Article
Chemistry, Multidisciplinary
Yan Zhang, Chun-Yuan Chen, Yi-Wei Liu, Shan-Shan Rao, Yi-Juan Tan, Yu-Xuan Qian, Kun Xia, Jie Huang, Xi-Xi Liu, Chun-Gu Hong, Hao Yin, Jia Cao, Shi-Kai Feng, Ze-Hui He, You-You Li, Zhong-Wei Luo, Ben Wu, Zi-Qi Yan, Tuan-Hui Chen, Meng-Lu Chen, Yi-Yi Wang, Zhen-Xing Wang, Zheng-Zhao Liu, Ming-Jie Luo, Xiong-Ke Hu, Ling Jin, Teng-Fei Wan, Tao Yue, Si-Yuan Tang, Hui Xie
Summary: This study reveals that osteocytes regulate the differentiation of BMSCs into osteoblasts or adipocytes by secreting neuropeptide Y (NPY), with increased NPY expression associated with aging and osteoporosis. Deletion of NPY in osteocytes leads to high bone mass phenotype and attenuated bone-fat imbalance. The study suggests a new mode of neuronal control of bone metabolism through ANS-induced regulation of osteocyte NPY.
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Terumasa Umemoto, Alban Johansson, Shah Adil Ishtiyaq Ahmad, Michihiro Hashimoto, Sho Kubota, Kenta Kikuchi, Haruki Odaka, Takumi Era, Daisuke Kurotaki, Goro Sashida, Toshio Suda
Summary: By studying the mitochondrial metabolism and ATP citrate lyase (ACLY) in hematopoietic stem cells (HSCs), we have gained new insights into the regulation of HSCs during hematopoietic regeneration.
Article
Biochemistry & Molecular Biology
Zhao-hua Deng, Jing Zhong, Hai-lin Jiang, Hyun-Woo Jeong, Jian-wei Chen, Ya-hai Shu, Ming Tan, Ralf H. Adams, Ke-ping Xie, Qi Chen, Yang Liu
Summary: Antipsychotic agent haloperidol induces vascular defects in bone marrow, affecting hematopoiesis and hematopoietic stem/progenitor cells. This effect is reversible after withdrawal of haloperidol. Mechanistically, haloperidol blocks the secretion of VEGF-A from HSPCs.
Article
Biology
Sobhika Agarwala, Keun-Young Kim, Sebastien Phan, Saeyeon Ju, Ye Eun Kong, Guillaume A. Castillon, Eric A. Bushong, Mark H. Ellisman, Owen J. Tamplin
Summary: This study tracks single endogenous HSPCs using light microscopy and identifies their exact location and contacts with surrounding cells using scanning electron microscopy. It reveals the interactions and ultrastructure between hematopoietic stem cells and their microenvironment.
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Yan Man, Zhixiang Lu, Xiangmei Yao, Yuemin Gong, Tonghua Yang, Yajie Wang
Summary: PGF is a life-threatening complication that occurs after transplantation and predicting and preventing it remains challenging. This study finds that CD34(+) cells, bone marrow microenvironment, and factors like viral infection and iron overload are closely related to the occurrence of PGF. The article summarizes the common risk factors and potential mechanism of PGF, as well as discusses the safety and efficacy of new strategies for treating it.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Julia Froebel, Theresa Landspersky, Guelce Percin, Christina Schreck, Susann Rahmig, Alessandro Ori, Daniel Nowak, Marieke Essers, Claudia Waskow, Robert A. J. Oostendorp
Summary: The bone marrow environment, known as the niche, plays a vital role in maintaining blood cell formation throughout life. Different types of stress can disrupt the niche, leading to deregulation of hematopoietic stem cells and their function. Both acute and chronic insults can alter the cellular composition and structure of the niche, ultimately affecting hematopoiesis and increasing susceptibility to diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kirsty Mcdowell, Carly Adamson, Colette Jackson, Ross Campbell, Paul Welsh, Mark C. Petrie, John J. V. Mcmurray, Pardeep S. Jhund, Neil Herring
Summary: The study found that higher levels of peripherally measured NPY in heart failure patients are associated with an increased risk of cardiovascular and all-cause death, even after adjusting for other potential prognostic factors such as BNP levels. However, higher NPY levels are not associated with an increased risk of heart failure hospitalization.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Multidisciplinary Sciences
Cheng Su, Xiao Zheng, Yanjin He, Li Long, Wenchuan Chen
Summary: This study identified aberrant expression of circRNAs in hUCMSCs during osteogenic differentiation, constructed competing endogenous RNA networks using bioinformatics tools, elucidated underlying mechanisms, and validated the osteogenic-promoting effect of a specific circRNA.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Takahide Arai, Hideaki Kanazawa, Kensuke Kimura, Masahito Munakata, Hiroyuki Yamakawa, Ken Shinmura, Shinsuke Yuasa, Motoaki Sano, Keiichi Fukuda
Summary: Long-term emotional or physical stress may lead to stress cardiomyopathy and transient left ventricular ballooning, but the precise mechanisms are still unclear. In this study, researchers established an animal model of epilepsy-induced stress cardiomyopathy and found that neuropeptide Y (NPY) was upregulated in the cardiac sympathetic nerves and could interrupt beta-adrenergic signaling in cardiomyocytes, resulting in cardiac dysfunction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell & Tissue Engineering
Valentina Pensato, Maria Antonella Laginestra, Paolo Falvo, Stefania Orecchioni, Giovanna Talarico, Elena De Marchi, Samantha Bruno, Sara Mongiorgi, Giulia Mitola, Francesco Bertolini, Elena Adinolfi, Michele Cavo, Antonio Curti, Valentina Salvestrini
Summary: The study demonstrates that CD34+ cells derived from umbilical cord blood express functional TAS2Rs, which play a crucial role in sensing and regulating fluctuation within the bone marrow microenvironment.
