Article
Geriatrics & Gerontology
Ryan K. Shahidehpour, Rebecca E. Higdon, Nicole G. Crawford, Janna H. Neltner, Eseosa T. Ighodaro, Ela Patel, Douglas Price, Peter T. Nelson, Adam D. Bachstetter
Summary: The study found an age-associated increase in dystrophic microglia in the hippocampus and frontal cortex, but this increase was proportional to the total number of microglia, suggesting aging alone does not explain the presence of dystrophic microglia. Dystrophic microglia, rather than hypertrophic microglia, were found to be the disease-associated microglia morphology. Furthermore, changes in iron homeostasis in dystrophic microglia were identified as a potential molecular mechanism driving the degeneration of microglia in neurodegenerative disease.
NEUROBIOLOGY OF AGING
(2021)
Article
Biology
Ashley C. Bolte, Daniel A. Shapiro, Arun B. Dutta, Wei Feng Ma, Katherine R. Bruch, Michael A. Kovacs, Ana Royo Marco, Hannah E. Ennerfelt, John R. Lukens, Florent Ginhoux
Summary: Emerging evidence suggests that the meningeal compartment plays important roles in neurological disorders, but knowledge about meningeal biology is still limited. This study used high-throughput RNA sequencing to investigate the transcriptional response of the meninges to traumatic brain injury (TBI) and aging. The results showed changes in gene expression in major meningeal cell populations, as well as differential outcomes between young and aged mice following TBI.
Article
Neurosciences
Rodney M. Ritzel, Junyun He, Yun Li, Tuoxin Cao, Niaz Khan, Bosung Shim, Boris Sabirzhanov, Taryn Aubrecht, Bogdan A. Stoica, Alan I. Faden, Long-Jun Wu, Junfang Wu
Summary: The study reveals that microglia directly regulate acidosis after traumatic brain injury, exacerbating neural damage. Inhibiting microglia can reduce extracellular acidosis, ROS production, and inflammation, leading to neuroprotection and functional recovery. Additionally, the voltage-gated proton channel Hv1 in microglia plays a crucial role in integrating inflammation and acidosis during head injury.
Article
Neurosciences
Lynde M. Wangler, Chelsea E. Bray, Jonathan M. Packer, Zoe M. Tapp, Amara C. Davis, Shane M. O'Neil, Kara Baetz, Michelle Ouvina, Mollie Witzel, Jonathan P. Godbout
Summary: The neurobiological mechanisms underlying worsened functional outcomes after traumatic brain injury (TBI) in the elderly remain unclear. This study found that aged mice showed more severe cognitive impairment, gliosis, and neuroinflammation after TBI compared to adult mice. Age was associated with enhanced expression of cytokine/chemokine, complement, innate immune, and interferon-associated inflammatory genes in the cortex. Type I interferon (IFN) signaling was significantly enhanced in the aged brain after TBI. Overall, TBI promoted amplified IFN signaling in aged mice, resulting in extended inflammation and gliosis.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Xiaojing Zheng, Tiantian Mi, Rong Wang, Zihan Zhang, Wenyan Li, Junli Zhao, Peiyan Yang, Haibin Xia, Qinwen Mao
Summary: This study found that PGRN-deficient mice showed stronger neuroinflammation after TBI, with neuronal death and impaired spatial learning and memory. The data suggests that PGRN may play a potential role in therapy for TBI.
