Article
Agriculture, Dairy & Animal Science
Xiao Wang, Wei Liu, Ying Liu, Yulan Jiao, Chang Rong, Qi Liu, Wanyu Shi
Summary: Early use of florfenicol (FFC) can adversely affect the health of broilers and cause kidney injury. This study used transcriptome and proteome sequencing to explore the regulatory effect of FFC on specific signal pathways in injured kidneys. The results showed that FFC exposure significantly altered the expression levels of hundreds of genes and proteins in chick kidneys, including those involved in the cell adhesion molecules signaling pathway. Further analysis revealed that these changes were associated with inflammation and apoptosis in renal tissues.
Article
Hematology
Farah Abdel Rahman, Sascha D'Almeida, Tina Zhang, Morad Asadi, Tarik Bozoglu, Dario Bongiovanni, Moritz von Scheidt, Steffen Dietzel, Edzard Schwedhelm, Rabea Hinkel, Karl Ludwig Laugwitz, Christian Kupatt, Tilman Ziegler
Summary: In sepsis, S1P acts as an antagonist to pericyte loss, vascular hyperpermeability, and systemic hypotension, resulting in increased survival in mice. By preserving the deposition of VE-cadherin and N-cadherin, S1P may achieve this effect through reduction of protein phosphorylation and increased nuclear translocation of MRTF-A.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Pharmacology & Pharmacy
Sreelakshmi N. Menon, Farzana Zerin, Emmanuella Ezewudo, Nimi P. Simon, Sreeranjini N. Menon, Morgan L. Daniel, Andrea J. Green, Ajay Pandey, Charles E. Mackay, Sherif Hafez, Nader H. Moniri, Raquibul Hasan
Summary: Neflamapimod effectively inhibits endothelial cell activation, adhesion molecule expression, and leukocyte attachment, thereby reducing vascular inflammation.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Mengdie Yin, Chao Li, Jiali Jiang, Jingqing Le, Bangyue Luo, Fang Yang, Yifan Fang, Mingyue Yang, Zhenhua Deng, Wenxin Ni, Jingwei Shao
Summary: Atherosclerosis is a leading cause of human morbidity and mortality worldwide, characterized by pathological constriction of blood vessels due to chronic low-grade inflammation and lipid deposition. Cell adhesion molecules play a key role in regulating the inflammatory response and endothelial function, with potential therapeutic strategies based on CAM inhibitors showing promising results in combating atherosclerotic progression.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Hematology
Vijay Kondreddy, Jhansi Magisetty, Shiva Keshava, L. Vijaya Mohan Rao, Usha R. Pendurthi
Summary: The study aims to investigate the role of Gab2 in inflammatory signaling pathways and its contribution to vascular dysfunction. The results show that silencing Gab2 can significantly attenuate the expression of TF, cell adhesion molecules, and inflammatory cytokines/chemokines induced by cytokines.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Giacomo S. Amelio, Livia Provitera, Genny Raffaeli, Ilaria Amodeo, Silvia Gulden, Valeria Cortesi, Francesca Manzoni, Nicola Pesenti, Matteo Tripodi, Valentina Pravata, Caterina Lonati, Gaia Cervellini, Fabio Mosca, Giacomo Cavallaro
Summary: This study investigates the perinatal endothelial phenotype in very preterm infants and its predictive value on neonatal mortality and hemodynamic and respiratory complications. The results suggest that very preterm infants have a proinflammatory endothelial phenotype, possibly resulting from a combination of pathological prenatal inheritance and premature extrauterine transition.
