Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances

Performance Characteristics of Commercial Immunoassays for the Detection of IgG and IgM Antibodies to β2Glycoprotein I and an Initial Assessment of Newly Developed Reference Materials for Assay Calibration

(2016) Rohan Willis et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Complement and thrombosis in the antiphospholipid syndrome

(2016) Kenji Oku et al.   AUTOIMMUNITY REVIEWS

Clinical significance and correlations between anti-β2 glycoprotein I IgA assays in antiphospholipid syndrome and/or systemic lupus erythematosus

(2016) Anne E. Tebo et al.   CLINICA CHIMICA ACTA

‘Non-Criteria’ Neurologic Manifestations of Antiphospholipid Syndrome: A Hidden Kingdom to be Discovered

(2016) Md. Islam et al.   CNS & Neurological Disorders-Drug Targets

Complement inhibition by hydroxychloroquine prevents placental and fetal brain abnormalities in antiphospholipid syndrome

(2016) Maria Laura Bertolaccini et al.   JOURNAL OF AUTOIMMUNITY

Role of anti-domain 1-β2 glycoprotein I antibodies in the diagnosis and risk stratification of antiphospholipid syndrome

(2016) A.-S. De Craemer et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The IgG and IgM isotypes of anti-annexin A5 antibodies: relevance for primary antiphospholipid syndrome

(2016) Mirjana Bećarević   JOURNAL OF THROMBOSIS AND THROMBOLYSIS

Lupus, antiphospholipid syndrome and epilepsy: an update

(2016) A Rosati et al.   LUPUS

Hughes syndrome and epilepsy: when to test for antiphospholipid antibodies?

(2016) M H A Noureldine et al.   LUPUS

Systematic review of case reports of antiphospholipid syndrome following infection

(2016) N Abdel-Wahab et al.   LUPUS

Evaluation of phosphatidylserine-dependent antiprothrombin antibody testing for the diagnosis of antiphospholipid syndrome: results of an international multicentre study

(2016) O Amengual et al.   LUPUS

A unique antiphospholipid assay recognizing phospholipid mixture compared with criteria antiphospholipid immunoassays in lupus patients

(2016) Y Zuo et al.   LUPUS

Autoantibodies to domain 1 of beta 2 glycoprotein I determined using a novel chemiluminescence immunoassay demonstrate association with thrombosis in patients with antiphospholipid syndrome

(2016) M Mahler et al.   LUPUS

Anti-beta-2 glycoprotein I epitope specificity: from experimental models to diagnostic tools

(2016) P L Meroni   LUPUS

Measuring IgA Anti-β2-Glycoprotein I and IgG/IgA Anti-Domain I Antibodies Adds Value to Current Serological Assays for the Antiphospholipid Syndrome

(2016) Charis Pericleous et al.   PLoS One

Functional Magnetic Resonance Imaging of Working Memory and Executive Dysfunction in Systemic Lupus Erythematosus and Antiphospholipid Antibody-Positive Patients

(2016) E. Kozora et al.   ARTHRITIS CARE & RESEARCH

Antiglutamate Receptor Antibodies and Cognitive Impairment in Primary Antiphospholipid Syndrome and Systemic Lupus Erythematosus

(2016) Maria Gerosa et al.   Frontiers in Immunology

Chronic inflammation of the placenta: definition, classification, pathogenesis, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The relevance of “non-criteria” clinical manifestations of antiphospholipid syndrome: 14th International Congress on Antiphospholipid Antibodies Technical Task Force Report on Antiphospholipid Syndrome Clinical Features

(2015) Mirhelen M. Abreu et al.   AUTOIMMUNITY REVIEWS

Complement activation in antiphospholipid syndrome and its inhibition to prevent rethrombosis after arterial surgery

(2015) P. L. Meroni et al.   BLOOD

Factor H Autoantibodies in Patients with Antiphospholipid Syndrome and Thrombosis

(2015) A. Foltyn Zadura et al.   JOURNAL OF RHEUMATOLOGY

AKT/mTORC pathway in antiphospholipid-related vasculopathy: a new player in the game

(2015) G Canaud et al.   LUPUS

Development and initial validation of a damage index (DIAPS) in patients with thrombotic antiphospholipid syndrome (APS)

(2015) M-C Amigo et al.   LUPUS

Current treatment of antiphospholipid syndrome: lights and shadows

(2015) Gerard Espinosa et al.   Nature Reviews Rheumatology

A case of relapsing and refractory catastrophic anti-phospholipid syndrome successfully managed with eculizumab, a complement 5 inhibitor

(2015) Surabhi Wig et al.   RHEUMATOLOGY

Antiphospholipid Syndrome and the Kidney

(2015) Savino Sciascia et al.   SEMINARS IN NEPHROLOGY

Neuropsychiatric presentations of antiphospholipid antibodies

(2015) Jean-Christophe Gris et al.   THROMBOSIS RESEARCH

Distinctions Between Diagnostic and Classification Criteria?

