Review
Plant Sciences
Francois Jobert, Sandeep Yadav, Stephanie Robert
Summary: Auxin is a plant growth regulator that modifies the mechanical properties of the cell wall by regulating the pectin composition. This review explores how auxin activity affects pectin chemistry at different levels and its impact on plant growth and development.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Chemistry, Multidisciplinary
Daniel Fu, John Reif
Summary: Structural DNA nanotechnology allows for the design and assembly of diverse DNA nanostructures with both static and dynamic properties, opening up possibilities for applications in medicine, biosensing, nanofabrication, and other interdisciplinary fields. This pioneering biotechnology has the potential to define and drive specific directions of progress in nanoscience applications.
APPLIED SCIENCES-BASEL
(2021)
Review
Cell Biology
Laura Maeso-Alonso, Lorena Lopez-Ferreras, Margarita M. Marques, Maria C. Marin
Summary: The TP73 gene, a member of the p53 family, plays a crucial role in regulating cell proliferation and cell death. Apart from its growth suppression effects, p73 is also involved in governing various aspects of tissue physiology. Acting as a tissue architect, p73 is essential for maintaining the organization and homeostasis of different complex microenvironments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Editorial Material
Clinical Neurology
Adrian Scutelnic, Aikaterini Galimanis, Michael Horn, Lidia Sabater, Niklaus Meier
Summary: There is a growing body of evidence linking anti-KLHL11 encephalitis with various tumors. However, early clinical evaluations may not consider the possibility of anti-KLHL11 encephalitis when the presence of a tumor is uncertain and the clinical syndrome resembles other causes. We present a case of a patient with clinical features of anti-KLHL11 encephalitis, where no active tumor was found, but a burnt-out germ cell tumor was suspected. This highlights the importance of considering anti-KLHL11 encephalitis even in the absence of an active tumor.
Review
Biochemistry & Molecular Biology
Vincent Jean-Pierre, Agathe Boudet, Pauline Sorlin, Quentin Menetrey, Raphael Chiron, Jean-Philippe Lavigne, Helene Marchandin
Summary: Staphylococcus aureus is a major human pathogen that can survive and cause diseases in various clinical settings, including Cystic Fibrosis. In Cystic Fibrosis, S. aureus is the most commonly identified opportunistic pathogen, and its colonization/infection can become chronic in about one third of patients. S. aureus's ability to form biofilm is a crucial factor contributing to its persistence and protection in the lungs of CF patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Renee L. Hastings, Steven Boeynaems
Summary: Protein phase separation is a novel paradigm in cell biology that provides insights into how cells compartmentalize biochemical reactions and encode function in liquid-like assemblies. This understanding offers immense opportunities for designing and sculpting biological matter to create new functionalized materials and tools for synthetic biology. Studies suggest that designer condensates have potential applications in industry and medicine.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Xinyi Lv, Leichen Wang, Anqing Mei, Yan Xu, Xiaohong Ruan, Wenjun Wang, Jinjun Shao, Dongliang Yang, Xiaochen Dong
Summary: Bacterial biofilm-related infectious diseases have a severe impact on human health. The low permeability and enrichment of therapeutic agents within the biofilm pose a challenge for treatment. This article summarizes the current progress in nanotechnology methods to improve the penetrability of therapeutic agents and discusses the challenges and future implementations of engineered delivery systems to manage biofilm infections.
Review
Cell Biology
Anastassiia Vertii
Summary: The exponential development of methods investigating spatial genome organization at different levels has led to an appreciation of the chromatin landscape's role in gene regulation and cell fate. The 3D chromatin organization includes various levels such as loops, domains, euchromatin, heterochromatin, nuclear bodies, and chromosome territories, all of which are influenced by factors like cell division and stress. Understanding how stress exposure shapes the chromatin landscape is a new and fascinating area of research, motivating exploration in this field.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Mrinmoy Sarkar, Tristan Nguyen, Esheksha Gundre, Olajumoke Ogunlusi, Mohanad El-Sobky, Biplab Giri, Tapasree Roy Sarkar
Summary: Stromal heterogeneity of tumor microenvironment (TME) is crucial for malignancy and therapeutic resistance. Cancer-associated fibroblasts (CAFs) play a significant role in the tumor stroma, posing challenges to current therapies for breast cancer and other types of cancer. The positive feedback loop between CAFs and cancer cells contributes to the establishment of malignancy and reduces the efficacy of anti-cancer treatments. Understanding CAF-induced therapeutic resistance is important for improving cancer therapy outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Lee Marie Raytek, Mehran Dastmalchi
Summary: Perception and uptake of nitrate play a vital role in plant development. An existing transcription factor NLP7, known for its involvement in nitrate signaling, has been found to function as a nitrate sensor. This discovery has been utilized to create a fluorescent nitrate biosensor.
Article
Geosciences, Multidisciplinary
Xindi Chen, Changkuan Zhang, Ian H. Townend, David M. Paterson, Zheng Gong, Qin Jiang, Qian Feng, Xiping Yu
Summary: Cohesive extracellular polymeric substances (EPS) produced by microorganisms on Earth act as bed stabilizers in sedimentary systems, but under wave action they can lead to destabilization, increased sediment mobility, liquefaction, and mechanical oscillation. Understanding the role of EPS in seabed mobility is crucial for managing the vulnerability of coastal wetlands to waves.
GEOPHYSICAL RESEARCH LETTERS
(2021)
Article
Environmental Sciences
Aleksandra Hagberg, Shashank Gupta, Olena Rzhepishevska, Jerker Fick, Mette Burmolle, Madeleine Ramstedt
Summary: Low concentrations of pharmaceutical substances in the environment may have effects on biological systems, such as bacterial consortia living on riverbed substrates. A study conducted in Sweden found 19 different pharmaceuticals in water downstream from a sewage treatment plant, with differences observed in microbial composition between samples upstream and downstream.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Analytical
Noemi Poma, Federico Vivaldi, Andrea Bonini, Pietro Salvo, Arno Kirchhain, Zeliha Ates, Bernardo Melai, Daria Bottai, Arianna Tavanti, Fabio Di Francesco
Summary: Future strategies for detecting and monitoring biofilm formation in both industry and human health are crucial due to the negative impact of biofilms. Various electrochemical techniques including potentiometric, voltammetric, and impedance-based sensors are being used to provide an overview of biofilm detection and monitoring processes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Infectious Diseases
Kirti Upmanyu, Qazi Mohd. Haq, Ruchi Singh
Summary: The number of antibiotic-resistant Acinetobacter baumannii infections in hospital settings is increasing rapidly. The World Health Organization has identified carbapenem-resistant A. baumannii as a priority pathogen for drug discovery. In this study, we screened 400 compounds provided as a Pandemic Response Box to identify potential compounds with antibacterial and antibiofilm activity against A. baumannii. We found that compound MMV396785 showed promising in vitro efficacy against A. baumannii, inhibiting biofilm formation by 93% and eradicating pre-formed biofilms by 60-77.4%.
Article
Microbiology
Madita Brauer, Christian Lassek, Christian Hinze, Juliane Hoyer, Dorte Becher, Dieter Jahn, Susanne Sievers, Katharina Riedel
Summary: The anaerobic pathogen Clostridioides difficile is capable of forming highly resistant endospores in unfavorable conditions. A proteomics approach revealed significant differences in cell surface proteins and enzymes related to energy and stress metabolism in different forms of biofilm-like growth. The data also indicated the induction of the sigma factor SigL/RpoN in aggregate biofilms, suggesting its important role in biofilm formation.
FRONTIERS IN MICROBIOLOGY
(2021)