Article
Cell & Tissue Engineering
Joshua Tay, Valerie Barbier, Falak M. Helwani, Gareth R. Price, Jean-Pierre Leyesque, Ingrid G. Winkler
Summary: The study reveals that PGI(2) enriched in the endosteum is a novel regulator of HSCs that promotes regenerative potential by enhancing STAT3 signaling in HSCs, protecting HSC potential in vivo, and restoring HSC homing potential.
Article
Immunology
Chaoran Xu, Qia Zhang, Yi Zhang, Huaijun Chen, Tianchi Tang, Junjie Wang, Siqi Xia, Gao Chen, Jianmin Zhang
Summary: Skull bone marrow shows lateralization after stroke, promoting inflammation in the meninges, and inhibition of osteopontin expression can improve neurological function.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Endocrinology & Metabolism
Francesca Dassie, Mattia Albiero, Silvia Bettini, Roberta Cappellari, Gabriella Milan, Stefano Ciciliot, Jurgen K. Naggert, Angelo Avogaro, Roberto Vettor, Pietro Maffei, Gian Paolo Fadini
Summary: Alstrom syndrome (AS) is a rare genetic disease caused by ALMS1 mutations, characterized by short stature, and vision and hearing loss. Patients with AS develop the metabolic syndrome, long-term organ complications, and die prematurely. The association between AS and a shortage of hematopoietic stem/progenitor cells (HSPCs) was explored, which is linked to metabolic diseases and predicts diabetic complications.
Article
Clinical Neurology
Eugene J. Park, Woo-Kie Min, Seungbo Sim
Summary: This study proposed a novel bicortical laminar screw (BLS) and analyzed its related parameters using CT. The results indicate that BLS fixation is a feasible alternative option for posterior fixation in the subaxial cervical spine.
GLOBAL SPINE JOURNAL
(2022)
Article
Multidisciplinary Sciences
Eugene J. Park, Seungho Chung, Woo-Kie Min
Summary: The study found that ACDF can increase the recovery of cervical lordosis postoperatively, leading to reciprocal changes in occipitocervical parameters.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Anatoly Mikhailik, Tatyana Michurina, Krikor Dikranian, Stephen Hearn, Vladimir Maxakov, Saul S. Siller, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia Peunova
Summary: This passage discusses the crucial role of nitric oxide in regulating the polarity and ciliary beat frequency of multiciliated cells in the airway, and how this impacts airway flow. It also suggests a potential explanation for the low levels of exhaled nitric oxide in ciliopathies due to deficiencies in NO availability in ciliated cells.
LIFE SCIENCE ALLIANCE
(2021)
Article
Biochemistry & Molecular Biology
Aitak Farzi, Chi Kin Ip, Felicia Reed, Ronaldo Enriquez, Geraldine Zenz, Marija Durdevic, Lei Zhang, Peter Holzer, Herbert Herzog
Summary: The lack of PYY in mice results in distinct changes in gut microbiome composition, especially under high-fat diet conditions. Pyy-KO mice showed an increased abundance of Bacteroidetes phylum and specific genera within it, indicating a gene-environment interaction between diet and gut microbiome that can impact gut homeostasis.
Article
Immunology
Bonah Kim, Hee Young Kim, Won-Woo Lee
Summary: Zinc, an essential microelement, plays immunoregulatory roles by influencing signaling pathways to enhance immune function. Zinc deficiency impairs immunity and increases susceptibility to infection. The interaction between Zip6-mediated zinc influx and TCR activation regulates T-cell responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lei Zhang, Julia Koller, Chi Kin Ip, Gopana Gopalasingam, Nikita Bajaj, Nicola J. Lee, Ronaldo F. Enriquez, Herbert Herzog
Summary: This study investigated the physiological effects of NPFF signaling deficiency using a Npff(-/-) mouse model, showing that the lack of NPFF signaling influences repetitive behaviors, anxiety-related behaviors, and water intake in both male and female mice.
