Schwann cell interactions with axons and microvessels in diabetic neuropathy

In vivo evidence of reduced nodal and paranodal conductances in type 1 diabetes

(2016) Natalie C.G. Kwai et al.   CLINICAL NEUROPHYSIOLOGY

Gender-specific differences in diabetic neuropathy in BTBR ob/ob mice

(2016) Phillipe D. O’Brien et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Effects of High Glucose on Cell Viability and Differentiation in Primary Cultured Schwann Cells: Potential Role of ERK Signaling Pathway

(2016) Di Liu et al.   NEUROCHEMICAL RESEARCH

Insulin influenced expression of myelin proteins in diabetic peripheral neuropathy

(2016) Kuruvanthe S. Rachana et al.   NEUROSCIENCE LETTERS

The Effects of Capillary Transit Time Heterogeneity (CTH) on the Cerebral Uptake of Glucose and Glucose Analogs: Application to FDG and Comparison to Oxygen Uptake

(2016) Hugo Angleys et al.   Frontiers in Computational Neuroscience

p75 Neurotrophin Receptor Regulates Energy Balance in Obesity

(2016) Bernat Baeza-Raja et al.   Cell Reports

LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia

(2016) Shuangmei Liu et al.   Molecular Brain

Modulating Molecular Chaperones Improves Mitochondrial Bioenergetics and Decreases the Inflammatory Transcriptome in Diabetic Sensory Neurons

(2015) Jiacheng Ma et al.   ACS Chemical Neuroscience

Impaired Hedgehog signalling-induced endothelial dysfunction is sufficient to induce neuropathy: implication in diabetes

(2015) Candice Chapouly et al.   CARDIOVASCULAR RESEARCH

Macrophage-Induced Blood Vessels Guide Schwann Cell-Mediated Regeneration of Peripheral Nerves

(2015) Anne-Laure Cattin et al.   CELL

Mitochondrial Dysfunction in Diabetic Neuropathy: a Series of Unfortunate Metabolic Events

(2015) Paul Fernyhough   Current Diabetes Reports

GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop

(2015) Ferdinando Giacco et al.   DIABETES

The proinflammatory cytokine, interleukin-17A, augments mitochondrial function and neurite outgrowth of cultured adult sensory neurons derived from normal and diabetic rats

(2015) Tarek Habash et al.   EXPERIMENTAL NEUROLOGY

Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation

(2015) Wu Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proinflammatory Proteins S100A8/S100A9 Activate NK Cells via Interaction with RAGE

(2015) Kenta Narumi et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy of ranirestat in patients with mild-to-moderate diabetic sensorimotor polyneuropathy

(2015) Michael Polydefkis et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

The p75 neurotrophin receptor: at the crossroad of neural repair and death

(2015) RickB Meeker et al.   Neural Regeneration Research

Peripheral neuron plasticity is enhanced by brief electrical stimulation and overrides attenuated regrowth in experimental diabetes

(2015) B. Singh et al.   NEUROBIOLOGY OF DISEASE

BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses

(2015) Phillipe D. O'Brien et al.   NEUROBIOLOGY OF DISEASE

Diabetes and the plasticity of sensory neurons

(2015) Douglas W. Zochodne   NEUROSCIENCE LETTERS

The Role of Oxidative Stress in Diabetic Neuropathy: Generation of Free Radical Species in the Glycation Reaction and Gene Polymorphisms Encoding Antioxidant Enzymes to Genetic Susceptibility to Diabetic Neuropathy in Population of Type I Diabetic Patients

(2014) Mark A. Babizhayev et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Standard and Emerging Treatment Options for Diabetic Neuropathy

(2014) Nicholas Tentolouris et al.   CURRENT PHARMACEUTICAL DESIGN

The effects of capillary dysfunction on oxygen and glucose extraction in diabetic neuropathy

(2014) Leif Østergaard et al.   DIABETOLOGIA

Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents

(2014) Menachem Hanani et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Changes in the Basal Membrane of Dorsal Root Ganglia Schwann Cells Explain the Biphasic Pattern of the Peripheral Neuropathy in Streptozotocin-Induced Diabetic Rats

(2014) Maria Becker et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Allodynia and hyperalgesia in neuropathic pain: clinical manifestations and mechanisms

(2014) Troels S Jensen et al.   LANCET NEUROLOGY

Peripheral Nerve Injury Modulates Neurotrophin Signaling in the Peripheral and Central Nervous System

(2014) Mette Richner et al.   MOLECULAR NEUROBIOLOGY

Regulating excitability of peripheral afferents: emerging ion channel targets

(2014) Stephen G Waxman et al.   NATURE NEUROSCIENCE

Metabolic regulator LKB1 is crucial for Schwann cell–mediated axon maintenance

(2014) Bogdan Beirowski et al.   NATURE NEUROSCIENCE

Does the epidermal nerve fibre density measured by skin biopsy in patients with peripheral neuropathies correlate with neuropathic pain?