Article
Biochemistry & Molecular Biology
Taiki Tojo, Minako Yamaoka-Tojo
Summary: This study investigated the molecular and cellular mechanisms underlying stenotic calcification of the aortic valve. Gene expression analysis of human aortic stenosis and normal aortic valve tissue identified differentially expressed genes (DEGs) associated with valve calcification and disease progression. Protein-protein interaction analysis revealed hub genes that could serve as potential biomarkers and therapeutic targets for aortic stenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Noureddine Ben Khalaf, Dalal Al-Mehatab, Dahmani M. Fathallah
Summary: In this study, it was shown that ERp72 is overexpressed on vascular endothelial cells in the early phase of the inflammatory response following skeletal muscle injury. This upregulation of ERp72 may potentially play a role in skeletal muscle inflammation and modulate leukocyte-endothelial cell interactions.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Rehabilitation
Jannis Papathanasiou, Ivo Petrov, Dorothea Tsekoura, Yannis Dionyssiotis, Arthur S. Ferreira, Agnaldo J. Lopes, Concetta Ljoka, Calogero Foti
Summary: This study aimed to quantify the effects of 12-week group-based high-intensity aerobic interval training (HIAIT)/modified group-based HIAIT intervention (m-Ullevaal) vs. moderate continuous training (MICT) on serum levels of proinflammatory biomarkers in patients with chronic heart failure. The results showed that HIAIT/m-Ullevaal intervention significantly reduced the levels of proinflammatory biomarkers in patients with CHF.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Cell Biology
Zichao Luo, Erlinda The, Peijian Zhang, Yufeng Zhai, Qingzhou Yao, Lihua Ao, Qingchun Zeng, David A. Fullerton, Xianzhong Meng
Summary: This study found that monocytes enhance inflammatory responses in aortic valve interstitial cells (AVICs) to soluble extracellular matrix (ECM) protein. Monocyte beta(2)-integrin interacts with AVIC ICAM-1 to augment AVIC inflammatory responses by enhancing the activation of YAP and NF-kappa B signaling pathways.
INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sara Franceschelli, Federica De Cecco, Mirko Pesce, Patrizio Ripari, Maria Teresa Guagnano, Arturo Bravo Nuevo, Alfredo Grilli, Silvia Sancilio, Lorenza Speranza
Summary: This study aimed to investigate whether hydroxytyrosol (HT), a phenolic compound with anti-inflammatory and antioxidant properties, can reduce cholesterol accumulation in foam cells derived from THP-1 macrophages, and to explore the underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Junqi Wang, Xiaoping Chen
Summary: This review summarizes the roles of JAMs in the development of atherosclerosis and predicts future research directions.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Maximilian Mauler, Nancy Schanze, Krystin Krauel, Claudia Schoenichen, Franziska Glatzki, Susanna Poeschl, Daniela Stallmann, Julius Mezger, Nadine Gauchel, Diana Sharipova, Marina Rieder, Ingo Hilgendorf, Thilo Witsch, Christoph Bode, Daniel Duerschmied
Summary: Peripheral serotonin seems to have no effect on endothelial adhesion molecule expression, despite its influence on neutrophil function. The inflammatory release of peripheral serotonin appears to be unnecessary for regulating endothelial adhesion molecules.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Medicine, General & Internal
Amedeo Tirandi, Cosimo Sgura, Federico Carbone, Fabrizio Montecucco, Luca Liberale
Summary: Ischemic stroke is the second leading cause of death globally and a major cause of morbidity. Current therapeutic options are limited to early reperfusion strategies, while pharmacological neuroprotective strategies have failed to enter clinical practice despite promising results in experiments. Inflammation plays a significant role in the pathophysiology of ischemic stroke, and inflammatory mediators have been investigated as potential prognostic markers and therapeutic targets. This article summarizes the available evidence on the role of cytokines, soluble adhesion molecules, and adipokines in the pathophysiology, prognosis, and therapy of ischemic stroke.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Clinical Neurology
