Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Holly C. Hunsberger, Sharay E. Setti, Carolyn C. Rudy, Daniel S. Weitzner, Jeremiah C. Pfitzer, Kelli L. McDonald, Hao Hong, Subhrajit Bhattacharya, Vishnu Suppiramaniam, Miranda N. Reed
Summary: This study using a mouse model found that increased expression of P301L Tau in aged mice leads to memory deficits, potentially due to late-stage tau pathology and dysregulation of glutamate release and uptake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Shannon N. Leslie, Jean Kanyo, Dibyadeep Datta, Rashaun S. Wilson, Caroline Zeiss, Alvaro Duque, TuKiet T. Lam, Amy F. T. Arnsten, Angus C. Nairn
Summary: Age is a significant risk factor for Alzheimer's disease, and this study identified age-related changes in tau phosphorylation in the prefrontal cortex of rhesus monkeys, suggesting the importance of the natural aging process in tau phosphorylation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Dibyadeep Datta
Summary: Aging rhesus macaques serve as an invaluable model for studying the etiological mechanisms of sporadic Alzheimer's disease (AD) and exploring novel therapeutic strategies. These macaques naturally exhibit amyloid and tau pathology, synaptic dysfunction, and cognitive impairments similar to human AD. Unique molecular mechanisms in the newly evolved primate dorsolateral prefrontal cortex, involving feedforward cyclic adenosine monophosphate (cAMP)-Protein kinase A (PKA)-calcium signaling, play a critical role in higher-order cognition. However, genetic predispositions and age-related insults can exacerbate these signaling pathways and lead to downstream effects, increasing susceptibility to atrophy.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Jenna N. Adams, Theresa M. Harrison, Anne Maass, Suzanne L. Baker, William J. Jagust
Summary: This study aimed to investigate the mechanisms underlying the initial accumulation of tau pathology and the predictive roles of age, AP, and neural activity in tau accumulation. The results showed that older age, higher neural activity, and higher baseline EC tau levels were associated with tau accumulation. Additionally, AP facilitated the spread of tau.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jenna N. Adams, Anne Maass, David Berron, Theresa M. Harrison, Suzanne L. Baker, Wesley P. Thomas, Morgan Stanfill, William J. Jagust
Summary: Tau deposition in aging and Alzheimer's disease affects medial temporal lobe (MTL) neural function, impacting repetition suppression. Different levels of tau pathology are associated with activity changes in distinct MTL subregions, with high tau pathology leading to widespread neural dysfunction.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Gabrielle Zuniga, Bess Frost
Summary: Emerging evidence suggests that errors in RNA processing contribute to neurodegeneration. Neurons are particularly vulnerable to these errors, which can lead to accumulation of misprocessed RNA transcripts. Furthermore, the protein tau, implicated in Alzheimer's disease and related disorders, is also involved in deficits in RNA processing and clearance.
PROGRESS IN NEUROBIOLOGY
(2023)
Review
Cell Biology
Marine Tournissac, Manon Leclerc, Josue Valentin-Escalera, Milene Vandal, Cristina R. Bosoi, Emmanuel Planel, Frederic Calon
Summary: Alzheimer's disease (AD) is a complex age-related neurodegenerative disease associated with central and peripheral metabolic anomalies, such as impaired glucose utilization and insulin resistance. Correcting thermoregulatory impairments could slow the progression and delay the onset of AD.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Cecilia Tremblay, Geidy E. Serrano, Anthony J. Intorcia, Lucia Sue, Jeffrey R. Wilson, Charles H. Adler, Holly A. Shill, Erika Driver-Dunckley, Shyamal H. Mehta, Thomas G. Beach
Summary: The decline of olfactory function is frequently observed in aging. This study found that tau pathology is commonly observed in the olfactory bulb of normally aging individuals, but it does not independently contribute to age-related olfactory decline. Further involvement of the brain seems to be necessary for age-related olfactory impairment.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth C. Mormino, Tyler N. Toueg, Carmen Azevedo, Jessica B. Castillo, Wanjia Guo, Ayesha Nadiadwala, Nicole K. Corso, Jacob N. Hall, Audrey Fan, Alexandra N. Trelle, Marc B. Harrison, Madison P. Hunt, Sharon J. Sha, Gayle Deutsch, Michelle James, Carolyn A. Fredericks, Mary Ellen Koran, Michael Zeineh, Kathleen Poston, Michael D. Greicius, Mehdi Khalighi, Guido A. Davidzon, Bin Shen, Greg Zaharchuk, Anthony D. Wagner, Frederick T. Chin
Summary: In vivo measurements using (18)F-PI-2620 PET scans revealed significant differences in brain regions associated with Alzheimer's disease across different stages of the disease. This indicates the potential of (18)F-PI-2620 as a tool for visualizing tau aggregations in AD.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Review
Medicine, Research & Experimental
Caitlin S. Latimer, Katherine L. Lucot, C. Dirk Keene, Brenna Cholerton, Thomas J. Montine
Summary: Alzheimer's disease is a pervasive, relentlessly progressive neurodegenerative disorder that requires autopsy confirmation for diagnosis. Significant progress has been made in understanding the disease, largely due to research on genetic pathways.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 16, 2021
(2021)
Review
Biology
Trae Carroll, Sanjib Guha, Keith Nehrke, Gail V. W. Johnson
Summary: The spatial progression of Alzheimer's Disease cases in the brain follows a well-defined route, and recent research suggests that certain neurons may be more vulnerable to AD stress, potentially leading to selective vulnerability. Modifications of tau protein have been implicated in this selective vulnerability, with specific phosphorylation sites disrupting proper tau function and initiating early pathological changes.
