Review
Cell Biology
Yu'e Liu, Chao Chen, Xinye Wang, Yihong Sun, Jin Zhang, Juxiang Chen, Yufeng Shi
Summary: Mitochondria play a crucial role in both energy supply and regulation of key metabolites involved in epigenetic regulation. Tumorigenesis is influenced by gene mutations and the tumor microenvironment, with mitochondria and epigenetics being essential for tumor initiation, evolution, metastasis, and recurrence. Targeting mitochondrial metabolism and epigenetics holds promise for cancer treatment.
Review
Cell Biology
Sutong Xu, Xi Zhang, Chenming Liu, Qiulu Liu, Huazhen Chai, Yuping Luo, Siguang Li
Summary: Mitochondria play a crucial role in the epigenetic regulation of neurodegenerative diseases by impacting mitochondrial homeostasis through epigenetic modification of nuclear genes. Bidirectional communication between mitochondria and nucleus, mediated by intermediate metabolites, contributes to this regulation, while abnormal modification of mitochondrial DNA also plays a part in disease development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Physiology
Elizabeth R. Nunn, Abhijit B. Shinde, Elma Zaganjor
Summary: Obesity has negative effects on health, including metabolic syndrome, type II diabetes, insulin resistance, and various cancers. Understanding the mechanisms of adipose tissue expansion is important for developing therapeutic approaches.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Oncology
Elisabet Cuyas, Sara Verdura, Begona Martin-Castillo, Javier A. Menendez
Summary: Research suggests that the anti-diabetic drug metformin can modulate the chromatin state of cancer cells, affecting their function. Metformin has the ability to target global metabolic pathways or specific metabolic enzymes, regulating the production of chromatin-modifying metabolites, and indirectly or directly adjusting the activation status of chromatin-modifying enzymes.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Reema Singh, Ian G. Mills
Summary: Prostate cancer is a high-incidence cancer linked to increased mitochondrial metabolic activity. Genomic drivers such as the androgen receptor, c-Myc, PTEN, and p53 are associated with metabolic dysregulation and progression of prostate cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sanjit K. Dhar, Timothy Scott, Chi Wang, Teresa W. M. Fan, Daret K. St Clair
Summary: This study reveals the regulatory role of mitochondrial-generated superoxide radicals in gene expression and establishes a new paradigm that recognizes O2· as an initiator of metabolic reprogramming and epigenetic regulation in response to mitochondrial dysfunction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Anna Shteinfer-Kuzmine, Ankit Verma, Tasleem Arif, Or Aizenberg, Avijit Paul, Varda Shoshan-Barmaz
Summary: VDAC1 plays a central role in controlling energy production, cell growth, Ca2+ homeostasis, and apoptosis in tumor cells. Depletion of VDAC1 can inhibit tumor growth and affect tumor-associated processes and signaling pathways.
Article
Biochemistry & Molecular Biology
Nadine Abdel Hadi, Emeline Boet, Airelle Lahalle, Laura Lauture, Alice Refeyton, Gabriela Reyes-Castellanos, Nathalie Caplet, Alice Carrier, Laurent Le Cam, Nathalie M. Mazure, Jean-Ehrland Ricci, Stephane Rocchi, Jean-Emmanuel Sarry, Sophie Vasseur, Marija Vlaski-Lafarge, Rodrigue Rossignol, Frederic Bost
Summary: The 4th International Metabolism and Cancer meeting was originally scheduled to take place in Bordeaux, France, but was held virtually with around 600 participants from 47 countries attending daily. The meeting featured 21 speakers, including Nobel Prize winner Sir Peter J. Ratcliffe, and covered topics such as redox and energy metabolism, hypoxia, metabolic profiling, epigenetic control, signaling, and cancer metabolism. A summary of the scientific highlights of the event is provided in this report.
