Article
Biochemistry & Molecular Biology
Maria Elisabetta Clementi, Beatrice Sampaolese, Gabriele Di Sante, Francesco Ria, Rosa Di Liddo, Vincenzo Romano Spica, Fabrizio Michetti
Summary: The study demonstrated that the expression of S100B in astrocytoma cells plays a crucial role in the activation of reactive astrocytic processes, including cytotoxicity, ROS and NOS activation. Silencing S100B in astrocytoma cells effectively protected the cells from amyloid beta-peptide-induced damage, reducing cell death, oxygen radical generation and nitric oxide synthase activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu, Riqiang Yan
Summary: This study found that the absence of BACE1 in astrocytes could enhance the clearance of amyloid beta peptide, possibly through regulating the expression of upstream factors CLU and Cxcl14 in the insulin receptor pathway. Therefore, inhibiting BACE1 in astrocytes is a potential strategy for enhancing amyloid beta clearance.
MOLECULAR NEURODEGENERATION
(2023)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Andrey Y. Vinokurov, Olga A. Stelmashuk, Polina A. Ukolova, Evgeny A. Zherebtsov, Andrey Y. Abramov
Summary: The brain produces various reactive oxygen species at different rates in different brain regions, with the brain stem and cerebellum being more sensitive to oxidative stress. Mitochondrial ROS has minor implications to total ROS production, and levels of lipid peroxidation and GSH vary across brain regions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Eri Mukai, Shimpei Fujimoto, Nobuya Inagaki
Summary: The dysfunction of pancreatic beta-cells is crucial in the development of type 2 diabetes mellitus, characterized by impaired glucose stimulation and reduced ATP production. High glucose metabolism leads to the generation of reactive oxygen species in mitochondria, which affects beta-cells due to low expression of antioxidant enzymes. Activating the antioxidant defense factor Nrf2 may improve beta-cell dysfunction caused by ROS.
Review
Medicine, Research & Experimental
Samir Kumar Beura, Rishika Dhapola, Abhishek Ramachandra Panigrahi, Pooja Yadav, Dibbanti Harikrishna Reddy, Sunil Kumar Singh
Summary: Alzheimer's disease, a common neurodegenerative disorder, is associated with platelet hyperactivity and ROS generation, which may contribute to disease progression.
Review
Biochemistry & Molecular Biology
Marta Valenza, Roberta Facchinetti, Giorgia Menegoni, Luca Steardo, Caterina Scuderi
Summary: Alzheimer's disease treatments are not curative, new approaches are needed. Astrocytes are targeted as a specific method. Studies suggest that palmitoylethanolamide may have a potential therapeutic effect by modulating astrocytes.
Article
Agriculture, Multidisciplinary
Chia-Cheng Wei, Shang-Wei Li, Chia-Tung Wu, Chun Ming How, Min-Hsiung Pan
Summary: This study using a nematode model found that dietary exposure to MG may exacerbate AD pathology, as high levels of MG exposure led to decreased locomotive behaviors, increased A beta protein accumulation, impaired 5-HT reuptake, increased oxidative stress, and disrupted autophagy pathway. Treatment with the citrus flavonoid nobiletin reduced MG-induced toxicity.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Neurosciences
Tamar Smit, Natasja A. C. Deshayes, David R. Borchelt, Willem Kamphuis, Jinte Middeldorp, Elly M. Hol
Summary: This review focuses on the impact of reactive astrocytes on cognitive function in Alzheimer's disease, using a mouse model to study the potential effects of targeting reactive astrocytes as a treatment for AD. Studies suggest that interventions targeting astrocytes can benefit cognition in AD.
Article
Neurosciences
Vaibhav Walia, Deepak Kaushik, Vineet Mittal, Kuldeep Kumar, Ravinder Verma, Jatin Parashar, Rokeya Akter, Md Habibur Rahman, Saurabh Bhatia, Ahmed Al-Harrasi, Chenmala Karthika, Tanima Bhattacharya, Hitesh Chopra, Ghulam Md Ashraf
Summary: Alzheimer's disease is the sixth leading cause of death in elderly patients, characterized by progressive neuronal degeneration and cognitive impairment. Oxidative stress plays a key role in the pathogenesis of AD.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Chemistry, Physical
Yuanyuan Ma, Zhongju Ye, Chen Zhang, Yanjun Zhao, Hai-bin Luo, Lehui Xiao
Summary: Cor-Rhb can inhibit the fibrillation of Aβ peptides, interact directly with mature fibrils, and reduce Aβ-mediated cytotoxicity. It shows great potential as a multifunctional therapeutic agent.
Article
Immunology
Nicola Davis, Bibiana C. Mota, Larissa Stead, Emily O. C. Palmer, Laura Lombardero, Rafael Rodriguez-Puertas, Vincenzo de Paola, Samuel J. Barnes, Magdalena Sastre
Summary: This study explored the role of astrocytes in Alzheimer's disease by pharmacologically ablating them in brain culture slices. The results suggest that astrocytes contribute to Aβ clearance and synaptic plasticity, playing a protective role in AD.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Alice Filippini, Valentina Salvi, Vincenzo Dattilo, Chiara Magri, Stefania Castrezzati, Robert Veerhuis, Daniela Bosisio, Massimo Gennarelli, Isabella Russo
Summary: The accumulation of amyloid-beta in Alzheimer's disease (AD) brains causes reactive astrogliosis and neuroinflammatory response. This study investigates the role of leucine-rich repeat kinase 2 (LRRK2) in regulating astrocytic activation in response to amyloid-beta(1-42) (A beta(1-42)). The results demonstrate that LRRK2 kinase activity modulates astrocytic reactivity and functions in the presence of A beta(1-42) deposits, suggesting a potential contribution of PD-linked LRRK2 to AD-related neuroinflammation and pathogenesis.
Article
Clinical Neurology
Nicola Spotorno, Olof Strandberg, Geraline Vis, Erik Stomrud, Markus Nilsson, Oskar Hansson
Summary: Metrics of cortical microstructural alteration derived from diffusion MRI are highly sensitive to multiple aspects of the Alzheimer's disease pathological cascade, particularly the associations with Aβ-PET and GFAP, making them important outcome measures in clinical trials for disease-modifying therapies.
Review
Immunology
Deepali Singh
Summary: Neuroinflammation is caused by the misfiring of immune cells in the central nervous system and can have both positive and negative effects on neurodevelopment and post-injury tissue. Chronic or uncontrolled inflammatory responses may lead to neurodegenerative diseases, while abnormal activation of glial cells can mediate neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Masanori Itakura, Hidemitsu Nakajima, Yuko Semi, Shusaku Higashida, Yasu-Taka Azuma, Tadayoshi Takeuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Biochemistry & Molecular Biology
Masanori Itakura, Hidemitsu Nakajima, Takeya Kubo, Yuko Semi, Satoshi Kume, Shusaku Higashida, Akihiro Kaneshige, Mitsuru Kuwamura, Naoki Harada, Akinori Kita, Yasu-Taka Azuma, Ryoichi Yamaji, Takashi Inui, Tadayoshi Takeuchi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Hidemitsu Nakajima, Takeya Kubo, Hideshi Ihara, Takatoshi Hikida, Teruko Danjo, Masatoshi Nakatsuji, Neelam Shahani, Masanori Itakura, Yoko Ono, Yasu-Taka Azuma, Takashi Inui, Atsushi Kamiya, Akira Sawa, Tadayoshi Takeuchi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Takeya Kubo, Hidemitsu Nakajima, Masatoshi Nakatsuji, Masanori Itakura, Akihiro Kaneshige, Yasu-Taka Azuma, Takashi Inui, Tadayoshi Takeuchi
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2016)
Article
Biochemistry & Molecular Biology
Hidemitsu Nakajima, Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Naoki Harada, Takeshi Izawa, Yasu-Taka Azuma, Mitsuru Kuwamura, Ryouichi Yamaji, Tadayoshi Takeuchi