(2015) Rohit Aggarwal et al.   ARTHRITIS CARE & RESEARCH

Clinical Characterization of Antiphospholipid Syndrome by Detection of IgG Antibodies Against β2-Glycoprotein I Domain 1 and Domain 4/5: Ratio of Anti-Domain 1 to Anti-Domain 4/5 As a Useful New Biomarker for Antiphospholipid Syndrome

(2015) Laura Andreoli et al.   Arthritis & Rheumatology

“New” Antigenic Targets and Methodological Approaches for Refining Laboratory Diagnosis of Antiphospholipid Syndrome

(2015) Roberta Misasi et al.   Journal of Immunology Research

IgA Antiphospholipid Antibodies and Anti-Domain 1 of Beta 2 Glycoprotein 1 Antibodies are Associated with Livedo Reticularis and Heart Valve Disease in Antiphospholipid Syndrome

(2015) Marek Cieśla et al.   Advances in Clinical and Experimental Medicine

Eculizumab Prevents Recurrent Antiphospholipid Antibody Syndrome and Enables Successful Renal Transplantation

(2014) B. E. Lonze et al.   AMERICAN JOURNAL OF TRANSPLANTATION

AB0393 Comparison of multi-line dot assay and enzyme-linked immunosorbent assay for detection of autoantibody profile in antiphospholipid syndrome

(2014) E. Alexandrova et al.   ANNALS OF THE RHEUMATIC DISEASES

Antibodies to domain I of β-2-glycoprotein I and IgA antiphospholipid antibodies in patients with ‘seronegative’ antiphospholipid syndrome

(2014) Laura Cousins et al.   ANNALS OF THE RHEUMATIC DISEASES

The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review

(2014) Savino Sciascia et al.   ANNALS OF THE RHEUMATIC DISEASES

Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicentre prospective study of 1000 patients

(2014) R Cervera et al.   ANNALS OF THE RHEUMATIC DISEASES

14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

(2014) Maria Laura Bertolaccini et al.   AUTOIMMUNITY REVIEWS

Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome

(2014) V. M. Ripoll et al.   BLOOD

A non-complement-fixing antibody to  2 glycoprotein I as a novel therapy for antiphospholipid syndrome

(2014) C. Agostinis et al.   BLOOD

IgA anticardiolipin and IgA anti-β2 glycoprotein I antibody positivity determined by fluorescence enzyme immunoassay in primary antiphospholipid syndrome

(2014) Elena Mattia et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Targeted therapy in antiphospholipid syndrome

(2014) Savino Sciascia et al.   CURRENT OPINION IN RHEUMATOLOGY

Autoantibodies involved in neuropsychiatric manifestations associated with systemic lupus erythematosus: a systematic review

(2014) Savino Sciascia et al.   JOURNAL OF NEUROLOGY

Domain I: the hidden face of antiphospholipid syndrome

(2014) C Pericleous et al.   LUPUS

International standards for IgG and IgM anti-β2glycoprotein antibody measurement

(2014) R Willis et al.   LUPUS

Antibodies to phosphatidylserine/prothrombin complex and the antiphospholipid syndrome

(2014) S Sciascia et al.   LUPUS

An independent validation of the Global Anti-Phospholipid Syndrome Score in a Japanese cohort of patients with autoimmune diseases

(2014) K Oku et al.   LUPUS

What do we know about the cardiac valve lesion in the antiphospholipid syndrome (APS)?

