Article
Geriatrics & Gerontology
Xiaomeng Chen, Yi Liu, Valerie Thompson, Nadia M. Chu, Elizabeth A. King, Jeremy D. Walston, Jon A. Kobashigawa, Darshana M. Dadhania, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: The assessment of frailty in kidney transplant centers has an impact on pre- and post-transplant outcomes, especially in older patients. Using validated frailty assessment tools improves survival rates and can help allocate healthcare resources more effectively.
Review
Surgery
Adnan Sharif
Summary: Kidney transplantation is the preferred treatment for kidney failure patients, but the shortage of organs often leads to death or removal from the waiting list before receiving a kidney. Maximizing the use of deceased donor kidneys requires careful decision-making and understanding the relationship between donor characteristics and transplant outcomes.
TRANSPLANT INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Jia-Jin Chen, George Kuo, Tao Han Lee, Huang-Yu Yang, Hsin Hsu Wu, Kun-Hua Tu, Ya-Chung Tian
Summary: A systematic review and meta-analysis on the impact of COVID-19 on kidney transplant recipients revealed high rates of mortality, intensive care unit admission, acute kidney injury, kidney replacement therapy, with advancing age associated with higher mortality. Regional differences in outcomes were also detected. Further research on treatments and risk factors identification is needed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Wieteke Kleinherenbrink, Marije Baas, Gizal Nakhsbandi, Dennis A. Hesselink, Joke Roodnat, Brenda C. de Winter, Luuk Hilbrands, Teun van Gelder
Summary: The study found that delayed graft function and rejection significantly increased the risk of CMV disease in renal transplant recipients. Valganciclovir prophylaxis may not provide sufficient protection for CMV IgG-seronegative recipients receiving a kidney from CMV IgG-seropositive donor, especially those with delayed graft function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Transplantation
Adrian Post, Daan Kremer, Dion Groothof, Ulrike Seidel, Patricia Huebbe, Casper F. M. Franssen, Ido P. Kema, Kai Lueersen, Gerald Rimbach, Stephan J. L. Bakker
Summary: This study aimed to investigate whether urinary lithium excretion is associated with adverse long-term kidney graft outcomes and patient survival. Through testing the urinary lithium concentration in 642 stable kidney transplant recipients, it was found that higher urinary lithium excretion was associated with a lower risk of graft failure, kidney function decline, and all-cause mortality. These findings suggest that dietary lithium intake may be a modifiable risk factor for adverse long-term kidney graft outcomes and patient survival.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Immunology
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Pierre Tiberghien, Didier Ducloux
Summary: Early red blood cell transfusion after kidney transplantation is associated with increased transplant failure.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Saifu Yin, Xianding Wang, Linde Li, Zhongli Huang, Yu Fan, Turun Song, Tao Lin
Summary: Vitamin D deficiency is common early after kidney transplant and is associated with higher risk of death and adverse outcomes.
Article
Immunology
Lukas Frischknecht, Yun Deng, Caroline Wehmeier, Olivier de Rougemont, Jean Villard, Sylvie Ferrari-Lacraz, Dela Golshayan, Monique Gannage, Isabelle Binet, Urs Wirthmueller, Daniel Sidler, Thomas Schachtner, Stefan Schaub, Jakob Nilsson
Summary: This study investigates the impact of pre-transplant donor specific antibodies (DSA) on kidney transplantation outcomes. The results show that DSA is associated with increased risk of antibody-mediated rejection, graft loss, and accelerated decline in eGFR. The target HLA antigen and mean fluorescence intensity (MFI) of DSA play significant roles in the outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Christopher D. Blosser, Gregory Haber, Eric A. Engels
Summary: Over the past 30 years in the United States, there has been no significant overall change in cancer incidence among kidney transplant recipients. Despite improvements for non-Hodgkin lymphoma, cancer remains a major cause of morbidity and mortality for these individuals.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Ajit P. Limaye, Klemens Budde, Atul Humar, Flavio Vincenti, Dirk R. J. Kuypers, Robert P. Carroll, Nicole Stauffer, Yoshihiko Murata, Julie M. Strizki, Valerie L. Teal, Christopher L. Gilbert, Barbara A. Haber
Summary: This study compared the efficacy and safety of letermovir with valganciclovir in preventing cytomegalovirus (CMV) disease in kidney transplant recipients. Results showed that letermovir was as effective as valganciclovir in preventing CMV disease over 52 weeks, with lower rates of leukopenia or neutropenia, supporting its use for this indication.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Surgery
Kyla L. Naylor, S. Joseph Kim, John Paul Kuwornu, Stephanie N. Dixon, Amit X. Garg, Megan K. McCallum, Gregory A. Knoll
Summary: The association between pre-transplant dialysis duration and post-transplant outcomes varies, and longer time on dialysis is associated with an increased rate of several adverse post-transplant outcomes.
