Hyperactivation of HUSH complex function by Charcot–Marie–Tooth disease mutation in MORC2

MORC2mutations cause axonal Charcot-Marie-Tooth disease with pyramidal signs

(2016) Obaid M. Albulym et al.   ANNALS OF NEUROLOGY

Severe axonal Charcot-Marie-Tooth disease with proximal weakness caused byde novomutation in theMORC2gene

(2016) Petra Laššuthová et al.   BRAIN

MORC2 mutation causes severe spinal muscular atrophy-phenotype, cerebellar atrophy, and diaphragmatic paralysis

(2016) Gudrun Schottmann et al.   BRAIN

Clinico-genetics in Korean Charcot-Marie-Tooth disease type 2Z withMORC2mutations

(2016) Young Se Hyun et al.   BRAIN

MORC2mutations in a cohort of Chinese patients with Charcot–Marie–Tooth disease type 2

(2016) Xin Zhao et al.   BRAIN

Structure and Function of CW Domain Containing Proteins

(2016) Yanli Liu et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins

(2016) Yanli Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The landscape of accessible chromatin in mammalian preimplantation embryos

(2016) Jingyi Wu et al.   NATURE

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

An interactive environment for agile analysis and visualization of ChIP-sequencing data

(2016) Mads Lerdrup et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin

(2016) Sisi Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes

(2016) Justin S. Becker et al.   TRENDS IN GENETICS

Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens

(2016) Richard T. Timms et al.   Nature Communications

An interactive environment for agile analysis and visualization of ChIP-sequencing data

(2016) Mads Lerdrup et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex

(2016) Richard T. Timms et al.   Cell Reports

Mutations in theMORC2gene cause axonal Charcot–Marie–Tooth disease

(2015) Teresa Sevilla et al.   BRAIN

Genome-wide binding and mechanistic analyses of Smchd1-mediated epigenetic regulation

(2015) Kelan Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

(2015) I. A. Tchasovnikarova et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Chromosome boundary elements and regulation of heterochromatin spreading

(2014) Jiyong Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The first mouse mutants of D14Abb1e (Fam208a) show that it is critical for early development

(2014) Sarah K. Harten et al.   MAMMALIAN GENOME

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Molecular mechanisms of retroviral integration site selection

(2014) Mamuka Kvaratskhelia et al.   NUCLEIC ACIDS RESEARCH

MORC1 represses transposable elements in the mouse male germline

(2014) William A. Pastor et al.   Nature Communications

Chromatin Position Effects Assayed by Thousands of Reporters Integrated in Parallel

(2013) Waseem Akhtar et al.   CELL

The MORC family

(2013) Da-Qiang Li et al.   Epigenetics

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

(2013) Hiroko Koike-Yusa et al.   NATURE BIOTECHNOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing

(2012) G. Moissiard et al.   SCIENCE

MORC2 Signaling Integrates Phosphorylation-Dependent, ATPase-Coupled Chromatin Remodeling during the DNA Damage Response

(2012) Da-Qiang Li et al.   Cell Reports

Compaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge

(2011) D. J. Grau et al.   GENES & DEVELOPMENT

The Polycomb complex PRC2 and its mark in life

(2011) Raphaël Margueron et al.   NATURE

Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion

(2010) Kenji Kokura et al.   EMBO JOURNAL

The Biology of Chromatin Remodeling Complexes

(2009) Cedric R. Clapier et al.   Annual Review of Biochemistry

Periphilin is strongly expressed in the murine nervous system and is indispensable for murine development

(2009) Anne S. Soehn et al.   GENESIS

Haploid Genetic Screens in Human Cells Identify Host Factors Used by Pathogens

(2009) J. E. Carette et al.   SCIENCE