Rebecca Isabella Sienel, Hiroharu Kataoka, Seong-Woong Kim, Fatma Burcu Seker, Nikolaus Plesnila
Summary: This study reveals that the adhesion of leukocytes to the cerebrovascular endothelium is transient and inhibiting this process can partially prevent ischemic brain injury.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, Timothy Collier, Andrew L. Clark, Mamas A. Mamas, Hans-Peter Brunner-La Rocca, Stephane Heymans, Arantxa Gonzalez, Fozia Z. Ahmed, Johannes Petutschnigg, Blerim Mujaj, Joe Cuthbert, Philippe Rouet, Pierpaolo Pellicori, Beatrice Mariottoni, Franco Cosmi, Frank Edelmann, Lutgarde Thijs, Jan A. Staessen, Mark Hazebroek, Job Verdonschot, Patrick Rossignol, Nicolas Girerd, John G. Cleland, Faiez Zannad
Summary: The study examined the effects of spironolactone on blood pressure in patients at risk for heart failure, finding that it had a significant blood pressure-lowering effect, especially in those with lower baseline blood pressure levels. Spironolactone may be considered for blood pressure management in patients at risk for developing heart failure.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Editorial Material
Peripheral Vascular Disease
Scott Leopold, Rhian Touyz, Anna F. Dominiczak, Joseph T. Flynn, Anna Szyndler, Justin P. Zachariah
Article
Cardiac & Cardiovascular Systems
Dongmei Wei, Sander Trenson, Jan M. Van Keer, Jesus Melgarejo, Ella Cutsforth, Lutgarde Thijs, Tianlin He, Agnieszka Latosinska, Agnieszka Ciarka, Thomas Vanassche, Lucas Van Aelst, Stefan Janssens, Johan Van Cleemput, Harald Mischak, Jan A. Staessen, Peter Verhamme, Zhen-Yu Zhang
Summary: This study identified and validated a urinary proteomic signature for the surveillance of cardiac allograft vasculopathy (CAV). The proteins in the signature may offer insights into CAV pathological processes and warrant further investigation into personalized treatment targets.
Article
Cardiac & Cardiovascular Systems
Carlo Maj, Erika Salvi, Lorena Citterio, Oleg Borisov, Marco Simonini, Valeria Glorioso, Cristina Barlassina, Nicola Glorioso, Lutgarde Thijs, Tatiana Kuznetsova, Francesco P. Cappuccio, Zhen-Yu Zhang, Jan A. Staessen, Daniele Cusi, Chiara Lanzani, Paolo Manunta
Summary: Genome-wide association studies have identified numerous genetic loci associated with hypertension, indicating a polygenic architecture. By assessing polygenic risk scores, it was found that risk alleles are enriched in hypertensive cases, while protective alleles may be enriched in normotensive controls. Moreover, pathway-specific analysis revealed an association of hypertension with specific biological pathways, such as the calcium signaling pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Peripheral Vascular Disease
Jing Chen, Xin Chen, Anna F. Dominiczak, Robert M. Carey, Cheryl L. Laffer, Fernando Elijovich, Sandra J. Taler, Tanja Dudenbostel, Rhian M. Touyz, Ji-Guang Wang
Article
Genetics & Heredity
Nhu Ngoc Le, Tran Q. B. Tran, Stefanie Lip, Linsay McCallum, John McClure, Anna F. Dominiczak, Dipender Gill, Sandosh Padmanabhan
Summary: The genetic predisposition to high systolic blood pressure is associated with an increased risk of cardiovascular diseases such as coronary artery disease, stroke, heart failure, atrial fibrillation, and type 2 diabetes mellitus. Similarly, genetic predisposition to high diastolic blood pressure is associated with an increased risk of stroke and coronary artery disease.
Article
Pediatrics
Liselotte Van Loo, Karel Allegaert, Elena Levtchenko, Zhenyu Zhang, Jan A. Staessen, Anke Raaijmakers
Summary: This study investigated endothelial integrity in healthy controls and extremely low birth weight (ELBW) survivors. The results suggest that perfused boundary region (PBR) may not be a suitable biomarker for endothelial integrity in ELBW survivors, despite observations of changes in blood pressure and vascularization. These findings highlight the importance of studying and understanding the complex structure of the endothelial glycocalyx in ELBW survivors.
