期刊
NATURE REVIEWS MICROBIOLOGY
卷 15, 期 10, 页码 621-629出版社
NATURE RESEARCH
DOI: 10.1038/nrmicro.2017.66
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资金
- European Molecular Biology Organization (EMBO) Young Investigator Program
- VIDI fellowship from the Netherlands Organization for Scientific Research, Earth and Life Sciences (NWO-ALW) [864.12.001]
- European Research Council [337399-PneumoCell]
- Swiss Federal Institute of Technology Lausanne (EPFL)
- Swiss National Science Foundation [31003A_162551]
- Swiss National Science Foundation (NRP72 program) [407240_167061]
- European Research Council (ERC) [309064-VIR4ENV]
- Swiss National Science Foundation (SNF) [407240_167061, 31003A_162551] Funding Source: Swiss National Science Foundation (SNF)
Natural competence enables bacteria to take up exogenous DNA. The evolutionary function of natural competence remains controversial, as imported DNA can act as a source of substrates or can be integrated into the genome. Exogenous homologous DNA can also be used for genome repair. In this Opinion article, we propose that predation of non-related neighbouring bacteria coupled with competence regulation might function as an active strategy for DNA acquisition. Competence-dependent kin-discriminated killing has been observed in the unrelated bacteria Vibrio cholerae and Streptococcus pneumoniae. Importantly, both the regulatory networks and the mode of action of neighbour predation differ between these organisms, with V. cholerae using a type VI secretion system and S. pneumoniae secreting bacteriocins. We argue that the forced release of DNA from killed bacteria and the transfer of non-clonal genetic material have important roles in bacterial evolution.
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