期刊
NEUROBIOLOGY OF LEARNING AND MEMORY
卷 137, 期 -, 页码 36-47出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2016.10.012
关键词
Entorhinal cortex; Executive functions; Functional connectivity; Hippocampus; Memory
资金
- Eveyln F. McKnight Brain Research Foundation
- National Institute on Aging at the National Institutes of Health (Claude D. Pepper Older Americans Independence Center Scholar Award Grant) [P30 AG028740, R01 AG049711, R01 AG029421, R03 1R03AG049411]
- University of Florida Howard Hughes Medical Institute Science for Life
- University of Florida Research Opportunity Seed Fund
The ability to use information from the physical world to update behavioral strategies is critical for survival across species. The prefrontal cortex (PFC) supports behavioral flexibility; however, exactly how this brain structure interacts with sensory association cortical areas to facilitate the adaptation of response selection remains unknown. Given the role of the perirhinal cortex (PER) in higher-order perception and associative memory, the current study evaluated whether PFC-PER circuits are critical for the ability to perform biconditional object discriminations when the rule for selecting the rewarded object shifted depending on the animal's spatial location in a 2-arm maze. Following acquisition to criterion performance on an object-place paired association task, pharmacological blockade of communication between the PFC and PER significantly disrupted performance. Specifically, the PFC-PER disconnection caused rats to regress to a response bias of selecting an object on a particular side regardless of its identity. Importantly, the PFC-PER disconnection did not interfere with the capacity to perform object-only or location-only discriminations, which do not require the animal to update a response rule across trials. These findings are consistent with a critical role for PFC-PER circuits in rule shifting and the effective updating of a response rule across spatial locations. Published by Elsevier Inc.
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