Article
Immunology
James P. Barrett, Susan M. Knoblach, Surajit Bhattacharya, Heather Gordish-Dressman, Bogdan A. Stoica, David J. Loane
Summary: Aging negatively affects brain inflammatory processes, especially in the context of traumatic brain injury (TBI), where aged mice show exacerbated neuroinflammation and IFN-I signaling compared to their younger counterparts. The activation of cGAS and IFN-I pathways in the aged TBI brain may serve as a mechanistic link between neuroinflammation and neurodegeneration.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Ilia G. Komoltsev, Liya V. Tret'yakova, Stepan O. Frankevich, Natalia I. Shirobokova, Aleksandra A. Volkova, Alexey V. Butuzov, Margarita R. Novikova, Alexey A. Kvichansky, Yulia V. Moiseeva, Mikhail V. Onufriev, Alexey P. Bolshakov, Natalia V. Gulyaeva
Summary: The study showed that neuroinflammatory processes in the dorsal and ventral hippocampus were different in the ipsilateral and contralateral hemispheres during the early period after TBI, with distant hippocampal damage and varying timelines of neuroinflammatory responses.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Geriatrics & Gerontology
Fangjie Shao, Xiaoyu Wang, Haijian Wu, Qun Wu, Jianmin Zhang
Summary: Traumatic brain injury (TBI) is a common disease in the central nervous system with high mortality and morbidity. Patients with TBI often suffer from neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The pathological mechanisms connecting these two processes are not fully understood. Further investigation of the pathophysiological mechanisms of TBI and TBI-induced neurodegeneration is crucial for developing accurate treatment options for these notorious consequences.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ilia Komoltsev, Daria Shalneva, Olga Kostyunina, Aleksandra Volkova, Stepan Frankevich, Natalia Shirobokova, Anastasia Belikova, Sofia Balan, Olesya Chizhova, Olga Salyp, Daria Bashkatova, Pavel Kostrukov, Aleksandra Soloveva, Margarita Novikova, Natalia Gulyaeva
Summary: Acute and chronic corticosterone (CS) elevations after traumatic brain injury (TBI) may cause hippocampal damage and late posttraumatic behavioral pathology. This study found that CS-dependent changes were present 3 months post TBI, with objective memory impairments and delayed spatial memory deficits. Moderate CS elevation predicted delayed mortality and masked the extent of morphological and behavioral deficits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gaylia Jean Harry
Summary: Changes in microglia are commonly associated with neurodegeneration, but it is not clear if they initiate the process. Communication between microglia and neurons helps maintain the cells in a surveillance state, suggesting a partnership role rather than an initiating one in neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Yee Liew, Thaarvena Retinasamy, Alina Arulsamy, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mohd Farooq Shaikh
Summary: This systematic review investigates the shared molecular mechanisms of neuroinflammation in Alzheimer's disease (AD) and epilepsy. The study finds a direct association between neuroinflammation and the progression of AD and epilepsy. However, more research is needed to develop standardized monitoring guidelines for preventing epilepsy and delaying the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Summary: Cumulative evidence indicates that IFN-I signaling plays a significant role in immune cell-mediated neuropathology in neurodegenerative diseases. This study shows that IFNAR deficiency leads to reduced expression of IFN-I-stimulated genes, decreased microgliosis and monocyte infiltration, and molecular alteration in reactive microglia following TBI. Furthermore, the IFNAR-dependent modulation of the neuroimmune response provides protection against secondary neuronal death, white matter disruption, and neurobehavioral dysfunction.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Yi-He Chen, Rong-Rong Lin, Qing-Qing Tao
Summary: Alzheimer's disease is the most common cause of dementia and is increasing with global aging trends. In addition to the known core pathologies of AD, neuroinflammation has been recognized as playing an important role. Recent evidence has shown that P2X7R plays a critical role in neuroinflammation and AD pathogenesis.
