期刊
NEUROBIOLOGY OF AGING
卷 54, 期 -, 页码 54-58出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2017.02.014
关键词
White matter; Aging; Brain MRI; APOE; Vascular risk; Longitudinal
资金
- Research into Ageing programme grant
- Age UK
- UK Medical Research Council [G0701120, G1001245, MR/M013111/1]
- Scottish Funding Council through the SINAPSE Collaboration
- Row Fogo Charitable Trust [BRO-D.FID3668413]
- UK Biotechnology and Biological Sciences Research Council
- Medical Research Council
- BBSRC [BB/F019394/1] Funding Source: UKRI
- MRC [G1001245, MR/N003403/1, MR/M013111/1, G0701120] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F019394/1] Funding Source: researchfish
- Medical Research Council [MR/K026992/1, MR/N003403/1, MR/M013111/1, G0701120, G1001245] Funding Source: researchfish
We examined whether apolipoprotein E (APOE) status interacts with vascular risk factors (VRFs) to predict the progression of white matter hyperintensities (WMHs) on brain MRI scans over a specific period of life in older age when the risk of dementia increases. At age 73 years, baseline VRFs were assessed via self-reported history of diabetes, hypertension, smoking, and hypercholesterolemia, and via objective measures of blood HbA1c, body mass index, diastolic and systolic blood pressure, and blood high-density lipoprotein to total cholesterol (HDL) ratio. APOE e4 allele was coded as either present or absent. WMH progression was measured on MRI over 3 years in 434 older adults, in a same-year-of-birth cohort. APOE e4 carriers with either a self-reported diagnosis of diabetes (beta = 0.160, p = 0.002) or higher glycated hemoglobin levels (beta = 0.114, p = 0.014) exhibited greater WMH progression, and the former survived correction for multiple testing. All other APOE-VRF interactions were nonsignificant (beta(interaction) < 0.056, p > 0.228). The results suggest that carrying the APOE risk e4 allele increases the risk of greater age-related WMH progression over the early part of the eighth decade of life, when combined with poorer glycemic control. The interaction effect was robust to co-occurring VRFs, suggesting a possible target for mitigating brain and cognitive aging at this age. (C) 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据