Article
Cell Biology
Dmitry I. Maltsev, Kennelia A. Mellanson, Vsevolod V. Belousov, Grigori N. Enikolopov, Oleg V. Podgorny
Summary: The detection of synthetic thymidine analogues incorporated into replicating DNA during the S-phase of the cell cycle is a valuable methodology for evaluating proliferative activity. Recent studies have shown that different thymidine analogues exhibit similar labeling kinetics and clearance rates from blood serum, with a bioavailability time of approximately 1 hour in vivo. This finding is significant for the practical use of multiple S-phase labeling with various analogues.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sergey Shuvaev, Alexander Lazutkin, Roman Kiryanov, Konstantin Anokhin, Grigori Enikolopov, Alexei A. Koulakov
Summary: This study introduces an algorithm called CORGI for the registration of perinatal brains. The algorithm utilizes image preprocessing, attention-gated simulated annealing, and classical multidimensional scaling to improve the accuracy of registration. Tested on samples of perinatal mouse brains, the algorithm shows promising results and automates brain registration tasks with a short runtime, making it significant for studying brain development dynamics.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Yuechuan Xue, Zachary Gursky, Brittany Monte, Sunil Koundal, Xiaodan Liu, Hedok Lee, Tatyana Michurina, Kennelia A. Mellanson, Lucy Zhao, Alice Nemajerova, Kristopher T. Kahle, Ken-Ichi Takemaru, Grigori Enikolopov, Natalia Peunova, Helene Benveniste
Summary: This study investigated the impact of ciliopathies on CNS fluid homeostasis. The results showed that sustained glymphatic transport and impaired solute drainage via the cribriform plate to the nasal cavity were observed in models of ciliopathy, along with the occurrence of hydrocephalus. This research is important for understanding how ciliopathies contribute to disruption of CNS fluid homeostasis.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Endocrinology & Metabolism
Jennifer Oraha, Ronaldo F. Enriquez, Herbert Herzog, Nicola J. Lee
Summary: This study found that C57BL/6J mice exhibit sex-specific behavioral and metabolic responses to the introduction and sustained intake of a high-fat diet (HFD), but consistent responses to a dieting situation. Males showed immediate and significant weight gain, while females displayed stronger resistance to the obesifying effects of HFD. This sex disparity may be attributed to inherent sex differences in neurological signaling pathways and fat utilization. Interestingly, both sexes showed similar responses to returning to a normal diet.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Cell Biology
Vashe Chandrakanthan, Prunella Rorimpandey, Fabio Zanini, Diego Chacon, Jake Olivier, Swapna Joshi, Young Chan Kang, Kathy Knezevic, Yizhou Huang, Qiao Qiao, Rema A. Oliver, Ashwin Unnikrishnan, Daniel R. Carter, Brendan Lee, Chris Brownlee, Carl Power, Robert Brink, Simon Mendez-Ferrer, Grigori Enikolopov, William Walsh, Berthold Gottgens, Samir Taoudi, Dominik Beck, John E. Pimanda
Summary: Chandrakanthan et al. have identified Mesp1-derived PDGFRA(+) stromal cells as aortic endothelial precursor cells that regulate the generation of long-term hematopoietic stem cells during development. This study provides a new potential tool for generating engraftable hematopoietic stem cells.
NATURE CELL BIOLOGY
(2022)
Article
Cell Biology
Anna Ivanova, Olesya Gruzova, Elizaveta Ermolaeva, Olga Astakhova, Sheed Itaman, Grigori Enikolopov, Alexander Lazutkin
Summary: This study examines the effects of thymidine analogs on adult hippocampal neurogenesis and perinatal somatic development of mice. The results show that thymidine analogs can effectively label cells but may have long-term effects on cell survival. Additionally, higher doses of thymidine analogs adversely affect somatic maturation and brain growth in mouse pups.
Article
Cell Biology
Sheed Itaman, Grigori Enikolopov, Oleg V. Podgorny
Summary: Tissue-specific somatic stem cells are characterized by their ability to be in a state of prolonged reversible cell cycle arrest. Maintaining a balance between cell quiescence and division is crucial for tissue homeostasis. However, detecting de novo dividing cells in quiescent stem cells has been challenging. In this study, a novel method based on double labeling with thymidine analogues was presented and experimentally verified to detect de novo dividing stem cells in situ.
Article
Medicine, General & Internal
Kang-San Lee, Eugene J. Park, Woo-Kie Min
Summary: In this case series, we examined the surgical outcomes of patients with locked facet distractive flexion injury (LF-DFI), focusing on the surgical approach and reduction maneuver. The study found that a posterior approach with partial facetectomy for LF reduction is considered a safer surgical technique than an anterior approach.
Article
Orthopedics
Eugene J. Park, Bo-Gil Jeong, Woo-Kie Min
Summary: This study analyzed the anatomical structures encountered during anterior approaches in the cervicothoracic junction (CTJ) and evaluated the feasibility of previously reported surgical corridors. The intercarotid artery angle (ICAA) and intercarotid artery distance (ICAD) were larger in men. The shape of the brachiocephalic trunk (BCT) was often convex and located inside the body. The accessible levels for anterior approaches were T1, T3, and T5. Preoperative analysis of vascular structures and accessible levels is essential for deciding the appropriate surgical corridor and reducing complications.
CLINICS IN ORTHOPEDIC SURGERY
(2023)