(2014) A. Truini et al.   PAIN

Fuzi Attenuates Diabetic Neuropathy in Rats and Protects Schwann Cells from Apoptosis Induced by High Glucose

(2014) Jing Han et al.   PLoS One

TLR4 Activation Promotes Podocyte Injury and Interstitial Fibrosis in Diabetic Nephropathy

(2014) Jin Ma et al.   PLoS One

Neutralization of Schwann Cell-Secreted VEGF Is Protective to In Vitro and In Vivo Experimental Diabetic Neuropathy

(2014) Michela M. Taiana et al.   PLoS One

Channelopathies, painful neuropathy, and diabetes: which way does the causal arrow point?

(2014) Janneke G.J. Hoeijmakers et al.   TRENDS IN MOLECULAR MEDICINE

Painful diabetic neuropathy

(2014) A. Peltier et al.   BMJ-British Medical Journal

Long-Chain Acyl Coenzyme A Synthetase 1 Overexpression in Primary Cultured Schwann Cells Prevents Long Chain Fatty Acid-Induced Oxidative Stress and Mitochondrial Dysfunction

(2013) Lucy M. Hinder et al.   ANTIOXIDANTS & REDOX SIGNALING

CD8+T Cell-Mediated Cytotoxicity toward Schwann Cells Promotes Diabetic Peripheral Neuropathy

(2013) Wei Tang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neurovascular Function and Sudorimetry in Health and Disease

(2013) Aaron I. Vinik et al.   Current Diabetes Reports

Aldose Reductase Drives Hyperacetylation of Egr-1 in Hyperglycemia and Consequent Upregulation of Proinflammatory and Prothrombotic Signals

(2013) S. Vedantham et al.   DIABETES

Mechanisms and Management of Diabetic Painful Distal Symmetrical Polyneuropathy

(2013) Solomon Tesfaye et al.   DIABETES CARE

Glucose-Induced Metabolic Memory in Schwann Cells: Prevention by PPAR Agonists

(2013) Esther S. Kim et al.   ENDOCRINOLOGY

The Rho-kinase inhibitor fasudil restores normal motor nerve conduction velocity in diabetic rats by assuring the proper localization of adhesion-related molecules in myelinating Schwann cells

(2013) Yasushi Kanazawa et al.   EXPERIMENTAL NEUROLOGY

Diabetic Schwann cells suffer from nerve growth factor and neurotrophin-3 underproduction and poor associability with axons

(2013) Indranil Dey et al.   GLIA

Communication between neuronal somata and satellite glial cells in sensory ganglia

(2013) Li-Yen M. Huang et al.   GLIA

Curcumin Attenuates Diabetic Neuropathic Pain by Downregulating TNF-α in a Rat Model

(2013) Yue Li et al.   International Journal of Medical Sciences

Advances in peripheral nerve regeneration

(2013) Jami Scheib et al.   Nature Reviews Neurology

Reappraising neuropathic pain in humans—how symptoms help disclose mechanisms

(2013) Andrea Truini et al.   Nature Reviews Neurology

The neuroinflammatory role of Schwann cells in disease

(2013) Elke Ydens et al.   NEUROBIOLOGY OF DISEASE

Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy

(2013) Andreu Viader et al.   NEURON

Chronic Pain with Neuropathic Characteristics in Diabetic Patients: A French Cross-Sectional Study

(2013) Didier Bouhassira et al.   PLoS One

Proteome analysis reveals antiangiogenic environments in chronic wounds of diabetes mellitus type 2 patients