CLINICAL TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Cihan Heybeli, Andrew J. Bentall, Mariam Priya Alexander, Hatem Amer, Francis K. Buadi, Angela Dispenzieri, David Dingli, Morie A. Gertz, Naim Issa, Prashant Kapoor, Aleksandra Kukla, Shaji Kumar, Elizabeth C. Lorenz, S. Vincent Rajkumar, Carrie A. Schinstock, Nelson Leung
Summary: Data on kidney transplantation outcomes for patients with multiple myeloma are limited. This study investigated the outcomes of kidney transplantation in multiple myeloma patients between 1994 and 2019. The results showed that patients who received bortezomib treatment had better outcomes, but there was still a risk of relapse. Further research is needed to determine which patients benefit from kidney transplantation.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Anna Radajewska, Anna Krzywonos-Zawadzka, Iwona Bil-Lula
Summary: Kidney transplantation is the standard procedure for treating end-stage renal disease, and machine perfusion has been proven to be a better solution for organ preservation and monitoring.
Article
Urology & Nephrology
David Massicotte-Azarniouch, Manish M. Sood, Dean A. Fergusson, Michael Chasse, Alan Tinmouth, Greg A. Knoll
Summary: This study found that post-kidney transplant RBCT was not associated with rejection, but may increase the risk of death-censored graft loss. The risk of DCGL increased with the number of RBCTs received.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Immunology
Maria O. Lopez-Oliva, Virginia Martinez, Aranzazu Rodriguez-Sanz, Laura Alvarez, M. Jose Santana, Rafael Selgas, Carlos Jimenez, Teresa Bellon
CLINICAL IMMUNOLOGY
(2020)
Article
Surgery
Maria J. Perez-Saez, Miquel Blasco, Dolores Redondo-Pachon, Pedro Ventura-Aguiar, Teresa Bada-Bosch, Isabel Perez-Flores, Edoardo Melilli, Luis A. Sanchez-Camara, Maria O. Lopez-Oliva, Cristina Canal, Amir Shabaka, Nuria Garra-Moncau, Paloma L. Martin-Moreno, Veronica Lopez, Roman Hernandez-Gallego, Orlando Siverio, Cristina Galeano, Jordi Espi-Reig, Carlos J. Cabezas, Maria T. Rodrigo, Laura Llinas-Mallol, Maria J. Fernandez-Reyes, Leonidas Cruzado-Vega, Lourdes Perez-Tamajon, Raquel Santana-Estupinan, Maria C. Ruiz-Fuentes, Guadalupe Tabernero, Sofia Zarraga, Juan C. Ruiz, Alex Gutierrez-Dalmau, Auxiliadora Mazuecos, Emilio Sanchez-Alvarez, Marta Crespo, Julio Pascual
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Immunology
Aurora Paez-Vega, Sara Cantisan, Maria L. Aguera, Marta Suner, Carmen Facundo, Jose R. Yuste, Mario Fernandez-Ruiz, Miguel Montejo, Dolores Redondo-Pachon, Maria O. Lopez-Oliva, Ana Fernandez-Rodriguez, Maria C. Farinas, Domingo Hernandez, Oscar Len, Patricia Munoz, Jorge Valle-Arroyo, Cristian Rodelo-Haad, Elisa Cordero, Julian Torre-Cisneros
Summary: This study focused on CMV-seropositive kidney transplant recipients, with over half of patients recovering or maintaining CMV-CMI within the first month post-transplantation. Pretransplant IFN-γ level showed a strong association with the recovery kinetics, while the ATG dose was not associated with CMV-CMI.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Julia Garcia Urban, Katia Gurrado, Paola C. Brea Rivas, Dina Abou Elrous, Monica Zubimendi Machain, Maria Romero Gomez, Julio Garcia Rodriguez, Blanca Vicandi Plaza, Laura Yebenes Gregorio, Eugenia Garcia Fernandez, Carlos Jimenez Martin, Maria-Ovidia Lopez Oliva, Elena Gonzalez Garcia, Gabriel Ledesma Sanchez, Gilda Carreno Cornejo, Rafael Selgas Gutierrez, Alejandro Zarauza Santovena, Marta Melgosa Hijosa, Carlota Fernandez Camblor, Yasmina Mozo del Castillo, Luisa Sisinni, David Bueno Sanchez, Antonio Perez-Martinez, Elena Sanchez Zapardiel, Eduardo Lopez Granados, Jaime Monserrat Villatoro, Rafael Hernandez Zabala, Alberto M. Borobia, Jesus Frias, Elena Ramirez
TRANSPLANT INFECTIOUS DISEASE
(2020)
Article
Surgery