PEDIATRIC RESEARCH
(2023)
Article
Peripheral Vascular Disease
Jesus D. Melgarejo, Meike W. Vernooij, M. Arfan Ikram, Zhen-Yu Zhang, Daniel Bos
Summary: Intracranial arteriosclerosis mediates the link between blood pressure and cerebral small vessel disease. Internal elastic lamina calcification, as a marker of arterial stiffness, is the main mechanism explaining this association.
Article
Nutrition & Dietetics
Francois Haddad, Xiao Li, Dalia Perelman, Everton Jose Santana, Tatiana Kuznetsova, Nicholas Cauwenberghs, Vincent Busque, Kevin Contrepois, Michael P. Snyder, Mary B. Leonard, Christopher Gardner
Summary: The study quantified the bias introduced by ratiometric scaling of resting energy expenditure (REE) using total body weight (BW) in obesity or weight loss intervention. Allometric scaling of REE based on lean body mass (LBM) and fat mass (FM) removed body composition biases and should be considered in obesity and weight-based intervention studies.
CLINICAL NUTRITION ESPEN
(2023)
Article
Peripheral Vascular Disease
Ben Grobman, Ruth-Alma N. Turkson-Ocran, Jan A. Staessen, Yu-Ling Yu, Lewis A. Lipsitz, Kenneth J. Mukamal, Stephen P. Juraschek
Summary: Using data from the Syst-Eur trial, this study examined the effect of hypertension treatment on the incidence of orthostatic hypotension based on different body positions. The results showed that active hypertension treatment did not increase the risk of orthostatic hypotension, regardless of the testing protocol used.
Review
Spectroscopy
De-Wei An, Yu-Ling Yu, Dries S. S. Martens, Agnieszka Latosinska, Zhen-Yu Zhang, Harald Mischak, Tim S. S. Nawrot, Jan A. A. Staessen
Summary: Using urinary proteomics profiling (UPP) as an example, this review presents a workflow for analyzing omics data in large study populations. The workflow includes planning and considering sample size, data preprocessing, statistical steps for data curation, selecting covariables, relating outcomes to markers, demonstrating the added value of UPP markers, and pathway analysis. The review also touches on multiomics studies and machine learning. In conclusion, analyzing adverse health outcomes in relation to omics biomarkers requires careful planning, data preparation, statistical analysis, and presentation.
MASS SPECTROMETRY REVIEWS
(2023)
Article
Public, Environmental & Occupational Health
Jill Vanthienen, Marine Vassilev Petrov, Thuy Mai Luu, Anik Cloutier, Anke Raaijmakers, Jan A. Staessen, Zhenyu Zhang, Thomas Salaets, Annouschka Laenen, Anne Smits, Anne-Monique Nuyt, Adrien Flahault, Karel Allegaert
Summary: The study found no significant difference in QT(c-Bazett) intervals between former preterm and/or extremely low birth weight cases and term-born controls.
Article
Peripheral Vascular Disease
Catriona E. Brown, Helen Casey, Anna F. Dominiczak, Shona Kerr, Archie Campbell, Christian Delles
Summary: A study on the Scottish population found that women with a history of preeclampsia have a higher risk of cardiovascular events in the future. Among women with pregnancies, the proportion of cardiovascular events in the preeclampsia group was 25/5253, compared to 193/5253 in the normotensive group. The study highlights the importance of implementing uniform guidelines to improve the health of women with this medical history.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Peripheral Vascular Disease
Yu-Ling Yu, De-Wei An, Wen-Yi Yang, Peter Verhamme, Karel Allegaert, Tim S. Nawrot, Jan A. Staessen
Summary: The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure and renal function responses in workers without previous occupational lead exposure over a period of 6 years. The results showed that there was no significant correlation between the changes in blood pressure and renal function and the increase in blood lead level. Therefore, it can be concluded that modern lead-handling facilities operating under current safety rules are safe.
JOURNAL OF CLINICAL HYPERTENSION
(2023)