(2013) Christoph Krisp et al.   PROTEOMICS

Novel pathogenic pathways in diabetic neuropathy

(2013) Jennifer Zenker et al.   TRENDS IN NEUROSCIENCES

Peripheral nervous system insulin resistance in ob/ob mice

(2013) Caleb W Grote et al.   Acta Neuropathologica Communications

Hypertension-induced peripheral neuropathy and the combined effects of hypertension and diabetes on nerve structure and function in rats

(2012) Joshua A. Gregory et al.   ACTA NEUROPATHOLOGICA

Interplay of sorbitol pathway of glucose metabolism, 12/15-lipoxygenase, and mitogen-activated protein kinases in the pathogenesis of diabetic peripheral neuropathy

(2012) Roman Stavniichuk et al.   BIOCHEMICAL PHARMACOLOGY

Impaired adenosine monophosphate-activated protein kinase signalling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and peripheral neuropathy in diabetes

(2012) Subir K. Roy Chowdhury et al.   BRAIN

Diabetic neuropathy

(2012) Brian C. Callaghan et al.   CURRENT OPINION IN NEUROLOGY

Peripheral nociceptor sensitization mediates allodynia in patients with distal symmetric polyneuropathy

(2012) A. Truini et al.   JOURNAL OF NEUROLOGY

NADPH Oxidase-4 Maintains Neuropathic Pain after Peripheral Nerve Injury

(2012) W. Kallenborn-Gerhardt et al.   JOURNAL OF NEUROSCIENCE

p38 MAPK Activation Promotes Denervated Schwann Cell Phenotype and Functions as a Negative Regulator of Schwann Cell Differentiation and Myelination

(2012) D. P. Yang et al.   JOURNAL OF NEUROSCIENCE

Diabetic neuropathy: clinical manifestations and current treatments

(2012) Brian C Callaghan et al.   LANCET NEUROLOGY

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

The role of aberrant mitochondrial bioenergetics in diabetic neuropathy

(2012) Subir K. Roy Chowdhury et al.   NEUROBIOLOGY OF DISEASE

A Central Role for the ERK-Signaling Pathway in Controlling Schwann Cell Plasticity and Peripheral Nerve Regeneration In Vivo

(2012) Ilaria Napoli et al.   NEURON

Developmental regulation of insulin receptor gene in sciatic nerves and role of insulin on glycoprotein P0 in the Schwann cells

(2012) Abhijith Shettar et al.   PEPTIDES

Impaired neurovascular repair in subjects with diabetes following experimental intracutaneous axotomy

(2011) G. J. Ebenezer et al.   BRAIN

Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K.

(2011) C. A. Abbott et al.   DIABETES CARE

Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells

(2011) Trevor Askwith et al.   EXPERIMENTAL NEUROLOGY

Hypoxia-inducible factor 1 mediates increased expression of NADPH oxidase-2 in response to intermittent hypoxia

(2011) Guoxiang Yuan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Diabetes-induced myelin abnormalities are associated with an altered lipid pattern: protective effects of LXR activation

(2011) Gaia Cermenati et al.   JOURNAL OF LIPID RESEARCH

Impaired sensory nerve function and axon morphology in mice with diabetic neuropathy

(2011) Richard C. Lennertz et al.   JOURNAL OF NEUROPHYSIOLOGY

Schwann Cell Mitochondrial Metabolism Supports Long-Term Axonal Survival and Peripheral Nerve Function

(2011) A. Viader et al.   JOURNAL OF NEUROSCIENCE

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Local insulin and the rapid regrowth of diabetic epidermal axons

(2011) GuiFang Guo et al.   NEUROBIOLOGY OF DISEASE

Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

(2011) Hsinlin T. Cheng et al.   NEUROBIOLOGY OF DISEASE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Global Inhibition of Reactive Oxygen Species (ROS) Inhibits Paclitaxel-Induced Painful Peripheral Neuropathy

(2011) Mehmet Fidanboylu et al.   PLoS One

Neuronal Growth Cone Retraction Relies on Proneurotrophin Receptor Signaling Through Rac

(2011) K. Deinhardt et al.   Science Signaling

Lipotoxicity-mediated cell dysfunction and death involve lysosomal membrane permeabilization and cathepsin L activity

(2010) Frankis G. Almaguel et al.   BRAIN RESEARCH

Increased susceptibility to ischemia and macrophage activation in STZ-diabetic rat nerve