Elisabeth Coll, Mario Fernandez-Ruiz, J. Emilio Sanchez-Alvarez, Jose R. Martinez-Fernandez, Marta Crespo, Jorge Gayoso, Teresa Bada-Bosch, Federico Oppenheimer, Francesc Moreso, Maria O. Lopez-Oliva, Edoardo Melilli, Marisa L. Rodriguez-Ferrero, Carlos Bravo, Elena Burgos, Carme Facundo, Inmaculada Lorenzo, Inigo Yanez, Cristina Galeano, Ana Roca, Mercedes Cabello, Manuel Gomez-Bueno, Ma Dolores Garcia-Cosio, Javier Graus, Laura Llado, Alicia de Pablo, Carmelo Loinaz, Beatriz Aguado, Domingo Hernandez, Beatriz Dominguez-Gil
Summary: This study reported the experience of solid organ and hematopoietic stem cell transplant recipients diagnosed with COVID-19 in Spain until July 13, 2020. The incidence of COVID-19 in transplant recipients was higher than the general population. Most patients required hospitalization, and adjusting immunosuppression could improve survival rates. Risk factors for death included age, lung transplantation, and hospital-acquired COVID-19.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Ligia C. Pierrotti, Elena Perez-Nadales, Mario Fernandez-Ruiz, Belen Gutierrez-Gutierrez, Ban Hock Tan, Jordi Carratala, Isabel Oriol, Mical Paul, Noa Cohen-Sinai, Francisco Lopez-Medrano, Rafael San-Juan, Miguel Montejo, Maristela P. Freire, Elisa Cordero, Miruna D. David, Esperanza Merino, Seema Mehta Steinke, Paolo A. Grossi, Angela Cano, Elena M. Seminari, Maricela Valerio, Filiz Gunseren, Meenakshi Rana, Alessandra Mularoni, Pilar Martin-Davila, Christian van Delden, Melike Hamiyet Demirkaya, Zeliha Kocak Tufan, Belen Loeches, Ranganathan N. Iyer, Fabio Soldani, Britt-Marie Eriksson, Benoit Pilmis, Marco Rizzi, Julien Coussement, Wanessa T. Clemente, Emmanuel Roilides, Alvaro Pascual, Luis Martinez-Martinez, Jesus Rodriguez-Bano, Julian Torre-Cisneros, Jose Maria Aguado
Summary: This retrospective study assessed the efficacy of BLBLI-based therapy compared to carbapenems for ESBL-E bloodstream infection secondary to UTI in kidney transplant recipients. The results suggest that BLBLI-based therapy may be as effective as carbapenems in this specific population, although potential confounding factors and sample size limitations should be considered.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Immunology
Jose Maria Portoles, Carlos Jimenez, Dario Janeiro, Maria O. Lopez-Oliva, Alvaro Ortega-Carrion, Daniel Blanquez, Luis Arribas, Carlos Gomez, Teresa Diez, Julio Pascual, Isabel Portero
Summary: Immunosuppressive drugs are crucial for treating autoimmune disorders and preventing rejection post organ transplant, but individual variations in drug response can affect efficacy. In vitro assays measuring immune cell responses to drugs offer promise for personalized immunosuppressive therapy. The Immunobiogram assay quantitatively measures a patient's immune response to a variety of immunosuppressants, aiding in tailored treatment and understanding resistance mechanisms.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Maria Ruiz-Ruigomez, Mario Fernandez-Ruiz, Jose Tiago Silva, Elisa Vidal, Julia Origuen, Antonia Calvo-Cano, Enrique Luna-Huerta, Esperanza Merino, Domingo Hernandez, Cristina Jironda-Gallegos, Rosa Escudero-Sanchez, Francesca Gioia, Antonio Moreno, Cristina Roca, Elisa Cordero, Dario Janeiro, Beatriz Sanchez-Sobrino, Maria Milagro Montero, Dolores Redondo, Francisco Javier Candel, Isabel Perez-Flores, Carlos Arminanzas, Claudia Gonzalez-Rico, Maria Carmen Farinas, Emilio Rodrigo, Belen Loeches, Maria O. Lopez-Oliva, Miguel Montejo, Ricardo Lauzurica, Juan Pablo Horcajada, Julio Pascual, Amado Andres, Jose Maria Aguado, Francisco Lopez-Medrano
Summary: Oral fosfomycin appears to be a suitable and safe alternative for the treatment of asymptomatic bacteriuria after kidney transplant, including episodes caused by multidrug-resistant uropathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Aurora Paez-Vega, Belen Gutierrez-Gutierrez, Maria L. Aguera, Carme Facundo, Dolores Redondo-Pachon, Marta Suner, Maria O. Lopez-Oliva, Jose R. Yuste, Miguel Montejo, Cristina Galeano-Alvarez, Juan C. Ruiz-San Millan, Ibai Los-Arcos, Domingo Hernandez, Mario Fernandez-Ruiz, Patricia Munoz, Jorge Valle-Arroyo, Angela Cano, Alberto Rodriguez-Benot, Marta Crespo, Cristian Rodelo-Haad, Maria A. Lobo-Acosta, Jose C. Garrido-Gracia, Elisa Vidal, Luis Guirado, Sara Cantisan, Julian Torre-Cisneros
