Article
Immunology
Kai Yu, Yulong Ji, Min Liu, Fugeng Shen, Xiaoxing Xiong, Lijuan Gu, Tianzhu Lu, Yingze Ye, Shi Feng, Jianying He
Summary: In this study, the researchers found that CKS2 is overexpressed in glioma and is associated with the prognosis of overall survival in patients. The methylation status of CKS2 is negatively correlated with its expression level, and CKS2 expression is closely related to tumor immunity. Silencing CKS2 can inhibit the proliferation and invasion of glioma cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Ophthalmology
Leopold Schmetterer, Hendrik Scholl, Gerhard Garhoefer, Lucas Janeschitz-Kriegl, Federico Corvi, Srinivas R. Sadda, Felipe A. Medeiros
Summary: With the increasing number of interventional clinical trials in ophthalmology, novel targets and endpoints are being identified. Visual acuity, the gold standard endpoint for clinical trials, may not be sufficient for some indications, such as geographic atrophy and inherited retinal disease. Glaucoma drugs have been approved based on their ability to lower intraocular pressure (IOP), but recent findings suggest that not all drugs have the same effect on visual field progression at the same level of IOP reduction. Therefore, there is a need for novel surrogate endpoints in glaucoma trials. This article summarizes potential candidates for clinical endpoints in ophthalmology, with a focus on retinal disease and glaucoma, and evaluates their potential to serve as endpoints in pivotal trials.
PROGRESS IN RETINAL AND EYE RESEARCH
(2023)
Article
Environmental Sciences
Simone Caetani Machado, Bruna Maciel Souza, Luiz Paulo de Aguiar Marciano, Ana Flavia Souza Pereira, Maisa Ribeiro Pereira Lima Brigagao, Andre Luiz Machado Viana, Maria Rita Rodrigues, Isarita Martins
Summary: The study evaluated potential endpoint biomarkers for triazole exposure in Minas Gerais, Brazil, with significant differences found in plasma concentration of androstenedione and glycineconjugated bile acids. However, further research is needed to determine the applicability of oxidative stress, testosterone levels, unconjugated, and taurine conjugated bile acids as biomarkers for triazole exposure, as no statistical significance was reached between the groups.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tomasz Pienkowski, Tomasz Kowalczyk, Noemi Garcia-Romero, Angel Ayuso-Sacido, Michal Ciborowski
Summary: The diagnosis of glioma relies on imaging methods that cannot differentiate between different stages and subtypes. Patients are usually diagnosed in the symptomatic stage. Molecular alterations and tumor biomarkers can be used to diagnose asymptomatic gliomas. A multiomics approach can track physiological changes and serve as a non-invasive diagnostic method.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Review
Oncology
Yirizhati Aili, Nuersimanguli Maimaitiming, Yusufu Mahemuti, Hu Qin, Yongxin Wang, Zengliang Wang
Summary: Gliomas are central nervous system tumors with poor prognosis, where exosomal miRNA plays a significant role in their occurrence, development, invasion, metastasis, and treatment resistance. Further systematic research on the association of exosomal miRNA in gliomas is needed for innovative diagnosis and treatment approaches.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Tomasz Pienkowski, Tomasz Kowalczyk, Adam Kretowski, Michal Ciborowski
Summary: Brain tumors, particularly gliomas, present challenges in diagnosis and treatment. Proteomic biomarkers offer potential for improved diagnostic accuracy and personalized therapies, but limitations exist in distinguishing specific tumor subtypes with single markers. Correlations between proposed proteins may aid in therapeutic decision-making and targeting disrupted pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Ionut-Gabriel Funingana, Pubudu Piyatissa, Marika Reinius, Cathal McCague, Bristi Basu, Evis Sala
Summary: This review aims to identify the challenges and opportunities for discovering new imaging-based biomarkers in single-site solid tumors, focusing on segmentation, validation, and data sharing strategies.
Article
Hematology
Jason Gotlib
Summary: Polycythemia vera is a myeloproliferative neoplasm driven by mutations, and treatment selection should consider various variables. Obtaining high-level evidence is challenging due to low event rates and longer-term endpoints.
Article
Medicine, Research & Experimental
Phei Er Saw, Xiaoding Xu, Bo Ram Kang, Jungsul Lee, Yeo Song Lee, Chungyeul Kim, Hyungsin Kim, Shin-Hyuk Kang, Yoo Jin Na, Hong Joo Moon, Joo Han Kim, Youn-Kwan Park, Wonki Yoon, Jong Hyun Kim, Taek-Hyun Kwon, Chulhee Choi, Sangyong Jon, Kyuha Chong
Summary: This study evaluates the practicality of using EDB-FN as a biomarker and therapeutic target for malignant gliomas through patient data analysis and nanoparticle technology, demonstrating its potential as an effective drug delivery target and biomarker for MG.