(2010) Hitoshi Nukada et al.   BRAIN RESEARCH

Hyperglycemia magnifies Schwann cell dysfunction and cell death triggered by PA-induced lipotoxicity

(2010) Amelia Padilla et al.   BRAIN RESEARCH

Diminished Superoxide Generation Is Associated With Respiratory Chain Dysfunction and Changes in the Mitochondrial Proteome of Sensory Neurons From Diabetic Rats

(2010) E. Akude et al.   DIABETES

Mitochondrial Respiratory Chain Dysfunction in Dorsal Root Ganglia of Streptozotocin-Induced Diabetic Rats and Its Correction by Insulin Treatment

(2010) S. K. R. Chowdhury et al.   DIABETES

New Therapeutic and Biomarker Discovery for Peripheral Diabetic Neuropathy: PARP Inhibitor, Nitrotyrosine, and Tumor Necrosis Factor-α

(2010) Viktor R. Drel et al.   ENDOCRINOLOGY

Chronic blockade of interleukin-1 (IL-1) prevents and attenuates neuropathic pain behavior and spontaneous ectopic neuronal activity following nerve injury

(2010) Eran Gabayl et al.   EUROPEAN JOURNAL OF PAIN

Toll-like receptor expression in the peripheral nerve

(2010) Sofie Goethals et al.   GLIA

RAGE-TXNIP axis is required for S100B-promoted Schwann cell migration, fibronectin expression and cytokine secretion

(2010) O. Sbai et al.   JOURNAL OF CELL SCIENCE

Interleukin-17 Contributes to Neuroinflammation and Neuropathic Pain Following Peripheral Nerve Injury in Mice

(2010) Cristina Fabiola Kim et al.   JOURNAL OF PAIN

Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not

(2010) Vassiliki Nikoletopoulou et al.   NATURE

PPARα: an emerging therapeutic target in diabetic microvascular damage

(2010) Anne Hiukka et al.   Nature Reviews Endocrinology

NF-κB subunits are differentially distributed in cells of lumbar dorsal root ganglia in naïve and diabetic rats

(2010) L.N. Berti-Mattera et al.   NEUROSCIENCE LETTERS

Mechanism of diabetic neuropathy: Where are we now and where to go?

(2010) Soroku Yagihashi et al.   Journal of Diabetes Investigation

Expression of neurotrophic factors in diabetic muscle--relation to neuropathy and muscle strength

(2009) C. S. Andreassen et al.   BRAIN

Abnormal calcium homeostasis in peripheral neuropathies

(2009) Paul Fernyhough et al.   CELL CALCIUM

S100A8/A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3

(2009) Saeid Ghavami et al.   CELL RESEARCH

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Caveolin-1 and Altered Neuregulin Signaling Contribute to the Pathophysiological Progression of Diabetic Peripheral Neuropathy

(2009) J. F. McGuire et al.   DIABETES

Dyslipidemia-Induced Neuropathy in Mice: The Role of oxLDL/LOX-1

(2009) A. M. Vincent et al.   DIABETES

Subclinical Inflammation and Diabetic Polyneuropathy: MONICA/KORA Survey F3 (Augsburg, Germany)

(2009) C. Herder et al.   DIABETES CARE

Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors

(2009) Raheleh Masoudi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyperglycemia Alters the Schwann Cell Mitochondrial Proteome and Decreases Coupled Respiration in the Absence of Superoxide Production

(2009) Liang Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort

(2009) Rodica Pop-Busui et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Axonal ion channels from bench to bedside: A translational neuroscience perspective

(2009) Arun V. Krishnan et al.   PROGRESS IN NEUROBIOLOGY

Reduced NGF secretion by Schwann cells under the high glucose condition decreases neurite outgrowth of DRG neurons

(2008) Takahiro Tosaki et al.   EXPERIMENTAL NEUROLOGY

Hyperglycemia and downregulation of caveolin-1 enhance neuregulin-induced demyelination

(2008) Cuijuan Yu et al.   GLIA

Elevated lipid peroxidation and DNA oxidation in nerve from diabetic rats: effects of aldose reductase inhibition, insulin, and neurotrophic factors

(2008) Joice M. Cunha et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-κB pathways

(2007) Yingming Jiang et al.   MOLECULAR IMMUNOLOGY

Glucose neurotoxicity

(2007) David R. Tomlinson et al.   NATURE REVIEWS NEUROSCIENCE