Summary: For CMV-seropositive kidney transplant recipients receiving ATG induction, it is safe and effective to discontinue prophylaxis when CMV-CMI is recovered, as there is no significant increase in the incidence of CMV replication or disease. Immunoguided prevention is not inferior to prophylaxis in preventing CMV complications.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Allergy
S. Bautista-Villanueva, C. Galleani, R. Barranco, T. Bellon, M. Blanco, I Garcia-Moguel
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Elena Cantero-Navarro, Sandra Rayego-Mateos, Macarena Orejudo, Lucia Tejedor-Santamaria, Antonio Tejera-Munoz, Ana Belen Sanz, Laura Marquez-Exposito, Vanessa Marchant, Laura Santos-Sanchez, Jesus Egido, Alberto Ortiz, Teresa Bellon, Raul R. Rodrigues-Diez, Marta Ruiz-Ortega
Summary: Inflammation plays a crucial role in kidney disease, with immune cells contributing to both repair and progression depending on the stage of injury. The plasticity and complexity of immune cells pose challenges in translating findings from mouse models to human renal diseases.
FRONTIERS IN MEDICINE
(2021)
Article
Transplantation
Borja Quiroga, Maria Jose Soler, Alberto Ortiz, Amparo Bernat, Ana Beatriz Munoz Diaz, Carlos Jesus Jarava Mantecon, Virginia Olinda Gomez Perez, Carmen Calderon Gonzalez, Michal Cervienka, Auxiliadora Mazuecos, Juan Manuel Cazorla, Manuel Carnerero Di Riso, Shaira Martinez, Mayra Ortega Diaz, Rafael Lucena Valverde, Maria Gabriela Sanchez Marquez, Carolina Lancho Novillo, Emilio Gonzalez Parra, Carolina Gracia-Iguacel, Maria Teresa Rodrigo De Tomas, Maria Cinta Aguilar Cervera, Martin Giorgi, Patricia Munoz Ramos, Nicolas Macias Carmona, Nestor Toapanta, Secundino Cigarran, Juan Carlos Ruiz San Millan, Raquel Santana Estupinan, Marta Crespo, Blanca Villacorta Linaza, Maria Isabel Jimeno Martin, Laura Rodriguez-Osorio Jimenez, Sagrario Soriano, Dione Gonzalez Ferri, Maria Soledad Pizarro Sanchez, Alejandra Yugueros, Alba Leyva, Jose Rojas, Ron T. Gansevoort, Patricia de Sequera
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Allergy
Aranzazu Rodriguez-Sanz, Rafael Sanchez-Villanueva, Javier Dominguez-Ortega, Laura Alvarez, Ana Fiandor, Pilar Nozal, Paloma Sanz, Maria-Soledad Pizarro-Sanchez, Elena Andres, Antonio Cabezas, Alejandro Perez-Alba, M. Auxiliadora Bajo, Rafael Selgas, Teresa Bellon
Summary: By analyzing clinical and laboratory data, this study characterized hypersensitivity reactions to polysulfone hemodialysis and identified various endotypes, along with suitable biomarkers. Further research is needed to unravel the exact mechanisms involved in these reactions.
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Teresa Bellon, Olga Gonzalez-Valle, Elena Sendagorta, Victoria Lerma, Javier Martinez Del Rio, Celia Martinez, Guillermo Servera, Carlos Gonzalez-Herrada, Lucia Cachafeiro, Jose A. Lorente, Rosario Cabanas, Pedro Herranz, Francisco de Abajo
Summary: This study found a positive correlation between IL-15 serum levels and the percentage of detached skin in SJS/TEN patients. Higher expression levels of IL-15 and IL-15RA genes were found in affected skin. The results suggest that the effects of IL-15 in SJS/TEN patients may be dependent on the expression of its private receptor IL-15R alpha in affected skin.
Article
Allergy
Rosario Cabanas, Elena Ramirez, Teresa Bellon
Summary: Identifying culprit drugs in SCARs is a complex task, but a safe approach involves combining causality algorithms, LTT, and skin tests.
CURRENT TREATMENT OPTIONS IN ALLERGY
(2021)