Review
Immunology
Xiaoke Wu, Mengmeng Shi, Yajun Lian, Haifeng Zhang
Summary: Liquid biopsy strategies can detect changes in circulating biomarkers for noninvasive diagnosis, monitoring, and treatment of diseases, including cancers. Glioma is a common intracranial malignancy with poor prognosis, and early diagnosis and treatment are crucial for patient outcomes. Exosomal circRNAs play a role in the onset and progression of glioma. Detecting exosomal circRNAs by liquid biopsy has significant potential for monitoring dynamic changes in glioma. This review provides an overview of liquid biopsy biomarkers and discusses the potential application of exosomal circRNAs in diagnosing, treating, and prognostic evaluation of glioma patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Mary M. Reilly, David N. Herrmann, Davide Pareyson, Steven S. Scherer, Richard S. Finkel, Stephan Zuechner, Joshua Burns, Michael E. Shy
Summary: Heritable neurological disorders provide insights into disease mechanisms, facilitating the development of novel therapeutic approaches. The challenges of measuring disease progression in rare and slowly progressive neurogenetic diseases are addressed through the development of clinical outcome assessments and disease biomarkers in inherited peripheral neuropathies. It is proposed that carefully developed biomarkers from imaging, plasma, or skin can predict meaningful progression in functional and patient-reported outcome assessments, enabling feasible clinical trials within a shorter duration for these rare and ultra-rare disorders.
ANNALS OF NEUROLOGY
(2023)
Review
Oncology
Malik Galijasevic, Ruth Steiger, Stephanie Mangesius, Julian Mangesius, Johannes Kerschbaumer, Christian Franz Freyschlag, Nadja Gruber, Tanja Janjic, Elke Ruth Gizewski, Astrid Ellen Grams
Summary: This review provides an insight into the use of magnetic resonance spectroscopy (MRS) in the diagnosis and follow-up of gliomas. It covers both proton and phosphorous MRS techniques in clinical and scientific practice, including preoperative grade prediction and post-treatment follow-up. The review also discusses the current research utility and possible future strategies of proton and phosphorous MRS in glioma research.
Article
Engineering, Environmental
Alex Rodrigues Gomes, Italo Nascimento Freitas, Thiarlen Marinho da Luz, Abraao Tiago Batista Guimaraes, Amanda Pereira da Costa Araujo, Chinnaperumal Kamaraj, Md. Mostafizur Rahman, Abu Reza Md. Towfiqul Islam, Andres Hugo Arias, Fabia Barbosa da Silva, Sengodan Karthi, Omar Cruz-Santiago, Fabiano Guimaraes Silva, Guilherme Malafaia
Summary: Recently, there has been increasing attention on the impacts of microplastics (MPs) on plants. This study aimed to evaluate the effects of polyethylene MPs (PE MPs) on Salvinia auriculata, a freshwater vascular plant. The results showed that exposure to PE MPs caused changes in plant growth/development, epidermal thickness, leaf necrosis, chlorosis, and root deformations. Additionally, exposure to PE MPs resulted in lower chlorophyll content, cell membrane damage, and redox imbalance. The study highlights the potential hazards of putting MPs in freshwater environments from an ecotoxicological perspective.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Clinical Neurology
Jimin He, Yao Jiang, Liang Liu, Zhihua Zuo, Chun Zeng
Summary: A meta-analysis was conducted on 24 studies involving a total of 2,170 glioma patients and 1,456 healthy participants, which revealed the potential of circulating miRNAs as diagnostic biomarkers for gliomas, pending validation through large prospective studies.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Juan Yue, Roujie Huang, Zehao Lan, Bo Xiao, Zhaohui Luo
Summary: This paper summarizes the potential crucial role of glycosylation in the discovery of novel biomarkers and targeted treatment options for gliomas by regulating protein glycosylation changes and abnormal expression of glycosylation-related proteins.
BIOMARKER RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robin Wang, Zhicheng Jiao, Li Yang, Ji Whae Choi, Zeng Xiong, Kasey Halsey, Thi My Linh Tran, Ian Pan, Scott A. Collins, Xue Feng, Jing Wu, Ken Chang, Lin-Bo Shi, Shuai Yang, Qi-Zhi Yu, Jie Liu, Fei-Xian Fu, Xiao-Long Jiang, Dong-Cui Wang, Li-Ping Zhu, Xiao-Ping Yi, Terrance T. Healey, Qiu-Hua Zeng, Tao Liu, Ping-Feng Hu, Raymond Y. Huang, Yi-Hui Li, Ronnie A. Sebro, Paul J. L. Zhang, Jianxin Wang, Michael K. Atalay, Wei-Hua Liao, Yong Fan, Harrison X. Bai
Summary: This study successfully developed an artificial intelligence system that integrates chest CT and clinical data to predict the risk of future deterioration to critical illness in COVID-19 patients. The AI system accurately triaged patients, identified high-risk individuals, and guided personalized treatment.
EUROPEAN RADIOLOGY
(2022)
Article
Oncology
Raymond Y. Huang, Whitney B. Pope
HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
(2022)
Editorial Material
Oncology
Rifaquat Rahman, Raymond Y. Huang
Article
Clinical Neurology
Marianela Schiava, Rachel Amos, Henriette VanRuiten, Michael P. McDermott, Williams B. Martens, Stephanie Gregory, Anna Mayhew, Elaine McColl, Rabi Tawil, Tracey Willis, Kate Bushby, Robert C. Griggs, Michela Guglieri
Summary: This article describes the clinical and genetic characteristics of a sample of young glucocorticoid-naive boys with DMD, highlighting the importance of early diagnosis and providing information for future clinical trial study design.
Article
Clinical Neurology
Jennifer Vermilion, Erika F. Augustine, Heather R. Adams, Amy Vierhile, Alyssa T. Collins, Michael P. McDermott, Thomas G. O'Connor, Roger Kurlan, Edwin van Wijngaarden, Jonathan W. Mink
Summary: The study found no significant differences in risky behaviors between youth with TS and control youth, but ADHD was more common in youth with TS, and those who were bullied in school had higher ADHD symptom severity scores.
PEDIATRIC NEUROLOGY
(2022)
Article
Veterinary Sciences
Michael P. McDermott, Malcolm A. Cobb, Iain J. Robbe, Rachel S. Dean
Summary: This study aimed to analyze the frequency and types of dialogue directed to animals by veterinary surgeons in routine companion animal consultations. The results showed that pet-directed speech was present in all consultations, with codes such as 'praise,' 'small talk,' and 'explanation' being the most common.
Article
Multidisciplinary Sciences
John D. Isaacs, Sarah Brockbank, Ayako Wakatsuki Pedersen, Catharien Hilkens, Amy Anderson, Philip Stocks, Dennis Lendrem, Jessica Tarn, Graham R. Smith, Ben Allen, John Casement, Julie Diboll, Rachel Harry, Faye A. H. Cooles, Andrew P. Cope, Gemma Simpson, Ruth Toward, Hayley Noble, Angela Parke, Wing Wu, Fiona Clarke, David Scott, Ian C. Scott, James Galloway, Heidi Lempp, Fowzia Ibrahim, Samana Schwank, Gemma Molyneux, Tomi Lazarov, Frederic Geissmann, Carl S. Goodyear, Iain B. McInnes, Iona Donnelly, Ashley Gilmour, Aysin Tulunay Virlan, Duncan Porter, Frederique Ponchel, Paul Emery, Jehan El-Jawhari, Rekha Parmar, Michael F. McDermott, Benjamin A. Fisher, Steve P. Young, Philip Jones, Karim Raza, Andrew Filer, Costantino Pitzalis, Michael R. Barnes, David S. Watson, Rafael Henkin, Georgina Thorborn, Liliane Fossati-Jimack, Stephen Kelly, Frances Humby, Michele Bombardieri, Sharmila Rana, Zhilong Jia, Katriona Goldmann, Myles Lewis, Sandra Ng, Adriano Barbosa-Silva, Evan Tzanis, Amaya Gallagher-Syed, Christopher R. John, Michael R. Ehrenstein, Gioia Altobelli, Sandra Martins, Dao Nguyen, Humayara Ali, Coziana Ciurtin, Maya Buch, Deborah Symmons, Jane Worthington, Ian N. Bruce, Jamie C. Sergeant, Suzanne M. M. Verstappen, Fiona Stirling, Adwoa Hughes-Morley, Brian Tom, Vernon Farewell, Yujie Zhong, Peter C. Taylor, Christopher D. Buckley, Sarah Keidel, Carolyn Cuff, Marc Levesque, Andrew Long, Zheng Liu, Samantha Lipsky, Bohdan Harvey, Michael Macoritto, Feng Hong, Sukru Kaymakcalan, Wayne Tsuji, Tony Sabin, Neil Ward, Susan Talbot, Desmond Padhji, Matthew Sleeman, Donna Finch, Athula Herath, Catharina Lindholm, Martin Jenkins, Meilien Ho, Sally Hollis, Chris Marshall, Gerry Parker, Matt Page, Hannah Edwards, Alexandru Cuza, Neil Gozzard, Ioannis Pandis, Anthony Rowe, Francisco Bonachela Capdevila, Matthew J. Loza, Mark Curran, Denny Verbeeck, Dan Baker, Christopher M. Mela, Ivana Vranic, Catherine T. Mela, Stephen Wright, Lucy Rowell, Emma Vernon, Nina Joseph, Neil Payne, Ravi Rao, Michael Binks, Alexandra Belson, Valerie Ludbrook, Kirsty Hicks, Hannah Tipney, Joanne Ellis, Samiul Hasan, Arnaud Didierlaurent, Wivine Burny, Andrea Haynes, Chris Larminie, Ray Harris, Daniela Dastros-Pitei, Claudio Carini, Blerina Kola, Scott Jelinsky, Martin Hodge, Mateusz Maciejewski, Daniel Ziemek, Peter Schulz-Knappe, Hans-Dieter Zucht, Petra Budde, Mark Coles, James A. Butler, Simon Read
Summary: This study conducted comprehensive clinical and molecular profiling of early, drug naive RA patients, establishing a high-quality sample biobank and performing multi-omic immune phenotyping. The data obtained is expected to provide important insights into the pathogenesis, progression, and therapeutic response of RA.