(2014) M-C Amigo   LUPUS

Efficacy of Eculizumab in a Patient With Immunoadsorption-Dependent Catastrophic Antiphospholipid Syndrome

(2014) Andreas Kronbichler et al.   MEDICINE

Renal involvement in antiphospholipid syndrome

(2014) Savino Sciascia et al.   Nature Reviews Nephrology

Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome

(2014) Guillaume Canaud et al.   NEW ENGLAND JOURNAL OF MEDICINE

Platelet Activation and Anti-Phospholipid Antibodies Collaborate in the Activation of the Complement System on Platelets in Systemic Lupus Erythematosus

(2014) Christian Lood et al.   PLoS One

Syndrome des antiphospholides « séronégatif », syndrome catastrophique, nouveaux anticoagulants : enseignements d’une observation de prise en charge difficile

(2014) F. Joalland et al.   REVUE DE MEDECINE INTERNE

The global anti-phospholipid syndrome score in primary APS

(2014) Savino Sciascia et al.   RHEUMATOLOGY

Contribution of anti-β2glycoprotein I IgA antibodies to the diagnosis of anti-phospholipid syndrome: potential interest of target domains to discriminate thrombotic and non-thrombotic patients

(2014) Laura Despierres et al.   RHEUMATOLOGY

Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of  2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis

(2014) C. Pericleous et al.   RHEUMATOLOGY

Thrombotic Risk Assessment in Systemic Lupus Erythematosus: Validation of the Global Antiphospholipid Syndrome Score in a Prospective Cohort

(2014) Savino Sciascia et al.   ARTHRITIS CARE & RESEARCH

Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

(2014) Pier Meroni et al.   ARTHRITIS RESEARCH & THERAPY

New Tests to Detect Antiphospholipid Antibodies: Anti-Domain I Beta-2-Glycoprotein-I Antibodies

(2014) Cecilia Beatrice Chighizola et al.   Current Rheumatology Reports

New Tests to Detect Antiphospholipid Antibodies: Antiprothrombin (aPT) and Anti-Phosphatidylserine/Prothrombin (aPS/PT) Antibodies

(2014) Savino Sciascia et al.   Current Rheumatology Reports

The Mosaic of “Seronegative” Antiphospholipid Syndrome

(2014) Fabrizio Conti et al.   Journal of Immunology Research

Eculizumab Improves Posttransplant Thrombotic Microangiopathy Due to Antiphospholipid Syndrome Recurrence but Fails to Prevent Chronic Vascular Changes

(2013) G. Canaud et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Heterogeneity between Diagnostic Tests for IgA anti-Beta2 Glycoprotein I: Explaining the Controversy in Studies of Association with Vascular Pathology

(2013) José A. Martínez-Flores et al.   ANALYTICAL CHEMISTRY

Value of Isolated IgA Anti-β2-Glycoprotein I Positivity in the Diagnosis of the Antiphospholipid Syndrome

(2013) Vijaya Murthy et al.   ARTHRITIS AND RHEUMATISM

Variability and diagnostic utility of antiphospholipid antibodies including lupus anticoagulants

(2013) E. J. Favaloro   International Journal of Laboratory Hematology

Standardization of autoantibody testing: a paradigm for serology in rheumatic diseases

(2013) Pier Luigi Meroni et al.   Nature Reviews Rheumatology

The Pathogenesis of the Antiphospholipid Syndrome

(2013) Bill Giannakopoulos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Terminal Complement Inhibitor Eculizumab in Atypical Hemolytic–Uremic Syndrome

(2013) C.M. Legendre et al.   NEW ENGLAND JOURNAL OF MEDICINE

Essential role of the p38 mitogen-activated protein kinase pathway in tissue factor gene expression mediated by the phosphatidylserine-dependent antiprothrombin antibody

(2013) Kenji Oku et al.   RHEUMATOLOGY

Seronegative antiphospholipid syndrome

(2013) R. Nayfe et al.   RHEUMATOLOGY

GAPSS: the Global Anti-Phospholipid Syndrome Score

(2013) S. Sciascia et al.   RHEUMATOLOGY

Coagulation and Brain

(2013) Jean-Christophe Gris et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Anti-prothrombin (aPT) and anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and the risk of thrombosis in the antiphospholipid syndrome

(2013) Savino Sciascia et al.   THROMBOSIS AND HAEMOSTASIS

Clinical Significance of IgA Anti-Cardiolipin and IgA Anti-β2Glycoprotein I Antibodies

(2013) Laura Andreoli et al.   Current Rheumatology Reports

Valvular Heart Disease in Antiphospholipid Syndrome

(2013) Stéphane Zuily et al.   Current Rheumatology Reports

The clinical relevance of IgA anticardiolipin and IgA anti-β2 glycoprotein I antiphospholipid antibodies