Review
Biochemistry & Molecular Biology
Anna Hau-Yee Kong, Aston Jiaxi Wu, Olivia Ka-Yi Ho, Maggie Ming-Ki Leung, Alexis Shiying Huang, Yuanyuan Yu, Ge Zhang, Aiping Lyu, Min Li, King-Ho Cheung
Summary: Neuroinflammation is a precursor to neurodegenerative diseases, and targeting it with aptamers offers potential diagnostic and therapeutic applications. This review summarizes the use of aptamers for diagnosing and treating inflammatory biomolecules and cells associated with neurodegenerative diseases. It also discusses the potential of short nucleotides for targeted brain delivery and the challenges of using aptamers as therapeutic agents. Overall, this review assesses the potential of aptamers as a pioneering approach for CNS target delivery and the treatment of neuroinflammation and neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Sarah E. Svirsky, Youming Li, Jeremy Henchir, Anna Rodina, Shaun W. Carlson, Gabriela Chiosis, C. Edward Dixon
Summary: This study investigates the formation of the epichaperome in traumatic brain injury (TBI) and suggests that this mechanism may contribute to protein misfolding, degradation, aggregation, and transport. Further understanding of this pathological mechanism can provide insights into the connection between TBI and increased risk of neurodegenerative diseases, as well as potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Saktimayee M. Roy, Valerie L. Grum-Tokars, James P. Schavocky, Faisal Saeed, Agnieszka Staniszewski, Andrew F. Teich, Ottavio Arancio, Adam D. Bachstetter, Scott J. Webster, Linda J. Van Eldik, George Minasov, Wayne F. Anderson, Jeffrey C. Pelletier, D. Martin Watterson
ACS CHEMICAL NEUROSCIENCE
(2015)
Article
Immunology
Heidi Y. Febinger, Hannah E. Thomasy, Maria N. Pavlova, Kristyn M. Ringgold, Paulien R. Barf, Amrita M. George, Jenna N. Grillo, Adam D. Bachstetter, Jenny A. Garcia, Astrid E. Cardona, Mark R. Opp, Carmelina Gemma
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Immunology
Adam D. Bachstetter, Scott J. Webster, Danielle S. Goulding, Jonathan E. Morton, D. Martin Watterson, Linda J. Van Eldik
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Clinical Neurology
Eseosa T. Ighodaro, Gregory A. Jicha, Frederick A. Schmitt, Janna H. Neltner, Erin L. Abner, Richard J. Kryscio, Charles D. Smith, Taylor Duplessis, Sonya Anderson, Ela Patel, Adam Bachstetter, Linda J. Van Eldik, Peter T. Nelson
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2015)
Article
Neurosciences
Scott J. Webster, Linda J. Van Eldik, D. Martin Watterson, Adam D. Bachstetter
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Adam D. Bachstetter, Linda J. Van Eldik, Frederick A. Schmitt, Janna H. Neltner, Eseosa T. Ighodaro, Scott J. Webster, Ela Patel, Erin L. Abner, Richard J. Kryscio, Peter T. Nelson
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2015)
Article
Endocrinology & Metabolism
Eseosa T. Ighodaro, Erin L. Abner, David W. Fardo, Ai-Ling Lin, Yuriko Katsumata, Frederick A. Schmitt, Richard J. Kryscio, Gregory A. Jicha, Janna H. Neltner, Sarah E. Monsell, Walter A. Kukull, Debra K. Moser, Frank Appiah, Adam D. Bachstetter, Linda J. Van Eldik, Peter T. Nelson
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2017)
Review
Biochemistry & Molecular Biology
Katrin I. Andreasson, Adam D. Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C. Lee, Donovan Low, Marina A. Lynch, Alon Monsonego, M. Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A. Sandusky, Maj-Linda B. Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J. Van Eldik
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Neurosciences
Rachel K. Rowe, Gavin I. Ellis, Jordan L. Harrison, Adam D. Bachstetter, Gregory F. Corder, Linda J. Van Eldik, Bradley K. Taylor, Francesc Marti, Jonathan Lifshitz
Article
Immunology
Zhengqiu Zhou, Adam D. Bachstetter, Claudia B. Spani, Saktimayee M. Roy, D. Martin Watterson, Linda J. Van Eldik
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Critical Care Medicine
Mei Liu, Adam D. Bachstetter, Wayne A. Cass, Jonathan Lifshitz, Guoying Bing
JOURNAL OF NEUROTRAUMA
(2017)
Article
Immunology
Rachel K. Rowe, Jordan L. Harrison, Hongtao Zhang, Adam D. Bachstetter, David P. Hesson, Bruce F. O'Hara, Mark I. Greene, Jonathan Lifshitz
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Multidisciplinary Sciences
Adam D. Bachstetter, Zhengqiu Zhou, Rachel K. Rowe, Bin Xing, Danielle S. Goulding, Alyssa N. Conley, Pradoldej Sompol, Shelby Meier, Jose F. Abisambra, Jonathan Lifshitz, D. Martin Watterson, Linda J. Van Eldik
Article
Clinical Neurology
Vanessa D. Smith, Adam D. Bachstetter, Eseosa Ighodaro, Kelly Roberts, Erin L. Abner, David W. Fardo, Peter T. Nelson
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