Article
Rheumatology
Faye A. H. Cooles, Jessica Tarn, Dennis W. Lendrem, Najib Naamane, Chung M. A. Lin, Ben Millar, Nicola J. Maney, Amy E. Anderson, Nishanthi Thalayasingam, Julie Diboll, Vincent Bondet, Darragh Duffy, Michael R. Barnes, Graham R. Smith, Sandra Ng, David Watson, Rafael Henkin, Andrew P. Cope, Louise N. Reynard, Arthur G. Pratt, John D. Isaacs
Summary: The interferon gene signature (IGS) in early, treatment naive rheumatoid arthritis (eRA) patients can negatively affect initial treatment response by causing sustained, epigenetically mediated increases in lymphocyte activation and proliferation. This highlights the importance of the IGS as a prognostic biomarker and suggests the rationale for targeting IFN-alpha in selected eRA patients.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Cell Biology
Flora Magnotti, Daria Chirita, Sarah Dalmon, Amandine Martin, Pauline Bronnec, Jeremy Sousa, Olivier Helynck, Wonyong Lee, Daniel L. Kastner, Jae Jin Chae, Michael F. McDermott, Alexandre Belot, Michel Popoff, Pascal Seve, Sophie Georgin-Lavialle, Helene Munier-Lehmann, Tu Anh Tran, Ellen De Langhe, Carine Wouters, Yvan Jamilloux, Thomas Henry
Summary: This study identifies an unconventional activation mechanism of the pyrin inflammasome and explains the impact of endogenous steroid catabolites on autoinflammation, providing an explanation for steroid fever after steroid injection.
Article
Oncology
Sana Abbasi, Helia Rivand, Fatemeh Eshaghi, Mohammad Amin Moosavi, Saeid Amanpour, Michael F. Mcdermott, Marveh Rahmati
Summary: This study aimed to sensitize colorectal cancer cells to chemotherapy by targeting the IRE1a/XBP1 pathway. The results showed that the IRE1a inhibitor 4 mu 8C inhibited CRC cell growth and enhanced the cytotoxicity of 5-FU. In vivo experiments demonstrated that 4 mu 8C inhibited tumor growth and significantly enhanced drug responses when combined with 5-FU.
Letter
Hematology
Adam Al-Hakim, Alyssa Cull, Joanna Topping, Fatima Nadat, Joanna Milek, Razan F. Alhefzi, Michael F. McDermott, Roger Owen, Catherine Cargo, James G. Poulter, David G. Kent, Sinisa Savic, ImmunAID Consortium
Letter
Clinical Neurology
Theodore H. Schwartz, Michael W. McDermott
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Psychology, Multidisciplinary
Ethan Hayes, Michael McDermott
ANNALS OF BEHAVIORAL MEDICINE
(2022)
Article
Clinical Neurology
Maria R. H. Castro, Stephen T. Magill, Ramin A. Morshed, Jacob S. Young, Steve E. Braunstein, Michael W. McDermott, Edward F. Chang
Summary: Most patients with facial sensory symptoms caused by meningiomas or vestibular schwannomas (VSs) experienced improvement after tumor resection. Surgery led to immediate and sustained improvement in pain and paresthesias, whereas numbness was slower to improve. Patients with smaller tumors and complete decompression of the trigeminal nerve were more likely to experience improvement in facial pain.
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Jamison Seabury, Jennifer Weinstein, Spencer Rosero, Anika Varma, Ellen Wagner, Christine Zizzi, Nuran Dilek, Michael McDermott, Aaron Kaat, Lawrence Saubermann, Larissa Temple, Scott Rogoff, Chad Heatwole, Zach Rose
