Histologically defined intratumoral sequencing uncovers evolutionary cues into conserved molecular events driving gliomagenesis

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer

(2016) Yasufumi Matsuda et al.   CANCER SCIENCE

Novel insights into vascularization patterns and angiogenic factors in glioblastoma subclasses

(2016) Siobhan Conroy et al.   JOURNAL OF NEURO-ONCOLOGY

Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer

(2016) Pedro M. Enriquez-Navas et al.   Science Translational Medicine

Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma

(2016) Ke Hu et al.   Oncotarget

Molecular mechanisms of OLIG2 transcription factor in brain cancer

(2016) Igor F. Tsigelny et al.   Oncotarget

BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

(2016) Dapeng Wang et al.   Scientific Reports

Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

(2016) Nicole R. Parker et al.   Scientific Reports

Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis

(2015) Antony Prabhu et al.   NEURO-ONCOLOGY

MetaboAnalyst 3.0—making metabolomics more meaningful

(2015) Jianguo Xia et al.   NUCLEIC ACIDS RESEARCH

Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity

(2015) Mona Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy

(2015) Savalan Babapoor-Farrokhran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme

(2015) Davide Barbagallo et al.   Oncotarget

Targeting miR-381-NEFL axis sensitizes glioblastoma cells to temozolomide by regulating stemness factors and multidrug resistance factors

(2015) Zeyou Wang et al.   Oncotarget

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

(2015) Daniel Nichol et al.   PLoS Computational Biology

Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma

(2014) Tatsuya Ozawa et al.   CANCER CELL

The mTOR signaling pathway as a treatment target for intracranial neoplasms

(2014) D. Pachow et al.   NEURO-ONCOLOGY

Molecular Subtypes of Glioblastoma Are Relevant to Lower Grade Glioma

(2014) Xiaowei Guan et al.   PLoS One

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma

(2014) A. P. Patel et al.   SCIENCE

Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression

(2014) J. P. Sullivan et al.   Cancer Discovery

Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial

(2013) Mark R. Gilbert et al.   JOURNAL OF CLINICAL ONCOLOGY

miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma

(2013) L. K. Mathew et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Microenvironment Strongly Impacts Master Transcriptional Regulators and Gene Expression Class of Glioblastoma

(2012) Lee A.D. Cooper et al.   AMERICAN JOURNAL OF PATHOLOGY

The Metabolomic Signature of Malignant Glioma Reflects Accelerated Anabolic Metabolism

(2012) P. Chinnaiyan et al.   CANCER RESEARCH

Evolutionary Approaches to Prolong Progression-Free Survival in Breast Cancer

(2012) A. S. Silva et al.   CANCER RESEARCH

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Radiation-Induced G2 Checkpoint Activation with the Wee-1 Inhibitor MK-1775 in Glioblastoma Cell Lines

(2011) B. Sarcar et al.   MOLECULAR CANCER THERAPEUTICS

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

Enrichment of Foxp3+ CD4 Regulatory T Cells in Migrated T Cells to IL-6- and IL-8-Expressing Tumors through Predominant Induction of CXCR1 by IL-6

(2010) S. Eikawa et al.   JOURNAL OF IMMUNOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE