidad, Amanda Jensen, Monica Holder, Allison Elsner, Nelson Rosen, Aaron Garrison, Beth Rymeski, Jason S. Frischer
Summary: This study evaluated the outcomes of sacral nerve stimulation (SNS) in patients with medically refractory fecal incontinence or severe constipation. A retrospective cohort study was conducted on patients who underwent SNS placement after failed medical management at a single center. The rates of involuntary bowel movements were compared pre- and post-SNS using a bowel severity score questionnaire.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Review
Biology
Ronny Rodrigues Correia, Luis Felipe Orsi Gameiro, Nathalia Grion Trevisane, Matheus Bertanha, Erika Veruska Paiva Ortolan, Pedro Luiz Toledo de Arruda Lourencao
Summary: This study conducted a systematic review of randomized clinical trials on the effects of transcutaneous neuromodulation in treating constipation and retentive fecal incontinence in children and adolescents. The analysis of three studies revealed that transcutaneous neuromodulation is an effective adjuvant treatment modality that improves children's constipation and retentive fecal incontinence. The included studies demonstrated a high methodological quality and a high degree of confidence based on the GRADE system.
Article
Neurosciences
Liyun Wang, Payam Gharibani, Yi Yang, Yu Guo, Jieyun Yin
Summary: This study investigated the effects of sacral nerve stimulation (SNS) on Loperamide-induced constipation in rats. The results showed that SNS with appropriate parameters improved whole colon transit time, resolved constipation, reversed the detrimental effects of Loperamide on enteric neurons, and increased the expressions of GDNF and p-AKT in colon tissue. The findings suggest that SNS may be a potential treatment for opioid-induced constipation.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Gerrit E. Gmel, Paul F. Vollebregt, Marjolein E. G. Thijssen, Rosana Santos Escapa, Eleanor McAlees, Dave Mugan, John L. Parker, Charles H. Knowles
Summary: This study aimed to determine if electrophysiological responses can be recorded directly from the S3 sacral nerve during therapeutic SNM in patients with fecal incontinence, and to characterize such responses in order to better understand the mechanism of action (MOA) and changes in stimulation with posture. The findings show both neural and myoelectric responses, highlighting the heterogeneity of these responses and confirming that electrode lead position can change with posture.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Gastroenterology & Hepatology
Shaman Rajindrajith, Niranga Manjuri Devanarayana, Nikhil Thapar, Marc Alexander Benninga
Summary: Functional fecal incontinence is a common problem in children, with constipation-associated FI and nonretentive FI being the two types. While traditional interventions like toilet training and laxatives work for most children with constipation-associated FI, those with nonretentive FI may require more psychological-based therapy.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Binit Katuwal, Jasneet Bhullar
Summary: Fecal incontinence is a common and debilitating condition caused by various factors. Conservative/medical management is the first-line treatment, and sacral nerve stimulation has emerged as an effective option for those suitable for surgical intervention.
CLINICS IN COLON AND RECTAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Assia Daikh, Fabienne Reymond, Dorothee Lombardo, Caroline Thuillier, Pierrick Bedouch, Jean-Luc Faucheron
Summary: Sacral nerve neuromodulation (SNM) is a safe and effective therapy for managing fecal and/or urinary incontinence. This study evaluated the lifespan of InterStim(TM) and InterStim(TM) II generators and the long-term hospital costs associated with SNM therapy. The results showed that the lifespan of InterStim(TM) II is shorter than the first-generation device, leading to increased hospital costs over time.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Gastroenterology & Hepatology
Judith Evers, P. Ronan O'Connell, James F. X. Jones
Summary: This study investigated the changes in the transmission of sensory anorectal stimuli in a rodent model of fecal incontinence and the effects of sacral nerve stimulation on defecation behavior. The results showed that chronic sacral nerve stimulation using miniature telemetric devices is feasible in rats and can improve fecal incontinence symptoms. The amplitude of anorectal evoked potentials was found to be negatively correlated with the behavioral signs of fecal incontinence.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Surgery
Luigi Brusciano, Antonio Brillantino, Gianluca Pellino, Franco Marinello, Coen I. M. Baeten, Alex Digesu, Gabriele Naldini, Claudio Gambardella, Francesco Saverio Lucido, Alessandro Sturiale, Giorgia Gualtieri, Stefan Riss, Ludovico Docimo
Summary: Sacral nerve modulation is a safe and effective treatment for fecal and double incontinence, improving symptoms, quality of life, and sexual function in the long term.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Anthony Y. Lin, Chris Varghese, Niranchan Paskaranandavadivel, Sean Seo, Peng Du, Phil Dinning, Ian P. Bissett, Greg O'Grady
Summary: The rectosigmoid brake was suppressed in patients with faecal incontinence, and sacral neuromodulation (SNM) may exert a therapeutic effect by modulating this rectosigmoid brake.