Article
Geriatrics & Gerontology
Molly R. LaPoint, Suzanne L. Baker, Susan M. Landau, Theresa M. Harrison, William J. Jagust
Summary: This study used PIB-PET imaging to investigate the progression of regional amyloid accumulation in cognitively normal older adults, finding that amyloid accumulates near-simultaneously throughout the brain and is associated with higher AD pathology. Carriers of the apolipoprotein-E e 4 allele had faster amyloid accumulation, and faster accumulation was associated with greater tau burden in most brain regions.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Xi Chen, Kaitlin E. Cassady, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Summary: Studies suggest that tau deposition begins in the anterolateral entorhinal cortex during normal aging and is facilitated by the presence of beta-amyloid, potentially marking the onset of Alzheimer's disease. Higher tau deposition in the anterior-temporal memory network is associated with faster memory decline, especially in individuals with beta-amyloid. When all three tau measures are considered, only tau in the anterior-temporal region significantly predicts memory decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Theresa M. Harrison, Tyler J. Ward, Alice Murphy, Suzanne L. Baker, Pablo A. Dominguez, Robert Koeppe, Prashanthi Vemuri, Samuel N. Lockhart, Youngkyoo Jung, Danielle J. Harvey, Laura Lovato, Arthur W. Toga, Joseph Masdeu, Hwamee Oh, Darren R. Gitelman, Neelum Aggarwal, Heather M. Snyder, Laura D. Baker, Charles DeCarli, William J. Jagust, Susan M. Landau, US POINTER Study Grp
Summary: The POINTER Imaging ancillary study is evaluating the effect of risk reduction strategies in older adults at increased risk for cognitive decline. Different methods for minimizing off-target signal (OTS) effects did not significantly improve the performance metrics, as OTS contamination cancels out in the data.
Article
Biotechnology & Applied Microbiology
Melanie Alpaugh, Maria Masnata, Aurelie de Rus Jacquet, Eva Lepinay, Helena L. Denis, Martine Saint-Pierre, Peter Davies, Emmanuel Planel, Francesca Cicchetti
Summary: This study suggests that attenuating tau pathology could mitigate behavioral and molecular hallmarks associated with Huntington's disease.
Article
Clinical Neurology
Geoffrey Canet, Emma Zub, Charleine Zussy, Celia Hernandez, Marine Blaquiere, Valentin Garcia, Mathieu Vitalis, Frederic DeBock, Maria Moreno-Montano, Etienne Audinat, Catherine Desrumaux, Emmanuel Planel, Laurent Givalois, Nicola Marchi
Article
Geriatrics & Gerontology
Isabelle Guisle, Geoffrey Canet, Serena Petry, Parissa Fereydouni-Forouzandeh, Francoise Morin, Remi Kerauden, Robert A. Whittington, Frederic Calon, Sebastien S. Hebert, Emmanuel Planel
Summary: The study found that sauna bathing or menthol treatment may lower tau protein phosphorylation levels by increasing body temperature, potentially serving as effective therapeutic strategies for Alzheimer's disease and other tauopathies.
NEUROBIOLOGY OF AGING
(2022)
Article
Biochemistry & Molecular Biology
Charleine Zussy, Rijo John, Theo Urgin, Lea Otaegui, Claire Vigor, Niyazi Acar, Geoffrey Canet, Mathieu Vitalis, Francoise Morin, Emmanuel Planel, Camille Oger, Thierry Durand, Shinde L. Rajshree, Laurent Givalois, Padma V. Devarajan, Catherine Desrumaux
Summary: Polyunsaturated fatty acids (PUFAs), especially DHA, play a crucial role in brain development and function. Low levels of DHA have been associated with cognitive impairment and AD. The relationship between dietary DHA intake and cognitive decline remains inconclusive. The oxidizability of DHA and its limited accessibility to the brain may contribute to these inconsistencies. New strategies to enhance DHA supply to the brain are needed.
Article
Neurosciences
Serena Petry, Behnaz Nateghi, Remi Keraudren, Nicolas Sergeant, Emmanuel Planel, Sebastien S. Hebert, Isabelle St-Amour
Summary: This study investigates the alternative splicing of tau protein in HD patients and identifies abnormal splicing events in the putamen. Differences in exon 2 splicing coincide with increased tau hyperphosphorylation, aggregation, and markers of neurodegeneration, suggesting a potential biomarker or therapeutic target.