(2012) Hector Meijide et al.   AUTOIMMUNITY REVIEWS

8-Isoprostane, prostaglandin E2, C-reactive protein and serum amyloid A as markers of inflammation and oxidative stress in antiphospholipid syndrome: a pilot study

(2012) Savino Sciascia et al.   INFLAMMATION RESEARCH

Performance of two new, automated chemiluminescence assay panels for anticardiolipin and anti-beta2-glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome

(2012) F. Van Hoecke et al.   International Journal of Laboratory Hematology

Detection of antiphospholipid antibodies by automated chemiluminescence assay

(2012) Antonella Capozzi et al.   JOURNAL OF IMMUNOLOGICAL METHODS

What Have We Learned about Antiphospholipid Syndrome from Patients and Antiphospholipid Carrier Cohorts?

(2012) Vittorio Pengo et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Prevalence of antibodies to prothrombin in solid phase (aPT) and to phosphatidylserine-prothrombin complex (aPS/PT) in patients with and without lupus anticoagulant

(2012) Savino Sciascia et al.   THROMBOSIS AND HAEMOSTASIS

Eculizumab in Acute Recurrence of Thrombotic Microangiopathy After Renal Transplantation

(2011) K. Hadaya et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called ‘seronegative APS’)

(2011) Jose Luis Rodriguez-Garcia et al.   ANNALS OF THE RHEUMATIC DISEASES

Autoantibodies as biomarkers for the prediction of neuropsychiatric events in systemic lupus erythematosus

(2011) J. G. Hanly et al.   ANNALS OF THE RHEUMATIC DISEASES

Risk Scale for the diagnosis of antiphospholipid syndrome

(2011) S. Sciascia et al.   ANNALS OF THE RHEUMATIC DISEASES

Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitope

(2011) Bas de Laat et al.   ARTHRITIS AND RHEUMATISM

Efficacy of the antiphospholipid score for the diagnosis of antiphospholipid syndrome and its predictive value for thrombotic events

(2011) Kotaro Otomo et al.   ARTHRITIS AND RHEUMATISM

In vivo distribution of  2 glycoprotein I under various pathophysiologic conditions

(2011) C. Agostinis et al.   BLOOD

 2-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator

(2011) K. Gropp et al.   BLOOD

Thin-layer chromatography immunostaining in detecting anti-phospholipid antibodies in seronegative anti-phospholipid syndrome

(2011) F. Conti et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Evaluation of a new set of automated chemiluminescense assays for anticardiolipin and anti-beta2-glycoprotein I antibodies in the laboratory diagnosis of the antiphospholipid syndrome

(2011) Lies Persijn et al.   THROMBOSIS RESEARCH

Single-step autoantibody profiling in antiphospholipid syndrome using a multi-line dot assay

(2011) Karl Egerer et al.   ARTHRITIS RESEARCH & THERAPY

Severe Vascular Lesions and Poor Functional Outcome in Kidney Transplant Recipients with Lupus Anticoagulant Antibodies

(2010) G. Canaud et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome

(2010) E. Ortona et al.   BLOOD

Analytical and clinical performance of a new, automated assay panel for the diagnosis of antiphospholipid syndrome

(2010) P. DE MOERLOOSE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Antiphospholipid syndrome

(2010) Guillermo Ruiz-Irastorza et al.   LANCET

Seronegative Autoimmune Diseases

(2009) Cristiano Alessandri et al.   Annals of the New York Academy of Sciences

Profiling of rheumatoid arthritis associated autoantibodies

(2009) Karsten Conrad et al.   AUTOIMMUNITY REVIEWS

Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome

(2009) Katrien Devreese et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Update of the guidelines for lupus anticoagulant detection

(2009) V. PENGO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

In vivoinhibition of antiphospholipid antibody-induced pathogenicity utilizing the antigenic target peptide domain I of β2-glycoprotein I: proof of concept

(2009) Y. IOANNOU et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The association between circulating antibodies against domain I of beta2-glycoprotein I and thrombosis: an international multicenter study

(2009) B. DE LAAT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies

(2009) EIB Peerschke et al.   LUPUS

Complement activation in patients with primary antiphospholipid syndrome

(2008) K Oku et al.   ANNALS OF THE RHEUMATIC DISEASES