期刊
NATURE CELL BIOLOGY
卷 19, 期 4, 页码 263-265出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3504
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- Grants-in-Aid for Scientific Research [16H01209, 26291044] Funding Source: KAKEN
Although the mitochondrial inner membrane rhomboid peptidase PARL is known to participate in critical signalling cascades, its role in apoptosis has remained unclear. PARL is now shown to process the mitochondrial pro-apoptotic protein Smac ( also known as DIABLO) for its subsequent release into the cytosol where it antagonizes XIAP-mediated caspase inhibition to promote apoptosis.
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