COLORECTAL DISEASE
(2022)
Article
Pediatrics
Carlos Velasco-Benitez, Eder Villamarin, Melissa Mendez, Alfredo Linero, Gregory Hungria, Miguel Saps
Summary: Functional constipation in children can be improved with conventional treatments, but some children may have poor treatment outcomes. This study found that transcutaneous PTNS shows significant improvement in stool consistency, fecal incontinence, abdominal pain, and hematochezia, suggesting it could be a promising noninvasive treatment for children with functional constipation. However, more extensive studies are needed for further validation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Gastroenterology & Hepatology
Aaron J. Dawes, Juan O. Mariscal, Peter J. White, Emily F. Midura, Anne E. Sirany, Ann C. Lowry, Christine C. Jensen, Amy J. Thorsen
Summary: This study aimed to determine whether patients with rectoanal intussusception achieve similar benefits from device implantation to patients without rectoanal intussusception. The results showed that rectoanal intussusception does not affect the clinical outcomes or quality of life after sacral nerve stimulation for fecal incontinence. Therefore, patients with fecal incontinence and rectoanal intussusception can be considered for sacral nerve stimulation placement.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Medicine, General & Internal
Sofie Dagmar Studsgaard Slot, Simon Mark Dahl Baunwall, Anton Emmanuel, Peter Christensen, Klaus Krogh
Summary: The study found that most SCI patients with NBD have unmet needs for improved bowel care. MENTOR has shown promise as a tool for evaluating the treatment of NBD in a non-hospital setting.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Alfonso Javier Ibanez-Vera, Rosa Maria Mondejar-Ros, Vanessa Franco-Bernal, Guadalupe Molina-Torres, Esther Diaz-Mohedo
Summary: This review aims to determine the effectiveness of posterior tibial nerve stimulation (PTNS) in reducing episodes of fecal incontinence in adults. However, the results are inconclusive and more research is needed to support its recommendation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
K. Ong, L. Bordeianou, M. Brunner, S. Buntzen, M. H. S. Collie, A. Hanly, C. W. Hunt, K. E. Matzel, P. R. O'Connell, M. Rydningen, L. Savitt, A. Totaro, C. J. Vaizey, Y. Maeda
Summary: This study aimed to determine whether the paradigm of surgical intervention for faecal incontinence has changed between 2000 and 2013. The results showed an increasing use of sacral neuromodulation over time, indicating a shift in the surgical intervention paradigm for faecal incontinence.
COLORECTAL DISEASE
(2021)
Letter
Pediatrics
Mana H. Vriesman, Ilan J. Koppen, Marieke van Dijk, Marc A. Benninga
JOURNAL OF PEDIATRICS
(2020)
Article
Gastroenterology & Hepatology
Paul T. Heitmann, Lukasz Wiklendt, Nikhil Thapar, Osvaldo Borrelli, Carlo Di Lorenzo, Desalegn T. Yacob, Desiree F. Baaleman, Mana H. Vriesman, Samuel Nurko, Khalil El-Chammas, Ajay Kaul, Marc A. Benninga, Ilan J. N. Koppen, David A. Wattchow, Simon J. H. Brookes, Phil G. Dinning
NEUROGASTROENTEROLOGY AND MOTILITY
(2020)
Review
Pediatrics
Ilan J. N. Koppen, Marc A. Benninga
Summary: Defecation is a complex physiological process relying on intricate mechanisms involving the autonomic and somatic nervous system, pelvic floor muscles, and anal sphincter complex. Anorectal dysfunction can lead to constipation, a bothersome disorder that significantly impacts the daily lives of children and their families. This review focuses on different mechanisms underlying anorectal dysfunction and specific treatment options for improving defecation dynamics in children with functional constipation.
FRONTIERS IN PEDIATRICS
(2022)
Article
Gastroenterology & Hepatology
Desiree F. Baaleman, Mana H. Vriesman, Marc A. Benninga, Neetu Bali, Karla H. Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L. Lu, Ilan J. N. Koppen
Summary: This study aimed to evaluate the clinical utility and tolerability of the new 3D-ARM catheter in children with constipation. The results showed that although the 3D-ARM provided more detailed visualization, it caused more discomfort compared to HR-ARM and resulted in inconsistent visualization of the recto-anal inhibitory reflex.
NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Desiree F. Baaleman, Mana H. Vriesman, Ilan J. N. Koppen, Kim M. Osborne, Marc A. Benninga, Miguel Saps, Desale Yacob, Peter L. Lu, Frederick W. Woodley, Carlo Di Lorenzo
Summary: This study aimed to assess the effectiveness and feasibility of a brief session of hypnosis in reducing distress in children with functional constipation undergoing anorectal manometry. The results showed that hypnosis was able to significantly lower distress levels prior to the procedure and was well-received by both the children and their parents.
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2022)
Article
Gastroenterology & Hepatology
Desiree F. Baaleman, Carrie A. M. Wegh, Maxime T. A. Hoogveld, Marc A. Benninga, Ilan J. N. Koppen
Summary: This study investigated the clinical effectiveness and patient experience of transanal irrigation (TAI) in children with constipation or fecal incontinence. The results showed that TAI with a Navina system is an effective bowel management system for children with intractable constipation or fecal incontinence. It significantly improved treatment success rates and health-related quality of life.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Genetics & Heredity
Ilan J. N. Koppen, Leonie A. A. Menke, Wytske M. M. Westra, Femke Struik, Simone Mesman, Michiel P. P. Van Wijk, Sylvia A. A. Huisman
Summary: This article discusses two cases of unexpected deaths due to gastrointestinal complications in individuals with PTHS, highlighting the importance of screening and managing gastrointestinal symptoms in this population. It also provides an overview of the literature on how fatal gastrointestinal complications may be related to PTHS.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Letter
Gastroenterology & Hepatology
Desiree F. Baaleman, Carrie A. M. Wegh, Maxime T. A. Hoogveld, Marc A. Benninga, Ilan J. N. Koppen
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2023)
Review
Pediatrics
Anna de Geus, Ilan J. N. Koppen, Robert B. Flint, Marc A. Benninga, Merit M. Tabbers
Summary: Functional constipation is a common problem in childhood that greatly affects the social, physical, and emotional functioning of affected children and their caregivers. The diagnosis is based on the Rome IV criteria. Non-pharmacological treatment involves education, lifestyle advice, and toilet training, while pharmacological treatment includes disimpaction and maintenance treatment with polyethylene glycol as the first choice laxative. Additional pharmacological treatment options are available, but more high-quality research is needed. If children remain symptomatic, botulinum toxin injections in the anal sphincter can be considered as an alternative treatment option.
Meeting Abstract
Gastroenterology & Hepatology
Desiree F. Baaleman, Mana H. Vriesman, Peter L. Lu, Marc A. Benninga, Neetu Bali, Karla Vaz, Desale Yacob, Carlo Di Lorenzo, Ilan J. Koppen
Meeting Abstract
Gastroenterology & Hepatology
Desiree F. Baaleman, Mana H. Vriesman, Peter L. Lu, Marc A. Benninga, Marc A. Levitt, Richard J. Wood, Desale Yacob, Carlo Di Lorenzo, Ilan J. Koppen
Article
Critical Care Medicine
J. M. J. van der Zande, I. J. N. Koppen, G. Biesbroek, I. M. Kuipers, J. B. M. van Woensel
Summary: Children infected with SARS-CoV-2 may develop multisystem inflammatory syndrome (MIS-C), which shares similar clinical symptoms with Kawasaki disease but differs in that MIS-C patients often exhibit gastrointestinal symptoms or cardiovascular involvement.
NETHERLANDS JOURNAL OF CRITICAL CARE
(2022)
Article
Pediatrics
Kelly M. A. Dreuning, Joep P. M. Derikx, Johan E. van Limbergen, Frea Kruisinga, Ilan J. N. Koppen
Summary: The infant with chylous ascites was unexpectedly found during surgery for bilateral inguinal hernia repair. With treatment and monitoring, the condition was controlled and the symptoms disappeared, allowing the child to successfully transition to regular feeding.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Candice K. Park, Lyon Wang, Ilan J. Koppen, Seth A. Alpert, Karen A. Diefenbach, Marc A. Levitt, Richard J. Wood, Neetu Bali, Karla Vaz, Desale Yacob, Carlo Di Lorenzo, Peter L. Lu
Meeting Abstract
Gastroenterology & Hepatology
Desiree F. Baaleman, Mana H. Vriesman, Kim Osborne, Ilan J. Koppen, Marc A. Benninga, Miguel Saps, Desale Yacob, Peter L. Lu, Frederick W. Woodley, Carlo Di Lorenzo