Article
Biochemistry & Molecular Biology
Karyn Robichaud, Paul M. Craig
Summary: Wastewater effluent is a stressor for aquatic organisms' metabolism. This study identified the presence of miRNA in darter mitochondria and predicted their role in regulating translation of mitochondrial genes. Experimental results confirmed the relationship between miRNA abundance and cytochrome c oxidase activity in darters.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Antonia Piazzesi, Yiru Wang, Joshua Jackson, Lena Wischhof, Viktoria Zeisler-Diehl, Enzo Scifo, Ina Oganezova, Thorben Hoffmann, Pablo Gomez Martin, Fabio Bertan, Chester J. J. Wrobel, Frank C. Schroeder, Dan Ehninger, Kristian Haendler, Joachim L. Schultze, Lukas Schreiber, Gerhild Van Echten-Deckert, Pierluigi Nicotera, Daniele Bano
Summary: Mitochondrial dysfunction can be influenced by enhanced metabolic flexibility, which can extend the lifespan of mitochondrial mutants. CEST-2.2, a carboxylesterase mainly localized in the intestine, has been found to stimulate the survival of mitochondrial deficient animals. Through transcriptome and lipidome analysis, it has been shown that CEST-2.2 promotes lipid metabolism and fatty acid beta-oxidation, enhancing the respiratory capacity of mitochondria and extending the lifespan of mutant nematodes.
Review
Psychology, Multidisciplinary
Marco Filippi, Rainer Kraehenmann, Patrick Fissler
Summary: This paper introduces energy-related sensations, including sensation of energy and fatigue, as well as subjective energizability and fatigability. It discusses whether these sensations are separate constructs or two ends of a single dimension. The paper then describes different components of the bodily energy metabolism system and reviews the link between sensation of fatigue and different components of energy metabolism. Finally, the paper provides an overview of different treatments affecting energy-related sensations and metabolism, and outlines future research perspectives.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Oncology
Kelsey L. McLaughlin, Margaret A. M. Nelson, Hannah S. Coalson, James T. Hagen, McLane M. Montgomery, Ashley R. Wooten, Tonya N. Zeczycki, Nasreen A. Vohra, Kelsey H. Fisher-Wellman
Summary: Hepatocellular carcinoma (HCC) is the most common form of liver cancer worldwide. Mitochondria play a central role in the malignant metabolic reprogramming in HCC, which may promote disease progression. Comprehensive evaluation of the mitochondrial phenotype in HCC revealed a significant decrease in CI-linked respiration and the ability of tumor mitochondria to retain calcium and generate membrane potential. However, acute treatment with an adenylate kinase inhibitor restored CI-linked respiration in tumor mitochondria.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Chloe D. Goldsmith, Thomasina Donovan, Nicole Vlahovich, David B. Pyne
Summary: This perspective article discusses how exercise can delay T cell ageing by analyzing the relationship between metabolism and epigenetics, proposing a potential impact of exercise on CD4+ T cell plasticity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jorge Beleza, Jelena Stevanovic-Silva, Pedro Coxito, Hugo Rocha, Paulo Santos, Antonio Ascensao, Joan Ramon Torrella, Jose Magalhaes
Summary: Mothers' strategies to improve the intrauterine environment can positively impact their offspring's performance and muscle biomarkers. Gestational exercise can modulate the effects of a high-fat, high-sucrose diet on male offspring, leading to increased workload performance and alterations in mitochondrial density and functional markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Anabela La Colla, Carolina Anahi Camara, Sabrina Campisano, Andrea Nancy Chisari
Summary: Early-life malnutrition has a critical impact on fetal development and can lead to metabolic diseases later in life. Imbalances in early nutrition have been associated with long-term metabolic disorders, affecting mitochondrial function and epigenetic mechanisms. Consequently, mitochondrial dysfunction, epigenetic alterations, and early-life nutrition are important contributing factors in the pathogenesis of NAFLD.
NUTRITION RESEARCH REVIEWS
(2022)