Article
Pharmacology & Pharmacy
Marie-Pier Roy, Frederic Calon, David Simonyan, Luc Bergeron
Summary: This study compared the risk of neutropenia associated with piperacillin-tazobactam (P/T) and cefazolin in an adult population and described the characteristics of neutropenia episodes observed. The results showed that the risk of neutropenia appeared to be similar between P/T and cefazolin.
CANADIAN JOURNAL OF HOSPITAL PHARMACY
(2022)
Article
Oncology
Emilie Wong Chong, France-Helene Joncas, Nabil G. Seidah, Frederic Calon, Caroline Diorio, Anne Gangloff
Summary: This study aimed to compare the circulating levels of lipid-related factors in women with breast cancer and those with premalignant or benign breast lesions. The results showed that PCSK9 levels were significantly higher in women with breast cancer and positively correlated with disease severity. However, no association was found between ANGPTL3 or Lp(a) levels and breast disease status.
Article
Clinical Neurology
Manon Leclerc, Philippe Bourassa, Cyntia Tremblay, Vicky Caron, Camille Sugere, Vincent Emond, David A. Bennett, Frederic Calon
Summary: This study reveals that impairment of insulin receptors at the blood-brain barrier contributes to brain insulin resistance in Alzheimer's disease, in association with beta-amyloid pathology, based on experiments with human brain samples and animal models.
Article
Multidisciplinary Sciences
Razan Sheta, Maxime Teixeira, Walid Idi, Marion Pierre, Aurelie de Rus Jacquet, Vincent Emond, Cornelia E. Zorca, Benoit Vanderperre, Thomas M. Durcan, Edward A. Fon, Frederic Calon, Mohamed Chahine, Abid Oueslati
Summary: Using human derived induced pluripotent stem cells (hiPSCs) to differentiate into dopaminergic neurons provides a valuable experimental model for investigating the mechanisms of Parkinson's disease (PD). However, current approaches have limitations such as lengthy protocols and variability in neuron yield. This study presents an improved method that combines neurogenin-2 programming with commercially available midbrain differentiation kits to quickly and efficiently generate mature and functional induced DA neurons. The resulting neurons showed similarities to A9 midbrain neurons and exhibited selective vulnerability to 6-hydroxydopamine, making them a suitable in vitro model for studying PD and screening neuroprotective compounds.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Mohammed Amir Husain, Annick Vachon, Raphael Chouinard-Watkins, Milene Vandal, Frederic Calon, Melanie Plourde
Summary: The metabolism of docosahexaenoic acid (DHA) is different in APOE4 carriers, and it affects cognitive performance. There is a plasma-liver-brain axis of DHA in APOE4 mice, which is influenced by genotype and diet. APOE4 mice rely more on plasma DHA, especially in cognitive performance.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Neurosciences
Stephanie Levert, Julie Pilliod, Etienne Aumont, Sandrine Armanville, Cyntia Tremblay, Frederic Calon, Nicole Leclerc
Summary: In this study, the interaction between Tau and FLNA proteins was explored, as well as the impact of FLNA on Tau pathology. The results showed that overexpression of FLNA led to the accumulation of Tau protein in cells, increased its phosphorylation and cleavage by Caspase-3, but did not increase its aggregation. Additionally, FLNA overexpression also induced the accumulation of annexin A2. However, in AD brains, the increase in FLNA did not correlate with Tau pathology.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Geriatrics & Gerontology
Etienne Aumont, Cyntia Tremblay, Stephanie Levert, David A. Bennett, Frederic Calon, Nicole Leclerc
Summary: This study aimed to describe the differences in FLNA levels across different stages of Alzheimer's disease and found that insoluble FLNA could be used as a marker to identify prodromal AD.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Olivier Landry, Arnaud Francois, Meryl-Farelle Oye Mintsa Mi-Mba, Marie-Therese Traversy, Cyntia Tremblay, Vincent Emond, David A. Bennett, Karen H. Gylys, Joseph D. Buxbaum, Frederic Calon
Summary: Synaptic loss is closely related to Alzheimer's disease (AD) neuropathology and symptoms. The deficiency of Shank3 protein is associated with severe cognitive symptoms in children. This study found that the loss of Shank3a in the parietal cortex of individuals with AD is associated with cognitive decline. The deficiency of Shank3a in AD mice exacerbates cognitive impairment and anxious behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Editorial Material
Cell Biology
Aurelie de Rus Jacquet, Sophie Laye, Frederic Calon
Summary: Understanding how natural products promote brain health is crucial for improving the lives of individuals with neurodegenerative disorders. This article discusses the mechanisms involved and recent technological advancements.
CELL REPORTS MEDICINE
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)