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Masanori Itakura, Tomoko Kohda, Takeya Kubo, Yuko Semi, Yasu-Taka Azuma, Hidemitsu Nakajima, Shunji Kozaki, Tadayoshi Takeuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Veterinary Sciences
Masanori Itakura, Tomoko Kohda, Takeya Kubo, Yuko Semi, Kazuhiro Nishiyama, Yasu-Taka Azuma, Hidemitsu Nakajima, Shunji Kozaki, Tadayoshi Takeuchi
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Sayumi Hirose, Yusuke Hioki, Hiroaki Miyashita, Naoya Hirade, Jun Yoshitake, Takahiro Shibata, Ryosuke Kikuchi, Tadashi Matsushita, Miho Chikazawa, Masanori Itakura, Mimin Zhang, Koji Nagata, Koji Uchida
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Sei-Young Lim, Kosuke Yamaguchi, Masanori Itakura, Miho Chikazawa, Tomonari Matsuda, Koji Uchida
Summary: This study reveals that the accumulation of pyrP due to apoE deficiency can influence clonal diversity in the B cell repertoire, linking covalent protein modification, lipoprotein metabolism, and innate immunity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Masanori Itakura, Kosuke Yamaguchi, Roma Kitazawa, Sei-Young Lim, Yusuke Anan, Jun Yoshitake, Takahiro Shibata, Lumi Negishi, Hikari Sugawa, Ryoji Nagai, Koji Uchida
Summary: Reducing sugars can react with proteins to form advanced glycation end products (AGEs), which are pathogenic molecules involved in inflammation and human diseases. This study identifies histone as a cell-surface receptor for AGEs and suggests that AGEs may also play a role in homeostatic response by binding to histone.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Kosuke Yamaguchi, Masanori Itakura, Mona Tsukamoto, Sei-Young Lim, Koji Uchida
Summary: Antioxidants can react with proteins when they are converted into their oxidized forms. Polyphenols have been identified as histone ligands, and the histone tail domain is involved in the interaction with polyphenol-modified proteins. The interaction between polyphenol-modified proteins and histones can exert a protective effect.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Hidemitsu Nakajima
Summary: GAPDH interacts with JNK and promotes its activation under oxidative stress, which is dependent on the oxidation of the active-site cysteine (Cys152) in GAPDH. Inhibition of GAPDH expression reduces JNK activation and attenuates the translocation of Bax protein to mitochondria. Therefore, GAPDH plays a significant role in the JNK signaling pathway under oxidative stress.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ryunosuke Endo, Kazuki Uchiyama, Sei-Young Lim, Masanori Itakura, Takahiro Adachi, Koji Uchida
Summary: This study identified acrolein-modified bovine serum albumin as the most efficient trigger for IgM production in PerC cells and showed that acrolein-specific epitopes accelerated the differentiation of B-1a cells to plasma cells. The presence of an acrolein-specific IgM-B cell receptor was suggested by specific binding of acrolein-modified bovine serum albumin to B-1a cells. The establishment of a hybridoma producing acrolein-specific IgM from PerC cells and the identification of the IgM heavy chain gene segments of acrolein-specific B cells confirmed the presence of innate B cells expressing the acrolein-specific BCR.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hidemitsu Nakajima, Masanori Itakura, Keishi Sato, Sunao Nakamura, Yasu-Taka Azuma, Tadayoshi Takeuchi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Hui-Ting Huang, Shun-Fen Tzeng
Summary: Our study demonstrates the role of interleukin-33 (IL-33) in a demyelinating mouse model induced by cuprizone (CPZ), showing that IL-33 can alleviate the reduction of APC+ OLs and the decline of IL-33 levels in the corpus callosum, and promote the expression of myelin basic protein (MBP).
NEUROCHEMISTRY INTERNATIONAL
(2024)